James M. Holton

14.2k citations

76 papers · 7.3k indexed · 2 hit papers · h-index 42

Impact in

Structural Biology top 0.2%
- Advanced Electron Microscopy Techniques and Applications
Radiation top 0.5%
- Advanced X-ray Imaging Techniques

Papers in

Structural Biology 8
- Advanced Electron Microscopy Techniques and Applications 8
Radiation 17
- Advanced X-ray Imaging Techniques 12
- X-ray Spectroscopy and Fluorescence Analysis 12

Co-authors: Tom Alber M.A. Borovinskaya J.H.D. Cate Wen Zhang B.S. Schuwirth Antón Vila‐Sanjurjo C.W. Hau James S. Fraser
Journals: Proceedings of the National Academy of Sciences (9 papers)Journal of Synchrotron Radiation (7 papers)Nature Structural & Molecular Biology (4 papers)Acta Crystallographica Section D Structural Biology (3 papers)Molecular Cell (3 papers)
Partner nations: United States United Kingdom Germany

In The Last Decade

James M. Holton

73 papers receiving 7.2k citations

Hit Papers

align trajectories log scale

Large language models generate functional protein sequences across diverse families 2023 · 487 citations

Peers

Countries citing papers authored by James M. Holton

Since Specialization

Citations

This map shows the geographic impact of James M. Holton's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by James M. Holton with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites James M. Holton more than expected).

Fields of papers citing papers by James M. Holton

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by James M. Holton. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by James M. Holton. The network helps show where James M. Holton may publish in the future.

