James Inglese

19.8k citations

192 papers · 13.8k indexed · 8 hit papers · h-index 59

Impact in

Cellular and Molecular Neuroscience top 0.5%
- Neuropeptides and Animal Physiology
- Neuroscience and Neuropharmacology Research
- Photoreceptor and optogenetics research
Molecular Biology top 0.2%
- Receptor Mechanisms and Signaling
- Protein Kinase Regulation and GTPase Signaling
- Ion channel regulation and function
- bioluminescence and chemiluminescence research

Papers in

Biophysics 13
- Cell Image Analysis Techniques 11
Computational Theory and Mathematics 35
- Computational Drug Discovery Methods 35

Co-authors: Robert J. Lefkowitz Douglas S. Auld Christopher P. Austin Walter J. Koch Anton Simeonov Ajit Jadhav Natasha Thorne Richard T. Premont
Journals: Journal of Biological Chemistry (18 papers)Assay and Drug Development Technologies (14 papers)Proceedings of the National Academy of Sciences (13 papers)Journal of Medicinal Chemistry (10 papers)Analytical Biochemistry (9 papers)
Partner nations: United States France Japan

In The Last Decade

James Inglese

188 papers receiving 13.4k citations

Hit Papers

8 papers align trajectories log scale

Quantitative high-throughput screening: A titration-based approach that efficiently identifies biological activities in large chemical libraries 2006 · 623 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2006 Proceedings of the National Academy of Sciences
1995 The FASEB Journal
1994 Journal of Biological Chemistry
1994 Journal of Biological Chemistry
1994 Nature
1993 Journal of Biological Chemistry
1993 Journal of Biological Chemistry
1992 Science

Peers

Countries citing papers authored by James Inglese

Since Specialization

Citations

This map shows the geographic impact of James Inglese's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by James Inglese with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites James Inglese more than expected).

Fields of papers citing papers by James Inglese

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by James Inglese. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by James Inglese. The network helps show where James Inglese may publish in the future.

