Denis C. Guttridge

23.9k citations

146 papers · 16.8k indexed · 7 hit papers · h-index 61

Molecular Biology top 0.2%
Physiology top 0.2%
Cancer Research top 0.2%
Oncology top 1%
Immunology top 1%

Co-authors: Albert S. Baldwin Kenneth C.H. Fearon Marty W. Mayo Katherine J. Ladner David J. Glass Swarnali Acharyya Lee V. Madrid Cun-Yu Wang
Topics: Muscle Physiology and Disorders (59 papers)Nutrition and Health in Aging (34 papers)NF-κB Signaling Pathways (34 papers)
Cited by: Cancer Research Physiology Rehabilitation
Journals: Science Proceedings of the National Academy of Sciences Journal of Biological Chemistry
Partner nations: United States United Kingdom France

In The Last Decade

Denis C. Guttridge

143 papers receiving 16.6k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

NF-κB Controls Cell Growth and Differentiation through Transcriptional Regulation of Cyclin D1

1999 1.1k citations Denis C. Guttridge, Albert S. Baldwin et al. profile →
Cancer-associated cachexia

2018 1.1k citations Denis C. Guttridge et al. profile →
Cancer Cachexia: Mediators, Signaling, and Metabolic Pathways

2012 902 citations Denis C. Guttridge et al. profile →
NF-κB-Induced Loss of MyoD Messenger RNA: Possible Role in Muscle Decay and Cachexia

2000 763 citations Denis C. Guttridge, Albert S. Baldwin et al. profile →
Akt Suppresses Apoptosis by Stimulating the Transactivation Potential of the RelA/p65 Subunit of NF-κB

2000 572 citations Denis C. Guttridge, Albert S. Baldwin et al. profile →
NF-κB Induces Expression of the Bcl-2 Homologue A1/Bfl-1 To Preferentially Suppress Chemotherapy-Induced Apoptosis

1999 521 citations Denis C. Guttridge, Albert S. Baldwin et al. profile →
Microglia Induce Motor Neuron Death via the Classical NF-κB Pathway in Amyotrophic Lateral Sclerosis

2014 508 citations Katherine J. Ladner, Denis C. Guttridge et al. profile →

Peers

Countries citing papers authored by Denis C. Guttridge

Since Specialization

Citations

This map shows the geographic impact of Denis C. Guttridge's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Denis C. Guttridge with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Denis C. Guttridge more than expected).

Fields of papers citing papers by Denis C. Guttridge

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Denis C. Guttridge. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Denis C. Guttridge. The network helps show where Denis C. Guttridge may publish in the future.