Co-authors

The 25 scholars most cited alongside James M. Holton, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with James M. Holton Line = papers co-authored together James M. Holton links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work
1	Testing the limits: serial crystallography using unpatterned fixed targets IUCrJ ·A. Gorel, Robert L. Shoeman, Elisabeth Hartmann, Stanisław Niziński, Martin V. Appleby, Emma V. Beale, Florian Dworkowski, Guillaume Gotthard, John H. Beale, James M. Holton, R. Bruce Doak, Thomas R. M. Barends, Ilme Schlichting	2025	0
2	Deep residual networks for crystallography trained on synthetic data Acta Crystallographica Section D Structural Biology ·Derek Mendez, James M. Holton, Artem Y. Lyubimov, Sabine Hollatz, Irimpan I. Mathews, Aleksander Cichosz, Vardan Martirosyan, Teo Zeng, Ryan Stofer, Ruobin Liu, Jinhu Song, S.E. McPhillips, Mike Soltis, Aina E. Cohen	2024	2
3	Accelerating x‐ray tracing for exascale systems using Kokkos Concurrency and Computation Practice and Experience ·Felix Wittwer, Nicholas K. Sauter, Derek Mendez, Billy K. Poon, Aaron S. Brewster, James M. Holton, Michael E. Wall, William E. Hart, Deborah Bard, Johannes Blaschke	2023	0
4	Water Networks in Photosystem II Using Crystalline Molecular Dynamics Simulations and Room-Temperature XFEL Serial Crystallography Journal of the American Chemical Society ·Margaret Doyle, Asmit Bhowmick, David C. Wych, Louise Lassalle, Philipp S. Simon, James M. Holton, Nicholas K. Sauter, Vittal K. Yachandra, Jan Kern, Junko Yano, Michael E. Wall	2023	19
5	Large language models generate functional protein sequences across diverse families Nature Biotechnology ·Ali Madani, Ben Krause, Eric R. Greene, Subu Subramanian, Benjamin P. Mohr, James M. Holton, J.L. Olmos, Caiming Xiong, Zachary Z. Sun, Richard Socher, James S. Fraser, Nikhil Naik Hit paper breakdown →	2023	487
6	The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and x-ray diffraction at room temperature Science Advances ·G.J. Correy, Daniel W. Kneller, G.N. Phillips, Swati Pant, Silvia Russi, Aina E. Cohen, G. Meigs, James M. Holton, Stefan Gahbauer, Michael C. Thompson, Alan Ashworth, Leighton Coates, Andrey Kovalevsky, Flora Meilleur, James S. Fraser	2022	24
7	Radiation damage and dose limits in serial synchrotron crystallography at cryo- and room temperatures Proceedings of the National Academy of Sciences ·E. De la Mora, Nicolas Coquelle, Charles S. Bury, Martin Rosenthal, James M. Holton, Ian Carmichael, Elspeth F. Garman, Manfred Burghammer, Jacques‐Philippe Colletier, Martin H. Weik	2020	88
8	Covalent Modification and Regulation of the Nuclear Receptor Nurr1 by a Dopamine Metabolite Cell chemical biology ·John M. Bruning, Yan Wang, Francesca Oltrabella, Boxue Tian, Svetlana A. Kholodar, Harrison Liu, Paulomi Bhattacharya, Su Guo, James M. Holton, Robert J. Fletterick, Matthew P. Jacobson, Pamela M. England	2019	48
9	Guide-bound structures of an RNA-targeting A-cleaving CRISPR–Cas13a enzyme Nature Structural & Molecular Biology ·Gavin J. Knott, Alexandra East-Seletsky, Joshua C. Cofsky, James M. Holton, Emeric Charles, Mitchell R. O’Connell, Jennifer A. Doudna	2017	129
10	A systematic review of the clinical applications and complications of bone marrow aspirate concentrate in management of bone defects and nonunions International Orthopaedics ·Mohamed A. Imam, James M. Holton, Lukas Ernstbrunner, Wojciech Pepke, Florian Grubhofer, Ali Narvani, Martyn Snow	2017	66
11	Crystallographic data processing for free-electron laser sources Acta Crystallographica Section D Biological Crystallography ·Thomas A. White, Anton Barty, Francesco Stellato, James M. Holton, Richard A. Kirian, Nadia A. Zatsepin, Henry N. Chapman	2013	84
12	Implementation and performance of SIBYLS: a dual endstation small-angle X-ray scattering and macromolecular crystallography beamline at the Advanced Light Source Journal of Applied Crystallography ·Scott Classen, Greg L. Hura, James M. Holton, Robert P. Rambo, Ivan Rodic, Patrick J. McGuire, Kevin Dyer, Michal Hammel, G. Meigs, Kenneth A. Frankel, John A. Tainer	2013	202
13	Molecular functions of the histone acetyltransferase chaperone complex Rtt109–Vps75 Nature Structural & Molecular Biology ·Christopher Berndsen, Toshiaki Tsubota, Scott E. Lindner, Susan Lee, James M. Holton, Paul D. Kaufman, James L. Keck, John M. Denu	2008	97
14	Structural basis for aminoglycoside inhibition of bacterial ribosome recycling Nature Structural & Molecular Biology ·M.A. Borovinskaya, R.D. Pai, Wen Zhang, B.S. Schuwirth, James M. Holton, Go Hirokawa, Hideko Kaji, Akira Kaji, J.H.D. Cate	2007	291
15	Structures of the Bacterial Ribosome at 3.5 A Resolution Science ·B.S. Schuwirth, M.A. Borovinskaya, C.W. Hau, Wen Zhang, Antón Vila‐Sanjurjo, James M. Holton, J.H.D. Cate Hit paper breakdown →	2005	1178
16	Structural Basis for Recruitment of Ubc12 by an E2 Binding Domain in NEDD8's E1 Molecular Cell ·Danny T. Huang, Amir Paydar, Min Zhuang, M. Brett Waddell, James M. Holton, Brenda A. Schulman	2005	164
17	Ubiquitin Recognition by the Human TSG101 Protein Molecular Cell ·Wesley I. Sundquist, Heidi Schubert, Brian N. Kelly, Gina C. Hill, James M. Holton, Christopher P. Hill	2004	180
18	SIBYLS - A SAXS and protein crystallography beamline at the ALS eScholarship (California Digital Library) ·Christine B. Trame, Alastair A. MacDowell, Richard Celestre, H. A. Padmore, Daniella Cambie, Edward E. Domning, Robert Duarte, Nicholas Kelez, D. Plate, James M. Holton, Kenneth A. Frankel, Susan E. Tsutakawa, Hiro Tsuruta, John A. Tainer, Priscilla K. Cooper	2003	2
19	The Structure of the APPBP1-UBA3-NEDD8-ATP Complex Reveals the Basis for Selective Ubiquitin-like Protein Activation by an E1 Molecular Cell ·Helen Walden, Michael Podgorski, Danny T. Huang, David W. Miller, Rebecca J. Howard, Daniel L. Minor, James M. Holton, Brenda A. Schulman	2003	225
20	Covariance analysis of RNA recognition motifs identifies functionally linked amino acids Journal of Molecular Biology ·Scott Crowder, James M. Holton, Tom Alber	2001	12

About James M. Holton

James M. Holton is a scholar working on Structural Biology, Radiation, Materials Chemistry, Molecular Biology and Virology, having authored 76 papers that have together received 7.3k indexed citations. Recurring topics across this work include Enzyme Structure and Function (33 papers), Protein Structure and Dynamics (15 papers), Advanced X-ray Imaging Techniques (12 papers), X-ray Spectroscopy and Fluorescence Analysis (12 papers), RNA and protein synthesis mechanisms (9 papers), Advanced Electron Microscopy Techniques and Applications (8 papers), Bacterial Genetics and Biotechnology (7 papers) and Ubiquitin and proteasome pathways (6 papers). The work is most often cited by research in Structural Biology (618 citations), Radiation (928 citations), Molecular Biology (4.9k citations), Materials Chemistry (1.9k citations) and Molecular Medicine (177 citations). James M. Holton has collaborated with scholars based in United States, United Kingdom and Germany. Frequent co-authors include Tom Alber, M.A. Borovinskaya, J.H.D. Cate, Wen Zhang, B.S. Schuwirth, Antón Vila‐Sanjurjo, C.W. Hau, James S. Fraser, Kenneth A. Frankel and Brenda A. Schulman. Their work appears in journals such as Proceedings of the National Academy of Sciences, Journal of Synchrotron Radiation, Nature Structural & Molecular Biology, Acta Crystallographica Section D Structural Biology and Molecular Cell.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact