Martin Kircher

40.8k total citations · 13 hit papers
71 papers, 15.1k citations indexed

About

Martin Kircher is a scholar working on Molecular Biology, Genetics and Cancer Research. According to data from OpenAlex, Martin Kircher has authored 71 papers receiving a total of 15.1k indexed citations (citations by other indexed papers that have themselves been cited), including 61 papers in Molecular Biology, 25 papers in Genetics and 11 papers in Cancer Research. Recurrent topics in Martin Kircher's work include Genomics and Phylogenetic Studies (19 papers), Genomics and Rare Diseases (14 papers) and RNA and protein synthesis mechanisms (13 papers). Martin Kircher is often cited by papers focused on Genomics and Phylogenetic Studies (19 papers), Genomics and Rare Diseases (14 papers) and RNA and protein synthesis mechanisms (13 papers). Martin Kircher collaborates with scholars based in Germany, United States and Canada. Martin Kircher's co-authors include Jay Shendure, Daniela Witten, Gregory M. Cooper, Matthias Meyer, Brian J. O’Roak, Philipp Rentzsch, Janet Kelso, Svante Pääbo, Susanna Sawyer and Matthew W. Snyder and has published in prestigious journals such as Nature, Cell and Proceedings of the National Academy of Sciences.

In The Last Decade

Martin Kircher

68 papers receiving 15.0k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

A general framework for estimating the relative pathogenicity of human genetic variants

2014 3.6k citations Martin Kircher, Daniela Witten et al. Nature Genetics profile →
CADD: predicting the deleteriousness of variants throughout the human genome

2018 1.9k citations Daniela Witten, Gregory M. Cooper et al. Nucleic Acids Research profile →
Illumina Sequencing Library Preparation for Highly Multiplexed Target Capture and Sequencing

2010 1.4k citations Martin Kircher et al. profile →
Cell-free DNA Comprises an In Vivo Nucleosome Footprint that Informs Its Tissues-Of-Origin

2016 940 citations Martin Kircher, Jay Shendure et al. profile →
The evolution of gene expression levels in mammalian organs

2011 844 citations Martin Kircher et al. profile →
Deep proteome and transcriptome mapping of a human cancer cell line

2011 781 citations Martin Kircher, Janet Kelso et al. profile →
Double indexing overcomes inaccuracies in multiplex sequencing on the Illumina platform

2011 681 citations Martin Kircher et al. Nucleic Acids Research profile →
Denisova Admixture and the First Modern Human Dispersals into Southeast Asia and Oceania

2011 342 citations Martin Kircher et al. profile →
CADD-Splice—improving genome-wide variant effect prediction using deep learning-derived splice scores

2021 320 citations Max Schubach, Jay Shendure et al. profile →
Removal of deaminated cytosines and detection of in vivo methylation in ancient DNA

2009 293 citations Martin Kircher et al. Nucleic Acids Research profile →
Transcriptomes of germinal zones of human and mouse fetal neocortex suggest a role of extracellular matrix in progenitor self-renewal

2012 241 citations Martin Kircher et al. profile →
A Complete mtDNA Genome of an Early Modern Human from Kostenki, Russia

2010 192 citations Martin Kircher et al. profile →
CADD v1.7: using protein language models, regulatory CNNs and other nucleotide-level scores to improve genome-wide variant predictions

2024 112 citations Max Schubach, Thorben Maaß et al. Nucleic Acids Research profile →

Peers

Countries citing papers authored by Martin Kircher

Since Specialization

Citations

This map shows the geographic impact of Martin Kircher's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Martin Kircher with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Martin Kircher more than expected).

Fields of papers citing papers by Martin Kircher

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Martin Kircher. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Martin Kircher. The network helps show where Martin Kircher may publish in the future.

