Frank Friedlos

4.0k citations

59 papers · 3.2k · h-index 30

Impact in

Biotechnology top 0.5%
- Cancer Research and Treatments
Toxicology top 1%

Papers in

Molecular Biology 46
- Biochemical and Molecular Research 9
- DNA Repair Mechanisms 8
- DNA and Nucleic Acid Chemistry 8
- Melanoma and MAPK Pathways 6
Genetics 19
- Virus-based gene therapy research 19

Co-authors: Richard J. Knox (17 shared papers)J. J. Roberts (18 shared papers)Caroline J. Springer (27 shared papers)Richard Marais (21 shared papers)David Lydall (3 shared papers)Dan Niculescu‐Duvaz (11 shared papers)Marion P. Boland (4 shared papers)Roger F. Sherwood (4 shared papers)
Journals: Biochemical Pharmacology (13 papers)Journal of Medicinal Chemistry (11 papers)British Journal of Cancer (3 papers)Cancer Research (3 papers)Chemico-Biological Interactions (2 papers)
Partner nations: United Kingdom United States New Zealand

In The Last Decade

Frank Friedlos

59 papers receiving 3.1k citations

Peers

Countries citing papers authored by Frank Friedlos

Since Specialization

Citations

This map shows the geographic impact of Frank Friedlos's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Frank Friedlos with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Frank Friedlos more than expected).

Fields of papers citing papers by Frank Friedlos

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Frank Friedlos. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Frank Friedlos. The network helps show where Frank Friedlos may publish in the future.

