David Hangauer

2.5k citations

64 papers · 2.0k indexed · h-index 27

Impact in

Computational Theory and Mathematics top 2%
- Computational Drug Discovery Methods
Physical and Theoretical Chemistry top 5%
- Crystallography and molecular interactions

Papers in ⓘ

Molecular Biology 45
- Protein Structure and Dynamics 16
- Chemical Synthesis and Analysis 15
- PI3K/AKT/mTOR signaling in cancer 4
Oncology 17
- HER2/EGFR in Cancer Research 6

Co-authors: G. Klebe (11 shared papers)A. Heine (11 shared papers)A.F. Monzingo (1 shared paper)Brian W. Matthews (1 shared paper)Bernhard Baum (5 shared papers)Michael Smolinski (9 shared papers)J. Biela (4 shared papers)W. J. GREENLEE (2 shared papers)
Journals: Journal of Medicinal Chemistry (6 papers)Journal of Molecular Biology (5 papers)Bioorganic & Medicinal Chemistry Letters (4 papers)Cancer Research (4 papers)European Journal of Medicinal Chemistry (4 papers)
Partner nations: United States Germany South Korea

In The Last Decade

David Hangauer

64 papers receiving 1.9k citations

Peers

Countries citing papers authored by David Hangauer

Since Specialization

Citations

This map shows the geographic impact of David Hangauer's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by David Hangauer with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites David Hangauer more than expected).

Fields of papers citing papers by David Hangauer

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David Hangauer. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David Hangauer. The network helps show where David Hangauer may publish in the future.

Co-authors

The 25 scholars most cited alongside David Hangauer, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with David Hangauer Line = papers co-authored together David Hangauer links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

