Douglas A. Melton

73.0k citations

211 papers · 54.6k indexed · 25 hit papers · h-index 109

Molecular Biology top 0.01%
Surgery top 0.01%
Genetics top 0.01%
Endocrinology, Diabetes and Metabolism top 0.1%
Cell Biology top 0.1%

Co-authors: Paul A. Krieg Michael R. Rebagliati Tom Maniatis Peter S. Klein Kai Zinn Ali Hemmati‐Brivanlou Juliana Brown Yuval Dor
Topics: Pancreatic function and diabetes (92 papers)Pluripotent Stem Cells Research (61 papers)Congenital heart defects research (36 papers)
Cited by: Molecular Biology Genetics Surgery
Journals: Nature Science New England Journal of Medicine
Partner nations: United States United Kingdom Germany

In The Last Decade

Douglas A. Melton

209 papers receiving 53.0k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

1984 6.1k citations Douglas A. Melton et al. profile →
Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells

2005 3.4k citations Jacob Zucker, Douglas A. Melton et al. Cell profile →
A molecular mechanism for the effect of lithium on development.

1996 2.0k citations Douglas A. Melton et al. Proceedings of the National Academy of Sciences profile →
Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation

2004 1.8k citations Douglas A. Melton et al. Nature profile →
In vivo reprogramming of adult pancreatic exocrine cells to β-cells

2008 1.5k citations Qiao Zhou, Douglas A. Melton et al. Nature profile →
Generation of Functional Human Pancreatic β Cells In Vitro

2014 1.5k citations Felicia W. Pagliuca, Jeffrey R. Millman et al. Cell profile →
Functional messenger RNAs are produced by SP6in vitrotranscription of cloned cDNAs

1984 1.4k citations Douglas A. Melton et al. profile →
"Stemness": Transcriptional Profiling of Embryonic and Adult Stem Cells

2002 1.3k citations Douglas A. Melton et al. Science profile →
Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors

2002 1.2k citations Douglas A. Melton et al. profile →
Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds

2008 1.2k citations Alice E. Chen, Douglas A. Melton et al. profile →
Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2

2008 987 citations Douglas A. Melton et al. profile →
A Single-Cell Transcriptomic Map of the Human and Mouse Pancreas Reveals Inter- and Intra-cell Population Structure

2016 913 citations Maayan Baron, Adrian Veres et al. Cell Systems profile →
Effects of eight growth factors on the differentiation of cells derived from human embryonic stem cells

2000 853 citations Douglas A. Melton et al. Proceedings of the National Academy of Sciences profile →
Induction of Pancreatic Differentiation by Signals from Blood Vessels

2001 825 citations Eckhard Lammert, Ondine Cleaver et al. Science profile →
Insulin Staining of ES Cell Progeny from Insulin Uptake

2003 774 citations Douglas A. Melton et al. Science profile →
Derivation of Embryonic Stem-Cell Lines from Human Blastocysts

2004 733 citations Chad A. Cowan, Irina Klimanskaya et al. New England Journal of Medicine profile →
A maternal mRNA localized to the vegetal hemisphere in xenopus eggs codes for a growth factor related to TGF-β

1987 663 citations Douglas A. Melton et al. Cell profile →
Hedgehog signals regulate multiple aspects of gastrointestinal development

2000 652 citations Douglas A. Melton, Andrew P. McMahon et al. profile →
Marked differences in differentiation propensity among human embryonic stem cell lines

2008 628 citations Chad A. Cowan, Douglas A. Melton et al. profile →
Notch signaling controls multiple steps of pancreatic differentiation

2003 625 citations Douglas A. Melton et al. Proceedings of the National Academy of Sciences profile →
Nuclear Reprogramming of Somatic Cells After Fusion with Human Embryonic Stem Cells

2005 625 citations Chad A. Cowan, Douglas A. Melton et al. Science profile →
Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity

1994 602 citations Douglas A. Melton et al. Cell profile →
Charting cellular identity during human in vitro β-cell differentiation

2019 350 citations Adrian Veres, Jennifer Hyoje-Ryu Kenty et al. Nature profile →
Generation of stem cell-derived β-cells from patients with type 1 diabetes

2016 295 citations Jeffrey R. Millman, Mads Gürtler et al. profile →
Pancreas regeneration

2018 261 citations Qiao Zhou, Douglas A. Melton Nature profile →

Peers

Countries citing papers authored by Douglas A. Melton

Since Specialization

Citations

This map shows the geographic impact of Douglas A. Melton's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Douglas A. Melton with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Douglas A. Melton more than expected).

Fields of papers citing papers by Douglas A. Melton

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Douglas A. Melton. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Douglas A. Melton. The network helps show where Douglas A. Melton may publish in the future.

