Mitchell R. O’Connell

4.1k citations

29 papers · 3.0k indexed · 4 hit papers · h-index 18

Impact in

Business and International Management top 0.5%
- Innovation and Socioeconomic Development
Aging top 2%

Papers in ⓘ

Molecular Biology 28
- RNA and protein synthesis mechanisms 16
- CRISPR and Genetic Engineering 13
- RNA Research and Splicing 8
- Advanced biosensing and bioanalysis techniques 6
- RNA modifications and cancer 5
- RNA regulation and disease 4
Endocrinology 1

Co-authors: Jennifer A. Doudna (7 shared papers)Alexandra East-Seletsky (5 shared papers)David Burstein (2 shared papers)Robert Tjian (1 shared paper)Spencer C. Knight (1 shared paper)J.H.D. Cate (1 shared paper)Gavin J. Knott (3 shared papers)Matias Kaplan (1 shared paper)
Journals: Nucleic Acids Research (3 papers)Nature (2 papers)Molecular Cell (2 papers)Angewandte Chemie International Edition (2 papers)Advanced Materials Interfaces (2 papers)
Partner nations: United States Australia United Kingdom

In The Last Decade

Mitchell R. O’Connell

29 papers receiving 2.9k citations

Hit Papers

align trajectories log scale

RNA Targeting by Functionally Orthogonal Type VI-A CRISPR-Cas Enzymes 2017 · 218 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2017 Molecular Cell
2016 Nature
2016 Cell
2014 Nature

Peers

Countries citing papers authored by Mitchell R. O’Connell

Since Specialization

Citations

This map shows the geographic impact of Mitchell R. O’Connell's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Mitchell R. O’Connell with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Mitchell R. O’Connell more than expected).

Fields of papers citing papers by Mitchell R. O’Connell

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Mitchell R. O’Connell. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Mitchell R. O’Connell. The network helps show where Mitchell R. O’Connell may publish in the future.