Showing the 20 most-cited of 64 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	An interactive computer graphics study of thermolysin-catalyzed peptide cleavage and inhibition by N-carboxymethyl dipeptides Biochemistry ·David Hangauer, A.F. Monzingo, Brian W. Matthews	1984	216
2	Non-additivity of Functional Group Contributions in Protein–Ligand Binding: A Comprehensive Study by Crystallography and Isothermal Titration Calorimetry Journal of Molecular Biology ·Bernhard Baum, Laveena Muley, Michael Smolinski, A. Heine, David Hangauer, G. Klebe	2010	127
3	Dissecting the Hydrophobic Effect on the Molecular Level: The Role of Water, Enthalpy, and Entropy in Ligand Binding to Thermolysin Angewandte Chemie International Edition ·J. Biela, Nader N. Nasief, Michael Betz, A. Heine, David Hangauer, G. Klebe	2013	122
4	More than a Simple Lipophilic Contact: A Detailed Thermodynamic Analysis of Nonbasic Residues in the S1 Pocket of Thrombin Journal of Molecular Biology ·Bernhard Baum, Menshawy Mohamed, Mohamed F. Zayed, Christof Gerlach, A. Heine, David Hangauer, G. Klebe	2009	104
5	Design of a selective insulin receptor tyrosine kinase inhibitor and its effect on glucose uptake and metabolism in intact cells Biochemistry ·Richard Saperstein, Pasquale P. Vicario, H.V. Strout, Edward J. Brady, Eve E. Slater, William J. Greenlee, Debra L. Ondeyka, Arthur A. Patchett, David Hangauer	1989	96
6	Displacement of disordered water molecules from hydrophobic pocket creates enthalpic signature: Binding of phosphonamidate to the S1'-pocket of thermolysin Biochimica et Biophysica Acta (BBA) - General Subjects ·Lisa Englert, J. Biela, Mohamed F. Zayed, A. Heine, David Hangauer, G. Klebe	2010	76
7	Enhancement of Hydrophobic Interactions and Hydrogen Bond Strength by Cooperativity: Synthesis, Modeling, and Molecular Dynamics Simulations of a Congeneric Series of Thrombin Inhibitors Journal of Medicinal Chemistry ·Laveena Muley, Bernhard Baum, Michael Smolinski, Marek Freindorf, A. Heine, G. Klebe, David Hangauer	2010	76
8	Discovery of Novel Dual Mechanism of Action Src Signaling and Tubulin Polymerization Inhibitors (KX2-391 and KX2-361) Journal of Medicinal Chemistry ·Michael Smolinski, Yahao Bu, James L. Clements, Irwin H. Gelman, Taher Hegab, David L. Cutler, Jane Fang, Gerald J. Fetterly, Rudolf Kwan, Allen Barnett, Johnson Y. N. Lau, David Hangauer	2018	72
9	Thiazolyl N-benzyl-substituted acetamide derivatives: Synthesis, Src kinase inhibitory and anticancer activities European Journal of Medicinal Chemistry ·Asal Fallah‐Tafti, Alireza Foroumadi, Rakesh Kumar Tiwari, Amir Nasrolahi Shirazi, David Hangauer, Yahao Bu, Tahmineh Akbarzadeh, Keykavous Parang, Abbas Shafiee	2011	57
10	A phase 2 study of KX2-391, an oral inhibitor of Src kinase and tubulin polymerization, in men with bone-metastatic castration-resistant prostate cancer Cancer Chemotherapy and Pharmacology ·Emmanuel S. Antonarakis, Elisabeth I. Heath, Edwin M. Posadas, Evan Y. Yu, Michael R. Harrison, Justine Y. Bruce, Steve Y. Cho, Gregory E. Wilding, Gerald J. Fetterly, David Hangauer, Min-Fun R. Kwan, Lyn M. Dyster, Michael A. Carducci	2013	56
11	Expression of Src and FAK in Hepatocellular Carcinoma and the Effect of Src Inhibitors on Hepatocellular Carcinoma In Vitro Digestive Diseases and Sciences ·Grace Lau, Gillian M.G. Lau, Guoliang Yu, Irwin H. Gelman, Alan Gutowski, David Hangauer, Jane Fang	2008	55
12	KX-01, a novel Src kinase inhibitor directed toward the peptide substrate site, synergizes with tamoxifen in estrogen receptor α positive breast cancer Breast Cancer Research and Treatment ·Muralidharan Anbalagan, Latonya Carrier, Seth Glodowski, David Hangauer, Bin Shan, Brian G. Rowan	2011	51
13	Addition of trimethylsilyl cyanide to α-substituted ketones: Catalyst efficiency Tetrahedron Letters ·W. J. GREENLEE, David Hangauer	1983	50
14	Congeneric but Still Distinct: How Closely Related Trypsin Ligands Exhibit Different Thermodynamic and Structural Properties Journal of Molecular Biology ·Tobias Brandt, Nicole Holzmann, Laveena Muley, Maan T. Khayat, Christof Gerlach, Bernhard Baum, A. Heine, David Hangauer, G. Klebe	2010	45
15	Impact of Ligand and Protein Desolvation on Ligand Binding to the S1 Pocket of Thrombin Journal of Molecular Biology ·J. Biela, Maan T. Khayat, Hongwei Tan, Jia Kong, A. Heine, David Hangauer, G. Klebe	2012	44
16	Think Twice: Understanding the High Potency of Bis(phenyl)methane Inhibitors of Thrombin Journal of Molecular Biology ·Bernhard Baum, Laveena Muley, A. Heine, Michael Smolinski, David Hangauer, G. Klebe	2009	44
17	Prevention of noise-induced hearing loss with Src-PTK inhibitors Hearing Research ·Kelly C. Harris, Bohua Hu, David Hangauer, Donald Henderson	2005	43
18	Synthesis and use of 3-amino-4-phenyl-2-piperidones and 4-amino-2-benzazepin-3-ones as conformationally restricted phenylalanine isosteres in renin inhibitors Journal of Medicinal Chemistry ·Stephen E. de Laszlo, Bruce L. Bush, John Doyle, W. J. GREENLEE, David Hangauer, Thomas A. Halgren, Robert J. Lynch, Terry W. Schorn, Peter K. S. Siegl	1992	41
19	Peptidomimetic Src/Pretubulin Inhibitor KX-01 Alone and in Combination with Paclitaxel Suppresses Growth, Metastasis in Human ER/PR/HER2-Negative Tumor Xenografts Molecular Cancer Therapeutics ·Muralidharan Anbalagan, Alaa M. Ali, Ryan K. Jones, Carolyn G. Marsden, Mei Sheng, Latonya Carrier, Yahao Bu, David Hangauer, Brian G. Rowan	2012	39
20	The design and synthesis of substituted biphenyl libraries Bioorganic & Medicinal Chemistry ·Michael R. Pavia, Michael P. Cohen, Garrett J. Dilley, Gloria R. Dubuc, Tracy Durgin, Frank W. Forman, Mark E. Hediger, Guy Milot, Timothy S. Powers, Irving Sucholeiki, Shulan Zhou, David Hangauer	1996	37

About David Hangauer

David Hangauer is a scholar working on Molecular Biology, Oncology, Computational Theory and Mathematics, Organic Chemistry and Hematology, having authored 64 papers that have together received 2.0k indexed citations. Recurring topics across this work include Protein Structure and Dynamics (16 papers), Chemical Synthesis and Analysis (15 papers), Computational Drug Discovery Methods (9 papers), HER2/EGFR in Cancer Research (6 papers), Carbohydrate Chemistry and Synthesis (5 papers), Enzyme Structure and Function (5 papers), Monoclonal and Polyclonal Antibodies Research (4 papers) and PI3K/AKT/mTOR signaling in cancer (4 papers). The work is most often cited by research in Computational Theory and Mathematics (350 citations), Physical and Theoretical Chemistry (167 citations), Molecular Biology (1.3k citations), Organic Chemistry (524 citations) and Oncology (353 citations). David Hangauer has collaborated with scholars based in United States, Germany and South Korea. Frequent co-authors include G. Klebe, A. Heine, A.F. Monzingo, Brian W. Matthews, Bernhard Baum, Michael Smolinski, J. Biela, W. J. GREENLEE, Mohamed F. Zayed and Michael Betz. Their work appears in journals such as Journal of Medicinal Chemistry, Journal of Molecular Biology, Bioorganic & Medicinal Chemistry Letters, Cancer Research and European Journal of Medicinal Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact