Andrew K. Takle

1.2k citations

32 papers · 734 indexed · h-index 15

Organic Chemistry top 5%
- Synthesis of β-Lactam Compounds 7
- Synthesis and Catalytic Reactions 5
- Asymmetric Synthesis and Catalysis 4
- Carbohydrate Chemistry and Synthesis 4
- Synthetic Organic Chemistry Methods 3
Molecular Biology
- Melanoma and MAPK Pathways 6
- Protein Kinase Regulation and GTPase Signaling 6
- Chemical Synthesis and Analysis 5
Toxicology
Computational Theory and Mathematics top 10%
Pharmacology

Co-authors: Alessandra Gaiba A. Naylor Philip Kocieński Jason Witherington Vincent Bordas Robert W. Ward David G. Smith Brian P. Slingsby
Cited by: Organic Chemistry Molecular Biology Toxicology
Journals: Journal of the American Chemical Society (1 paper)The Journal of Organic Chemistry (3 papers)Tetrahedron (1 paper)
Partner nations: United Kingdom United States

In The Last Decade

Andrew K. Takle

32 papers receiving 701 citations

Peers

Countries citing papers authored by Andrew K. Takle

Since Specialization

Citations

This map shows the geographic impact of Andrew K. Takle's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Andrew K. Takle with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Andrew K. Takle more than expected).