Co-authorship network of co-authors of Martin Kircher

This figure shows the co-authorship network connecting the top 25 collaborators of Martin Kircher. A scholar is included among the top collaborators of Martin Kircher based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Martin Kircher. Martin Kircher is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Massively parallel reporter assays and mouse transgenic assays provide correlated and complementary information about neuronal enhancer activity 2025 ·Nature Communications ·Michael Kosicki, Dianne Laboy Cintrón, (unknown), Max Schubach, Nicholas F. Page, Ilias Georgakopoulos‐Soares, Jennifer A. Akiyama, Ingrid Plajzer-Frick, Catherine S. Novak, Momoe Kato, Riana D. Hunter, (unknown), Sarah Barton, Patrick Godfrey, (unknown), Stephan Sanders, Martin Kircher, L Pennacchio, Nadav Ahituv	4
2	Massively parallel jumping assay decodes Alu retrotransposition activity 2025 ·Nature Communications ·Navneet Matharu, Jingjing Zhao, (unknown), (unknown), (unknown), Zizheng Li, (unknown), (unknown), Sawitree Rattanasopha, Thomas J. Meyer, Lucia Carbone, Martin Kircher, Nadav Ahituv	1
3	cfDNA UniFlow: a unified preprocessing pipeline for cell-free DNA data from liquid biopsies 2024 ·GigaScience ·Sebastian Röner, (unknown), Michael R. Speicher, Martin Kircher	0
4	CADD v1.7: using protein language models, regulatory CNNs and other nucleotide-level scores to improve genome-wide variant predictions breakdown → 2024 ·Nucleic Acids Research ·Max Schubach, Thorben Maaß, (unknown), Sebastian Röner, Martin Kircher	112
5	Predicting the pathogenicity of missense variants using features derived from AlphaFold2 2023 ·Bioinformatics ·Axel Schmidt, Sebastian Röner, (unknown), Hannah Klinkhammer, Martin Kircher, Kerstin U. Ludwig	35
6	GCparagon: evaluating and correcting GC biases in cell-free DNA at the fragment level 2023 ·NAR Genomics and Bioinformatics ·(unknown), (unknown), Sebastian Röner, Martin Kircher, Michael R. Speicher	1
7	Results of genetic analysis of 11 341 participants enrolled in the My Life, Our Future hemophilia genotyping initiative in the United States 2022 ·Journal of Thrombosis and Haemostasis ·Jill M. Johnsen, (unknown), (unknown), (unknown), Beth Martin, Martin Kircher, Neil C. Josephson, Jay Shendure, Sarah Ruuska, Leonard A. Valentino, Glenn F. Pierce, (unknown), Dunlei Cheng, Michael Recht, Barbara A. Konkle	16
8	A systematic evaluation of the design and context dependencies of massively parallel reporter assays 2020 ·Nature Methods ·Jason C. Klein, Vikram Agarwal, Fumitaka Inoue, Aidan Keith, Beth Martin, Martin Kircher, Nadav Ahituv, Jay Shendure	113
9	lentiMPRA and MPRAflow for high-throughput functional characterization of gene regulatory elements 2020 ·Nature Protocols ·M. Grace Gordon, Fumitaka Inoue, Beth Martin, Max Schubach, Vikram Agarwal, Sean Whalen, (unknown), Jingjing Zhao, Tal Ashuach, Ryan Ziffra, Anat Kreimer, Ilias Georgakopoulos‐Soares, Nir Yosef, Chun Ye, Katherine S. Pollard, Jay Shendure, Martin Kircher, Nadav Ahituv	70
10	HemoMIPs—Automated analysis and result reporting pipeline for targeted sequencing data 2020 ·PLoS Computational Biology ·(unknown), Beth Martin, Martin Kircher	1
11	The impact of different negative training data on regulatory sequence predictions 2020 ·PLoS ONE ·(unknown), Max Schubach, Martin Kircher	8
12	Mutations in the translocon‐associated protein complex subunit SSR3 cause a novel congenital disorder of glycosylation 2019 ·Journal of Inherited Metabolic Disease ·Bobby G. Ng, Charles Marques Lourenço, Marie‐Estelle Losfeld, Kati J. Buckingham, Martin Kircher, Deborah A. Nickerson, Jay Shendure, Michael J. Bamshad, Hudson H. Freeze	19
13	Saturation mutagenesis of twenty disease-associated regulatory elements at single base-pair resolution 2019 ·Nature Communications ·Martin Kircher, Chenling Xiong, Beth Martin, Max Schubach, Fumitaka Inoue, Robert J.A. Bell, J Costello, Jay Shendure, Nadav Ahituv	131
14	Concurrent genome and epigenome editing by CRISPR-mediated sequence replacement 2019 ·BMC Biology ·Jes Alexander, Gregory M. Findlay, Martin Kircher, Jay Shendure	10
15	Multiplex assessment of protein variant abundance by massively parallel sequencing 2018 ·Nature Genetics ·Kenneth A. Matreyek, Lea M. Starita, Jason J. Stephany, Beth Martin, Melissa A. Chiasson, Vanessa E. Gray, Martin Kircher, Arineh Khechaduri, Jennifer N. Dines, Ronald J. Hause, Smita Bhatia, William E. Evans, Mary V. Relling, Wenjian Yang, Jay Shendure, Douglas M. Fowler	254
16	Encephalopathy caused by novel mutations in the CMP‐sialic acid transporter, SLC35A1 2017 ·American Journal of Medical Genetics Part A ·Bobby G. Ng, Carla Asteggiano, Martin Kircher, Kati J. Buckingham, Kimiyo Raymond, Deborah A. Nickerson, Jay Shendure, Michael J. Bamshad, (unknown), Hudson H. Freeze	26
17	A systematic comparison reveals substantial differences in chromosomal versus episomal encoding of enhancer activity 2016 ·Genome Research ·Fumitaka Inoue, Martin Kircher, Beth Martin, Gregory M. Cooper, Daniela Witten, Michael T. McManus, Nadav Ahituv, Jay Shendure	179
18	Expanding the Molecular and Clinical Phenotype of SSR4-CDG 2015 ·Human Mutation ·Bobby G. Ng, Kimiyo Raymond, Martin Kircher, Kati J. Buckingham, Tim Wood, Jay Shendure, Deborah A. Nickerson, Michael J. Bamshad, (unknown), Fabíola Paoli Monteiro, Brett H. Graham, (unknown), Rebecca Sparkes, Angela E. Scheuerle, Sara Cathey, Fernando Kok, James B. Gibson, Hudson H. Freeze	25
19	Characterization of ancient and modern genomes by SNP detection and phylogenomic and metagenomic analysis using PALEOMIX 2014 ·Nature Protocols ·Mikkel Schubert, Luca Ermini, Clio Der Sarkissian, Hákon Jónsson, Aurélien Ginolhac, Robert Schaefer, Michael D. Martin, Ruth Fernández, Martin Kircher, Molly E. McCue, Eske Willerslev, Ludovic Orlando	314
20	Addressing challenges in the production and analysis of illumina sequencing data 2011 ·BMC Genomics ·Martin Kircher, Patricia Heyn, Janet Kelso	114

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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