A. Heine

7.4k total citations · 1 hit paper
179 papers, 5.8k citations indexed

About

A. Heine is a scholar working on Molecular Biology, Materials Chemistry and Organic Chemistry. According to data from OpenAlex, A. Heine has authored 179 papers receiving a total of 5.8k indexed citations (citations by other indexed papers that have themselves been cited), including 116 papers in Molecular Biology, 59 papers in Materials Chemistry and 54 papers in Organic Chemistry. Recurrent topics in A. Heine's work include Enzyme Structure and Function (57 papers), Protein Structure and Dynamics (41 papers) and RNA and protein synthesis mechanisms (24 papers). A. Heine is often cited by papers focused on Enzyme Structure and Function (57 papers), Protein Structure and Dynamics (41 papers) and RNA and protein synthesis mechanisms (24 papers). A. Heine collaborates with scholars based in Germany, United States and Switzerland. A. Heine's co-authors include G. Klebe, Dietmar Stalke, Ian A. Wilson, David Hangauer, Michael Betz, Chi‐Huey Wong, Claudiu T. Supuran, H. Steuber, J. Biela and Bernhard Baum and has published in prestigious journals such as Science, Proceedings of the National Academy of Sciences and Journal of the American Chemical Society.

In The Last Decade

A. Heine

176 papers receiving 5.7k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Immune Versus Natural Selection: Antibody Aldolases with Enzymic Rates But Broader Scope

1997 333 citations A. Heine, Ian A. Wilson et al. Science profile →

Peers

Countries citing papers authored by A. Heine

Since Specialization

Citations

This map shows the geographic impact of A. Heine's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by A. Heine with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites A. Heine more than expected).

Fields of papers citing papers by A. Heine

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by A. Heine. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by A. Heine. The network helps show where A. Heine may publish in the future.

