John H. Griffin

34.9k citations

559 papers · 27.6k indexed · 6 hit papers · h-index 90

Impact in

Hematology top 0.01%
- Blood Coagulation and Thrombosis Mechanisms
- Hemophilia Treatment and Research
- Platelet Disorders and Treatments
Internal Medicine top 0.05%
- Venous Thromboembolism Diagnosis and Management

Papers in

Hematology 352
- Blood Coagulation and Thrombosis Mechanisms 330
- Hemophilia Treatment and Research 84
- Platelet Disorders and Treatments 29
Genetics 152
- Coagulation, Bradykinin, Polyphosphates, and Angioedema 144
- Venomous Animal Envenomation and Studies 49

Co-authors: Berislav V. Zloković José A. Fernández Laurent O. Mosnier András Gruber Mary J. Heeb Carol S. Wideman Tilman M. Hackeng Bonno N. Bouma
Journals: Blood (114 papers)Journal of Biological Chemistry (48 papers)Thrombosis and Haemostasis (35 papers)Proceedings of the National Academy of Sciences (18 papers)Thrombosis Research (17 papers)
Partner nations: United States Netherlands France

In The Last Decade

John H. Griffin

546 papers receiving 26.2k citations

Hit Papers

6 papers align trajectories log scale

Understanding COVID-19-associated coagulopathy 2022 · 191 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2022 Nature reviews. Immunology
2006 Blood
2006 Circulation Research
1999 Proceedings of the National Academy of Sciences
1984 Blood
1981 Journal of Clinical Investigation

Peers

Countries citing papers authored by John H. Griffin

Since Specialization

Citations

This map shows the geographic impact of John H. Griffin's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John H. Griffin with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John H. Griffin more than expected).

Fields of papers citing papers by John H. Griffin

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John H. Griffin. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John H. Griffin. The network helps show where John H. Griffin may publish in the future.

