Denis C. Guttridge

23.9k citations

146 papers · 16.8k indexed · 7 hit papers · h-index 61

Cancer Research top 0.2%
- NF-κB Signaling Pathways 34
- MicroRNA in disease regulation 10
Physiology top 0.2%
- Nutrition and Health in Aging 34
- Adipose Tissue and Metabolism 12
Rehabilitation top 0.2%
Molecular Biology top 0.2%
- Muscle Physiology and Disorders 59
Geriatrics and Gerontology top 0.5%
Immunology
- Immune Response and Inflammation 14
Rheumatology
- GDF15 and Related Biomarkers 11
Pulmonary and Respiratory Medicine
- Sarcoma Diagnosis and Treatment 10

Co-authors: Albert S. Baldwin Kenneth C.H. Fearon Marty W. Mayo Katherine J. Ladner David J. Glass Swarnali Acharyya Lee V. Madrid Cun-Yu Wang
Cited by: Cancer Research Physiology Rehabilitation
Journals: Science (1 paper)Proceedings of the National Academy of Sciences (3 papers)Journal of Biological Chemistry (7 papers)
Partner nations: United States United Kingdom France

In The Last Decade

Denis C. Guttridge

143 papers receiving 16.6k citations

Hit Papers

7 papers align trajectories log scale

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

2018 Nature Reviews Disease Primers
2014 Neuron
2012 Cell Metabolism
2000 Science
2000 Molecular and Cellular Biology
1999 Molecular and Cellular Biology
1999 Molecular and Cellular Biology

Peers

Countries citing papers authored by Denis C. Guttridge

Since Specialization

Citations

This map shows the geographic impact of Denis C. Guttridge's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Denis C. Guttridge with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Denis C. Guttridge more than expected).

Fields of papers citing papers by Denis C. Guttridge

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Denis C. Guttridge. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Denis C. Guttridge. The network helps show where Denis C. Guttridge may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Denis C. Guttridge, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Denis C. Guttridge Line = papers co-authored together Denis C. Guttridge links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Randomized Phase II Study of Nab-Paclitaxel and Gemcitabine With or Without Tocilizumab as First-Line Treatment in Advanced Pancreatic Cancer: Survival and Cachexia Journal of Clinical Oncology ·Inna M. Chen,Julia S. Johansen,Susann Theile,Libbie M. Silverman,Katherine R. Pelz,Kasper Madsen,Olav Dajani,Kristina Lim,Torben Lorentzen,Omnia Gaafer,Leonidas G. Koniaris,Anna C. Ferreira,Brian Neelon,Denis C. Guttridge,Michael C. Ostrowski,Teresa A. Zimmers,Dorte Nielsen	2025	8
2	Targeting protein tyrosine phosphatases for CDK6-induced immunotherapy resistance Cell Reports ·Xueliang Gao,Yongxia Wu,Joel M. Chick,Andrea M. Abbott,Baishan Jiang,Jingxin Wang,Susana Comte‐Walters,Roger H. Johnson,Nathaniel Oberholtzer,Michael I. Nishimura,Steven P. Gygi,Anand S. Mehta,Denis C. Guttridge,Lauren E. Ball,Shikhar Mehrotra,Piotr Siciński,Xue‐Zhong Yu,Haizhen Wang	2023	6
3	Redundant Signaling as the Predominant Mechanism for Resistance to Antibodies Targeting the Type-I Insulin-Like Growth Factor Receptor in Cells Derived from Childhood Sarcoma Molecular Cancer Therapeutics ·Terry J. Shackleford,Seethalakshmi Hariharan,Angelina V. Vaseva,Karina Alagoa,Maricruz Espinoza,Hemant K. Bid,Fuyang Li,Haihong Zhong,Doris A. Phelps,Ryan D. Roberts,Hakan Çam,Cheryl A. London,Denis C. Guttridge,Yidong Chen,Manjeet K. Rao,Yuzuru Shiio,Peter J. Houghton	2023	5
4	The RNA demethylase FTO is required for maintenance of bone mass and functions to protect osteoblasts from genotoxic damage Proceedings of the National Academy of Sciences ·Qian Zhang,Ryan C. Riddle,Qian Yang,Clifford R. Rosen,Denis C. Guttridge,Naomi Dirckx,Marie–Claude Faugere,Charles R. Farber,Thomas L. Clemens	2019	93
5	Dysregulated Myogenesis in Rhabdomyosarcoma Current topics in developmental biology ·Peter Y. Yu,Denis C. Guttridge	2017	10
6	The Bromodomain BET Inhibitor JQ1 Suppresses Tumor Angiogenesis in Models of Childhood Sarcoma Molecular Cancer Therapeutics ·Hemant K. Bid,Doris A. Phelps,Linlin Xaio,Denis C. Guttridge,Jiayuh Lin,Cheryl A. London,Laurence H. Baker,Xiaokui Mo,Peter J. Houghton	2016	66
7	Dissection of the Major Hematopoietic Quantitative Trait Locus in Chromosome 6q23.3 Identifies miR-3662 as a Player in Hematopoiesis and Acute Myeloid Leukemia Cancer Discovery ·Sophia E. Maharry,Christopher J. Walker,Sandya Liyanarachchi,Sujay Mehta,Mitra Patel,Maryam A. Bainazar,Xiaomeng Huang,Malori A. Lankenau,Kevin W. Hoag,Parvathi Ranganathan,Ramiro Garzon,James S. Blachly,Denis C. Guttridge,Clara D. Bloomfield,Albert de la Chapelle,Ann‐Kathrin Eisfeld	2016	13
8	Dual Inhibition of MEK and PI3K/Akt Rescues Cancer Cachexia through both Tumor-Extrinsic and -Intrinsic Activities Molecular Cancer Therapeutics ·Erin E. Talbert,Jennifer Yang,Thomas A. Mace,Matthew R. Farren,Alton B. Farris,Gregory Young,Omar Elnaggar,Zheng Che,Cynthia Timmers,Priyani Rajasekera,Jennifer M. Maskarinec,Mark Bloomston,Tanios Bekaii‐Saab,Denis C. Guttridge,Gregory B. Lesinski	2016	29
9	NBD delivery improves the disease phenotype of the golden retriever model of Duchenne muscular dystrophy Skeletal Muscle ·Joe N. Kornegay,Jennifer M. Peterson,Daniel J. Bogan,William O. Kline,Janet R. Bogan,Jennifer L. Dow,Zheng Fan,Jingxin Wang,Mihye Ahn,Hongtu Zhu,Martin Styner,Denis C. Guttridge	2014	27
10	Reining in nuclear factor-kappaB in skeletal muscle disorders Current Opinion in Clinical Nutrition & Metabolic Care ·Jonathan Shintaku,Denis C. Guttridge	2013	6
11	NF-κB inhibition delays DNA damage–induced senescence and aging in mice Journal of Clinical Investigation ·Jeremy S. Tilstra,Andria R. Robinson,Jin Wang,Siobhán Q. Gregg,Cheryl L. Clauson,Daniel P. Reay,Luigi Aurelio Nasto,Claudette M. St. Croix,Arvydas Ūsas,Nam Vo,Johnny Huard,Paula R. Clemens,Donna B. Stolz,Denis C. Guttridge,Simon C. Watkins,George A. Garinis,Yinsheng Wang,Laura J. Niedernhofer,Paul D. Robbins	2012	367
