J Costello

36.9k citations

142 papers · 10.6k indexed · 2 hit papers · h-index 48

Cancer Research top 0.5%
- Cancer Genomics and Diagnostics 13
- MicroRNA in disease regulation 13
Genetics top 0.2%
- Glioma Diagnosis and Treatment 44
Molecular Biology top 0.5%
- Epigenetics and DNA Methylation 60
- Genomics and Chromatin Dynamics 24
- RNA modifications and cancer 19
- Cancer-related gene regulation 14
Oncology top 2%
Genetics top 1%
- Glioma Diagnosis and Treatment 44
Physiology
- Telomeres, Telomerase, and Senescence 15

Co-authors: Raman P. Nagarajan Chibo Hong Mirang Kim Webster K. Cavenee Russell O. Pieper Christoph Plass Jun S. Song B Bernstein
Cited by: Cancer Research Genetics Molecular Biology
Journals: Neuro-Oncology (25 papers)Cancer Research (13 papers)Nature Communications (5 papers)
Partner nations: United States Canada Germany

In The Last Decade

J Costello

133 papers receiving 10.5k citations

Hit Papers

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Peers

Countries citing papers authored by J Costello

Since Specialization

Citations

This map shows the geographic impact of J Costello's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by J Costello with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites J Costello more than expected).

Fields of papers citing papers by J Costello

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by J Costello. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by J Costello. The network helps show where J Costello may publish in the future.