Co-authorship network of co-authors of Denis C. Guttridge

This figure shows the co-authorship network connecting the top 25 collaborators of Denis C. Guttridge. A scholar is included among the top collaborators of Denis C. Guttridge based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Denis C. Guttridge. Denis C. Guttridge is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work	Indexed citations
1	Randomized Phase II Study of Nab-Paclitaxel and Gemcitabine With or Without Tocilizumab as First-Line Treatment in Advanced Pancreatic Cancer: Survival and Cachexia 2025 ·Journal of Clinical Oncology ·Inna M. Chen,Julia S. Johansen,Susann Theile,(unknown),Katherine R. Pelz,Kasper Madsen,Olav Dajani,(unknown),Torben Lorentzen,(unknown),Leonidas G. Koniaris,(unknown),Brian Neelon,Denis C. Guttridge,Michael C. Ostrowski,Teresa A. Zimmers,Dorte Nielsen	8
2	Targeting protein tyrosine phosphatases for CDK6-induced immunotherapy resistance 2023 ·Cell Reports ·Xueliang Gao,Yongxia Wu,Joel M. Chick,Andrea M. Abbott,Baishan Jiang,Jingxin Wang,Susana Comte‐Walters,Roger H. Johnson,(unknown),Michael I. Nishimura,Steven P. Gygi,Anand S. Mehta,Denis C. Guttridge,Lauren E. Ball,(unknown),Piotr Siciński,Xue‐Zhong Yu,(unknown)	6
3	Redundant Signaling as the Predominant Mechanism for Resistance to Antibodies Targeting the Type-I Insulin-Like Growth Factor Receptor in Cells Derived from Childhood Sarcoma 2023 ·Molecular Cancer Therapeutics ·Terry J. Shackleford,(unknown),Angelina V. Vaseva,(unknown),(unknown),Hemant K. Bid,Fuyang Li,Haihong Zhong,Doris A. Phelps,Ryan D. Roberts,Hakan Çam,Cheryl A. London,Denis C. Guttridge,Yidong Chen,Manjeet K. Rao,Yuzuru Shiio,Peter J. Houghton	5
4	The RNA demethylase FTO is required for maintenance of bone mass and functions to protect osteoblasts from genotoxic damage 2019 ·Proceedings of the National Academy of Sciences ·Qian Zhang,Ryan C. Riddle,Qian Yang,(unknown),Denis C. Guttridge,Naomi Dirckx,Marie–Claude Faugere,Charles R. Farber,Thomas L. Clemens	93
5	Dysregulated Myogenesis in Rhabdomyosarcoma 2017 ·Current topics in developmental biology ·Peter Y. Yu,Denis C. Guttridge	10
6	The Bromodomain BET Inhibitor JQ1 Suppresses Tumor Angiogenesis in Models of Childhood Sarcoma 2016 ·Molecular Cancer Therapeutics ·Hemant K. Bid,Doris A. Phelps,(unknown),Denis C. Guttridge,Jiayuh Lin,Cheryl A. London,Laurence H. Baker,Xiaokui Mo,Peter J. Houghton	66
7	Dissection of the Major Hematopoietic Quantitative Trait Locus in Chromosome 6q23.3 Identifies miR-3662 as a Player in Hematopoiesis and Acute Myeloid Leukemia 2016 ·Cancer Discovery ·(unknown),Christopher J. Walker,Sandya Liyanarachchi,(unknown),(unknown),(unknown),Xiaomeng Huang,(unknown),(unknown),Parvathi Ranganathan,Ramiro Garzon,James S. Blachly,Denis C. Guttridge,Clara D. Bloomfield,Albert de la Chapelle,Ann‐Kathrin Eisfeld	13
8	Dual Inhibition of MEK and PI3K/Akt Rescues Cancer Cachexia through both Tumor-Extrinsic and -Intrinsic Activities 2016 ·Molecular Cancer Therapeutics ·Erin E. Talbert,Jennifer Yang,Thomas A. Mace,Matthew R. Farren,Alton B. Farris,Gregory Young,(unknown),(unknown),Cynthia Timmers,Priyani Rajasekera,(unknown),Mark Bloomston,Tanios Bekaii‐Saab,Denis C. Guttridge,Gregory B. Lesinski	29
9	NBD delivery improves the disease phenotype of the golden retriever model of Duchenne muscular dystrophy 2014 ·Skeletal Muscle ·Joe N. Kornegay,Jennifer M. Peterson,Daniel J. Bogan,William O. Kline,Janet R. Bogan,(unknown),Zheng Fan,Jingxin Wang,Mihye Ahn,Hongtu Zhu,Martin Styner,Denis C. Guttridge	27
10	Reining in nuclear factor-kappaB in skeletal muscle disorders 2013 ·Current Opinion in Clinical Nutrition & Metabolic Care ·Jonathan Shintaku,Denis C. Guttridge	6
11	NF-κB inhibition delays DNA damage–induced senescence and aging in mice 2012 ·Journal of Clinical Investigation ·Jeremy S. Tilstra,Andria R. Robinson,Jin Wang,Siobhán Q. Gregg,Cheryl L. Clauson,Daniel P. Reay,Luigi Aurelio Nasto,Claudette M. St. Croix,Arvydas Ūsas,Nam Vo,Johnny Huard,Paula R. Clemens,Donna B. Stolz,Denis C. Guttridge,Simon C. Watkins,George A. Garinis,Yinsheng Wang,Laura J. Niedernhofer,Paul D. Robbins	367
