Jennifer A. Doudna

116.8k citations
363 papers · 78.6k indexed · 69 hit papers · h-index 123
Co-authors
Emmanuelle CharpentierMartin JínekM. HauerInes FonfaraKrzysztof ChylinskiSamuel H. SternbergKaihong ZhouEnbo Ma
Topics
RNA and protein synthesis mechanisms (202 papers)CRISPR and Genetic Engineering (174 papers)RNA Research and Splicing (74 papers)
Cited by
Business and International ManagementAgingMolecular Biology
Journals
NatureScienceNew England Journal of Medicine
Partner nations
United StatesRussiaSwitzerland

In The Last Decade

Jennifer A. Doudna

359 papers receiving 77.1k citations

Hit Papers

A Programmable Dual-RNA–Guided DNA Endo...1996202620062016201220142013201820132.5k5.0k7.5k10.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
    2012 11.5k citations Martin Jínek, Krzysztof Chylinski et al. Science profile →
  2. The new frontier of genome engineering with CRISPR-Cas9
    2014 4.6k citations Jennifer A. Doudna, Emmanuelle Charpentier Science profile →
  3. Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression
    2013 3.7k citations Jennifer A. Doudna et al. Cell profile →
  4. CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity
    2018 3.1k citations Janice S. Chen, Enbo Ma et al. Science profile →
  5. CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes
    2013 2.7k citations Jennifer A. Doudna et al. Cell profile →
  6. RNA-programmed genome editing in human cells
    2013 1.6k citations Martin Jínek, Steven Lin et al. profile →
  7. RNA-guided genetic silencing systems in bacteria and archaea
    2012 1.4k citations Blake Wiedenheft, Samuel H. Sternberg et al. profile →
  8. CRISPR–Cas9 Structures and Mechanisms
    2017 1.4k citations Fuguo Jiang, Jennifer A. Doudna Annual Review of Biophysics profile →
  9. DNA interrogation by the CRISPR RNA-guided endonuclease Cas9
    2014 1.4k citations Samuel H. Sternberg, Martin Jínek et al. profile →
  10. High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity
    2013 1.2k citations Steven Lin, Enbo Ma et al. profile →
  11. Crystal Structure of a Group I Ribozyme Domain: Principles of RNA Packing
    1996 1.0k citations J.H.D. Cate, Kaihong Zhou et al. Science profile →
  12. CRISPR-Cas guides the future of genetic engineering
    2018 1.0k citations Gavin J. Knott, Jennifer A. Doudna Science profile →
  13. Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation
    2014 900 citations Martin Jínek, Fuguo Jiang et al. Science profile →
  14. Programmed DNA destruction by miniature CRISPR-Cas14 enzymes
    2018 895 citations Lucas B. Harrington, David Burstein et al. Science profile →
  15. Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery
    2014 894 citations Steven Lin, Jennifer A. Doudna et al. profile →
  16. Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
    2016 879 citations David Burstein, J.H.D. Cate et al. profile →
  17. Enhanced proofreading governs CRISPR–Cas9 targeting accuracy
    2017 872 citations Janice S. Chen, Lucas B. Harrington et al. profile →
  18. Molecular Mechanisms of RNA Interference
    2013 780 citations Jennifer A. Doudna et al. Annual Review of Biophysics profile →
  19. Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering
    2016 758 citations Jennifer A. Doudna et al. Cell profile →
  20. Structural Basis for Double-Stranded RNA Processing by Dicer
    2006 725 citations Kaihong Zhou, Jennifer A. Doudna et al. Science profile →
  21. The promise and challenge of therapeutic genome editing
    2020 682 citations Jennifer A. Doudna profile →
  22. Applications of CRISPR technologies in research and beyond
