Wayne C. Guida

12.0k total citations · 6 hit papers
94 papers, 10.0k citations indexed

About

Wayne C. Guida is a scholar working on Molecular Biology, Organic Chemistry and Oncology. According to data from OpenAlex, Wayne C. Guida has authored 94 papers receiving a total of 10.0k indexed citations (citations by other indexed papers that have themselves been cited), including 61 papers in Molecular Biology, 22 papers in Organic Chemistry and 19 papers in Oncology. Recurrent topics in Wayne C. Guida's work include Computational Drug Discovery Methods (19 papers), Biochemical and Molecular Research (17 papers) and Ubiquitin and proteasome pathways (10 papers). Wayne C. Guida is often cited by papers focused on Computational Drug Discovery Methods (19 papers), Biochemical and Molecular Research (17 papers) and Ubiquitin and proteasome pathways (10 papers). Wayne C. Guida collaborates with scholars based in United States, Switzerland and Australia. Wayne C. Guida's co-authors include George Chang, W. Clark Still, Thomas F. Hendrickson, Craig E. Caufield, Nigel G. J. Richards, F. MOHAMADI, Rob M. J. Liskamp, Mark A. Lipton, Regine S. Bohacek and Kenyon G. Daniel and has published in prestigious journals such as Proceedings of the National Academy of Sciences, Journal of the American Chemical Society and Journal of Biological Chemistry.

In The Last Decade

Wayne C. Guida

92 papers receiving 9.6k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Macromodel—an integrated software system for modeling organic and bioorganic molecules using molecular mechanics

1990 3.5k citations Wayne C. Guida et al. profile →
An internal-coordinate Monte Carlo method for searching conformational space

1989 959 citations Wayne C. Guida et al. profile →
The art and practice of structure-based drug design: A molecular modeling perspective

1996 753 citations Regine S. Bohacek, Colin McMartin et al. Medicinal Research Reviews profile →
Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity

2007 616 citations Wayne C. Guida, Harshani R. Lawrence et al. Proceedings of the National Academy of Sciences profile →
The Significance of Chirality in Drug Design and Development

2011 509 citations Wesley H. Brooks, Wayne C. Guida et al. Current Topics in Medicinal Chemistry profile →
Conformations of cycloheptadecane. A comparison of methods for conformational searching

1990 436 citations Wayne C. Guida et al. profile →

Peers

Countries citing papers authored by Wayne C. Guida

Since Specialization

Citations

This map shows the geographic impact of Wayne C. Guida's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Wayne C. Guida with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Wayne C. Guida more than expected).

Fields of papers citing papers by Wayne C. Guida

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Wayne C. Guida. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Wayne C. Guida. The network helps show where Wayne C. Guida may publish in the future.