Co-authors

The 25 scholars most cited alongside Frank Friedlos, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Frank Friedlos Line = papers co-authored together Frank Friedlos links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 59 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Mechanism of cytotoxicity of anticancer platinum drugs: evidence that cis-diamminedichloroplatinum(II) and cis-diammine-(1,1-cyclobutanedicarboxylato)platinum(II) differ only in the kinetics of their interaction with DNA. PubMed ·Richard J. Knox, Frank Friedlos, David Lydall, J. J. Roberts	1986	428
2	B-RAF is a therapeutic target in melanoma Oncogene ·Maria Karasarides, Antonio Chiloeches, Robert Hayward, Dan Niculescu‐Duvaz, Ian Scanlon, Frank Friedlos, Lesley Ogilvie, Douglas Hedley, Jan Martin, Christopher J. Marshall, Caroline J. Springer, Richard Marais	2004	360
3	The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)—I Biochemical Pharmacology ·Gillian M. Anlezark, Roger G. Melton, Roger F. Sherwood, Brian Coles, Frank Friedlos, Richard J. Knox	1992	183
4	Activated B-RAF Is an Hsp90 Client Protein That Is Targeted by the Anticancer Drug 17-Allylamino-17-Demethoxygeldanamycin Cancer Research ·Silvy da Rocha Dias, Frank Friedlos, Yvonne Light, Caroline J. Springer, Paul Workman, Richard Marais	2005	183
5	A new cytotoxic, DNA interstrand crosslinking agent, 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide, is formed from 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by a nitroreductase enzyme in walker carcinoma cells Biochemical Pharmacology ·Richard J. Knox, Frank Friedlos, Michael Jarman, J. J. Roberts	1988	127
6	The nitroreductase enzyme in walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to 5-(aziridin-1-YL)-4-hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2) Biochemical Pharmacology ·Richard J. Knox, Marion P. Boland, Frank Friedlos, Brian Coles, Christopher Southan, J. J. Roberts	1988	115
7	Self-Immolative Prodrugs: Candidates for Antibody-Directed Enzyme Prodrug Therapy in Conjunction with a Nitroreductase Enzyme Journal of Medicinal Chemistry ·Anthony B. Mauger, Philip J. Burke, Hanif H. Somani, Frank Friedlos, Richard J. Knox	1994	88
8	The bioactivation of CB 1954 and its use as a prodrug in antibody-directed enzyme prodrug therapy (ADEPT) Cancer and Metastasis Reviews ·Richard J. Knox, Frank Friedlos, Marion P. Boland	1993	87
9	Sensitization of colorectal and pancreatic cancer cell lines to the prodrug 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954) by retroviral transduction and expression of the E. coli nitroreductase gene. PubMed ·Green Nk, Youngs Dj, John P. Neoptolemos, Frank Friedlos, Knox Rj, Springer Cj, Anlezark Gm, Michael Np, Melton Rg, MJ Ford, Lawrence S. Young, Kerr Dj, Searle Pf	1997	86
10	The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)—II Biochemical Pharmacology ·Richard J. Knox, Frank Friedlos, Roger F. Sherwood, Roger G. Melton, Gillian M. Anlezark	1992	85
11	Attenuated Salmonella Targets Prodrug Activating Enzyme Carboxypeptidase G2 to Mouse Melanoma and Human Breast and Colon Carcinomas for Effective Suicide Gene Therapy Clinical Cancer Research ·Frank Friedlos, Panos Lehouritis, Lesley Ogilvie, Douglas Hedley, Lawrence Davies, David Bermudes, Ivan King, Jan Martin, Richard Marais, Caroline J. Springer	2008	76
12	Bioactivation of dinitrobenzamide mustards by an E. coli B nitroreductase Biochemical Pharmacology ·Gill Anlezark, Roger G. Melton, Roger F. Sherwood, William R. Wilson, William A. Denny, Brian D. Palmer, R.J. Knox, Frank Friedlos, Albert Williams	1995	73
13	Quantitative estimation of cisplatin-induced DNA interstrand cross-links and their repair in mammalian cells: Relationship to toxicity Pharmacology & Therapeutics ·J. J. Roberts, Frank Friedlos	1987	69
14	Mustard Prodrugs for Activation by Escherichia coli Nitroreductase in Gene-Directed Enzyme Prodrug Therapy Journal of Medicinal Chemistry ·Frank Friedlos, William A. Denny, Brian D. Palmer, Caroline J. Springer	1997	57
15	Bioactivation of CB 1954: Reaction of the active 4-hydroxylamino derivative with thioesters to form the ultimate DNA-DNA interstrand crosslinking species Biochemical Pharmacology ·Richard J. Knox, Frank Friedlos, Tania Marchbank, J. J. Roberts	1991	55
16	CB 1954 (2,4-dinitro-5-aziridinyl benzamide) becomes a DNA interstrand crosslinking agent in Walker tumour cells Biochemical and Biophysical Research Communications ·J. J. Roberts, Frank Friedlos, Richard J. Knox	1986	52
17	Gene-directed enzyme prodrug therapy: quantitative bystander cytotoxicity and DNA damage induced by CB1954 in cells expressing bacterial nitroreductase Gene Therapy ·Frank Friedlos, S Court, MJ Ford, WA Denny, Caroline J. Springer	1998	51
18	Catalytic properties of NAD(P)H:quinone acceptor oxidoreductase: study involving mouse, rat, human, and mouse-rat chimeric enzymes. Molecular Pharmacology ·Shiuan Chen, R.J. Knox, Alex D. Lewis, Frank Friedlos, Paul Workman, P S Deng, Margaret Fung, D Ebenstein, Kenneth K. Wu, Tsung-Po Tsai	1995	51
19	Suicide Gene Therapy of Human Colon Carcinoma Xenografts Using an Armed Oncolytic Adenovirus Expressing Carboxypeptidase G2 Cancer Research ·Silke Schepelmann, Lesley Ogilvie, Douglas Hedley, Frank Friedlos, Janet L. Martin, Ian Scanlon, Ping Chen, Richard Marais, Caroline J. Springer	2007	50
20	Quantitative aspects of the formation and loss of DNA interstrand crosslinks in Chinese hamster cells following treatment with cis-diamminedichloroplatinum(II) (cisplatin) I. Proportion of DNA-platinum reactions involved in DNA crosslinking Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis ·J. J. Roberts, Frank Friedlos	1981	49

About Frank Friedlos

Frank Friedlos is a scholar working on Molecular Biology, Genetics, Organic Chemistry, Biotechnology and Oncology, having authored 59 papers that have together received 3.2k indexed citations. Recurring topics across this work include Virus-based gene therapy research (19 papers), Cancer Research and Treatments (13 papers), Biochemical and Molecular Research (9 papers), Click Chemistry and Applications (9 papers), Metal complexes synthesis and properties (9 papers), DNA Repair Mechanisms (8 papers), DNA and Nucleic Acid Chemistry (8 papers) and Melanoma and MAPK Pathways (6 papers). The work is most often cited by research in Biotechnology (566 citations), Toxicology (146 citations), Oncology (942 citations), Molecular Biology (2.2k citations) and Organic Chemistry (688 citations). Frank Friedlos has collaborated with scholars based in United Kingdom, United States and New Zealand. Frequent co-authors include Richard J. Knox, J. J. Roberts, Caroline J. Springer, Richard Marais, David Lydall, Dan Niculescu‐Duvaz, Marion P. Boland, Roger F. Sherwood, Lawrence Davies and Roger G. Melton. Their work appears in journals such as Biochemical Pharmacology, Journal of Medicinal Chemistry, British Journal of Cancer, Cancer Research and Chemico-Biological Interactions.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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