    2016 659 citations Rodolphe Barrangou, Jennifer A. Doudna profile →
  23. Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity
    2020 633 citations Audronė Lapinaitė, Jennifer A. Doudna et al. profile →
  24. Crystal structure of a hepatitis delta virus ribozyme
    1998 596 citations Kaihong Zhou, Jennifer A. Doudna et al. profile →
  25. CRISPR technology: A decade of genome editing is only the beginning
    2023 580 citations Jennifer A. Doudna et al. Science profile →
  26. A three-dimensional view of the molecular machinery of RNA interference
    2008 560 citations Martin Jínek, Jennifer A. Doudna profile →
  27. Generation of knock-in primary human T cells using Cas9 ribonucleoproteins
    2015 533 citations Kathrin Schumann, Steven Lin et al. Proceedings of the National Academy of Sciences profile →
  28. Sequence- and Structure-Specific RNA Processing by a CRISPR Endonuclease
    2010 531 citations R.E. Haurwitz, Martin Jínek et al. Science profile →
  29. The chemical repertoire of natural ribozymes
    2002 512 citations Jennifer A. Doudna et al. profile →
  30. Programmable RNA recognition and cleavage by CRISPR/Cas9
    2014 500 citations Benjamin L. Oakes, Samuel H. Sternberg et al. profile →
  31. Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage
    2016 486 citations Fuguo Jiang, David W. Taylor et al. Science profile →
  32. Conformational control of DNA target cleavage by CRISPR–Cas9
    2015 472 citations Samuel H. Sternberg, Matias Kaplan et al. profile →
  33. Structural basis for CRISPR RNA-guided DNA recognition by Cascade
    2011 447 citations Blake Wiedenheft, Kaihong Zhou et al. Nature Structural & Molecular Biology profile →
  34. A Cas9–guide RNA complex preorganized for target DNA recognition
    2015 442 citations Fuguo Jiang, Kaihong Zhou et al. Science profile →
  35. Programmable RNA Tracking in Live Cells with CRISPR/Cas9
    2016 410 citations Jennifer A. Doudna et al. Cell profile →
  36. New CRISPR–Cas systems from uncultivated microbes
    2016 409 citations David Burstein, Lucas B. Harrington et al. profile →
  37. A prudent path forward for genomic engineering and germline gene modification
    2015 400 citations Jennifer A. Doudna, Martin Jínek et al. Science profile →
  38. CRISPR-CasΦ from huge phages is a hypercompact genome editor
    2020 394 citations Patrick Pausch, Basem Al-Shayeb et al. Science profile →
  39. Hepatitis C Virus IRES RNA-Induced Changes in the Conformation of the 40 S Ribosomal Subunit
    2001 384 citations Kaihong Zhou, Jennifer A. Doudna et al. Science profile →
  40. Cas1–Cas2 complex formation mediates spacer acquisition during CRISPR–Cas adaptive immunity
    2014 351 citations Jennifer A. Doudna et al. Nature Structural & Molecular Biology profile →
  41. RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions
    2011 350 citations Blake Wiedenheft, Kaihong Zhou et al. Proceedings of the National Academy of Sciences profile →
  42. Cornerstones of CRISPR–Cas in drug discovery and therapy
    2016 335 citations Christof Fellmann, Jennifer A. Doudna et al. profile →
  43. Insights into RNA structure and function from genome-wide studies
    2014 332 citations Jennifer A. Doudna et al. profile →
  44. CasX enzymes comprise a distinct family of RNA-guided genome editors
    2019 316 citations Junjie Liu, Benjamin L. Oakes et al. profile →
  45. Multiplexed RNA structure characterization with selective 2′-hydroxyl acylation analyzed by primer extension sequencing (SHAPE-Seq)
    2011 312 citations Jennifer A. Doudna et al. Proceedings of the National Academy of Sciences profile →
