Frank Friedlos

4.0k total citations
59 papers, 3.2k citations indexed

About

Frank Friedlos is a scholar working on Molecular Biology, Genetics and Organic Chemistry. According to data from OpenAlex, Frank Friedlos has authored 59 papers receiving a total of 3.2k indexed citations (citations by other indexed papers that have themselves been cited), including 46 papers in Molecular Biology, 19 papers in Genetics and 18 papers in Organic Chemistry. Recurrent topics in Frank Friedlos's work include Virus-based gene therapy research (19 papers), Cancer Research and Treatments (13 papers) and Click Chemistry and Applications (9 papers). Frank Friedlos is often cited by papers focused on Virus-based gene therapy research (19 papers), Cancer Research and Treatments (13 papers) and Click Chemistry and Applications (9 papers). Frank Friedlos collaborates with scholars based in United Kingdom, United States and New Zealand. Frank Friedlos's co-authors include Richard J. Knox, J. J. Roberts, Caroline J. Springer, Richard Marais, David Lydall, Dan Niculescu‐Duvaz, Marion P. Boland, Roger F. Sherwood, Lawrence Davies and Roger G. Melton and has published in prestigious journals such as Nucleic Acids Research, Cancer Research and Oncogene.

In The Last Decade

Frank Friedlos

59 papers receiving 3.1k citations

Peers

Countries citing papers authored by Frank Friedlos

Since Specialization

Citations

This map shows the geographic impact of Frank Friedlos's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Frank Friedlos with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Frank Friedlos more than expected).

Fields of papers citing papers by Frank Friedlos

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Frank Friedlos. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Frank Friedlos. The network helps show where Frank Friedlos may publish in the future.

