James Chen

2.9k total citations · 1 hit paper
33 papers, 1.8k citations indexed

About

James Chen is a scholar working on Molecular Biology, Genetics and Infectious Diseases. According to data from OpenAlex, James Chen has authored 33 papers receiving a total of 1.8k indexed citations (citations by other indexed papers that have themselves been cited), including 29 papers in Molecular Biology, 16 papers in Genetics and 9 papers in Infectious Diseases. Recurrent topics in James Chen's work include RNA and protein synthesis mechanisms (17 papers), Bacterial Genetics and Biotechnology (15 papers) and Bacteriophages and microbial interactions (6 papers). James Chen is often cited by papers focused on RNA and protein synthesis mechanisms (17 papers), Bacterial Genetics and Biotechnology (15 papers) and Bacteriophages and microbial interactions (6 papers). James Chen collaborates with scholars based in United States, Germany and Switzerland. James Chen's co-authors include Seth A. Darst, Elizabeth A. Campbell, Paul Dominic B. Olinares, Brian T. Chait, Hande Boyaci, Brandon Malone, Edward T. Eng, Eliza Llewellyn, Jin Young Kang and Kashyap Maruthi and has published in prestigious journals such as Nature, Cell and Proceedings of the National Academy of Sciences.

In The Last Decade

James Chen

33 papers receiving 1.7k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex

2020 320 citations James Chen, Brandon Malone et al. Cell profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
James Chen United States	23	1.1k	539	518	311	144	33	1.8k
Kèvin Knoops Netherlands	20	1.4k 1.2×	895 1.7×	473 0.9×	180 0.6×	300 2.1×	46	2.8k
Shaun Rawson United States	21	1.6k 1.4×	850 1.6×	158 0.3×	190 0.6×	158 1.1×	44	2.6k
Christos G. Savva United Kingdom	27	1.5k 1.4×	431 0.8×	410 0.8×	503 1.6×	89 0.6×	48	2.3k
Christian Dienemann Germany	25	2.1k 1.9×	1.2k 2.2×	288 0.6×	229 0.7×	232 1.6×	48	3.7k
Anja Seybert Germany	21	729 0.6×	292 0.5×	202 0.4×	126 0.4×	74 0.5×	27	1.4k
Charlotte Uetrecht Germany	29	1.3k 1.1×	519 1.0×	313 0.6×	730 2.3×	189 1.3×	75	2.8k
Dimitry Tegunov Germany	15	1.9k 1.7×	851 1.6×	239 0.5×	199 0.6×	145 1.0×	18	3.2k
Priyamvada Acharya United States	23	1.1k 1.0×	1.2k 2.2×	99 0.2×	179 0.6×	174 1.2×	56	2.3k
Arun Prasad Pandurangan United Kingdom	17	893 0.8×	159 0.3×	184 0.4×	81 0.3×	159 1.1×	37	1.3k
Paul Dominic B. Olinares United States	22	1.4k 1.3×	400 0.7×	267 0.5×	162 0.5×	63 0.4×	41	2.0k

Countries citing papers authored by James Chen

Since Specialization

Citations

This map shows the geographic impact of James Chen's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by James Chen with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites James Chen more than expected).

Fields of papers citing papers by James Chen

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by James Chen. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by James Chen. The network helps show where James Chen may publish in the future.

Co-authorship network of co-authors of James Chen

This figure shows the co-authorship network connecting the top 25 collaborators of James Chen. A scholar is included among the top collaborators of James Chen based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with James Chen. James Chen is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Chen, James, Lakshminarayan M. Iyer, Gregory Putzel, et al.. (2024). Identification of a depupylation regulator for an essential enzyme in Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences. 121(49). e2407239121–e2407239121. 3 indexed citations

Saecker, Ruth M., Mueller AU, Brandon Malone, et al.. (2024). Early intermediates in bacterial RNA polymerase promoter melting visualized by time-resolved cryo-electron microscopy. Nature Structural & Molecular Biology. 31(11). 1778–1788. 4 indexed citations