Co-authorship network of co-authors of Douglas A. Melton

This figure shows the co-authorship network connecting the top 25 collaborators of Douglas A. Melton. A scholar is included among the top collaborators of Douglas A. Melton based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Douglas A. Melton. Douglas A. Melton is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	A therapeutic convection–enhanced macroencapsulation device for enhancing β cell viability and insulin secretion 2021 ·Proceedings of the National Academy of Sciences ·Kisuk Yang,Eoin D. O’Cearbhaill,Sophie S. Liu,(unknown),Girish Chitnis,Allison E. Hamilos,Jun Xu,(unknown),Jaime A. Giraldo,(unknown),(unknown),Yuhan Lee,Ramona Pop,Róbert Langer,Douglas A. Melton,Dale L. Greiner,Jeffrey M. Karp	39
2	The promise of stem cell-derived islet replacement therapy 2021 ·Diabetologia ·Douglas A. Melton	64
3	A 3D culture platform enables development of zinc-binding prodrugs for targeted proliferation of β cells 2020 ·Science Advances ·Kisuk Yang,Miseon Lee,Peter A. Jones,Sophie S. Liu,(unknown),Jun Xu,Vedagopuram Sreekanth,Jamie L. Y. Wu,(unknown),(unknown),Ramona Pop,Yuhan Lee,Bridget K. Wagner,Douglas A. Melton,Amit Choudhary,Jeffrey M. Karp	26
4	Generation of hypoimmunogenic human pluripotent stem cells 2019 ·Proceedings of the National Academy of Sciences ·Xiao Han,Mengning Wang,(unknown),Paul J. Franco,Jennifer Hyoje-Ryu Kenty,(unknown),Yulei Xia,(unknown),Leonardo M. R. Ferreira,Jack L. Strominger,Douglas A. Melton,Torsten Meißner,Chad A. Cowan	239
5	Identifying gene expression programs of cell-type identity and cellular activity with single-cell RNA-Seq 2019 ·eLife ·Dylan Kotliar,Adrian Veres,M. Aurel Nagy,Shervin Tabrizi,Eran Hodis,Douglas A. Melton,Pardis C. Sabeti	221
6	Establishment of human pluripotent stem cell-derived pancreatic β-like cells in the mouse pancreas 2018 ·Proceedings of the National Academy of Sciences ·Haiting Ma,Katherine J. Wert,Dmitry Shvartsman,Douglas A. Melton,Rudolf Jaenisch	30
7	A Single-Cell Transcriptomic Map of the Human and Mouse Pancreas Reveals Inter- and Intra-cell Population Structurebreakdown → 2016 ·Cell Systems ·Maayan Baron,Adrian Veres,Samuel L. Wolock,(unknown),Renaud Gaujoux,Amedeo Vetere,(unknown),Bridget K. Wagner,Shai S. Shen-Orr,Allon M. Klein,Douglas A. Melton,Itai Yanai	913
8	Applied Developmental Biology 2016 ·Current topics in developmental biology ·Douglas A. Melton	16
9	Resolving Discrepant Findings on ANGPTL8 in β-Cell Proliferation: A Collaborative Approach to Resolving the Betatrophin Controversy 2016 ·PLoS ONE ·Aaron R. Cox,Ornella Barrandon,Erica P. Cai,(unknown),(unknown),(unknown),Carol J. Lam,Yi Peng,Douglas A. Melton,Jake A. Kushner	35
10	Generation of Functional Human Pancreatic β Cells In Vitrobreakdown → 2014 ·Cell ·Felicia W. Pagliuca,Jeffrey R. Millman,Mads Gürtler,Michael Segel,(unknown),(unknown),Quinn P. Peterson,Dale L. Greiner,Douglas A. Melton	1471
11	Extreme Makeover: Converting One Cell into Another 2008 ·Cell stem cell ·Qiao Zhou,Douglas A. Melton	185
12	Prospective isolation and global gene expression analysis of definitive and visceral endoderm 2007 ·Developmental Biology ·Richard I. Sherwood,(unknown),Ondine Cleaver,David A. Shaywitz,(unknown),Alice E. Chen,Todd R. Golub,Douglas A. Melton	111
13	Human Embryonic Stem Cells 2006 ·Methods in enzymology on CD-ROM/Methods in enzymology ·Hidenori Akutsu,Chad A. Cowan,Douglas A. Melton	14
14	The Molecular Biography of the Cell 2005 ·Cell ·David A. Shaywitz,Douglas A. Melton	6
15	Derivation of Embryonic Stem-Cell Lines from Human Blastocystsbreakdown → 2004 ·New England Journal of Medicine ·Chad A. Cowan,Irina Klimanskaya,Jill A. McMahon,(unknown),J. Witmyer,Jacob Zucker,Shunping Wang,Cynthia C. Morton,Andrew P. McMahon,Doug Powers,Douglas A. Melton	733
16	Role of endothelial cells in early pancreas and liver development 2002 ·Mechanisms of Development ·Eckhard Lammert,Ondine Cleaver,Douglas A. Melton	188
17	Induction of Pancreatic Differentiation by Signals from Blood Vesselsbreakdown → 2001 ·Science ·Eckhard Lammert,Ondine Cleaver,Douglas A. Melton	825
18	Xenopus Mad Proteins Transduce Distinct Subsets of Signals for the TGFβ Superfamily 1996 ·Cell ·Jonathan M. Graff,Anu Bansal,Douglas A. Melton	388
19	Pre-existent pattern in Xenopus animal pole cells revealed by induction with activin 1991 ·Nature ·Sergei Y. Sokol,Douglas A. Melton	179
20	Antisense RNA and DNA 1988 ·Douglas A. Melton	11

About Douglas A. Melton

Douglas A. Melton is a scholar working on Aging, Genetics and Molecular Biology, having authored 211 papers that have together received 54.6k indexed citations. Recurring topics across this work include Pancreatic function and diabetes (92 papers), Pluripotent Stem Cells Research (61 papers) and Congenital heart defects research (36 papers). The work is most often cited by research in Molecular Biology (40.1k citations), Genetics (13.2k citations) and Surgery (17.8k citations). Douglas A. Melton has collaborated with scholars based in United States, United Kingdom and Germany. Frequent co-authors include Paul A. Krieg, Michael R. Rebagliati, Tom Maniatis, Peter S. Klein, Kai Zinn, Ali Hemmati‐Brivanlou, Juliana Brown, Yuval Dor, Qiao Zhou and Jayaraj Rajagopal. Their work appears in journals such as Nature, Science and New England Journal of Medicine.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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