  46. Expanding the Biologist’s Toolkit with CRISPR-Cas9
    2015 306 citations Samuel H. Sternberg, Jennifer A. Doudna profile →
  47. Structures of the RNA-guided surveillance complex from a bacterial immune system
    2011 306 citations Blake Wiedenheft, Kaihong Zhou et al. profile →
  48. Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity
    2013 301 citations Jennifer A. Doudna et al. profile →
  49. Adaptive strategies of the influenza virus polymerase for replication in humans
    2009 300 citations Jennifer A. Doudna et al. Proceedings of the National Academy of Sciences profile →
  50. Disabling Cas9 by an anti-CRISPR DNA mimic
    2017 274 citations Fuguo Jiang, Junjie Liu et al. profile →
  51. Dynamics of CRISPR-Cas9 genome interrogation in living cells
    2015 265 citations Jennifer A. Doudna et al. Science profile →
  52. Integrase-mediated spacer acquisition during CRISPR–Cas adaptive immunity
    2015 263 citations Jennifer A. Doudna et al. profile →
  53. eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation
    2016 262 citations Jennifer A. Doudna, J.H.D. Cate et al. profile →
  54. Efficient genome editing in the mouse brain by local delivery of engineered Cas9 ribonucleoprotein complexes
    2017 253 citations Jennifer A. Doudna et al. profile →
  55. Rational design of a split-Cas9 enzyme complex
    2015 221 citations Samuel H. Sternberg, David W. Taylor et al. Proceedings of the National Academy of Sciences profile →
  56. RNA Targeting by Functionally Orthogonal Type VI-A CRISPR-Cas Enzymes
    2017 218 citations David Burstein, Gavin J. Knott et al. profile →
  57. A conformational checkpoint between DNA binding and cleavage by CRISPR-Cas9
    2017 215 citations Janice S. Chen, Samuel H. Sternberg et al. profile →
  58. CRISPR-Cpf1 mediates efficient homology-directed repair and temperature-controlled genome editing
    2017 206 citations Jennifer A. Doudna et al. Nature Communications profile →
  59. Tunable protein synthesis by transcript isoforms in human cells
    2016 202 citations Jennifer A. Doudna et al. profile →
  60. Real-time observation of DNA recognition and rejection by the RNA-guided endonuclease Cas9
    2016 199 citations Samuel H. Sternberg, Jennifer A. Doudna et al. Nature Communications profile →
  61. Rapid assessment of SARS-CoV-2–evolved variants using virus-like particles
    2021 193 citations Katarzyna M. Soczek, Jennifer A. Doudna et al. Science profile →
  62. Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2′,3′ cGAMP Signaling
    2015 192 citations Jennifer A. Doudna et al. profile →
  63. A Broad-Spectrum Inhibitor of CRISPR-Cas9
    2017 191 citations Lucas B. Harrington, Enbo Ma et al. Cell profile →
  64. Nucleosome breathing and remodeling constrain CRISPR-Cas9 function
    2016 166 citations Fuguo Jiang, Jennifer A. Doudna et al. profile →
  65. Controlling and enhancing CRISPR systems
    2020 136 citations Haridha Shivram, Brady F. Cress et al. profile →
  66. DNA capture by a CRISPR-Cas9–guided adenine base editor
    2020 130 citations Audronė Lapinaitė, Gavin J. Knott et al. Science profile →
  67. In vivo human T cell engineering with enveloped delivery vehicles
    2024 103 citations Min Hyung Kang, Marena Trinidad et al. profile →
  68. Lung and liver editing by lipid nanoparticle delivery of a stable CRISPR–Cas9 ribonucleoprotein
    2024 54 citations Kai Chen, Marena Trinidad et al. profile →
  69. Viral delivery of an RNA-guided genome editor for transgene-free germline editing in Arabidopsis
    2025 24 citations Benjamin A. Adler, Jillian F. Banfield et al. profile →

