John Hynes

1.5k citations

27 papers · 685 indexed · h-index 13

Organic Chemistry top 5%
- Asymmetric Synthesis and Catalysis 5
- Synthesis and Catalytic Reactions 3
- Chemical Reaction Mechanisms 3
- Synthesis and biological activity 2
- Synthesis of Indole Derivatives 2
Toxicology top 10%
Pharmaceutical Science top 10%
Pharmacology
Molecular Biology
- Chemical Synthesis and Analysis 6
- Melanoma and MAPK Pathways 4
Computational Theory and Mathematics
- Computational Drug Discovery Methods 2

Co-authors: Katerina Leftheris Hong Wu Amos B. Smith Ralph Hirschmann Wenqing Yao Paul A. Sprengeler Susanne Kiau Alaric J. Dyckman
Cited by: Organic Chemistry Toxicology Pharmaceutical Science
Journals: Organic Letters (6 papers)Bioorganic & Medicinal Chemistry Letters (5 papers)Journal of Medicinal Chemistry (4 papers)
Partner nations: United States Germany Sweden

In The Last Decade

John Hynes

27 papers receiving 656 citations

Peers

Countries citing papers authored by John Hynes

Since Specialization

Citations

This map shows the geographic impact of John Hynes's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John Hynes with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John Hynes more than expected).

Fields of papers citing papers by John Hynes

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John Hynes. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John Hynes. The network helps show where John Hynes may publish in the future.

