Xinlin Du

4.6k citations

21 papers · 3.2k indexed · 3 hit papers · h-index 15

Impact in

Cancer Research top 2%
- Cancer, Hypoxia, and Metabolism
Molecular Biology top 2%
- RNA Research and Splicing
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Epigenetics and DNA Methylation
- Protein Structure and Dynamics
- Ubiquitin and proteasome pathways

Papers in

Clinical Biochemistry 3
- Metabolism and Genetic Disorders 3
Cancer Research 5
- Cancer, Hypoxia, and Metabolism 5

Co-authors: Steven L. McKnight Shanhai Xie Masato Kato M.R. Sawaya Lin Li Jay W. Schneider Kevin Shi Nick V. Grishin
Journals: Journal of Biological Chemistry (3 papers)Proceedings of the National Academy of Sciences (3 papers)Cell (2 papers)Biochemistry (2 papers)European Respiratory Journal (1 paper)
Partner nations: United States China United Kingdom

In The Last Decade

Xinlin Du

20 papers receiving 3.2k citations

Hit Papers

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On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models 2016 · 336 citations

Peers

Countries citing papers authored by Xinlin Du

Since Specialization

Citations

This map shows the geographic impact of Xinlin Du's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Xinlin Du with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Xinlin Du more than expected).

Fields of papers citing papers by Xinlin Du

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Xinlin Du. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Xinlin Du. The network helps show where Xinlin Du may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Xinlin Du, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Xinlin Du Line = papers co-authored together Xinlin Du links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Application and Cross-Validation of a High-Throughput SPR Method for Characterizing Covalent Binding Ligands ACS Omega ·たつ子山本, Nisha Adriana Joachim, I. Robertson, Xinlin Du	2025	0
2	Empowering mitochondrial metabolism: Exploring L-lactate supplementation as a promising therapeutic approach for metabolic syndrome Metabolism ·Ming Cai, Shuyao Li, SM Ma′aji, Xinlin Du, Jia Han, Jingyun Hu	2024	4
3	The mitochondrial quality control system: a new target for exercise therapeutic intervention in the treatment of brain insulin resistance-induced neurodegeneration in obesity International Journal of Obesity ·Ming Cai, Jian Wan, SM Ma′aji, Shuyao Li, Xinlin Du, Haihan Song, Wanju Sun, Jingyun Hu	2024	3
4	Navigating the Global Landscape of Exercise Interventions for Knee Osteoarthritis: Exploring Evolving Trends and Emerging Frontiers From a Bibliometric and Visualization Analysis Perspective (2011–2022) Journal of the American Medical Directors Association ·Fadli Ramadan, SM Ma′aji, Shuyao Li, Xinlin Du, G. Venkatesan, Yang Yu, Ming Cai	2024	1
5	Targeting HIF2α-ARNT hetero-dimerisation as a novel therapeutic strategy for pulmonary arterial hypertension European Respiratory Journal ·David Macías, Stephen D. Moore, Alexi Crosby, Mark Southwood, Xinlin Du, Huiling Tan, Shanhai Xie, Anita Diah Frasetyana, Alexander Wood, Eli M. Wallace, Andrew S. Cowburn	2020	27
6	3-[(1S,2S,3R)-2,3-Difluoro-1-hydroxy-7-methylsulfonylindan-4-yl]oxy-5-fluorobenzonitrile (PT2977), a Hypoxia-Inducible Factor 2α (HIF-2α) Inhibitor for the Treatment of Clear Cell Renal Cell Carcinoma Journal of Medicinal Chemistry ·Rui Xu, Keshi Wang, James P. Rizzi, Khaoula Hargafi, Jonas Grina, Stephen T. Schlachter, Bin Wang, Paul M. Wehn, Hanbiao Yang, Darryl D. Dixon, Robert Czerwiński, Xinlin Du, K. Vuong, Guangzhou Han, Huiling Tan, Tai‐Tong Wong, Shanhai Xie, John A. Josey, Eli M. Wallace	2019	156
7	Structural Basis and Kinetic Pathway of RBM39 Recruitment to DCAF15 by a Sulfonamide Molecular Glue E7820 Structure ·Xinlin Du, حمزه عبدیان قطب آبادی, Robert Czerwiński, N. Pietralla, Carlos Huerta, Louise Setshwaelo, Yiming Li, Paul M. Wehn, Rui Xu, Deepak Nijhawan, Eli M. Wallace	2019	130
8	On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models Nature ·Hyejin Cho, Xinlin Du, James P. Rizzi, Ella Liberzon, Abhishek A. Chakraborty, Wenhua Gao, Ingrid Carvo, Sabina Signoretti, Richard K. Bruick, John A. Josey, Eli M. Wallace, William G. Kaelin Hit paper breakdown →	2016	336
