Helen Walden

7.4k total citations · 1 hit paper
58 papers, 5.0k citations indexed

About

Helen Walden is a scholar working on Molecular Biology, Epidemiology and Neurology. According to data from OpenAlex, Helen Walden has authored 58 papers receiving a total of 5.0k indexed citations (citations by other indexed papers that have themselves been cited), including 52 papers in Molecular Biology, 23 papers in Epidemiology and 8 papers in Neurology. Recurrent topics in Helen Walden's work include Ubiquitin and proteasome pathways (39 papers), Autophagy in Disease and Therapy (21 papers) and DNA Repair Mechanisms (17 papers). Helen Walden is often cited by papers focused on Ubiquitin and proteasome pathways (39 papers), Autophagy in Disease and Therapy (21 papers) and DNA Repair Mechanisms (17 papers). Helen Walden collaborates with scholars based in United Kingdom, Canada and United States. Helen Walden's co-authors include Francesca Morreale, Viduth K. Chaugule, Gary S. Shaw, Brenda A. Schulman, Lynn Burchell, Helle D. Ulrich, Donald E. Spratt, Miratul M. K. Muqit, Axel Knebel and Michael Podgorski and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Helen Walden

57 papers receiving 5.0k citations

Hit Papers

PINK1 is activated by mitochondrial membrane potential de... 2012 2026 2016 2021 2012 200 400 600
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65
    2012 726 citations Lynn Burchell, Helen Walden et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Helen Walden United Kingdom 34 3.9k 1.6k 950 790 584 58 5.0k
Guennadi Kozlov Canada 39 3.3k 0.8× 927 0.6× 368 0.4× 502 0.6× 1.2k 2.0× 102 4.5k
Corey E. Bakalarski United States 21 5.1k 1.3× 736 0.5× 1.3k 1.3× 217 0.3× 1.1k 1.9× 25 6.3k
Mark Peggie United Kingdom 42 4.0k 1.0× 897 0.6× 708 0.7× 339 0.4× 689 1.2× 56 5.9k
Gerald Marsischky United States 13 3.4k 0.9× 429 0.3× 857 0.9× 723 0.9× 687 1.2× 14 4.7k
Jean‐François Trempe Canada 28 2.7k 0.7× 1.7k 1.1× 221 0.2× 934 1.2× 674 1.2× 68 4.0k
Jeffrey P. MacKeigan United States 32 4.4k 1.1× 848 0.5× 969 1.0× 198 0.3× 732 1.3× 62 6.5k
Megan M. Cleland United States 14 3.3k 0.8× 1.2k 0.8× 214 0.2× 449 0.6× 525 0.9× 15 4.0k
Maria Perander Norway 17 2.1k 0.5× 2.2k 1.4× 281 0.3× 275 0.3× 804 1.4× 20 3.7k
Nicholas A. Morrice United Kingdom 36 3.3k 0.8× 335 0.2× 657 0.7× 318 0.4× 653 1.1× 64 4.2k
Hikaru Tsuchiya Japan 16 2.1k 0.5× 1.1k 0.7× 322 0.3× 382 0.5× 524 0.9× 21 2.7k

Countries citing papers authored by Helen Walden

Since Specialization
Citations

This map shows the geographic impact of Helen Walden's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Helen Walden with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Helen Walden more than expected).

Fields of papers citing papers by Helen Walden

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Helen Walden. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Helen Walden. The network helps show where Helen Walden may publish in the future.