Co-authors

The 25 scholars most cited alongside John H. Griffin, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with John H. Griffin Line = papers co-authored together John H. Griffin links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	An orthosteric/allosteric bivalent peptide agonist comprising covalently linked protease-activated receptor-derived peptides mimics in vitro and in vivo activities of activated protein C Journal of Thrombosis and Haemostasis ·Laura D Healy, José A. Fernández, Roberto Aiolfi, Laurent O. Mosnier, John H. Griffin	2024	3
2	Genetic Upregulation of Activated Protein C Mitigates Delayed Effects of Acute Radiation Exposure in the Mouse Plasma Metabolites ·Shivani Bansal, Yaoxiang Li, Sunil Bansal, William Klotzbier, Baldev Singh, Meth Jayatilake, Vijayalakshmi Sridharan, José A. Fernández, John H. Griffin, Hartmut Weiler, Marjan Boerma, Amrita K. Cheema	2024	0
3	Mitigation of trauma-induced endotheliopathy by activated protein C: A potential therapeutic for postinjury thromboinflammation The Journal of Trauma: Injury, Infection, and Critical Care ·Otto Thielen, Sanchayita Mitra, Margot DeBot, Terry R. Schaid, William Hallas, Lauren T. Gallagher, Christopher Erickson, Alexis Cralley, Preston Stafford, Christopher C. Silliman, Angelo D’Alessandro, Kirk C. Hansen, Angela Sauaia, Ernest E. Moore, Laurent O. Mosnier, John H. Griffin, Mitchell J. Cohen	2023	5
4	Thrombin-mediated activation of PAR1 enhances doxorubicin-induced cardiac injury in mice Blood Advances ·Steven P. Grover, Vanthana Bharathi, Jens Posma, John H. Griffin, Joseph S. Palumbo, Nigel Mackman, Silvio Antoniak	2022	4
5	Full‐length plasma skeletal muscle myosin isoform deficiency is associated with coagulopathy in acutely injured patients Journal of Thrombosis and Haemostasis ·Julia R. Coleman, Hiroshi Deguchi, Taichi K. Deguchi, Mitchel J. Cohen, Ernest E. Moore, John H. Griffin	2022	4
6	Activated Protein C (APC) and 3K3A-APC-Induced Regression of Choroidal Neovascularization (CNV) Is Accompanied by Vascular Endothelial Growth Factor (VEGF) Reduction Biomolecules ·Tami Livnat, Yehonatan Weinberger, José A. Fernández, Bashir Alaa, Gil Ben-David, Dahlia Palevski, Sarina Levy‐Mendelovich, Gili Kenet, Ivan Budnik, Yael Nisgav, John H. Griffin, Dov Weinberger	2021	6
7	Protection of ischemic white matter and oligodendrocytes in mice by 3K3A-activated protein C The Journal of Experimental Medicine ·Mikko T. Huuskonen, Yaoming Wang, Angeliki M. Nikolakopoulou, Axel Montagne, Zhonghua Dai, Divna Lazić, Abhay P. Sagare, Zhen Zhao, José A. Fernández, John H. Griffin, Berislav V. Zloković	2021	22
8	Activated Protein C Strengthens Cardiac Tolerance to Ischemic Insults in Aging Circulation Research ·Di Ren, Julia Fedorova, Kayla Davitt, Tran Ngoc Van Le, John H. Griffin, Patricia C. Liaw, Charles T. Esmon, Alireza R. Rezaie, Ji Li	2021	22
9	Different DOACs Control Inflammation in Cardiac Ischemia-Reperfusion Differently Circulation Research ·Ihsan Gadi, Sameen Fatima, Ahmed Elwakiel, Sumra Nazir, Moh’d Mohanad Al‐Dabet, Rajiv Rana, Fabian Bock, Jayakumar Manoharan, Dheerendra Gupta, Ronald Biemann, Bernhard Nieswandt, Ruediger C. Braun‐Dullaeus, Christian Besler, Markus Scholz, Robert Geffers, John H. Griffin, Charles T. Esmon, Shrey Kohli, Berend Isermann, Khurrum Shahzad	2020	30
10	C‐terminal residues of activated protein C light chain contribute to its anticoagulant and cytoprotective activities Journal of Thrombosis and Haemostasis ·Atsuki Yamashita, Yuqi Zhang, Michel F. Sanner, John H. Griffin, Laurent O. Mosnier	2020	3
11	Activated protein C and PAR1‐derived and PAR3‐derived peptides are anti‐inflammatory by suppressing macrophage NLRP3 inflammasomes Journal of Thrombosis and Haemostasis ·Laura D. Healy, José A. Fernández, Laurent O. Mosnier, John H. Griffin	2020	16
12	An engineered factor Va prevents bleeding induced by direct-acting oral anticoagulants by different mechanisms Blood Advances ·Annette von Drygalski, Vikas Bhat, Andrew J. Gale, Patricia M. Averell, Thomas J. Cramer, Darlene J. Elias, John H. Griffin, Laurent O. Mosnier	2020	8
13	Tissue factor pathway inhibitor primes monocytes for antiphospholipid antibody-induced thrombosis Blood ·Nadine Müller‐Calleja, Anne Hollerbach, Svenja Ritter, Denise Pedrosa, Dennis Strand, Claudine Graf, Christoph Reinhardt, Susanne Strand, Philippe Poncelet, John H. Griffin, Karl J. Lackner, Wolfram Ruf	2019	52
14	PAR1 biased signaling is required for activated protein C in vivo benefits in sepsis and stroke Blood ·Ranjeet Sinha, Yaoming Wang, Zhen Zhao, Xiao Xu, Laurent Burnier, Naveen Gupta, José A. Fernández, Greg Martin, S.V. Kupriyanov, Laurent O. Mosnier, Berislav V. Zloković, John H. Griffin	2018	74
15	Prothrombotic skeletal muscle myosin directly enhances prothrombin activation by binding factors Xa and Va Blood ·Hiroshi Deguchi, Ranjeet Sinha, Patrizia Marchese, Zaverio M. Ruggeri, Jevgenia Zilberman‐Rudenko, Owen J. T. McCarty, Mitchell J. Cohen, John H. Griffin	2016	28
16	Acylcarnitines are anticoagulants that inhibit factor Xa and are reduced in venous thrombosis, based on metabolomics data Blood ·Hiroshi Deguchi, Yajnavalka Banerjee, Sunia A. Trauger, Gary Siuzdak, Ewa Kalisiak, José A. Fernández, Linh Hoang, Minerva Tran, Subramanian Yegneswaran, Darlene J. Elias, John H. Griffin	2015	41
17	Motor Neuron Disease Occurring in a Mutant Dynactin Mouse Model Is Characterized by Defects in Vesicular Trafficking Journal of Neuroscience ·Fiona M. Laird, Mohamed H. Farah, Steven Ackerley, Ahmet Höke, Nicholas J. Maragakis, Jeffrey D. Rothstein, John H. Griffin, Donald L. Price, Lee J. Martin, Philip C. Wong	2008	143
18	Endotoxemia and sepsis mortality reduction by non-anticoagulant–activated protein C The Journal of Experimental Medicine ·E. J. Kerschen, José A. Fernández, Brian C. Cooley, Xia V. Yang, Rashmi Sood, Laurent O. Mosnier, Francis Castellino, Nigel Mackman, John H. Griffin, Hartmut Weiler	2007	243
19	Guillain - Barré syndrome Current Opinion in Neurology ·Tony W. Ho, John H. Griffin	1999	26
20	Antithrombotic effects of thrombin-induced activation of endogenous protein C in primates. Journal of Clinical Investigation ·Stephen R. Hanson, John H. Griffin, Laurence A. Harker, Adrian B. Kelly, CT Esmon, András Gruber	1993	149

About John H. Griffin

John H. Griffin is a scholar working on Hematology, Genetics, Internal Medicine, Cancer Research and Nutrition and Dietetics, having authored 559 papers that have together received 27.6k indexed citations. Recurring topics across this work include Blood Coagulation and Thrombosis Mechanisms (330 papers), Coagulation, Bradykinin, Polyphosphates, and Angioedema (144 papers), Hemophilia Treatment and Research (84 papers), Venous Thromboembolism Diagnosis and Management (51 papers), Protease and Inhibitor Mechanisms (50 papers), Venomous Animal Envenomation and Studies (49 papers), Vitamin K Research Studies (42 papers) and Platelet Disorders and Treatments (29 papers). The work is most often cited by research in Hematology (15.5k citations), Internal Medicine (3.5k citations), Genetics (6.9k citations), Nutrition and Dietetics (2.7k citations) and Cancer Research (2.3k citations). John H. Griffin has collaborated with scholars based in United States, Netherlands and France. Frequent co-authors include Berislav V. Zloković, José A. Fernández, Laurent O. Mosnier, András Gruber, Mary J. Heeb, Carol S. Wideman, Tilman M. Hackeng, Bonno N. Bouma, AJ Kleiss and Hiroshi Deguchi. Their work appears in journals such as Blood, Journal of Biological Chemistry, Thrombosis and Haemostasis, Proceedings of the National Academy of Sciences and Thrombosis Research.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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