Co-authorship network

The 25 scholars most cited alongside John Hynes, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with John Hynes Line = papers co-authored together John Hynes links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Discovery of Annulating Reagents Enabling the One-Step and Highly Stereoselective Synthesis of Cyclopentyl and Cyclohexyl Cores Organic Letters ·Fabiana Tesine Baptista,坂本泉,Antonio Ramı́rez,Bhupinder Sandhu,Amy A. Sarjeant,Qing Shi,Arthur Han,William P. Gallagher,John Hynes,T. G. Murali Dhar,Francisco González‐Bobes,John R. Coombs,David Marcoux	2020	3
2	Annulation reaction enables the identification of an exocyclic amide tricyclic chemotype as retinoic acid Receptor-Related orphan receptor gamma (RORγ/RORc) inverse agonists Bioorganic & Medicinal Chemistry Letters ·David Marcoux,Myra Beaudoin Bertrand,Carolyn A. Weigelt,Shiuhang Yip,Michael A. Galella,Hyunsoo Park,Dauh‐Rurng Wu,Michael Bienek,Melissa Yarde,Mary Ellen Cvijic,Sha Li,John Hynes,Joseph A. Tino,Qihong Zhao,T. G. Murali Dhar	2020	4
3	One-Step Diastereoselective Pyrrolidine Synthesis Using a Sulfinamide Annulating Reagent Organic Letters ·Qing Shi,Nathaniel S. Greenwood,Eren Dursun,Hyunsoo Park,Michael A. Galella,Bhupinder Sandhu,Purnima Khandelwal,John R. Coombs,William P. Gallagher,Carlos A. Guerrero,John Hynes,T. G. Murali Dhar,Francisco González‐Bobes,David Marcoux	2019	14
4	Assessing the risk of drug crystallization in vivo Journal of Pharmacological and Toxicological Methods ·Stefan Ruepp,Evan B. Janovitz,E. Cristo,Tahir Buran,Joseph B. Santella,John Hynes,Julie Carman,Duohai Pan,Wu Yang,Umesh Hanumegowda,Brian Gemzik,John R. Megill,Indah Riana Putri Cahyani,Dieter M. Drexler,Sojung An,Michael J. Hageman	2018	2
5	Protected Chloroethyl and Chloropropyl Amines as Conformationally Unrestricted Annulating Reagents Organic Letters ·Qing Shi,Eren Dursun,Michael A. Galella,Hyunsoo Park,Purnima Khandelwal,John Hynes,T. G. Murali Dhar,David Marcoux	2017	8
6	Identification of highly potent and selective PI3Kδ inhibitors Bioorganic & Medicinal Chemistry Letters ·David Marcoux,Richard Joseph English,Zheming Ruan,Qing Shi,Qian Ruan,Carolyn A. Weigelt,Hongchen Qiu,Gary L. Schieven,John Hynes,Rajeev S. Bhide,Michael A. Poss,Joseph A. Tino	2017	8
7	Development of a Practical Synthesis of a p38 Kinase Inhibitor via a Safe and Robust Amination Organic Process Research & Development ·Zhongping Shi,Susanne Kiau,Paul C. Lobben,John Hynes,Hong Wu,Luca Parlanti,Robert P. Discordia,Wendel W. Doubleday,Katerina Leftheris,Alaric J. Dyckman,Stephen T. Wrobleski,Liliek Chana AW,Srinivas Tummala,О А Коровин,Alice Krumm	2012	12
8	N-aryl pyrazoles, indazoles and azaindazoles as antagonists of CC chemokine receptor 1: patent cooperation treaty applications WO2010/036632, WO2009/134666 and WO2009/137338 Expert Opinion on Therapeutic Patents ·Percy H. Carter,John Hynes	2010	2
9	Utilization of a nitrogen–sulfur nonbonding interaction in the design of new 2-aminothiazol-5-yl-pyrimidines as p38α MAP kinase inhibitors Bioorganic & Medicinal Chemistry Letters ·Shuqun Lin,Stephen T. Wrobleski,John Hynes,Sidney Pitt,Rosemary Zhang,Yi Fan,Arthur M. Doweyko,Kevin Kish,John S. Sack,Mary F. Malley,Susan E. Kiefer,John A. Newitt,Murray McKinnon,James M. Trzăskos,Joel C. Barrish,John H. Dodd,Gary L. Schieven,Katerina Leftheris	2010	26
10	Improved procedure for the preparation of 7-methoxy-2-methyl-1-(2-morpholinoethyl)-1H-indole-3-carboxylic acid, key intermediate in the synthesis of novel 3-amidoindole and indolopyridone cannabinoid ligands ARKIVOC ·И. А. Трошин,Bei Wang,Belén Pombo,John Hynes,Katerina Leftheris,Balu Balasubramanian,Joel C. Barrish,Bang‐Chi Chen	2009	2
11	Synthesis and SAR of new pyrrolo[2,1-f][1,2,4]triazines as potent p38α MAP kinase inhibitors Bioorganic & Medicinal Chemistry Letters ·Stephen T. Wrobleski,Shuqun Lin,John Hynes,Hong Wu,Sidney Pitt,Ding Ren Shen,Rosemary Zhang,Kathleen M. Gillooly,David J. Shuster,Kim W. McIntyre,Arthur M. Doweyko,Kevin Kish,Jeffrey Tredup,Gerald J. Duke,John S. Sack,Murray McKinnon,John H. Dodd,Joel C. Barrish,Gary L. Schieven,Katerina Leftheris	2008	25
