J. Schiebel

1.1k citations

22 papers · 782 · h-index 14

Impact in

Computational Theory and Mathematics top 5%
- Computational Drug Discovery Methods
Molecular Medicine top 10%
- Antibiotic Resistance in Bacteria

Papers in

Molecular Biology 17
- Protein Structure and Dynamics 9
- Biochemical and Molecular Research 6
- Chemical Synthesis and Analysis 5
Materials Chemistry 10
- Enzyme Structure and Function 10

Co-authors: A. Heine (13 shared papers)G. Klebe (13 shared papers)Caroline Kisker (9 shared papers)Peter J. Tonge (7 shared papers)Andrew Chang (5 shared papers)Andreas Ostermann (4 shared papers)Roberto Gaspari (3 shared papers)Andrea Cavalli (2 shared papers)
Journals: Structure (3 papers)Journal of Medicinal Chemistry (3 papers)Angewandte Chemie International Edition (2 papers)Journal of Biological Chemistry (2 papers)Biochemistry (2 papers)
Partner nations: Germany United States Sweden

In The Last Decade

J. Schiebel

21 papers receiving 776 citations

Peers

Countries citing papers authored by J. Schiebel

Since Specialization

Citations

This map shows the geographic impact of J. Schiebel's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by J. Schiebel with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites J. Schiebel more than expected).

Fields of papers citing papers by J. Schiebel

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by J. Schiebel. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by J. Schiebel. The network helps show where J. Schiebel may publish in the future.

Co-authors

The 25 scholars most cited alongside J. Schiebel, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with J. Schiebel Line = papers co-authored together J. Schiebel links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 22 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Intriguing role of water in protein-ligand binding studied by neutron crystallography on trypsin complexes Nature Communications ·J. Schiebel, Roberto Gaspari, Tobias Wulsdorf, K. Ngo, Christian Sohn, Tobias E. Schrader, Andrea Cavalli, Andreas Ostermann, A. Heine, G. Klebe	2018	171
2	Six Biophysical Screening Methods Miss a Large Proportion of Crystallographically Discovered Fragment Hits: A Case Study ACS Chemical Biology ·J. Schiebel, Nedyalka Radeva, S.G. Krimmer, Xiaojie Wang, Martin Stieler, F.R. Ehrmann, Kan Fu, A. Metz, Franziska U. Huschmann, M.S. Weiss, U. Müeller, A. Heine, G. Klebe	2016	80
3	Staphylococcus aureus FabI: Inhibition, Substrate Recognition, and Potential Implications for In Vivo Essentiality Structure ·J. Schiebel, Andrew Chang, Hao Lu, Michael V. Baxter, Peter J. Tonge, Caroline Kisker	2012	74
4	High-Throughput Crystallography: Reliable and Efficient Identification of Fragment Hits Structure ·J. Schiebel, S.G. Krimmer, Karine Röwer, Anna Knörlein, Xiaojie Wang, Ah Young Park, Martin Stieler, F.R. Ehrmann, Kan Fu, Nedyalka Radeva, Michael Krug, Franziska U. Huschmann, Steffen Glöckner, M.S. Weiss, U. Müeller, G. Klebe, A. Heine	2016	60
5	Rational Design of Broad Spectrum Antibacterial Activity Based on a Clinically Relevant Enoyl-Acyl Carrier Protein (ACP) Reductase Inhibitor Journal of Biological Chemistry ·J. Schiebel, Andrew Chang, Sonam Shah, Yang Lü, Li Liu, Pan Pan, M.W. Hirschbeck, Mona Tareilus, Sandra Eltschkner, Weixuan Yu, Jason E. Cummings, Susan E. Knudson, Gopal R. Bommineni, Stephen G. Walker, Richard A. Slayden, Christoph Sotriffer, Peter J. Tonge, Caroline Kisker	2014	53
6	One Question, Multiple Answers: Biochemical and Biophysical Screening Methods Retrieve Deviating Fragment Hit Lists ChemMedChem ·J. Schiebel, Nedyalka Radeva, Helene Köster, A. Metz, Timo Krotzky, Maren Kuhnert, Wibke E. Diederich, A. Heine, Lars Neumann, Cédric Atmanène, Dominique Roecklin, Valérie Vivat‐Hannah, Jean‐Paul Renaud, Robert Meinecke, Nina Schlinck, Astrid Sitte, Franziska Popp, Markus Zeeb, G. Klebe	2015	52
7	Rational Optimization of Drug-Target Residence Time: Insights from Inhibitor Binding to the Staphylococcus aureus FabI Enzyme–Product Complex Biochemistry ·Andrew Chang, J. Schiebel, Weixuan Yu, Gopal R. Bommineni, Pan Pan, Michael V. Baxter, Avinash Khanna, Christoph Sotriffer, Caroline Kisker, Peter J. Tonge	2013	51
8	FadA5 a Thiolase from Mycobacterium tuberculosis : A Steroid-Binding Pocket Reveals the Potential for Drug Development against Tuberculosis Structure ·C. Schaefer, Rui Lu, Natasha M. Nesbitt, J. Schiebel, Nicole S. Sampson, Caroline Kisker	2014	38
9	Structural Basis for the Recognition of Mycolic Acid Precursors by KasA, a Condensing Enzyme and Drug Target from Mycobacterium Tuberculosis Journal of Biological Chemistry ·J. Schiebel, Kanishk Kapilashrami, Ágnes Fekete, Gopal R. Bommineni, C. Schaefer, Martin J. Mueller, Peter J. Tonge, Caroline Kisker	2013	35
10	An Ordered Water Channel in Staphylococcus aureus FabI: Unraveling the Mechanism of Substrate Recognition and Reduction Biochemistry ·J. Schiebel, Andrew Chang, Benjamin Merget, Gopal R. Bommineni, Weixuan Yu, Lauren A. Spagnuolo, Michael V. Baxter, Mona Tareilus, Peter J. Tonge, Caroline Kisker, Christoph Sotriffer	2015	27
11	Structures of endothiapepsin–fragment complexes from crystallographic fragment screening using a novel, diverse and affordable 96-compound fragment library Acta Crystallographica Section F Structural Biology Communications ·Franziska U. Huschmann, Janina Linnik, Karine Sparta, Monika Ühlein, Xiaojie Wang, A. Metz, J. Schiebel, A. Heine, G. Klebe, M.S. Weiss, U. Müeller	2016	26
12	Correlating drug–target kinetics and in vivo pharmacodynamics: long residence time inhibitors of the FabI enoyl-ACP reductase Chemical Science ·Fereidoon Daryaee, Andrew Chang, J. Schiebel, Yang Lü, Zhuo Zhang, Kanishk Kapilashrami, Stephen G. Walker, Caroline Kisker, Christoph Sotriffer, Stewart L. Fisher, Peter J. Tonge	2016	24
13	Charges Shift Protonation: Neutron Diffraction Reveals that Aniline and 2‐Aminopyridine Become Protonated Upon Binding to Trypsin Angewandte Chemie International Edition ·J. Schiebel, Roberto Gaspari, (unknown), K. Ngo, Hans‐Dieter Gerber, Andrea Cavalli, Andreas Ostermann, A. Heine, G. Klebe	2017	23
14	How Nothing Boosts Affinity: Hydrophobic Ligand Binding to the Virtually Vacated S₁′ Pocket of Thermolysin Journal of the American Chemical Society ·S.G. Krimmer, Jonathan Cramer, J. Schiebel, A. Heine, G. Klebe	2017	21
15	Experimental Active-Site Mapping by Fragments: Hot Spots Remote from the Catalytic Center of Endothiapepsin Journal of Medicinal Chemistry ·Nedyalka Radeva, S.G. Krimmer, Martin Stieler, Kan Fu, Xiaojie Wang, F.R. Ehrmann, A. Metz, Franziska U. Huschmann, M.S. Weiss, U. Müeller, J. Schiebel, A. Heine, G. Klebe	2016	13
16	Active Site Mapping of an Aspartic Protease by Multiple Fragment Crystal Structures: Versatile Warheads To Address a Catalytic Dyad Journal of Medicinal Chemistry ·Nedyalka Radeva, J. Schiebel, Xiaojie Wang, S.G. Krimmer, Kan Fu, Martin Stieler, F.R. Ehrmann, A. Metz, Thomas Rickmeyer, Michael Betz, Johan Winquist, Ah Young Park, Franziska U. Huschmann, M.S. Weiss, U. Müeller, A. Heine, G. Klebe	2016	12
17	A False‐Positive Screening Hit in Fragment‐Based Lead Discovery: Watch out for the Red Herring Angewandte Chemie International Edition ·Jonathan Cramer, J. Schiebel, Tobias Wulsdorf, Kristof Grohe, Eszter E. Najbauer, F.R. Ehrmann, Nedyalka Radeva, Nina Zitzer, Uwe Linne, Rasmus Linser, A. Heine, G. Klebe	2017	11
18	A Long Residence Time Enoyl-Reductase Inhibitor Explores an Extended Binding Region with Isoenzyme-Dependent Tautomer Adaptation and Differential Substrate-Binding Loop Closure ACS Infectious Diseases ·Sandra Eltschkner, Josef Kehrein, Thien Anh Le, Shabnam Davoodi, Benjamin Merget, Sneha Basak, Jonas D. Weinrich, J. Schiebel, Peter J. Tonge, Bernd Engels, Christoph Sotriffer, Caroline Kisker	2021	6
19	Ladungen verschieben Protonierungen: Neutronenbeugung zeigt, dass Anilin und 2‐Aminopyridin protoniert an Trypsin binden Angewandte Chemie ·J. Schiebel, Roberto Gaspari, (unknown), K. Ngo, Hans‐Dieter Gerber, Andrea Cavalli, Andreas Ostermann, A. Heine, G. Klebe	2017	3
20	How a Fragment Draws Attention to Selectivity Discriminating Features between the Related Proteases Trypsin and Thrombin Journal of Medicinal Chemistry ·(unknown), K. Ngo, J. Schiebel, Angela Ilse Marca Pizarroso, Linda C. Schmidt, Benjamin Wenzel, Torsten Steinmetzer, Andreas Ostermann, A. Heine, G. Klebe	2021	1

About J. Schiebel

J. Schiebel is a scholar working on Molecular Biology, Materials Chemistry, Organic Chemistry, Infectious Diseases and Computational Theory and Mathematics, having authored 22 papers that have together received 782 indexed citations. Recurring topics across this work include Enzyme Structure and Function (10 papers), Protein Structure and Dynamics (9 papers), Biochemical and Molecular Research (6 papers), Chemical Synthesis and Analysis (5 papers), Antimicrobial agents and applications (5 papers), Antimicrobial Resistance in Staphylococcus (3 papers), Computational Drug Discovery Methods (3 papers) and Microbial Natural Products and Biosynthesis (2 papers). The work is most often cited by research in Computational Theory and Mathematics (175 citations), Molecular Medicine (55 citations), Microbiology (47 citations), Molecular Biology (514 citations) and Organic Chemistry (185 citations). J. Schiebel has collaborated with scholars based in Germany, United States and Sweden. Frequent co-authors include A. Heine, G. Klebe, Caroline Kisker, Peter J. Tonge, Andrew Chang, Andreas Ostermann, Roberto Gaspari, Andrea Cavalli, Tobias Wulsdorf and Tobias E. Schrader. Their work appears in journals such as Structure, Journal of Medicinal Chemistry, Angewandte Chemie International Edition, Journal of Biological Chemistry and Biochemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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