12	Myeloid-Derived Suppressor Cell Inhibition of the IFN Response in Tumor-Bearing Mice Cancer Research ·Bethany L. Mundy-Bosse,Gregory B. Lesinski,Alena Cristina Jaime‐Ramirez,Kristen Benninger,Mahmood Khan,Periannan Kuppusamy,Kristan Guenterberg,Sri Vidya Kondadasula,Abhik Ray Chaudhury,Krista M. D. La Perle,Melanie Kreiner,Gregory Young,Denis C. Guttridge,William E. Carson	2011	149
13	IL-4R Drives Dedifferentiation, Mitogenesis, and Metastasis in Rhabdomyosarcoma Clinical Cancer Research ·Tohru Hosoyama,Mohammed Aslam,Jinu Abraham,Suresh I. Prajapati,Koichi Nishijo,Joel Michalek,Lee Ann Zarzabal,Laura D. Nelon,Denis C. Guttridge,Brian P. Rubin,Charles Keller	2011	52
14	IFN-α and Bortezomib Overcome Bcl-2 and Mcl-1 Overexpression in Melanoma Cells by Stimulating the Extrinsic Pathway of Apoptosis Cancer Research ·Gregory B. Lesinski,Ene T. Raig,Kristan Guenterberg,Lloyd Brown,Michael R. Go,Nisha Shah,Adrian Lewis,Megan Quimper,Erinn M. Hade,Gregory Young,Abhik Ray Chaudhury,Katherine J. Ladner,Denis C. Guttridge,Page Bouchard,William E. Carson	2008	44
15	IKK/NF-κB regulates skeletal myogenesis via a signaling switch to inhibit differentiation and promote mitochondrial biogenesis The Journal of Cell Biology ·Nadine Bakkar,Jingxin Wang,Katherine J. Ladner,Huating Wang,Jason M. Dahlman,Micheal Carathers,Swarnali Acharyya,Michael A. Rudnicki,Andrew D. Hollenbach,Denis C. Guttridge	2008	185
16	Interplay of IKK/NF-κB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy Journal of Clinical Investigation ·Swarnali Acharyya,S. Armando Villalta,Nadine Bakkar,Tepmanas Bupha‐Intr,Paul M.L. Janssen,Micheal Carathers,Zhi-Wei Li,Amer A. Beg,Sankar Ghosh,Zarife Sahenk,Michael Weinstein,Katherine L. Gardner,Jill A. Rafael‐Fortney,Michael Karin,James G. Tidball,Albert S. Baldwin,Denis C. Guttridge	2007	366
17	Apigenin Blocks Lipopolysaccharide-Induced Lethality In Vivo and Proinflammatory Cytokines Expression by Inactivating NF-κB through the Suppression of p65 Phosphorylation The Journal of Immunology ·Courtney Nicholas,Sanjay Batra,Melissa A. Vargo,Oliver Voß,Mikhail A. Gavrilin,Mark D. Wewers,Denis C. Guttridge,Erich Grotewold,Andrea I. Doseff	2007	295
18	ASC Directs NF-κB Activation by Regulating Receptor Interacting Protein-2 (RIP2) Caspase-1 Interactions The Journal of Immunology ·Anasuya Sarkar,Michelle Duncan,Judy Hart,Erin Hertlein,Denis C. Guttridge,Mark D. Wewers	2006	109
19	Cancer cachexia is regulated by selective targeting of skeletal muscle gene products Journal of Clinical Investigation ·Swarnali Acharyya,Katherine J. Ladner,Lori Nelsen,Jeffrey S. Damrauer,Peter J. Reiser,Steven J. Swoap,Denis C. Guttridge	2004	379
20	Cancer cachexia is regulated by selective targeting of skeletal muscle gene products Journal of Clinical Investigation ·Swarnali Acharyya,Katherine J. Ladner,Lori Nelsen,Jeffrey S. Damrauer,Peter J. Reiser,Steven J. Swoap,Denis C. Guttridge	2004	357

About Denis C. Guttridge

Denis C. Guttridge is a scholar working on Cancer Research, Physiology and Molecular Biology, having authored 146 papers that have together received 16.8k indexed citations. Recurring topics across this work include Muscle Physiology and Disorders (59 papers), Nutrition and Health in Aging (34 papers), NF-κB Signaling Pathways (34 papers), Immune Response and Inflammation (14 papers), Adipose Tissue and Metabolism (12 papers), GDF15 and Related Biomarkers (11 papers), Sarcoma Diagnosis and Treatment (10 papers) and MicroRNA in disease regulation (10 papers). The work is most often cited by research in Cancer Research (3.6k citations), Physiology (5.2k citations) and Rehabilitation (1.1k citations). Denis C. Guttridge has collaborated with scholars based in United States, United Kingdom and France. Frequent co-authors include Albert S. Baldwin, Kenneth C.H. Fearon, Marty W. Mayo, Katherine J. Ladner, David J. Glass, Swarnali Acharyya, Lee V. Madrid, Cun-Yu Wang, Richard G. Pestell and Chris Albanese. Their work appears in journals such as Science, Proceedings of the National Academy of Sciences and Journal of Biological Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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