Peers

Jennifer A. Doudna
Comparison fields: 5 of 199
  • Molecular Biology 71.4k
  • Genetics 12.3k
  • Plant Science 7.8k
  • Business and International Management 5.4k
  • Insect Science 4.9k
Replace Feng Zhang with:
Feng Zhang United States
Eugene V. Koonin United States
Kira S. Makarova United States
David R. Liu United States
Patrick D. Hsu United States
Jonathan S. Weissman United States
J. Keith Joung United States
Luciano A. Marraffini United States
F. Ann Ran United States
Emmanuelle Charpentier Germany
Jennifer A. Doudna relative to Feng Zhang United States Feng Zhang's profile →
Citations per field
00.5×1.5×
Feng Zhang · 1×
Citations per year

Countries citing papers authored by Jennifer A. Doudna

Since Specialization
Citations

This map shows the geographic impact of Jennifer A. Doudna's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Jennifer A. Doudna with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Jennifer A. Doudna more than expected).

Fields of papers citing papers by Jennifer A. Doudna

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Jennifer A. Doudna. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Jennifer A. Doudna. The network helps show where Jennifer A. Doudna may publish in the future.

Co-authorship network of co-authors of Jennifer A. Doudna

This figure shows the co-authorship network connecting the top 25 collaborators of Jennifer A. Doudna. A scholar is included among the top collaborators of Jennifer A. Doudna based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Jennifer A. Doudna. Jennifer A. Doudna is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
#WorkIndexed citations
1
Engineering self-deliverable ribonucleoproteins for genome editing in the brain
2024 ·Nature Communications ·Kai Chen,Elizabeth C. Stahl,Min Hyung Kang,(unknown),(unknown),Marena Trinidad,Jennifer A. Doudna
24
2
CRISPR–Cas9 bends and twists DNA to read its sequence
2022 ·Nature Structural & Molecular Biology ·Joshua C. Cofsky,Katarzyna M. Soczek,Gavin J. Knott,Eva Nogales,Jennifer A. Doudna
53
3
Diverse virus-encoded CRISPR-Cas systems include streamlined genome editors
2022 ·Cell ·Basem Al-Shayeb,Petr Skopintsev,Katarzyna M. Soczek,Elizabeth C. Stahl,Zheng Li,(unknown),Dylan C. J. Smock,(unknown),Patrick Pausch,Brady F. Cress,(unknown),Brian J. Staskawicz,David F. Savage,Steven E. Jacobsen,Jillian F. Banfield,Jennifer A. Doudna
93
4
Broad-spectrum CRISPR-Cas13a enables efficient phage genome editing
2022 ·Nature Microbiology ·Benjamin A. Adler,(unknown),Brady F. Cress,(unknown),Vivek K. Mutalik,Rodolphe Barrangou,Jillian F. Banfield,Jennifer A. Doudna
72
5
Potent CRISPR-Cas9 inhibitors from Staphylococcus genomes
2020 ·Proceedings of the National Academy of Sciences ·Kyle E. Watters,Haridha Shivram,Christof Fellmann,Rachel J. Lew,(unknown),Jennifer A. Doudna
54
6
Broad-spectrum enzymatic inhibition of CRISPR-Cas12a
2019 ·Nature Structural & Molecular Biology ·Gavin J. Knott,Brittney W. Thornton,Marco Lobba,Junjie Liu,Basem Al-Shayeb,Kyle E. Watters,Jennifer A. Doudna
97
7
Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs
2019 ·Nature Communications ·(unknown),James E. Lucas,Kyle E. Watters,Christof Fellmann,Andrew H. Ng,Benjamin M. Heineike,(unknown),Benjamin L. Oakes,Jiuxin Qu,Neha Prasad,Oren S. Rosenberg,David F. Savage,Hana El‐Samad,Jennifer A. Doudna,Tanja Kortemme
147
8
Programmable RNA recognition using a CRISPR-associated Argonaute
2018 ·Proceedings of the National Academy of Sciences ·Audronė Lapinaitė,Jennifer A. Doudna,J.H.D. Cate
37
9
CRISPR–Cas9 genome engineering of primary CD4+ T cells for the interrogation of HIV–host factor interactions
