Wayne C. Guida

12.0k total citations · 6 hit papers
94 papers, 10.0k citations indexed

About

Wayne C. Guida is a scholar working on Molecular Biology, Organic Chemistry and Oncology. According to data from OpenAlex, Wayne C. Guida has authored 94 papers receiving a total of 10.0k indexed citations (citations by other indexed papers that have themselves been cited), including 61 papers in Molecular Biology, 22 papers in Organic Chemistry and 19 papers in Oncology. Recurrent topics in Wayne C. Guida's work include Computational Drug Discovery Methods (19 papers), Biochemical and Molecular Research (17 papers) and Ubiquitin and proteasome pathways (10 papers). Wayne C. Guida is often cited by papers focused on Computational Drug Discovery Methods (19 papers), Biochemical and Molecular Research (17 papers) and Ubiquitin and proteasome pathways (10 papers). Wayne C. Guida collaborates with scholars based in United States, Switzerland and Australia. Wayne C. Guida's co-authors include George Chang, W. Clark Still, Craig E. Caufield, Thomas F. Hendrickson, F. MOHAMADI, Nigel G. J. Richards, Mark A. Lipton, Rob M. J. Liskamp, Regine S. Bohacek and Kenyon G. Daniel and has published in prestigious journals such as Proceedings of the National Academy of Sciences, Journal of the American Chemical Society and Journal of Biological Chemistry.

In The Last Decade

Wayne C. Guida

92 papers receiving 9.6k citations

Hit Papers

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What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Macromodel—an integrated software system for modeling organic and bioorganic molecules using molecular mechanics

1990 3.5k citations Wayne C. Guida et al. profile →
An internal-coordinate Monte Carlo method for searching conformational space

1989 959 citations Wayne C. Guida et al. profile →
The art and practice of structure-based drug design: A molecular modeling perspective

1996 753 citations Regine S. Bohacek, Colin McMartin et al. Medicinal Research Reviews profile →
Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity

2007 616 citations Wayne C. Guida, Harshani R. Lawrence et al. Proceedings of the National Academy of Sciences profile →
The Significance of Chirality in Drug Design and Development

2011 509 citations Wesley H. Brooks, Wayne C. Guida et al. profile →
Conformations of cycloheptadecane. A comparison of methods for conformational searching

1990 436 citations Wayne C. Guida et al. profile →

Author Peers

Peers are selected by citation overlap in the author's most active subfields. citations · hero ref

Author						Papers	Cites
Wayne C. Guida	5.5k	3.6k	1.6k	1.5k	1.3k	94	10.0k
Bernd Kuhn	6.9k 1.3×	3.5k 1.0×	889 0.6×	1.3k 0.8×	2.6k 1.9×	109	12.7k
Mark A. Murcko	6.1k 1.1×	2.3k 0.7×	1.1k 0.7×	699 0.5×	4.0k 3.0×	72	10.8k
Roderick E. Hubbard	7.7k 1.4×	1.5k 0.4×	724 0.5×	1.5k 1.0×	2.5k 1.9×	110	11.9k
Thomas F. Hendrickson	4.9k 0.9×	2.7k 0.7×	1.3k 0.8×	493 0.3×	831 0.6×	24	8.0k
Wolfgang Damm	4.7k 0.9×	2.3k 0.6×	576 0.4×	676 0.4×	2.0k 1.5×	29	9.1k
Weiliang Zhu	5.2k 0.9×	2.6k 0.7×	878 0.5×	844 0.6×	2.2k 1.7×	404	11.3k
Astrid Gräslund	10.7k 2.0×	1.4k 0.4×	886 0.6×	2.4k 1.6×	585 0.4×	349	16.0k
Michael J. Waring	9.9k 1.8×	4.1k 1.1×	730 0.5×	2.9k 1.9×	921 0.7×	263	13.9k
Tyler Day	6.1k 1.1×	1.9k 0.5×	491 0.3×	1.0k 0.7×	2.7k 2.0×	24	10.4k
Philip J. Hajduk	7.6k 1.4×	1.7k 0.5×	1.1k 0.7×	878 0.6×	3.1k 2.3×	92	10.3k

Countries citing papers authored by Wayne C. Guida

Since Specialization

Citations

This map shows the geographic impact of Wayne C. Guida's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Wayne C. Guida with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Wayne C. Guida more than expected).

Fields of papers citing papers by Wayne C. Guida

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Wayne C. Guida. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Wayne C. Guida. The network helps show where Wayne C. Guida may publish in the future.

Co-authorship network of co-authors of Wayne C. Guida

This figure shows the co-authorship network connecting the top 25 collaborators of Wayne C. Guida. A scholar is included among the top collaborators of Wayne C. Guida based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Wayne C. Guida. Wayne C. Guida is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Wei, Lulu, Xudong Wang, Ning Shen, et al.. (2024). Helical sulfonyl-γ-AApeptides modulating Aβ oligomerization and cytotoxicity by recognizing Aβ helix. Proceedings of the National Academy of Sciences. 121(6). e2311733121–e2311733121. 8 indexed citations

Husain, Ali, et al.. (2024). Chemical synthesis, in vitro testing, and in silico Nampt-based molecular docking of novel aniline aromatic ring-substituted 2-aminothiazole analogs. Canadian Journal of Physiology and Pharmacology. 103(3). 75–85.

Badole, Sachin L., Ravikumar Manickam, Kalyan C. Chapalamadugu, et al.. (2022). Cardioprotective Effects of 1-(3,6-Dibromo-carbazol-9-yl)-3-Phenylamino-Propan-2-Ol in Diabetic Hearts via Nicotinamide Phosphoribosyltransferase Activation. Journal of Pharmacology and Experimental Therapeutics. 382(2). 233–245. 11 indexed citations

Arango, Andres S., Chi Zhang, Jermaine L. Jenkins, et al.. (2019). A small-molecule competitive inhibitor of phosphatidic acid binding by the AAA+ protein NSF/Sec18 blocks the SNARE-priming stage of vacuole fusion. Journal of Biological Chemistry. 294(46). 17168–17185. 4 indexed citations

Patel, Rekha, et al.. (2019). A specific small-molecule inhibitor of protein kinase CδI activity improves metabolic dysfunction in human adipocytes from obese individuals. Journal of Biological Chemistry. 294(41). 14896–14910. 5 indexed citations

Jenkins, Jermaine L., Yan Wang, Wayne C. Guida, et al.. (2016). Phosphatidylinositol (3,4,5)-trisphosphate binds to sortilin and competes with neurotensin: Implications for very low density lipoprotein binding. Biochemical and Biophysical Research Communications. 479(3). 551–556. 8 indexed citations

Guida, Wayne C., Mark P. Sowden, Jermaine L. Jenkins, et al.. (2016). Sortilin facilitates VLDL-B100 secretion by insulin sensitive McArdle RH7777 cells. Biochemical and Biophysical Research Communications. 478(2). 546–552. 10 indexed citations

Brooks, Wesley H., et al.. (2016). Cupriphilic compounds to aid in proteasome inhibition. Bioorganic & Medicinal Chemistry Letters. 26(15). 3826–3829. 3 indexed citations

Doupnik, Craig A., et al.. (2014). A computational design approach for virtual screening of peptide interactions across K+ channel families. Computational and Structural Biotechnology Journal. 13. 85–94. 12 indexed citations

10.

Zhang, Xiaolei, Ying Sun, Roberta Pireddu, et al.. (2013). A Novel Inhibitor of STAT3 Homodimerization Selectively Suppresses STAT3 Activity and Malignant Transformation. Cancer Research. 73(6). 1922–1933. 122 indexed citations

11.

Pireddu, Roberta, Mathew P. Martin, Shen‐Shu Sung, et al.. (2012). Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2). MedChemComm. 3(6). 699–699. 44 indexed citations

12.

Balasis, Maria E., Kenichiro Doi, Norbert Berndt, et al.. (2012). Synthesis and evaluation of substituted hexahydronaphthalenes as novel inhibitors of the Mcl-1/BimBH3 interaction. Bioorganic & Medicinal Chemistry Letters. 22(18). 5961–5965. 4 indexed citations

13.

Lawrence, Harshani R., Aslamuzzaman Kazi, Yunting Luo, et al.. (2010). Synthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitors. Bioorganic & Medicinal Chemistry. 18(15). 5576–5592. 64 indexed citations

14.

Phan, Jason, Zhenyu Li, Baozong Li, et al.. (2009). Structure-based Design of High Affinity Peptides Inhibiting the Interaction of p53 with MDM2 and MDMX. Journal of Biological Chemistry. 285(3). 2174–2183. 138 indexed citations

15.

Ma, Yihong, Sandhya Boyapalle, Shen‐Shu Sung, et al.. (2008). A Small-Molecule E2F Inhibitor Blocks Growth in a Melanoma Culture Model. Cancer Research. 68(15). 6292–6299. 80 indexed citations

16.

Guida, Wayne C., et al.. (2005). Protein farnesyltransferase: Flexible docking studies on inhibitors using computational modeling. Cancer Research. 65. 932–932. 1 indexed citations

17.

Bohacek, Regine S., Colin McMartin, & Wayne C. Guida. (1996). The art and practice of structure-based drug design: A molecular modeling perspective. Medicinal Research Reviews. 16(1). 3–50. 753 indexed citations breakdown →

18.

Kolossváry, István & Wayne C. Guida. (1994). On searching the conformational space of cyclic molecules. Conformational interconversion pathways in trans-cyclosilkenes. Journal of Molecular Structure THEOCHEM. 308. 91–102. 2 indexed citations

19.

Guida, Wayne C., Robert D. Elliott, H. Jeanette Thomas, et al.. (1994). Structure-Based Design of Inhibitors of Purine Nucleoside Phosphorylase. 4. A Study of Phosphate Mimics. Journal of Medicinal Chemistry. 37(8). 1109–1114. 35 indexed citations

20.

Montgomery, John A., Shri Niwas, Jerry D. Rose, et al.. (1993). Structure-based design of inhibitors of purine nucleoside phosphorylase. 1. 9-(Arylmethyl) derivatives of 9-deazaguanine. Journal of Medicinal Chemistry. 36(1). 55–69. 98 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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