Co-authorship network

The 25 scholars most cited alongside J Costello, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with J Costello Line = papers co-authored together J Costello links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	The immortality mechanism of TERT promoter mutant cancers is self-reinforcing and reversible Molecular Cell ·Nicholas Stevers,Kenichi Hirota,Ron M. Aryel,Carter J. Barger,Chibo Hong,Jânio Roque Barros de Castro,Andrew McKinney,Eva Grigoriadou,Susan Curtis,Paolo Colombo,Abigail K. Suwala,Christina Appin,John D. Gordan,Annette M Molinaro,Jun S. Song,J Costello	2025	1
2	Activating the dark genome to illuminate cancer vaccine targets Nature Genetics ·Paolo Colombo,Hideho Okada,J Costello	2024	2
3	Deconstructing Intratumoral Heterogeneity through Multiomic and Multiscale Analysis of Serial Sections Cancers ·Patrick G. Schupp,Samuel J. Shelton,张鹏侠,竹内幾也,Brett Johnson,Tali Mazor,Kevin W. Kelley,Matthew B. Potts,Michael W. McDermott,Eric J. Huang,Daniel A. Lim,Russell O. Pieper,Mitchel S. Berger,J Costello,Joanna J. Phillips,Michael C. Oldham	2024	2
4	Deuterium Metabolic Imaging Reports on TERT Expression and Early Response to Therapy in Cancer Clinical Cancer Research ·Georgios Batsios,Céline Taglang,丸山富美子,Nicholas Stevers,Carter J. Barger,Anne Marie Gillespie,Sabrina M. Ronen,J Costello,Pavithra Viswanath	2022	25
5	Conserved features of TERT promoter duplications reveal an activation mechanism that mimics hotspot mutations in cancer Nature Communications ·Carter J. Barger,Abigail K. Suwala,Katarzyna M. Soczek,Albert Wang,Ivan Matus T,Chibo Hong,Jennifer A. Doudna,Susan M. Chang,Joanna J. Phillips,David A. Solomon,J Costello	2022	13
6	GABP couples oncogene signaling to telomere regulation in TERT promoter mutant cancer Cell Reports ·Andrew McKinney,Radhika Mathur,Nicholas Stevers,Annette M Molinaro,Susan M. Chang,Joanna J. Phillips,J Costello	2022	11
7	Cancer-specific loss of TERT activation sensitizes glioblastoma to DNA damage Proceedings of the National Academy of Sciences ·Alexandra M. Amen,Christof Fellmann,Katarzyna M. Soczek,J. F. Owens,Rachel J. Lew,Gavin J. Knott,Rifka Raihana,Andrew McKinney,Andrew Mancini,Jennifer A. Doudna,J Costello	2021	41
8	miRNA-independent function of long noncoding pri-miRNA loci Proceedings of the National Academy of Sciences ·Daniel He,David Wu,Sören Müller,Lin Wang,Jesse D. Champion,晋良石井,Siyuan Liu,Miao Cui,Sung Jun Hong,Miten Jain,Mikako Abe,Mark Akeson,J Costello,Aarón Díaz,Daniel A. Lim	2021	25
9	Glutamate Is a Noninvasive Metabolic Biomarker of IDH1-Mutant Glioma Response to Temozolomide Treatment Cancer Research ·Elavarasan Subramani,Marina Radoul,Chloé Najac,Georgios Batsios,P. Jennart,Donghyun Hong,Anne Marie Gillespie,Romelyn Delos Santos,Pavithra Viswanath,J Costello,Russell O. Pieper,Sabrina M. Ronen	2020	22
10	Saturation mutagenesis of twenty disease-associated regulatory elements at single base-pair resolution Nature Communications ·Martin Kircher,Chenling Xiong,Beth Martin,Max Schubach,Fumitaka Inoue,Robert J.A. Bell,J Costello,Jay Shendure,Nadav Ahituv	2019	131
11	Mutant IDH1 Expression Drives TERT Promoter Reactivation as Part of the Cellular Transformation Process Cancer Research ·Shigeo Ohba,Joydeep Mukherjee,Matheus F. Reis,Andrew Mancini,Tracy T. Chow,Matthew D. Wood,Lindsey Jones,Tali Mazor,Roxanne Marshall,Pavithra Viswanath,Kyle M. Walsh,Arie Perry,Robert J.A. Bell,Joanna J. Phillips,J Costello,Sabrina M. Ronen,Russell O. Pieper	2016	50
12	Somatic and Germline TP53 Alterations in Second Malignant Neoplasms from Pediatric Cancer Survivors Clinical Cancer Research ·Amy L. Sherborne,Vincent Lavergne,Katharine Yu,亨一小林,Ettore Rossini,Tali Mazor,Lei Xia,Andrew Horvai,Mignon L. Loh,Steven G. DuBois,Robert E. Goldsby,Joseph P. Neglia,Sue Hammond,Leslie L. Robison,Rosanna Wustrack,J Costello,Alice Nakamura,Kevin Shannon,Smita Bhatia,Jean L. Nakamura	2016	24
13	The Genetics of Splicing in Neuroblastoma Cancer Discovery ·Justin Chen,Christopher S. Hackett,Shile Zhang,Young Song,Robert J.A. Bell,Annette M. Molinaro,David A. Quigley,Allan Balmain,Jun S. Song,J Costello,W. Clay Gustafson,Terry Van Dyke,Pui–Yan Kwok,Javed Khan,William A. Weiss	2015	13
14	The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer Science ·Robert J.A. Bell,H. Tomas Rube,Alex Kreig,Andrew Mancini,Shaun D. Fouse,Raman P. Nagarajan,Serah Choi,Chibo Hong,Daniel He,Melike Pekmezci,John K. Wiencke,Margaret Wrensch,Susan M. Chang,Kyle M. Walsh,Sua Myong,Jun S. Song,J Costello	2015	398
15	The A/G Allele of Rs16906252 Predicts for MGMT Methylation and Is Selectively Silenced in Premalignant Lesions from Smokers and in Lung Adenocarcinomas Clinical Cancer Research ·Shuguang Leng,Amanda M. Bernauer,Chibo Hong,C. Kieu,Christin M. Yingling,Kristina G. Flores,Mathewos Tessema,Carmen S. Tellez,周田美,Elizabeth A. Burki,Maria A. Picchi,Christine A. Stidley,Michael D. Prados,J Costello,Frank D. Gilliland,Richard E. Crowell,Steven A. Belinsky	2011	46
16	Abnormal DNA Methylation of CD133 in Colorectal and Glioblastoma Tumors Cancer Research ·Joo Mi Yi,Hsing-Chen Tsai,Sabine C. Glöckner,Steven H. Lin,Joyce E. Ohm,Hariharan Easwaran,C. David James,J Costello,Gregory J. Riggins,Charles G. Eberhart,John Laterra,Angelo L. Vescovi,Nita Ahuja,James G. Herman,Kornel E. Schuebel,Stephen B. Baylin	2008	115
17	Genome-wide Hypomethylation in Human Glioblastomas Associated with Specific Copy Number Alteration, Methylenetetrahydrofolate Reductase Allele Status, and Increased Proliferation Cancer Research ·Benoît Cadieux,Tsui‐Ting Ching,Scott R. VandenBerg,J Costello	2006	178
18	Lack of Germ-Line Promoter Methylation in BRCA1 -Negative Families with Familial Breast Cancer Genetic Testing ·Ying Chen,Amanda E. Toland,Jane McLennan,Jane Fridlyand,(unknown),J Costello,John L. Ziegler	2006	19
19	Shared Epigenetic Mechanisms in Human and Mouse Gliomas Inactivate Expression of the Growth Suppressor SLC5A8 Cancer Research ·Chibo Hong,Alika K. Maunakea,Peter Jun,Andrew W. Bollen,John Hodgson,David Goldenberg,William A. Weiss,J Costello	2005	57
20	SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer Proceedings of the National Academy of Sciences ·Biao He,Liang You,Kazutsugu Uematsu,Keling Zang,Zhidong Xu,Amie Y. Lee,J Costello,Frank McCormick,David M. Jablons	2003	312

About J Costello

J Costello is a scholar working on Genetics, Cancer Research, Molecular Biology, Biotechnology and Structural Biology, having authored 142 papers that have together received 10.6k indexed citations. Recurring topics across this work include Epigenetics and DNA Methylation (60 papers), Glioma Diagnosis and Treatment (44 papers), Genomics and Chromatin Dynamics (24 papers), RNA modifications and cancer (19 papers), Telomeres, Telomerase, and Senescence (15 papers), Cancer-related gene regulation (14 papers), Cancer Genomics and Diagnostics (13 papers) and MicroRNA in disease regulation (13 papers). The work is most often cited by research in Cancer Research (2.8k citations), Genetics (1.9k citations), Molecular Biology (7.8k citations), Oncology (1.5k citations) and Genetics (1.4k citations). J Costello has collaborated with scholars based in United States, Canada and Germany. Frequent co-authors include Raman P. Nagarajan, Chibo Hong, Mirang Kim, Webster K. Cavenee, Russell O. Pieper, Christoph Plass, Jun S. Song, B Bernstein, Scott R. VandenBerg and Marco A. Marra. Their work appears in journals such as Neuro-Oncology, Cancer Research, Nature Communications, Proceedings of the National Academy of Sciences and Clinical Cancer Research.

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