Co-authorship network of co-authors of Frank Friedlos

This figure shows the co-authorship network connecting the top 25 collaborators of Frank Friedlos. A scholar is included among the top collaborators of Frank Friedlos based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Frank Friedlos. Frank Friedlos is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work	Indexed citations
1	Novel tricyclic pyrazole BRAF inhibitors with imidazole or furan central scaffolds 2010 ·Bioorganic & Medicinal Chemistry ·Dan Niculescu‐Duvaz, Ion Niculescu‐Duvaz, Bart M. J. M. Suijkerbuijk, Delphine Ménard, Alfonso Zambon, Arnaud Nourry, Lawrence Davies, (unknown), Frank Friedlos, Lesley Ogilvie, Douglas Hedley, Andrew K. Takle, David M. Wilson, Jean‐François Pons, (unknown), Richard Kirk, Neus Cantariño, Steven R. Whittaker, Richard Marais, Caroline J. Springer	28
2	A novel technique to monitor carboxypeptidase G2 expression in suicide gene therapy using ¹⁹F magnetic resonance spectroscopy 2009 ·NMR in Biomedicine ·Laura Mancini, Lawrence Davies, Frank Friedlos, (unknown), A S K Dzik-Jurasz, Caroline J. Springer, Martin O. Leach, Geoffrey S. Payne	8
3	Methods to Improve Efficacy in Suicide Gene Therapy Approaches: Targeting Prodrug-Activating Enzymes Carboxypeptidase G2 and Nitroreductase to Different Subcellular Compartments 2004 ·Humana Press eBooks ·Silke Schepelmann, Robert A. Spooner, Frank Friedlos, Richard Marais	4
4	B-RAF is a therapeutic target in melanoma 2004 ·Oncogene ·Maria Karasarides, Antonio Chiloeches, Robert Hayward, Dan Niculescu‐Duvaz, Ian Scanlon, Frank Friedlos, Lesley Ogilvie, Douglas Hedley, Jan Martin, Christopher J. Marshall, Caroline J. Springer, Richard Marais	360
5	A novel vascular endothelial growth factor-directed therapy that selectively activates cytotoxic prodrugs 2003 ·British Journal of Cancer ·(unknown), Frank Friedlos, (unknown), Stephen M. Stribbling, Jean‐Christian Roussel, Joseph Brueggen, Barbara Stolz, T. O'Reilly, J M Wood, A. Matter, Richard Marais, Caroline J. Springer	11
6	Appropriate subcellular localisation of prodrug-activating enzymes has important consequences for suicide gene therapy 2001 ·International Journal of Cancer ·Robert A. Spooner, (unknown), Hugh Paterson, Frank Friedlos, Caroline J. Springer, Richard Marais	12
7	Virus-directed enzyme prodrug therapy using retrovirally delivered E. coli nitroreductase and CB1954 1998 ·British Journal of Cancer ·Iain A. McNeish, (unknown), (unknown), Stephen M. Roberts, Rachel Kerr, Frank Friedlos, Caroline J. Springer, Peter F. Searle	2
8	Gene-directed enzyme prodrug therapy: quantitative bystander cytotoxicity and DNA damage induced by CB1954 in cells expressing bacterial nitroreductase 1998 ·Gene Therapy ·Frank Friedlos, (unknown), (unknown), (unknown), Caroline J. Springer	51
9	Involvement of DT-diaphorase (EC 1.6.99.2) in the DNA cross-linking and sequence selectivity of the bioreductive anti-tumour agent EO9 1997 ·British Journal of Cancer ·(unknown), Michael D. Wyatt, Frank Friedlos, (unknown), R.J. Knox, (unknown), Paul Workman	27
10	Virtual cofactors for an Escherichia coli nitroreductase enzyme: Relevance to reductively activated prodrugs in antibody directed enzyme prodrug therapy (ADEPT) 1995 ·Biochemical Pharmacology ·Richard J. Knox, Frank Friedlos, Michael Jarman, Lawrence Davies, Phyllis M. Goddard, (unknown), (unknown), Roger F. Sherwood	29
11	Identification, synthesis and properties of 5-(aziridin-1-YL)-2-nitro-4-nitrosobenzamide, A novel DNA crosslinking agent derived from CB1954 1993 ·Biochemical Pharmacology ·Richard J. Knox, Frank Friedlos, Patrick J. Biggs, William D. Flitter, Margaret Gaskell, Phyllis M. Goddard, Lawrence Davies, Michael Jarman	23
12	The bioactivation of CB 1954 and its use as a prodrug in antibody-directed enzyme prodrug therapy (ADEPT) 1993 ·Cancer and Metastasis Reviews ·Richard J. Knox, Frank Friedlos, Marion P. Boland	87
13	Identification of novel reduced pyridinium derivatives as synthetic co-factors for the enzyme DT diaphorase (NAD(P)H dehydrogenase (quinone), EC 1.6.99.2) 1992 ·Biochemical Pharmacology ·Frank Friedlos, Michael Jarman, Lawrence Davies, Marion P. Boland, Richard J. Knox	41
14	The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)—I 1992 ·Biochemical Pharmacology ·(unknown), Roger G. Melton, Roger F. Sherwood, Brian Coles, Frank Friedlos, Richard J. Knox	183
15	Caffeine, aminoimidazolecarboxamide and dicoumarol, inhibitors of NAD(P)H dehydrogenase (quinone) (DT diaphorase), prevent both the cytotoxicity and DNA interstrand crosslinking produced by 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) in walker cells 1989 ·Biochemical Pharmacology ·J. J. Roberts, Tania Marchbank, (unknown), Marion P. Boland, Frank Friedlos, Richard J. Knox	13
16	The nitroreductase enzyme in walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to 5-(aziridin-1-YL)-4-hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2) 1988 ·Biochemical Pharmacology ·Richard J. Knox, Marion P. Boland, Frank Friedlos, Brian Coles, Christopher Southan, J. J. Roberts	115
17	A new cytotoxic, DNA interstrand crosslinking agent, 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide, is formed from 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by a nitroreductase enzyme in walker carcinoma cells 1988 ·Biochemical Pharmacology ·Richard J. Knox, Frank Friedlos, Michael Jarman, J. J. Roberts	127
18	The effect of monofunctional or difunctional platinum adducts and of various other associated DNA damage on the expression of transfected DNA in mammalian cell lines sensitive or resistant to difunctional agents 1987 ·Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression ·R.J. Knox, David Lydall, Frank Friedlos, Connie Basham, J. J. Roberts	24
19	Quantitative estimation of cisplatin-induced DNA interstrand cross-links and their repair in mammalian cells: Relationship to toxicity 1987 ·Pharmacology & Therapeutics ·J. J. Roberts, Frank Friedlos	69
20	Caffeine-inhibited DNA repair in 7-bromomethylbenz(a)-anthracene-treated chinese hamster cells: Formation of breaks in parental DNA and inhibition of ligation of nascent DNA as a mechanism for enhancement of lethality and chromosome damage 1978 ·Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis ·Frank Friedlos, J. J. Roberts	9

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact