A. Heine

7.4k total citations · 1 hit paper
179 papers, 5.8k citations indexed

About

A. Heine is a scholar working on Molecular Biology, Materials Chemistry and Organic Chemistry. According to data from OpenAlex, A. Heine has authored 179 papers receiving a total of 5.8k indexed citations (citations by other indexed papers that have themselves been cited), including 116 papers in Molecular Biology, 59 papers in Materials Chemistry and 54 papers in Organic Chemistry. Recurrent topics in A. Heine's work include Enzyme Structure and Function (57 papers), Protein Structure and Dynamics (41 papers) and RNA and protein synthesis mechanisms (24 papers). A. Heine is often cited by papers focused on Enzyme Structure and Function (57 papers), Protein Structure and Dynamics (41 papers) and RNA and protein synthesis mechanisms (24 papers). A. Heine collaborates with scholars based in Germany, United States and Switzerland. A. Heine's co-authors include G. Klebe, Dietmar Stalke, Ian A. Wilson, David Hangauer, Michael Betz, Chi‐Huey Wong, Claudiu T. Supuran, H. Steuber, J. Biela and Bernhard Baum and has published in prestigious journals such as Science, Proceedings of the National Academy of Sciences and Journal of the American Chemical Society.

In The Last Decade

A. Heine

176 papers receiving 5.7k citations

Hit Papers

Immune Versus Natural Sel... 1997 2026 2006 2016 1997 100 200 300
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Immune Versus Natural Selection: Antibody Aldolases with Enzymic Rates But Broader Scope
    1997 333 citations A. Heine, Ian A. Wilson et al. Science profile →

Author Peers

Peers are selected by citation overlap in the author's most active subfields. citations · hero ref

Author Last Decade Papers Cites
A. Heine 3.6k 1.9k 1.1k 1.0k 685 179 5.8k
Ramy Farid 5.3k 1.5× 1.4k 0.7× 1.1k 1.0× 1.7k 1.6× 421 0.6× 48 8.2k
Wayne C. Guida 5.5k 1.5× 3.6k 1.9× 1.2k 1.1× 1.3k 1.3× 352 0.5× 94 10.0k
Doree Sitkoff 2.6k 0.7× 1.3k 0.7× 888 0.8× 444 0.4× 470 0.7× 27 4.9k
John J. Wendoloski 2.8k 0.8× 2.1k 1.1× 496 0.5× 1.3k 1.3× 274 0.4× 54 6.5k
Bernd Kuhn 6.9k 1.9× 3.5k 1.8× 1.4k 1.3× 2.6k 2.5× 718 1.0× 109 12.7k
Juswinder Singh 3.1k 0.9× 1.3k 0.7× 589 0.5× 974 0.9× 142 0.2× 57 4.9k
Araz Jakalian 3.2k 0.9× 1.4k 0.7× 790 0.7× 1.2k 1.2× 144 0.2× 27 5.7k
Claudio Dalvit 3.6k 1.0× 802 0.4× 916 0.8× 755 0.7× 176 0.3× 107 5.2k
Iñaki Tuñón 3.4k 0.9× 1.5k 0.8× 1.5k 1.4× 532 0.5× 444 0.6× 221 6.5k
Richard D. Taylor 3.4k 1.0× 3.0k 1.6× 526 0.5× 2.1k 2.0× 374 0.5× 28 7.0k

Countries citing papers authored by A. Heine

Since Specialization
Citations

This map shows the geographic impact of A. Heine's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by A. Heine with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites A. Heine more than expected).

Fields of papers citing papers by A. Heine

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by A. Heine. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by A. Heine. The network helps show where A. Heine may publish in the future.

Co-authorship network of co-authors of A. Heine

This figure shows the co-authorship network connecting the top 25 collaborators of A. Heine. A scholar is included among the top collaborators of A. Heine based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with A. Heine. A. Heine is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Bender, Daniela, et al.. (2024). Synthesis and structural characterization of new macrocyclic inhibitors of the Zika virus NS2B–NS3 protease. Archiv der Pharmazie. 357(9). e2400250–e2400250. 2 indexed citations
2.
Hüfner, T., et al.. (2023). Mutational Studies of Aldose Reductase to Trace a Transient Pocket Opening and to Explain Ligand Affinity Cliffs. ChemMedChem. 18(15). e202300222–e202300222.
3.
Wollenhaupt, J., et al.. (2023). Crystallographic Fragment Screening on the Shigella Type III Secretion System Chaperone IpgC. ACS Omega. 8(48). 46051–46065. 1 indexed citations
4.
Gemmecker, Gerd, Levon D. Movsisyan, Toni Pfaffeneder, et al.. (2022). 19F-NMR Unveils the Ligand-Induced Conformation of a Catalytically Inactive Twisted Homodimer of tRNA–Guanine Transglycosylase. ACS Chemical Biology. 17(7). 1745–1755. 1 indexed citations
5.
Heine, A., et al.. (2022). Boroleucine‐Derived Covalent Inhibitors of the ZIKV Protease. ChemMedChem. 18(3). e202200336–e202200336. 6 indexed citations
6.
Abdullin, Dinar, Caspar A. Heubach, Toni Pfaffeneder, et al.. (2021). Unraveling a Ligand‐Induced Twist of a Homodimeric Enzyme by Pulsed Electron–Electron Double Resonance. Angewandte Chemie International Edition. 60(43). 23419–23426. 7 indexed citations
7.
Metz, A., J. Wollenhaupt, Hans‐Dieter Gerber, et al.. (2021). Frag4Lead: growing crystallographic fragment hits by catalog using fragment-guided template docking. Acta Crystallographica Section D Structural Biology. 77(9). 1168–1182. 10 indexed citations
8.
Wagner, Björn, et al.. (2020). Protein-Induced Change in Ligand Protonation during Trypsin and Thrombin Binding: Hint on Differences in Selectivity Determinants of Both Proteins?. Journal of Medicinal Chemistry. 63(6). 3274–3289. 8 indexed citations
9.
Hernandez‐Alba, Oscar, François Debaene, Sarah Cianférani, et al.. (2020). The Importance of Charge in Perturbing the Aromatic Glue Stabilizing the Protein–Protein Interface of Homodimeric tRNA-Guanine Transglycosylase. ACS Chemical Biology. 15(11). 3021–3029. 3 indexed citations
10.
Heine, A., et al.. (2020). Structure‐Based Design of FXIIIa‐Blockers: Addressing a Transient Hydrophobic Pocket in the Active Site of FXIIIa. ChemMedChem. 15(10). 900–905. 4 indexed citations
11.
Hüfner, T., et al.. (2019). Strategies for Late-Stage Optimization: Profiling Thermodynamics by Preorganization and Salt Bridge Shielding. Journal of Medicinal Chemistry. 62(21). 9753–9771. 16 indexed citations
12.
Jonker, Hendrik R. A., Tobias Wulsdorf, Hans‐Dieter Gerber, et al.. (2018). Paradoxically, Most Flexible Ligand Binds Most Entropy-Favored: Intriguing Impact of Ligand Flexibility and Solvation on Drug–Kinase Binding. Journal of Medicinal Chemistry. 61(14). 5922–5933. 38 indexed citations
13.
Botzanowski, Thomas, Sarah Cianférani, Christoph P. Sager, et al.. (2018). Homodimer Architecture of QTRT2, the Noncatalytic Subunit of the Eukaryotic tRNA-Guanine Transglycosylase. Biochemistry. 57(26). 3953–3965. 10 indexed citations
14.
Möller, Gabriele, Jerzy Adamski, Martin Frotscher, et al.. (2018). Structure-based design and profiling of novel 17β-HSD14 inhibitors. European Journal of Medicinal Chemistry. 155. 61–76. 10 indexed citations
15.
Jumde, Varsha R., et al.. (2018). Design and Synthesis of Bioisosteres of Acylhydrazones as Stable Inhibitors of the Aspartic Protease Endothiapepsin. ChemMedChem. 13(21). 2266–2270. 6 indexed citations
16.
Pfaffeneder, Toni, Bruno Bernet, Christoph Hohn, et al.. (2018). Swapping Interface Contacts in the Homodimeric tRNA‐Guanine Transglycosylase: An Option for Functional Regulation. Angewandte Chemie International Edition. 57(32). 10085–10090. 9 indexed citations
17.
Schiebel, J., Roberto Gaspari, Hans‐Dieter Gerber, et al.. (2017). Ladungen verschieben Protonierungen: Neutronenbeugung zeigt, dass Anilin und 2‐Aminopyridin protoniert an Trypsin binden. Angewandte Chemie. 129(17). 4965–4969. 3 indexed citations
18.
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20.
Heine, A., Grace DeSantis, J.G. Luz, et al.. (2001). Observation of Covalent Intermediates in an Enzyme Mechanism at Atomic Resolution. Science. 294(5541). 369–374. 239 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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