2018 ·Nature Protocols ·Judd F. Hultquist,Joseph Hiatt,Kathrin Schumann,Michael McGregor,Theodore L. Roth,Paige Haas,Jennifer A. Doudna,Alexander Marson,Nevan J. Krogan
78
10
Programmed DNA destruction by miniature CRISPR-Cas14 enzymesbreakdown →
2018 ·Science ·Lucas B. Harrington,David Burstein,Janice S. Chen,David Páez-Espino,Enbo Ma,Isaac P. Witte,Joshua C. Cofsky,Nikos C. Kyrpides,Jillian F. Banfield,Jennifer A. Doudna
895
11
CRISPR–Cas9 Structures and Mechanismsbreakdown →
2017 ·Annual Review of Biophysics ·Fuguo Jiang,Jennifer A. Doudna
1373
12
High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding
2017 ·Proceedings of the National Academy of Sciences ·Evan A. Boyle,Johan O. L. Andreasson,Lauren Chircus,Samuel H. Sternberg,Michelle J. Wu,Chantal K. Guegler,Jennifer A. Doudna,William J. Greenleaf
143
13
Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavagebreakdown →
2016 ·Science ·Fuguo Jiang,David W. Taylor,Janice S. Chen,(unknown),Kaihong Zhou,(unknown),Eva Nogales,Jennifer A. Doudna
486
14
Generation of knock-in primary human T cells using Cas9 ribonucleoproteinsbreakdown →
2015 ·Proceedings of the National Academy of Sciences ·Kathrin Schumann,Steven Lin,Eric Boyer,Dimitre R. Simeonov,Meena Subramaniam,Rachel E. Gate,(unknown),Chun Ye,Jeffrey A. Bluestone,Jennifer A. Doudna,Alexander Marson
533
15
Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activationbreakdown →
2014 ·Science ·Martin Jínek,Fuguo Jiang,David W. Taylor,Samuel H. Sternberg,Emine Kaya,Enbo Ma,Carolin Anders,M. Hauer,Kaihong Zhou,Steven Lin,Matias Kaplan,Anthony T. Iavarone,Emmanuelle Charpentier,Eva Nogales,Jennifer A. Doudna
900
16
Precise and Heritable Genome Editing in Evolutionarily Diverse Nematodes Using TALENs and CRISPR/Cas9 to Engineer Insertions and Deletions
2013 ·Genetics ·Te‐Wen Lo,Catherine S. Pickle,Steven Lin,Edward J. Ralston,(unknown),(unknown),Qian Bian,Jennifer A. Doudna,Barbara J Meyer
149
17
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunitybreakdown →
2012 ·Science ·Martin Jínek,Krzysztof Chylinski,Ines Fonfara,M. Hauer,Jennifer A. Doudna,Emmanuelle Charpentier
11546
18
Sequence- and Structure-Specific RNA Processing by a CRISPR Endonucleasebreakdown →
2010 ·Science ·R.E. Haurwitz,Martin Jínek,Blake Wiedenheft,Kaihong Zhou,Jennifer A. Doudna
531
19
Structural Roles for Human Translation Factor eIF3 in Initiation of Protein Synthesis
2005 ·Science ·Bunpote Siridechadilok,Christopher S. Fraser,Richard Hall,Jennifer A. Doudna,Eva Nogales
225
20
Specificity of RNA–RNA helix recognition
2002 ·Proceedings of the National Academy of Sciences ·Daniel J. Battle,Jennifer A. Doudna
85

About Jennifer A. Doudna

Jennifer A. Doudna is a scholar working on Aging, Business and International Management and Molecular Biology, having authored 363 papers that have together received 78.6k indexed citations. Recurring topics across this work include RNA and protein synthesis mechanisms (202 papers), CRISPR and Genetic Engineering (174 papers) and RNA Research and Splicing (74 papers). The work is most often cited by research in Business and International Management (5.4k citations), Aging (3.6k citations) and Molecular Biology (71.4k citations). Jennifer A. Doudna has collaborated with scholars based in United States, Russia and Switzerland. Frequent co-authors include Emmanuelle Charpentier, Martin Jínek, M. Hauer, Ines Fonfara, Krzysztof Chylinski, Samuel H. Sternberg, Kaihong Zhou, Enbo Ma, Fuguo Jiang and Janice S. Chen. Their work appears in journals such as Nature, Science and New England Journal of Medicine.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

You can learn more about the impact of Jennifer A. Doudna by visiting their Pantheon page.

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