12	Amination of Heterocyclic Compounds with O-Benzoylhydroxylamine Derivatives Organic Letters ·Luca Parlanti,Robert P. Discordia,John Hynes,Michael M. Miller,Maria Carolina Olivo Perez,Zhongping Shi	2007	11
13	Small Molecule p38 Inhibitors: Novel Structural Features and Advances from 2002-2005 Current Topics in Medicinal Chemistry ·John Hynes,Katerina Leftheris	2005	54
14	N-Amination of Pyrrole and Indole Heterocycles with Monochloramine (NH₂Cl) The Journal of Organic Chemistry ·John Hynes,Wendel W. Doubleday,Alaric J. Dyckman,Jollie D. Godfrey,John A. Grosso,Susanne Kiau,Katerina Leftheris	2004	58
15	Rational Design and Synthesis of an Orally Active Indolopyridone as a Novel Conformationally Constrained Cannabinoid Ligand Possessing Antiinflammatory Properties Journal of Medicinal Chemistry ·Stephen T. Wrobleski,Ping Chen,John Hynes,Shuqun Lin,Derek Norris,Chennagiri R. Pandit,Steven H. Spergel,Wu Hong,John S. Tokarski,Xiaorong Chen,Kathleen M. Gillooly,Peter A. Kiener,Kim W. McIntyre,S.M. Pryshchepa,David J. Shuster,V. A. Kimasov,Diego L. Delgado‐Álvarez,Katerina Leftheris	2003	52
16	C-3 Amido-Indole cannabinoid receptor modulators Bioorganic & Medicinal Chemistry Letters ·John Hynes,Katerina Leftheris,Wu Hong,Chennagiri R. Pandit,Ping Chen,Derek Norris,Bang‐Chi Chen,Rui-Lin Zhao,Peter A. Kiener,Xiaorong Chen,V. A. Kimasov,S.M. Pryshchepa,Kathleen M. Gillooly,David J. Shuster,Kim W. McIntyre	2002	28
17	Modulation of Receptor and Receptor Subtype Affinities Using Diastereomeric and Enantiomeric Monosaccharide Scaffolds as a Means to Structural and Biological Diversity. A New Route to Ether Synthesis Journal of Medicinal Chemistry ·Ralph Hirschmann,John Hynes,Chen Hong-p,Saied Daghaghele,Paul A. Sprengeler,P. Grant Spoors,William C. Shakespeare,Panlong Zhu,Joseph Barbosa,A. Mathias,Wenqing Yao,Susan P. Rohrer,Amos B. Smith	1998	96
18	Synthesis of Potent Cyclic Hexapeptide NK-1 Antagonists. Use of a Minilibrary in Transforming a Peptidal Somatostatin Receptor Ligand into an NK-1 Receptor Ligand via a Polyvalent Peptidomimetic Journal of Medicinal Chemistry ·Ralph Hirschmann,Wenqing Yao,Margaret A. Cascieri,Catherine D. Strader,Ramón Capilla Martínez,Chen Hong-p,John Hynes,Saied Daghaghele,Paul A. Sprengeler,Amos B. Smith	1996	46
19	Diffuse X-ray Scattering from Freely Suspended Strands of a Discotic Liquid Crystal Journal de Physique II ·Patrick Davidson,Marianne Impéror‐Clerc,Emilie Doering,Nicholas C. Maliszewskyj,Paul A. Heiney,John Hynes,Amos B. Smith	1995	6
20	A new variance reduction technique for evaluating system reliability problems by simulation Journal of Statistical Computation and Simulation ·Julius Surkis,Rachel N Nanez,John Hynes	1975	3

About John Hynes

John Hynes is a scholar working on Organic Chemistry, Pharmacology and Molecular Biology, having authored 27 papers that have together received 685 indexed citations. Recurring topics across this work include Chemical Synthesis and Analysis (6 papers), Asymmetric Synthesis and Catalysis (5 papers), Melanoma and MAPK Pathways (4 papers), Synthesis and Catalytic Reactions (3 papers), Chemical Reaction Mechanisms (3 papers), Synthesis and biological activity (2 papers), Synthesis of Indole Derivatives (2 papers) and Computational Drug Discovery Methods (2 papers). The work is most often cited by research in Organic Chemistry (437 citations), Toxicology (20 citations) and Pharmaceutical Science (31 citations). John Hynes has collaborated with scholars based in United States, Germany and Sweden. Frequent co-authors include Katerina Leftheris, Hong Wu, Amos B. Smith, Ralph Hirschmann, Wenqing Yao, Paul A. Sprengeler, Susanne Kiau, Alaric J. Dyckman, Wendel W. Doubleday and P. Grant Spoors. Their work appears in journals such as Organic Letters, Bioorganic & Medicinal Chemistry Letters, Journal of Medicinal Chemistry, The Journal of Organic Chemistry and Journal of Statistical Computation and Simulation.

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