Fields of papers citing papers by Andrew K. Takle

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Andrew K. Takle. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Andrew K. Takle. The network helps show where Andrew K. Takle may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Andrew K. Takle, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Andrew K. Takle Line = papers co-authored together Andrew K. Takle links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Identification of pyrimidinyl piperazines as non-iminosugar glucocerebrosidase (GCase) pharmacological chaperones Bioorganic & Medicinal Chemistry Letters ·Tamaki Hoshikawa,Tôru Watanabe,Makoto Kotake,Nathalie Tiberghien,Chi-kit Woo,Siân Lewis,Thomas Briston,Mumta Koglin,James M. Staddon,Ben Powney,Anthony H.V. Schapira,Andrew K. Takle	2023	1
2	Advancing novel therapies for neurodegeneration through an innovative model for industry–academia collaborations: A decade of the Eisai–UCL experience Drug Discovery Today ·Peter J. Atkinson,Meera Swami,Nicola Ridgway,Malcolm C. Roberts,Jane Kinghorn,Thomas T. Warner,James M. Staddon,Andrew K. Takle	2023	1
3	The Role of Disulfide Bond Replacements in Analogues of the Tarantula Toxin ProTx-II and Their Effects on Inhibition of the Voltage-Gated Sodium Ion Channel Na_v1.7 Journal of the American Chemical Society ·Zoë V. F. Wright,Stephen McCarthy,Rachael Dickman,F.E. Reyes,Silvia Sánchez-Martínez,Adam Cryar,Ian R. Kilford,Adrian Hall,Andrew K. Takle,Maya Topf,Tamir Gonen,Konstantinos Thalassinos,Alethea B. Tabor	2017	43
4	Collaborative approaches to anticancer drug discovery and development: a Cancer Research UK perspective Drug Discovery Today ·Robert J. Williams,Ian Walker,Andrew K. Takle	2012	15
5	Novel tricyclic pyrazole BRAF inhibitors with imidazole or furan central scaffolds Bioorganic & Medicinal Chemistry ·Dan Niculescu‐Duvaz,Ion Niculescu‐Duvaz,Bart M. J. M. Suijkerbuijk,Delphine Ménard,Alfonso Zambon,Arnaud Nourry,Lawrence Davies,Helen Manne,Frank Friedlos,Lesley Ogilvie,Douglas Hedley,Andrew K. Takle,David M. Wilson,Jean‐François Pons,Tom Coulter,Richard Kirk,Neus Cantariño,Steven R. Whittaker,Richard Marais,Caroline J. Springer	2010	28
6	Orally active C-6 heteroaryl- and heterocyclyl-substituted imidazo[1,2-a]pyridine acid pump antagonists (APAs) Bioorganic & Medicinal Chemistry Letters ·Nick Bailey,Mark J. Bamford,Delphine Brissy,Joanna Brookfield,Emmanuel H. Demont,Richard L. Elliott,Neil Garton,Irene Farre-Gutierrez,Thomas G. Hayhow,Gail Hutley,A. Naylor,Terry A. Panchal,Hui-Xian Seow,David J. Spalding,Andrew K. Takle	2009	12
7	Aryl sulphonyl amides as potent agonists of the growth hormone secretagogue (ghrelin) receptor Bioorganic & Medicinal Chemistry Letters ·Jason Witherington,Lee Abberley,Benjamin R. Bellenie,Rio Boatman,Katharine L. Collis,David K. Dean,Alessandra Gaiba,N. Paul King,Nicola Shuker,Jon G.A. Steadman,Andrew K. Takle,Gareth J. Sanger,Sharon Butler,Fiona C. McKay,Alison I. Muir,Kim Winborn,Robert W. Ward,Tom D. Heightman	2008	2
8	Potent achiral agonists of the growth hormone secretagogue (ghrelin) receptor. Part 2: Lead optimisation Bioorganic & Medicinal Chemistry Letters ·Jason Witherington,Lee Abberley,Michael A. Briggs,Katharine L. Collis,David K. Dean,Alessandra Gaiba,N. Paul King,Helmut Kraus,Nicola Shuker,Jon G.A. Steadman,Andrew K. Takle,Gareth J. Sanger,Graham Wadsworth,Sharon Butler,Fiona C. McKay,Alison I. Muir,Kim Winborn,Tom D. Heightman	2008	12
9	The identification of potent, selective and CNS penetrant furan-based inhibitors of B-Raf kinase Bioorganic & Medicinal Chemistry Letters ·Andrew K. Takle,Mark J. Bamford,Susannah Davies,Robert P. Davis,David K. Dean,Alessandra Gaiba,Elaine Irving,Frank D. King,A. Naylor,Christopher A. Parr,Alison M. Ray,Alastair D. Reith,Beverley Smith,Penelope C. Staton,Jon G.A. Steadman,Tania O. Stean,David M. Wilson	2008	20
10	Pyridone derivatives as potent, orally bioavailable VLA-4 integrin antagonists Bioorganic & Medicinal Chemistry Letters ·Jason Witherington,Emma L. Blaney,Vincent Bordas,Richard L. Elliott,Alessandra Gaiba,Neil Garton,Philip M. Green,A. Naylor,David G. Smith,David J. Spalding,Andrew K. Takle,Robert W. Ward	2006	6
11	Pyridone derivatives as potent and selective VLA-4 integrin antagonists Bioorganic & Medicinal Chemistry Letters ·Jason Witherington,Vincent Bordas,Alessandra Gaiba,Phil M. Green,A. Naylor,Nigel Parr,David G. Smith,Andrew K. Takle,Robert W. Ward	2006	12