Co-authorship network of co-authors of Wayne C. Guida

This figure shows the co-authorship network connecting the top 25 collaborators of Wayne C. Guida. A scholar is included among the top collaborators of Wayne C. Guida based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Wayne C. Guida. Wayne C. Guida is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work	Indexed citations
1	Helical sulfonyl-γ-AApeptides modulating Aβ oligomerization and cytotoxicity by recognizing Aβ helix 2024 ·Proceedings of the National Academy of Sciences ·(unknown), (unknown), (unknown), Lulu Wei, Xudong Wang, Ning Shen, Timothy Odom, Xuming Li, William F. Lawless, (unknown), Martin Muschol, Wayne C. Guida, Chuanhai Cao, Libin Ye, Jianfeng Cai	8
2	Mechanistic Studies of 1-Deoxy-D-Xylulose-5-Phosphate Synthase from Deinococcus radiodurans 2018 ·PubMed ·Sumit Handa, Daniel R. Dempsey, Divya Ramamoorthy, (unknown), Wayne C. Guida, (unknown), (unknown), H. Lee Woodcock, David J. Merkler	11
3	Phosphatidylinositol (3,4,5)-trisphosphate binds to sortilin and competes with neurotensin: Implications for very low density lipoprotein binding 2016 ·Biochemical and Biophysical Research Communications ·(unknown), Jermaine L. Jenkins, (unknown), Yan Wang, Wayne C. Guida, Charles E. Sparks, Rutilio A. Fratti, Janet D. Sparks	8
4	Sortilin facilitates VLDL-B100 secretion by insulin sensitive McArdle RH7777 cells 2016 ·Biochemical and Biophysical Research Communications ·(unknown), Wayne C. Guida, Mark P. Sowden, Jermaine L. Jenkins, (unknown), Rutilio A. Fratti, Charles E. Sparks, Janet D. Sparks	10
5	Cupriphilic compounds to aid in proteasome inhibition 2016 ·Bioorganic & Medicinal Chemistry Letters ·(unknown), (unknown), (unknown), Wesley H. Brooks, Kenyon G. Daniel, Wayne C. Guida	3
6	A Novel Inhibitor of STAT3 Homodimerization Selectively Suppresses STAT3 Activity and Malignant Transformation 2013 ·Cancer Research ·Xiaolei Zhang, Ying Sun, Roberta Pireddu, Hua Yang, (unknown), Harshani R. Lawrence, Wayne C. Guida, Nicholas J. Lawrence, Saı̈d M. Sebti	122
7	Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2) 2012 ·MedChemComm ·Roberta Pireddu, (unknown), (unknown), Mathew P. Martin, Shen‐Shu Sung, Brian Alexander, J. Zhu, Wayne C. Guida, E. Schönbrunn, Saı̈d M. Sebti, Nicholas J. Lawrence	44
8	The Significance of Chirality in Drug Design and Development breakdown → 2011 ·Current Topics in Medicinal Chemistry ·Wesley H. Brooks, Wayne C. Guida, Kenyon G. Daniel	509
9	Shp2 protein tyrosine phosphatase inhibitor activity of estramustine phosphate and its triterpenoid analogs 2010 ·Bioorganic & Medicinal Chemistry Letters ·Latanya M. Scott, Liwei Chen, Kenyon G. Daniel, Wesley H. Brooks, Wayne C. Guida, Harshani R. Lawrence, Saı̈d M. Sebti, Nicholas J. Lawrence, Jie Wu	37
10	Inhibition of cellular Shp2 activity by a methyl ester analog of SPI-112 2010 ·Biochemical Pharmacology ·Liwei Chen, (unknown), Latanya M. Scott, Harshani R. Lawrence, Yuan Ren, Yunting Luo, Xin Wu, Shen‐Shu Sung, Wayne C. Guida, Saı̈d M. Sebti, Nicholas J. Lawrence, Jie Wu	31
11	Synthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitors 2010 ·Bioorganic & Medicinal Chemistry ·Harshani R. Lawrence, Aslamuzzaman Kazi, Yunting Luo, Robert D. Kendig, (unknown), (unknown), Kenyon G. Daniel, Daniel N. Santiago, Wayne C. Guida, Saı̈d M. Sebti	64
12	Identification of a disruptor of the MDM2-p53 protein–protein interaction facilitated by high-throughput in silico docking 2009 ·Bioorganic & Medicinal Chemistry Letters ·Harshani R. Lawrence, Zhenyu Li, M.L. Richard Yip, Shen‐Shu Sung, Nicholas J. Lawrence, Mark L. McLaughlin, Gregory J. McManus, Michael J. Zaworotko, Saı̈d M. Sebti, Jiandong Chen, Wayne C. Guida	22
13	Discovery of a novel proteasome inhibitor selective for cancer cells over non-transformed cells 2009 ·Cell Cycle ·Aslamuzzaman Kazi, Harshani R. Lawrence, Wayne C. Guida, Mark L. McLaughlin, Gregory M. Springett, Norbert Berndt, Richard Yip, Saı̈d M. Sebti	39
14	Structure-based Design of High Affinity Peptides Inhibiting the Interaction of p53 with MDM2 and MDMX 2009 ·Journal of Biological Chemistry ·Jason Phan, Zhenyu Li, (unknown), Baozong Li, Saı̈d M. Sebti, Wayne C. Guida, E. Schönbrunn, Jiandong Chen	138
15	A Small-Molecule E2F Inhibitor Blocks Growth in a Melanoma Culture Model 2008 ·Cancer Research ·Yihong Ma, (unknown), Sandhya Boyapalle, Shen‐Shu Sung, Harshani R. Lawrence, Wayne C. Guida, W. Douglas Cress	80
16	Discovery of a Novel Shp2 Protein Tyrosine Phosphatase Inhibitor 2006 ·Molecular Pharmacology ·Liwei Chen, Shen‐Shu Sung, M.L. Richard Yip, Harshani R. Lawrence, Yuan Ren, Wayne C. Guida, Saı̈d M. Sebti, Nicholas J. Lawrence, Jie Wu	236
17	Protein farnesyltransferase: Flexible docking studies on inhibitors using computational modeling 2005 ·Cancer Research ·Wayne C. Guida, Andrew D. Hamilton, (unknown), Saı̈d Sebti	1
18	Organic copper complexes as a new class of proteasome inhibitors and apoptosis inducers in human cancer cells 2003 ·Biochemical Pharmacology ·Kenyon G. Daniel, Puja Gupta, (unknown), Wayne C. Guida, Q. Ping Dou	261
19	The art and practice of structure-based drug design: A molecular modeling perspective breakdown → 1996 ·Medicinal Research Reviews ·Regine S. Bohacek, Colin McMartin, Wayne C. Guida	753
20	A rapid method for the computation, comparison and display of molecular volumes 1989 ·Journal of Molecular Graphics ·Regine S. Bohacek, Wayne C. Guida	8

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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