Co-authors

The 25 scholars most cited alongside Mitchell R. O’Connell, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Mitchell R. O’Connell Line = papers co-authored together Mitchell R. O’Connell links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 29 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection Nature ·Alexandra East-Seletsky, Mitchell R. O’Connell, Spencer C. Knight, David Burstein, J.H.D. Cate, Robert Tjian, Jennifer A. Doudna Hit paper breakdown →	2016	879
2	Programmable RNA recognition and cleavage by CRISPR/Cas9 Nature ·Mitchell R. O’Connell, Benjamin L. Oakes, Samuel H. Sternberg, Alexandra East-Seletsky, Matias Kaplan, Jennifer A. Doudna Hit paper breakdown →	2014	500
3	Programmable RNA Tracking in Live Cells with CRISPR/Cas9 Cell ·David A. Nelles, Mark Y. Fang, Mitchell R. O’Connell, Jia Xu, Sebastian Markmiller, Jennifer A. Doudna, G Yeo Hit paper breakdown →	2016	410
4	Molecular Mechanisms of RNA Targeting by Cas13-containing Type VI CRISPR–Cas Systems Journal of Molecular Biology ·Mitchell R. O’Connell	2018	254
5	RNA Targeting by Functionally Orthogonal Type VI-A CRISPR-Cas Enzymes Molecular Cell ·Alexandra East-Seletsky, Mitchell R. O’Connell, David Burstein, Gavin J. Knott, Jennifer A. Doudna Hit paper breakdown →	2017	218
6	Guide-bound structures of an RNA-targeting A-cleaving CRISPR–Cas13a enzyme Nature Structural & Molecular Biology ·Gavin J. Knott, Alexandra East-Seletsky, Joshua C. Cofsky, James M. Holton, Emeric Charles, Mitchell R. O’Connell, Jennifer A. Doudna	2017	129
7	RNA Binding and HEPN-Nuclease Activation Are Decoupled in CRISPR-Cas13a Cell Reports ·Akshay Tambe, Alexandra East-Seletsky, Gavin J. Knott, Jennifer A. Doudna, Mitchell R. O’Connell	2018	111
8	Single-Stranded DNA Cleavage by Divergent CRISPR-Cas9 Enzymes Molecular Cell ·Enbo Ma, Lucas B. Harrington, Mitchell R. O’Connell, Kaihong Zhou, Jennifer A. Doudna	2015	89
9	The structural analysis of protein–protein interactions by NMR spectroscopy PROTEOMICS ·Mitchell R. O’Connell, Roland Gamsjaeger, Joel P. Mackay	2009	64
10	New design strategies for ultra-specific CRISPR-Cas13a-based RNA detection with single-nucleotide mismatch sensitivity Nucleic Acids Research ·Adrian M. Molina Vargas, Souvik Sinha, Raven M. Osborn, Pablo Arantes, Amun C. Patel, Stephen Dewhurst, Dwight J. Hardy, Andrew Cameron, Giulia Palermo, Mitchell R. O’Connell	2023	43
11	Synthesis of the Bacteriocin Glycopeptide Sublancin 168 and S-Glycosylated Variants Organic Letters ·Yves S. Y. Hsieh, Brendan L. Wilkinson, Mitchell R. O’Connell, Joel P. Mackay, Jacqueline M. Matthews, Richard J. Payne	2012	37
12	Two-timing zinc finger transcription factors liaising with RNA Trends in Biochemical Sciences ·Jon Burdach, Mitchell R. O’Connell, Joel P. Mackay, Merlin Crossley	2012	33
13	Gold Nanoparticle Enabled Localized Surface Plasmon Resonance on Unique Gold Nanomushroom Structures for On‐Chip CRISPR‐Cas13a Sensing Advanced Materials Interfaces ·Jacob Waitkus, Yu Chang, Li Liu, Srinivasu Valagerahally Puttaswamy, Taerin Chung, Adrian M. Molina Vargas, Stephen J. Dollery, Mitchell R. O’Connell, Haogang Cai, Gregory J. Tobin, Nikhil Bhalla, Ke Du	2022	28
14	A rapid method for assessing the RNA-binding potential of a protein Nucleic Acids Research ·Katerina Bendak, Fionna E. Loughlin, Vivian G. Cheung, Mitchell R. O’Connell, Merlin Crossley, Joel P. Mackay	2012	27
15	Gold Nanoparticle‐Labeled CRISPR‐Cas13a Assay for the Sensitive Solid‐State Nanopore Molecular Counting Advanced Materials Technologies ·Li Liu, Zhiheng Xu, Kamel Awayda, Stephen J. Dollery, Mengdi Bao, Jianlin Fan, Denis Cormier, Mitchell R. O’Connell, Gregory J. Tobin, Ke Du	2022	22
16	Unveiling the RNA-mediated allosteric activation discloses functional hotspots in CRISPR-Cas13a Nucleic Acids Research ·Souvik Sinha, Adrian M. Molina Vargas, Pablo Arantes, Amun C. Patel, Mitchell R. O’Connell, Giulia Palermo	2023	19
17	A Structural Analysis of DNA Binding by Myelin Transcription Factor 1 Double Zinc Fingers Journal of Biological Chemistry ·Roland Gamsjaeger, Mitchell R. O’Connell, Liza Cubeddu, Nicholas E. Shepherd, Jason Lowry, Ann H. Kwan, Marylène Vandevenne, M.K. Swanton, Jacqueline M. Matthews, Joel P. Mackay	2013	18
18	Protein folding stabilities are a major determinant of oxidation rates for buried methionine residues Journal of Biological Chemistry ·Ethan J. Walker, John Q. Bettinger, Kevin Welle, Jennifer R. Hryhorenko, Adrian M. Molina Vargas, Mitchell R. O’Connell, Sina Ghaemmaghami	2022	17
19	Csx28 is a membrane pore that enhances CRISPR-Cas13b–dependent antiphage defense Science ·Arica R. VanderWal, Jung-Un Park, Bogdan Polevoda, Julia K. Nicosia, Adrian M. Molina Vargas, Elizabeth H. Kellogg, Mitchell R. O’Connell	2023	16
20	Aerosol Jet Printing-Enabled Dual-Function Electrochemical and Colorimetric Biosensor for SARS-CoV-2 Detection Analytical Chemistry ·Li Liu, Zhiheng Xu, Adrian M. Molina Vargas, Stephen J. Dollery, Michael G. Schrlau, Denis Cormier, Mitchell R. O’Connell, Gregory J. Tobin, Ke Du	2023	12

About Mitchell R. O’Connell

Mitchell R. O’Connell is a scholar working on Molecular Biology, Endocrinology, Clinical Biochemistry, Genetics and Biomedical Engineering, having authored 29 papers that have together received 3.0k indexed citations. Recurring topics across this work include RNA and protein synthesis mechanisms (16 papers), CRISPR and Genetic Engineering (13 papers), RNA Research and Splicing (8 papers), Advanced biosensing and bioanalysis techniques (6 papers), RNA modifications and cancer (5 papers), RNA regulation and disease (4 papers), Bacterial Genetics and Biotechnology (3 papers) and Biosensors and Analytical Detection (3 papers). The work is most often cited by research in Business and International Management (244 citations), Aging (115 citations), Molecular Biology (2.8k citations), Insect Science (216 citations) and Genetics (299 citations). Mitchell R. O’Connell has collaborated with scholars based in United States, Australia and United Kingdom. Frequent co-authors include Jennifer A. Doudna, Alexandra East-Seletsky, David Burstein, Robert Tjian, Spencer C. Knight, J.H.D. Cate, Gavin J. Knott, Matias Kaplan, Samuel H. Sternberg and Benjamin L. Oakes. Their work appears in journals such as Nucleic Acids Research, Nature, Molecular Cell, Angewandte Chemie International Edition and Advanced Materials Interfaces.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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