Co-authorship network of co-authors of Helen Walden

This figure shows the co-authorship network connecting the top 25 collaborators of Helen Walden. A scholar is included among the top collaborators of Helen Walden based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Helen Walden. Helen Walden is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Walden, Helen, et al.. (2025). USP1 in regulation of DNA repair pathways. DNA repair. 146. 103807–103807. 4 indexed citations
2.
Walden, Helen, et al.. (2025). Discovery of N-Hydroxypyridinedione-Based Inhibitors of HBV RNase H: Design, Synthesis, and Extended SAR Studies. International Journal of Molecular Sciences. 26(20). 10239–10239.
3.
Rintala‐Dempsey, Anne C., Giulia Salzano, Outi Kämäräinen, et al.. (2025). A substrate-interacting region of Parkin directs ubiquitination of the mitochondrial GTPase Miro1. The Journal of Cell Biology. 224(8). 3 indexed citations
4.
Rintala‐Dempsey, Anne C., Mehmet Gundogdu, Jacob D. Aguirre, et al.. (2024). Capturing the catalytic intermediates of parkin ubiquitination. Proceedings of the National Academy of Sciences. 121(32). e2403114121–e2403114121. 6 indexed citations
5.
Lemonidis, Kimon, Martin L. Rennie, Connor Arkinson, et al.. (2022). Structural and biochemical basis of interdependent FANCI‐FANCD2 ubiquitination. The EMBO Journal. 42(3). e111898–e111898. 12 indexed citations
6.
Rennie, Martin L., Connor Arkinson, Viduth K. Chaugule, Rachel Toth, & Helen Walden. (2021). Structural basis of FANCD2 deubiquitination by USP1−UAF1. Nature Structural & Molecular Biology. 28(4). 356–364. 38 indexed citations
7.
Rennie, Martin L., Kimon Lemonidis, Connor Arkinson, et al.. (2020). Differential functions of FANCI and FANCD2 ubiquitination stabilize ID2 complex on DNA. EMBO Reports. 21(7). e50133–e50133. 36 indexed citations
8.
Somma, Domenico, Matti Lepistö, Christian Tyrchan, et al.. (2020). The deubiquitinase USP7 uses a distinct ubiquitin-like domain to deubiquitinate NF-ĸB subunits. Journal of Biological Chemistry. 295(33). 11754–11763. 23 indexed citations
9.
Kumar, Atul, Viduth K. Chaugule, Tara Condos, et al.. (2017). Parkin–phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity. Nature Structural & Molecular Biology. 24(5). 475–483. 78 indexed citations
10.
Morreale, Francesca & Helen Walden. (2016). Types of Ubiquitin Ligases. Cell. 165(1). 248–248.e1. 346 indexed citations
11.
Hodson, Charlotte, Andrew G. Purkiss, Jennifer A. Miles, & Helen Walden. (2014). Structure of the Human FANCL RING-Ube2T Complex Reveals Determinants of Cognate E3-E2 Selection. Structure. 22(2). 337–344. 60 indexed citations
12.
Ballard, Clive, Pietro Roversi, & Helen Walden. (2013). Molecular replacements. Acta Crystallographica Section D Biological Crystallography. 69(11). 2165–2166. 4 indexed citations
13.
Walden, Helen & R.J. Martinez-Torres. (2012). Regulation of Parkin E3 ubiquitin ligase activity. Cellular and Molecular Life Sciences. 69(18). 3053–3067. 52 indexed citations
14.
Burchell, Lynn, Viduth K. Chaugule, & Helen Walden. (2012). Small, N-Terminal Tags Activate Parkin E3 Ubiquitin Ligase Activity by Disrupting Its Autoinhibited Conformation. PLoS ONE. 7(4). e34748–e34748. 34 indexed citations
15.
Chaugule, Viduth K., Lynn Burchell, Kathryn R. Barber, et al.. (2011). Autoregulation of Parkin activity through its ubiquitin‐like domain. The EMBO Journal. 30(14). 2853–2867. 262 indexed citations
16.
Ulrich, Helle D. & Helen Walden. (2010). Ubiquitin signalling in DNA replication and repair. Nature Reviews Molecular Cell Biology. 11(7). 479–489. 223 indexed citations
17.
Cole, A.R., et al.. (2010). The structure of the catalytic subunit FANCL of the Fanconi anemia core complex. Nature Structural & Molecular Biology. 17(3). 294–298. 56 indexed citations
18.
Theodossis, Alex, Helen Walden, Helen Connaris, et al.. (2004). The Structural Basis for Substrate Promiscuity in 2-Keto-3-deoxygluconate Aldolase from the Entner-Doudoroff Pathway in Sulfolobus solfataricus. Journal of Biological Chemistry. 279(42). 43886–43892. 72 indexed citations
19.
Walden, Helen, Michael Podgorski, Danny T. Huang, et al.. (2003). The Structure of the APPBP1-UBA3-NEDD8-ATP Complex Reveals the Basis for Selective Ubiquitin-like Protein Activation by an E1. Molecular Cell. 12(6). 1427–1437. 225 indexed citations
20.
Walden, Helen, Michael Podgorski, & Brenda A. Schulman. (2003). Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8. Nature. 422(6929). 330–334. 179 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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