12	Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice 2011 ·Cancer Research ·Bethany L. Mundy-Bosse,Gregory B. Lesinski,Alena Cristina Jaime‐Ramirez,Kristen Benninger,Mahmood Khan,Periannan Kuppusamy,Kristan Guenterberg,Sri Vidya Kondadasula,Abhik Ray Chaudhury,Krista M. D. La Perle,(unknown),Gregory Young,Denis C. Guttridge,William E. Carson	149
13	IL-4R Drives Dedifferentiation, Mitogenesis, and Metastasis in Rhabdomyosarcoma 2011 ·Clinical Cancer Research ·Tohru Hosoyama,Mohammed Aslam,Jinu Abraham,Suresh I. Prajapati,Koichi Nishijo,Joel Michalek,Lee Ann Zarzabal,(unknown),Denis C. Guttridge,Brian P. Rubin,Charles Keller	52
14	IFN-α and Bortezomib Overcome Bcl-2 and Mcl-1 Overexpression in Melanoma Cells by Stimulating the Extrinsic Pathway of Apoptosis 2008 ·Cancer Research ·Gregory B. Lesinski,(unknown),Kristan Guenterberg,(unknown),Michael R. Go,Nisha Shah,(unknown),(unknown),Erinn M. Hade,Gregory Young,Abhik Ray Chaudhury,Katherine J. Ladner,Denis C. Guttridge,Page Bouchard,William E. Carson	44
15	IKK/NF-κB regulates skeletal myogenesis via a signaling switch to inhibit differentiation and promote mitochondrial biogenesis 2008 ·The Journal of Cell Biology ·Nadine Bakkar,Jingxin Wang,Katherine J. Ladner,Huating Wang,Jason M. Dahlman,(unknown),Swarnali Acharyya,Michael A. Rudnicki,Andrew D. Hollenbach,Denis C. Guttridge	185
16	Interplay of IKK/NF-κB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy 2007 ·Journal of Clinical Investigation ·Swarnali Acharyya,S. Armando Villalta,Nadine Bakkar,Tepmanas Bupha‐Intr,Paul M.L. Janssen,(unknown),Zhi-Wei Li,Amer A. Beg,Sankar Ghosh,Zarife Sahenk,Michael Weinstein,(unknown),Jill A. Rafael‐Fortney,Michael Karin,James G. Tidball,Albert S. Baldwin,Denis C. Guttridge	366
17	Apigenin Blocks Lipopolysaccharide-Induced Lethality In Vivo and Proinflammatory Cytokines Expression by Inactivating NF-κB through the Suppression of p65 Phosphorylation 2007 ·The Journal of Immunology ·Courtney Nicholas,Sanjay Batra,Melissa A. Vargo,Oliver Voß,Mikhail A. Gavrilin,Mark D. Wewers,Denis C. Guttridge,Erich Grotewold,Andrea I. Doseff	295
18	ASC Directs NF-κB Activation by Regulating Receptor Interacting Protein-2 (RIP2) Caspase-1 Interactions 2006 ·The Journal of Immunology ·Anasuya Sarkar,Michelle Duncan,Judy Hart,Erin Hertlein,Denis C. Guttridge,Mark D. Wewers	109
19	Cancer cachexia is regulated by selective targeting of skeletal muscle gene products 2004 ·Journal of Clinical Investigation ·Swarnali Acharyya,Katherine J. Ladner,(unknown),Jeffrey S. Damrauer,Peter J. Reiser,Steven J. Swoap,Denis C. Guttridge	379
20	Cancer cachexia is regulated by selective targeting of skeletal muscle gene products 2004 ·Journal of Clinical Investigation ·Swarnali Acharyya,Katherine J. Ladner,(unknown),Jeffrey S. Damrauer,Peter J. Reiser,Steven J. Swoap,Denis C. Guttridge	357

About Denis C. Guttridge

Denis C. Guttridge is a scholar working on Cancer Research, Physiology and Molecular Biology, having authored 146 papers that have together received 16.8k indexed citations. Recurring topics across this work include Muscle Physiology and Disorders (59 papers), Nutrition and Health in Aging (34 papers) and NF-κB Signaling Pathways (34 papers). The work is most often cited by research in Cancer Research (3.6k citations), Physiology (5.2k citations) and Rehabilitation (1.1k citations). Denis C. Guttridge has collaborated with scholars based in United States, United Kingdom and France. Frequent co-authors include Albert S. Baldwin, Kenneth C.H. Fearon, Marty W. Mayo, Katherine J. Ladner, David J. Glass, Swarnali Acharyya, Lee V. Madrid, Cun-Yu Wang, Richard G. Pestell and Chris Albanese. Their work appears in journals such as Science, Proceedings of the National Academy of Sciences and Journal of Biological Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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