Co-authorship network

The 25 scholars most cited alongside James Inglese, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with James Inglese Line = papers co-authored together James Inglese links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	In vivo quantitative high-throughput screening for drug discovery and comparative toxicology Disease Models & Mechanisms ·Patricia Dranchak, Joanna WIERZOWIECKA, 橘彩路, Laurence Lamy, Yuhong Wang, Ruili Huang, Menghang Xia, Dingyin Tao, James Inglese	2023	6
2	Structure–activity relationship of ipglycermide binding to phosphoglycerate mutases Journal of Biological Chemistry ·Mareike M. Wiedmann, Patricia Dranchak, Mahesh Aitha, 橘彩路, Hyonok Yoon, M.M. Kashipathy, Badal Kumar Sahu, Laurence Lamy, Joseph M. Rogers, Dingyin Tao, K.P. Battaile, Ganesha Rai, Scott Lovell, Hiroaki Suga, James Inglese	2021	6
3	Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124 Proceedings of the National Academy of Sciences ·Douglas S. Auld, Scott Lovell, Natasha Thorne, Wendy Lea, David J. Maloney, Min Shen, Ganesha Rai, K.P. Battaile, Craig J. Thomas, Anton Simeonov, Robert P. Hanzlik, James Inglese	2010	148
4	A High-Throughput 1,536-Well Luminescence Assay for Glutathione S-Transferase Activity Assay and Drug Development Technologies ·Adam Yasgar, John Shultz, Wenhui Zhou, Hui Wang, Fen Huang, Nancy E. Murphy, Erika L. Abel, John DiGiovanni, James Inglese, Anton Simeonov	2010	14
5	Improving Success by Balanced Critical Evaluations of Assay Methods Assay and Drug Development Technologies ·James Inglese, Andrew D. Napper, Douglas S. Auld	2010	2
6	Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice Proceedings of the National Academy of Sciences ·Susanne Neumann, Wenwei Huang, Steve Titus, Gerd Krause, Gunnar Kleinau, Anna Teresa Alberobello, Wei Zheng, Noel Southall, James Inglese, Christopher P. Austin, Francesco S. Celi, Oksana Gavrilova, Craig J. Thomas, Bruce M. Raaka, Marvin C. Gershengorn	2009	94
7	Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay Molecular Cancer Therapeutics ·Christophe Marchand, Wendy Lea, Ajit Jadhav, Thomas S. Dexheimer, Christopher P. Austin, James Inglese, Yves Pommier, Anton Simeonov	2009	68
8	Identification of Pregnane X Receptor Ligands Using Time-Resolved Fluorescence Resonance Energy Transfer and Quantitative High-Throughput Screening Assay and Drug Development Technologies ·Sunita J. Shukla, Ðắc-Trung Nguyễn, Ryan MacArthur, Anton Simeonov, William J. Frazee, Tina M. Hallis, Bryan D. Marks, Upinder Singh, Sofa Sakinah, John A. Printen, Christopher P. Austin, James Inglese, Douglas S. Auld	2009	45
9	A quantitative high-throughput screen for modulators of IL-6signaling: a model for interrogating biological networks using chemical libraries Molecular BioSystems ·Ronald L. Johnson, Ruili Huang, Ajit Jadhav, Noel Southall, Stephanie Ruiz, Ryan MacArthur, Menghang Xia, Kun Bi, John A. Printen, Christopher P. Austin, James Inglese	2009	11
10	Identification of Chemical Compounds that Induce HIF-1α Activity Toxicological Sciences ·Menghang Xia, Ruili Huang, Yi Sun, Gregg L. Semenza, Shelley Force Aldred, Kristine L. Witt, James Inglese, Raymond R. Tice, Christopher P. Austin	2009	49
11	A Fluorescence-Based Thiol Quantification Assay for Ultra-High-Throughput Screening for Inhibitors of Coenzyme A Production Assay and Drug Development Technologies ·Caroline Chung, Kenji Ohwaki, Jonathan E. Schneeweis, Erica Stec, Jeffrey P. Varnerin, Paul N. Goudreau, Amy Chang, Jay Ramsey, Lihu Yang, Karen Cavu, Oleg Kornienko, Peter Hodder, James Inglese, Marc Ferrer, Berta Strulovici, Jun Kusunoki, Michael R. Tota, Toshimitsu Takagi	2008	37
12	A Robotic Platform for Quantitative High-Throughput Screening Assay and Drug Development Technologies ·Sam Michael, Douglas S. Auld, Mushraff Ali Khan, Ajit Jadhav, Wei Zheng, Natasha Thorne, Christopher P. Austin, James Inglese, Anton Simeonov	2008	108
13	A 1,536-Well-Based Kinetic HTS Assay for Inhibitors of Schistosoma mansoni Thioredoxin Glutathione Reductase Assay and Drug Development Technologies ·Wendy Lea, Ajit Jadhav, Ganesha Rai, Ahmed A. Sayed, Cynthia L. Cass, James Inglese, David L. Williams, Christopher P. Austin, Anton Simeonov	2008	16
14	Evaluation of Micro-Parallel Liquid Chromatography as a Method for HTS-Coupled Actives Verification Assay and Drug Development Technologies ·Anton Simeonov, Adam Yasgar, Mushraff Ali Khan, Wei Zheng, N. Shafqat, Udo Oppermann, Christopher P. Austin, James Inglese	2007	4
15	A Cell-Based Assay for I κ B α Stabilization Using A Two-Color Dual Luciferase-Based Sensor Assay and Drug Development Technologies ·R. Eric Davis, Ya‐Qin Zhang, Noel Southall, Louis M. Staudt, Christopher P. Austin, James Inglese, Douglas S. Auld	2007	21
16	High-throughput screening assays for the identification of chemical probes Nature Chemical Biology ·James Inglese, Ronald L. Johnson, Anton Simeonov, Menghang Xia, Wei Zheng, Christopher P. Austin, Douglas S. Auld	2007	473
17	Quantitative high-throughput screening: A titration-based approach that efficiently identifies biological activities in large chemical libraries Proceedings of the National Academy of Sciences ·James Inglese, Douglas S. Auld, Ajit Jadhav, Ronald L. Johnson, Anton Simeonov, Adam Yasgar, Wei Zheng, Christopher P. Austin Hit paper breakdown →	2006	623
18	A 1,536-Well cAMP Assay for Gs- and Gi-Coupled Receptors Using Enzyme Fragmentation Complementation Assay and Drug Development Technologies ·Michael J. Weber, Marc Ferrer, Wei Zheng, James Inglese, Berta Strulovici, Priya Kunapuli	2004	24
19	A β -Lactamase-Dependent Gal4-Estrogen Receptor β Transactivation Assay for the Ultra-High Throughput Screening of Estrogen Receptor β Agonists in a 3,456-Well Format Assay and Drug Development Technologies ·Norbert Peekhaus, Marc Ferrer, Keting Yin, Oleg Kornienko, Jonathan E. Schneeweis, H.P. Krautwasser, 谢作威, Lyndon J. Mitnaul, Jayne Chin, Paul Fischer, V. Vanherreweghe, Elizabeth T. Birzin, Wanda Chan, James Inglese, Berta Strulovici, Susan P. Rohrer, James M. Schaeffer	2003	26
20	A Fully Automated [ ³⁵ S]GTPγS Scintillation Proximity Assay for the High-Throughput Screening of G _i -Linked G Protein-Coupled Receptors Assay and Drug Development Technologies ·Marc Ferrer, Peter J Sobraske, Paul Zuck, Hermann Ernst Grassmann, Rina Senbonmatsu, Suzanne Mandala, Hugh Rosen, Shannon Berry, Satoshi Ozaki, James Inglese, Berta Strulovici	2003	33

About James Inglese

James Inglese is a scholar working on Biophysics, Computational Theory and Mathematics, Molecular Biology, Cellular and Molecular Neuroscience and Aging, having authored 192 papers that have together received 13.8k indexed citations. Recurring topics across this work include Receptor Mechanisms and Signaling (39 papers), Computational Drug Discovery Methods (35 papers), bioluminescence and chemiluminescence research (19 papers), Protein Kinase Regulation and GTPase Signaling (16 papers), Biochemical and Molecular Research (12 papers), Cell Image Analysis Techniques (11 papers), Photoreceptor and optogenetics research (10 papers) and Neurobiology and Insect Physiology Research (9 papers). The work is most often cited by research in Cellular and Molecular Neuroscience (2.9k citations), Molecular Biology (9.9k citations), Computational Theory and Mathematics (1.8k citations), Biophysics (487 citations) and Cell Biology (964 citations). James Inglese has collaborated with scholars based in United States, France and Japan. Frequent co-authors include Robert J. Lefkowitz, Douglas S. Auld, Christopher P. Austin, Walter J. Koch, Anton Simeonov, Ajit Jadhav, Natasha Thorne, Richard T. Premont, Wei Zheng and Ronald L. Johnson. Their work appears in journals such as Journal of Biological Chemistry, Assay and Drug Development Technologies, Proceedings of the National Academy of Sciences, Journal of Medicinal Chemistry and Analytical Biochemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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