AU, Mueller, James Chen, Mengyu Wu, et al.. (2023). A general mechanism for transcription bubble nucleation in bacteria. Proceedings of the National Academy of Sciences. 120(14). e2220874120–e2220874120. 3 indexed citations

Malone, Brandon, Jason K. Perry, Paul Dominic B. Olinares, et al.. (2023). Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature. 614(7949). 781–787. 42 indexed citations

Chen, James, et al.. (2023). Structure of an endogenous mycobacterial MCE lipid transporter. Nature. 620(7973). 445–452. 28 indexed citations

Cao, Xinyun, et al.. (2022). Basis of narrow-spectrum activity of fidaxomicin on Clostridioides difficile. Nature. 604(7906). 541–545. 39 indexed citations

Chen, James, Qi Wang, Brandon Malone, et al.. (2022). Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication–transcription complex. Nature Structural & Molecular Biology. 29(3). 250–260. 48 indexed citations

Saecker, Ruth M., James Chen, Brandon Malone, et al.. (2021). Structural origins of Escherichia coli RNA polymerase open promoter complex stability. Proceedings of the National Academy of Sciences. 118(40). 24 indexed citations

Malone, Brandon, James Chen, Qi Wang, et al.. (2021). Structural basis for backtracking by the SARS-CoV-2 replication–transcription complex. Proceedings of the National Academy of Sciences. 118(19). 84 indexed citations

10.

Chen, James, Hande Boyaci, & Elizabeth A. Campbell. (2020). Diverse and unified mechanisms of transcription initiation in bacteria. Nature Reviews Microbiology. 19(2). 95–109. 66 indexed citations

11.

Lilić, Mirjana, James Chen, Hande Boyaci, et al.. (2020). The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase. Proceedings of the National Academy of Sciences. 117(48). 30423–30432. 27 indexed citations

12.

Olinares, Paul Dominic B., Jin Young Kang, Eliza Llewellyn, et al.. (2020). Native Mass Spectrometry-Based Screening for Optimal Sample Preparation in Single-Particle Cryo-EM. Structure. 29(2). 186–195.e6. 21 indexed citations

13.

Chen, James, Brandon Malone, Eliza Llewellyn, et al.. (2020). Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex. Cell. 182(6). 1560–1573.e13. 320 indexed citations breakdown →

14.

Chen, James, Saumya Gopalkrishnan, Albert Y. Chen, et al.. (2020). Stepwise Promoter Melting by Bacterial RNA Polymerase. Molecular Cell. 78(2). 275–288.e6. 75 indexed citations

15.

Dandey, Venkata P., William C. Budell, Hui Wei, et al.. (2020). Time-resolved cryo-EM using Spotiton. Nature Methods. 17(9). 897–900. 94 indexed citations

16.

Chen, James, Saumya Gopalkrishnan, Albert Y. Chen, et al.. (2019). E. coli TraR allosterically regulates transcription initiation by altering RNA polymerase conformation. eLife. 8. 52 indexed citations

17.

Chen, James, Alex J. Noble, Jin Young Kang, & Seth A. Darst. (2019). Eliminating effects of particle adsorption to the air/water interface in single-particle cryo-electron microscopy: Bacterial RNA polymerase and CHAPSO. SHILAP Revista de lepidopterología. 1. 100005–100005. 76 indexed citations

18.

Boyaci, Hande, James Chen, Rolf Jansen, Seth A. Darst, & Elizabeth A. Campbell. (2019). Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding. Nature. 565(7739). 382–385. 78 indexed citations

19.

Myasnikov, Alexander G., James Chen, Corinne Crucifix, et al.. (2018). Structural Basis for NusA Stabilized Transcriptional Pausing. Molecular Cell. 69(5). 816–827.e4. 121 indexed citations

20.

Chen, James, Karen M. Wassarman, Katherine Leon, et al.. (2017). 6S RNA Mimics B-Form DNA to Regulate Escherichia coli RNA Polymerase. Molecular Cell. 68(2). 388–397.e6. 55 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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