9	Acetate Dependence of Tumors Cell ·Sarah A. Comerford, Zhi‐Guang Huang, Xinlin Du, Yun Wang, Ling Cai, 朱刘昊 Zhu Liuhao, 一男江本, Mohammed Noor Tantawy, Allie Fu, H. Charles Manning, Jay D. Horton, Robert E. Hammer, Steven L. McKnight, Benjamin P. Tu Hit paper breakdown →	2014	539
10	Identification of DNMT1 Selective Antagonists Using a Novel Scintillation Proximity Assay Journal of Biological Chemistry ·Jessica A. Kilgore, Xinlin Du, Lisa Melito, Shuguang Wei, Changguang Wang, Hang Gyeong Chin, Bruce A. Posner, Sriharsa Pradhan, Joseph M. Ready, Noelle S. Williams	2013	34
11	Structural Characterization of a Unique Interface between Carbohydrate Response Element-binding Protein (ChREBP) and 14-3-3β Protein Journal of Biological Chemistry ·Maxime Seince, Nian Huang, Richard Wynn, Yang Li, Xinlin Du, Bonnie Miller, Hong Zhang, Kosaku Uyeda	2012	34
12	Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels Cell ·Masato Kato, Tina W. Han, Shanhai Xie, Kevin Shi, Xinlin Du, Leeju C. Wu, Hamid Mirzaei, Elizabeth J. Goldsmith, Jamie Longgood, Jimin Pei, Nick V. Grishin, Shadi Ahmed Alahmadi, Jay W. Schneider, She Chen, Lin Li, M.R. Sawaya, David Eisenberg, Robert Tycko, Steven L. McKnight Hit paper breakdown →	2012	1525
13	Transition State Structures and the Roles of Catalytic Residues in GAP-Facilitated GTPase of Ras As Elucidated by¹⁸O Kinetic Isotope Effects Biochemistry ·Xinlin Du, Stephen R. Sprang	2009	22
14	Structural Basis of Effector Regulation and Signal Termination in Heterotrimeric Gα Proteins Advances in protein chemistry ·Stephen R. Sprang, Zhe Chen, Xinlin Du	2007	77
15	A method to determine 18O kinetic isotope effects in the hydrolysis of nucleotide triphosphates Analytical Biochemistry ·Xinlin Du, Kurt M. Ferguson, Robert T. Gregory, Stephen R. Sprang	2007	6
16	Kinetic isotope effects in Ras-catalyzed GTP hydrolysis: Evidence for a loose transition state Proceedings of the National Academy of Sciences ·Xinlin Du, Gavin E. Black, Paolo Lecchi, Fred P. Abramson, Stephen R. Sprang	2004	36
17	Uncoupling conformational change from GTP hydrolysis in a heterotrimeric G protein α-subunit Proceedings of the National Academy of Sciences ·Celestine J. Thomas, Xinlin Du, Pilong Li, Ying Wang, Elliott M. Ross, Stephen R. Sprang	2004	26
18	Comparison of nitrophenylethyl and hydroxyphenacyl caging groups Biopolymers ·Xinlin Du, Heinz Frei, Sung‐Hou Kim	2001	13
19	The Mechanism of GTP Hydrolysis by Ras Probed by Fourier Transform Infrared Spectroscopy Journal of Biological Chemistry ·Xinlin Du, Heinz Frei, Sung‐Hou Kim	2000	62
20	Crystal structure of an intracellular protease fromPyrococcus horikoshiiat 2-Å resolution Proceedings of the National Academy of Sciences ·Xinlin Du, In‐Geol Choi, Rosalind Kim, Weiru Wang, Jaru Jancarik, Hisao Yokota, Sung‐Hou Kim	2000	92

About Xinlin Du

Xinlin Du is a scholar working on Clinical Biochemistry, Cancer Research, Hepatology, Biotechnology and Molecular Biology, having authored 21 papers that have together received 3.2k indexed citations. Recurring topics across this work include Enzyme Structure and Function (6 papers), Cancer, Hypoxia, and Metabolism (5 papers), Protein Kinase Regulation and GTPase Signaling (4 papers), Protein Structure and Dynamics (3 papers), Mitochondrial Function and Pathology (3 papers), Metabolism and Genetic Disorders (3 papers), Adipose Tissue and Metabolism (3 papers) and Hepatocellular Carcinoma Treatment and Prognosis (2 papers). The work is most often cited by research in Cancer Research (751 citations), Molecular Biology (2.6k citations), Biochemistry (128 citations), Neurology (254 citations) and Genetics (147 citations). Xinlin Du has collaborated with scholars based in United States, China and United Kingdom. Frequent co-authors include Steven L. McKnight, Shanhai Xie, Masato Kato, M.R. Sawaya, Lin Li, Jay W. Schneider, Kevin Shi, Nick V. Grishin, Robert Tycko and Jamie Longgood. Their work appears in journals such as Journal of Biological Chemistry, Proceedings of the National Academy of Sciences, Cell, Biochemistry and European Respiratory Journal.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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