Co-authorship network of co-authors of A. Heine

This figure shows the co-authorship network connecting the top 25 collaborators of A. Heine. A scholar is included among the top collaborators of A. Heine based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with A. Heine. A. Heine is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Synthesis and structural characterization of new macrocyclic inhibitors of the Zika virus NS2B–NS3 protease 2024 ·Archiv der Pharmazie ·(unknown), (unknown), (unknown), (unknown), Daniela Bender, Eberhard Hildt, A. Heine, Torsten Steinmetzer	2
2	Mutational Studies of Aldose Reductase to Trace a Transient Pocket Opening and to Explain Ligand Affinity Cliffs 2023 ·ChemMedChem ·(unknown), (unknown), T. Hüfner, A. Heine, G. Klebe	0
3	¹⁹F-NMR Unveils the Ligand-Induced Conformation of a Catalytically Inactive Twisted Homodimer of tRNA–Guanine Transglycosylase 2022 ·ACS Chemical Biology ·(unknown), Gerd Gemmecker, (unknown), Levon D. Movsisyan, Toni Pfaffeneder, A. Heine, Klaus Reuter, François Diederich, Michael Sattler, G. Klebe	1
4	Unraveling a Ligand‐Induced Twist of a Homodimeric Enzyme by Pulsed Electron–Electron Double Resonance 2021 ·Angewandte Chemie International Edition ·(unknown), Dinar Abdullin, Caspar A. Heubach, Toni Pfaffeneder, (unknown), A. Heine, Klaus Reuter, François Diederich, Olav Schiemann, G. Klebe	7
5	How a Fragment Draws Attention to Selectivity Discriminating Features between the Related Proteases Trypsin and Thrombin 2021 ·Journal of Medicinal Chemistry ·(unknown), (unknown), J. Schiebel, (unknown), Linda C. Schmidt, (unknown), Torsten Steinmetzer, Andreas Ostermann, A. Heine, G. Klebe	1
6	Protein-Induced Change in Ligand Protonation during Trypsin and Thrombin Binding: Hint on Differences in Selectivity Determinants of Both Proteins? 2020 ·Journal of Medicinal Chemistry ·(unknown), (unknown), (unknown), Björn Wagner, A. Heine, G. Klebe	8
7	The Importance of Charge in Perturbing the Aromatic Glue Stabilizing the Protein–Protein Interface of Homodimeric tRNA-Guanine Transglycosylase 2020 ·ACS Chemical Biology ·(unknown), (unknown), (unknown), (unknown), (unknown), Oscar Hernandez‐Alba, François Debaene, Sarah Cianférani, A. Heine, G. Klebe, Klaus Reuter	3
8	Structure‐Based Design of FXIIIa‐Blockers: Addressing a Transient Hydrophobic Pocket in the Active Site of FXIIIa 2020 ·ChemMedChem ·(unknown), (unknown), (unknown), A. Heine, Martin Hils, Ralf Pasternack, G. Klebe	4
9	Paradoxically, Most Flexible Ligand Binds Most Entropy-Favored: Intriguing Impact of Ligand Flexibility and Solvation on Drug–Kinase Binding 2018 ·Journal of Medicinal Chemistry ·(unknown), Hendrik R. A. Jonker, Tobias Wulsdorf, Hans‐Dieter Gerber, Krishna Saxena, D. Kudlinzki, Sridhar Sreeramulu, Giacomo Parigi, Claudio Luchinat, A. Heine, Harald Schwalbe, G. Klebe	38
10	Design and Synthesis of Bioisosteres of Acylhydrazones as Stable Inhibitors of the Aspartic Protease Endothiapepsin 2018 ·ChemMedChem ·Varsha R. Jumde, Milon Mondal, (unknown), (unknown), (unknown), (unknown), A. Heine, G. Klebe, Anna K. H. Hirsch	6
11	Swapping Interface Contacts in the Homodimeric tRNA‐Guanine Transglycosylase: An Option for Functional Regulation 2018 ·Angewandte Chemie International Edition ·(unknown), (unknown), Toni Pfaffeneder, Bruno Bernet, Christoph Hohn, Elisabeth Schäfer, Thomas Botzanowski, Sarah Cianférani, A. Heine, Klaus Reuter, François Diederich, G. Klebe	9
12	Austausch der Proteinkontaktflächen in der homodimeren tRNA‐Guanin‐Transglycosylase: ein Weg der funktionellen Regulation 2018 ·Angewandte Chemie ·(unknown), (unknown), Toni Pfaffeneder, Bruno Bernet, Christoph Hohn, Elisabeth Schäfer, Thomas Botzanowski, Sarah Cianférani, A. Heine, Klaus Reuter, François Diederich, G. Klebe	2
13	Structure-based design and profiling of novel 17β-HSD14 inhibitors 2018 ·European Journal of Medicinal Chemistry ·(unknown), (unknown), Gabriele Möller, Jerzy Adamski, Martin Frotscher, (unknown), (unknown), Marc Le Borgne, Laurent Ettouati, Pierre Falson, Sebastian Müller, (unknown), A. Heine, G. Klebe, Sandrine Marchais‐Oberwinkler	10
14	On the Implication of Water on Fragment‐to‐Ligand Growth in Kinase Binding Thermodynamics 2018 ·ChemMedChem ·(unknown), Tobias Wulsdorf, Hendrik R. A. Jonker, Krishna Saxena, D. Kudlinzki, V.L. Linhard, Sridhar Sreeramulu, A. Heine, Harald Schwalbe, G. Klebe	8
15	Homodimer Architecture of QTRT2, the Noncatalytic Subunit of the Eukaryotic tRNA-Guanine Transglycosylase 2018 ·Biochemistry ·(unknown), (unknown), (unknown), Thomas Botzanowski, Sarah Cianférani, Christoph P. Sager, G. Klebe, A. Heine, Klaus Reuter	10
16	Ladungen verschieben Protonierungen: Neutronenbeugung zeigt, dass Anilin und 2‐Aminopyridin protoniert an Trypsin binden 2017 ·Angewandte Chemie ·J. Schiebel, Roberto Gaspari, (unknown), (unknown), Hans‐Dieter Gerber, Andrea Cavalli, Andreas Ostermann, A. Heine, G. Klebe	3
17	Charges Shift Protonation: Neutron Diffraction Reveals that Aniline and 2‐Aminopyridine Become Protonated Upon Binding to Trypsin 2017 ·Angewandte Chemie International Edition ·J. Schiebel, Roberto Gaspari, (unknown), (unknown), Hans‐Dieter Gerber, Andrea Cavalli, Andreas Ostermann, A. Heine, G. Klebe	23
18	How Nothing Boosts Affinity: Hydrophobic Ligand Binding to the Virtually Vacated S₁′ Pocket of Thermolysin 2017 ·Journal of the American Chemical Society ·S.G. Krimmer, Jonathan Cramer, J. Schiebel, A. Heine, G. Klebe	21
19	Elucidating the Origin of Long Residence Time Binding for Inhibitors of the Metalloprotease Thermolysin 2016 ·ACS Chemical Biology ·Jonathan Cramer, S.G. Krimmer, (unknown), Tobias Wulsdorf, Robert Karlsson, A. Heine, G. Klebe	14
20	Observation of Covalent Intermediates in an Enzyme Mechanism at Atomic Resolution 2001 ·Science ·A. Heine, Grace DeSantis, J.G. Luz, Michael L. Mitchell, Chi‐Huey Wong, Ian A. Wilson	239

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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