12	(1H-Imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: A novel class of potent MSK-1-inhibitors Bioorganic & Medicinal Chemistry Letters ·Mark J. Bamford,Michael J. Alberti,Nicholas Bailey,Susannah Davies,David K. Dean,Alessandra Gaiba,Stephen L. Garland,John D. Harling,David Jung,Terence A. Panchal,Christopher A. Parr,Jon G.A. Steadman,Andrew K. Takle,James T. Townsend,David M. Wilson,Jason Witherington	2005	30
13	The identification of potent and selective imidazole-based inhibitors of B-Raf kinase Bioorganic & Medicinal Chemistry Letters ·Andrew K. Takle,Murray J. B. Brown,Susannah Davies,David K. Dean,Gerraint Francis,Alessandra Gaiba,Alex Hird,Frank D. King,Peter J. Lovell,A. Naylor,Alastair D. Reith,Jon G.A. Steadman,David M. Wilson	2005	170
14	(1H-Imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: Further optimisation as highly potent and selective MSK-1-inhibitors Bioorganic & Medicinal Chemistry Letters ·Mark J. Bamford,Nicholas Bailey,Susannah Davies,David K. Dean,Leann Francis,Terence A. Panchal,Christopher A. Parr,Sanjeet S. Sehmi,Jon G.A. Steadman,Andrew K. Takle,James T. Townsend,David M. Wilson	2005	19
15	Chiral oxime ethers in asymmetric synthesis. O-(1-Phenylbutyl)benzyloxyacetaldoxime, a versatile reagent for the asymmetric synthesis of protected 1,2-aminoalcohols, α-amino acid derivatives, and 2-hydroxymethyl nitrogen heterocycles including iminosugars Organic & Biomolecular Chemistry ·Tracey S. Cooper,Alexander S. Larigo,Pierre Laurent,Christopher J. Moody,Andrew K. Takle	2005	16
16	Asymmetric synthesis of N-protected amino acids by the addition of organolithium carboxyl synthons to ROPHy/SOPHy-derived aldoximes and ketoximesChiral oxime ethers in asymmetric synthesis. Part 6.1 Organic & Biomolecular Chemistry ·Tracey S. Cooper,Pierre Laurent,Christopher J. Moody,Andrew K. Takle	2004	30
17	6-Aryl-pyrazolo[3,4-b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3) Bioorganic & Medicinal Chemistry Letters ·Jason Witherington,Vincent Bordas,Alessandra Gaiba,Neil Garton,A. Naylor,Anthony D. Rawlings,Brian P. Slingsby,David G. Smith,Andrew K. Takle,Robert W. Ward	2003	103
18	6-Heteroaryl-pyrazolo[3,4-b]pyridines: potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3) Bioorganic & Medicinal Chemistry Letters ·Jason Witherington,Vincent Bordas,Alessandra Gaiba,A. Naylor,Anthony D. Rawlings,Brian P. Slingsby,David G. Smith,Andrew K. Takle,Robert W. Ward	2003	73
19	Novel C-2 Substituted Carbapenem Derivatives. Part IV. Synthesis and Biological Activity of Five Membered Heteroaromatic Derivatives. The Journal of Antibiotics ·Clive L. Branch,George Burton,GRAHAM J. CLARKE,Steven Coulton,James Douglas,A. J. EGLINGTON,A. W. GUEST,Jeremy Hinks,Nicholas W. Hird,REBECCA K. HOLLAND,ERIC HUNT,SARAH J. KNOTT,Stephen F. Moss,A. Naylor,Michael J. Pearson,Andrew K. Takle	1998	6
20	Novel C-2 Substituted Carbapenem Derivatives. Part I. Synthesis and Biological Activity of Non-aromatic Heterocyclic Derivatives. The Journal of Antibiotics ·George Burton,NICOLA J. C. CLEAR,A. J. EGLINGTON,A. W. GUEST,Eric Hunt,A. Naylor,Michael J. Pearson,Andrew K. Takle	1996	5

About Andrew K. Takle

Andrew K. Takle is a scholar working on Organic Chemistry, Pharmacology and Immunology and Allergy, having authored 32 papers that have together received 734 indexed citations. Recurring topics across this work include Synthesis of β-Lactam Compounds (7 papers), Melanoma and MAPK Pathways (6 papers), Protein Kinase Regulation and GTPase Signaling (6 papers), Chemical Synthesis and Analysis (5 papers), Synthesis and Catalytic Reactions (5 papers), Asymmetric Synthesis and Catalysis (4 papers), Carbohydrate Chemistry and Synthesis (4 papers) and Synthetic Organic Chemistry Methods (3 papers). The work is most often cited by research in Organic Chemistry (498 citations), Molecular Biology (310 citations) and Toxicology (15 citations). Andrew K. Takle has collaborated with scholars based in United Kingdom and United States. Frequent co-authors include Alessandra Gaiba, A. Naylor, Philip Kocieński, Jason Witherington, Vincent Bordas, Robert W. Ward, David G. Smith, Brian P. Slingsby, David K. Dean and Susannah Davies. Their work appears in journals such as Journal of the American Chemical Society, The Journal of Organic Chemistry and Tetrahedron.

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