William S. Chen

5.3k total citations · 3 hit papers
25 papers, 3.6k citations indexed

About

William S. Chen is a scholar working on Molecular Biology, Pulmonary and Respiratory Medicine and Cancer Research. According to data from OpenAlex, William S. Chen has authored 25 papers receiving a total of 3.6k indexed citations (citations by other indexed papers that have themselves been cited), including 13 papers in Molecular Biology, 10 papers in Pulmonary and Respiratory Medicine and 8 papers in Cancer Research. Recurrent topics in William S. Chen's work include Prostate Cancer Treatment and Research (9 papers), Cancer Genomics and Diagnostics (5 papers) and PI3K/AKT/mTOR signaling in cancer (4 papers). William S. Chen is often cited by papers focused on Prostate Cancer Treatment and Research (9 papers), Cancer Genomics and Diagnostics (5 papers) and PI3K/AKT/mTOR signaling in cancer (4 papers). William S. Chen collaborates with scholars based in United States, Canada and Sweden. William S. Chen's co-authors include Nissim Hay, Mei-Ling Chen, Cheri S. Lazar, Gordon N. Gill, Michael G. Rosenfeld, Xiao-ding Peng, Martin Poenie, Roger Y. Tsien, Juhua Chen and Tatiana V. Byzova and has published in prestigious journals such as Nature, Cell and Nature Medicine.

In The Last Decade

William S. Chen

23 papers receiving 3.5k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Growth retardation and increased apoptosis in mice with homozygous disruption of the akt1 gene

2001 777 citations William S. Chen, Kathrin Gottlob et al. Genes & Development profile →
Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2

2003 693 citations Xiao-ding Peng, Mei-Ling Chen et al. Genes & Development profile →
Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor

1987 542 citations William S. Chen, Cheri S. Lazar et al. profile →

Peers

Countries citing papers authored by William S. Chen

Since Specialization

Citations

This map shows the geographic impact of William S. Chen's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by William S. Chen with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites William S. Chen more than expected).

Fields of papers citing papers by William S. Chen

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by William S. Chen. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by William S. Chen. The network helps show where William S. Chen may publish in the future.

Co-authorship network of co-authors of William S. Chen

This figure shows the co-authorship network connecting the top 25 collaborators of William S. Chen. A scholar is included among the top collaborators of William S. Chen based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with William S. Chen. William S. Chen is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Utility of metastasis-directed radiotherapy with and without hormonal therapy in management of oligometastatic prostate cancer 2025 ·JNCI Cancer Spectrum ·William S. Chen, (unknown), (unknown), (unknown), (unknown), Amir Ashraf‐Ganjouei, (unknown), Alon Witztum, (unknown), Steven N. Seyedin, Roxanna Juarez, Peter R. Carroll, Felix Y. Feng, Eric J. Small, Thomas A. Hope, Julian C. Hong	0
2	Racial variation in the advanced prostate cancer genome 2025 ·Prostate Cancer and Prostatic Diseases ·(unknown), (unknown), (unknown), (unknown), Adam Foye, Jake Vinson, Julian C. Hong, Stephen J. Freedland, Joshi J. Alumkal, Himisha Beltran, Colm Morrissey, Peter S. Nelson, Arul M. Chinnaiyan, Rahul Aggarwal, Eric J. Small, David A. Quigley, Martin Sjöström, Shuang G. Zhao, William S. Chen	0
3	Predicting cancer drug TARGETS - TreAtment Response Generalized Elastic-neT Signatures 2021 ·npj Genomic Medicine ·Nicholas R. Rydzewski, Erik R. Peterson, Joshua M. Lang, Menggang Yu, (unknown), Martin Sjöström, (unknown), (unknown), Kyle T. Helzer, (unknown), William S. Chen, Raunak Shrestha, Meng Zhang, David A. Quigley, Rahul Aggarwal, Eric J. Small, Daniel Wahl, Felix Y. Feng, Shuang G. Zhao	16
4	An integrated functional and clinical genomics approach reveals genes driving aggressive metastatic prostate cancer 2021 ·Nature Communications ·Rajdeep Das, Martin Sjöström, Raunak Shrestha, (unknown), Emily A. Egusa, Lisa N. Chesner, William S. Chen, Jonathan Chou, Donna K. Dang, (unknown), Alex Y. Ge, Junjie T. Hua, Shaheen Kabir, David A. Quigley, Eric J. Small, Alan Ashworth, Felix Y. Feng, Luke A. Gilbert	24
5	Genomic and clinical characterization of stromal infiltration markers in prostate cancer 2020 ·Cancer ·Brandon A. Mahal, Mohammed Alshalalfa, Shuang G. Zhao, Himisha Beltran, William S. Chen, Fallon Chipidza, Elai Davicioni, R. Jeffrey Karnes, Sheng‐Yu Ku, Tamara L. Lotan, Vinayak Muralidhar, Timothy R. Rebbeck, Edward M. Schaeffer, Daniel E. Spratt, Felix Y. Feng, Paul L. Nguyen	9
6	The comprehensive methylation landscape of metastatic castration-resistant prostate cancer (mCRPC) identifies new phenotypic subtypes: Results from the West Coast Prostate Cancer Dream Team (WCDT). 2020 ·Journal of Clinical Oncology ·Eric J. Small, Shuang Zhao, William S. Chen, Haolong Li, Adam Foye, Martin Sjöström, Jun Hua, Rahul Aggarwal, Joshi J. Alumkal, Tomasz M. Beer, Martin Gleave, Matthew B. Rettig, Owen N. Witte, Primo Lara, Arul M. Chinnaiyan, Christopher Maher, David A. Quigley, Felix Y. Feng	1
7	Novel RB1-Loss Transcriptomic Signature Is Associated with Poor Clinical Outcomes across Cancer Types 2019 ·Clinical Cancer Research ·William S. Chen, Mohammed Alshalalfa, Shuang G. Zhao, Yang Liu, Brandon A. Mahal, David A. Quigley, Ting Wei, Elai Davicioni, Timothy R. Rebbeck, Philip W. Kantoff, Christopher A. Maher, Karen E. Knudsen, Eric J. Small, Paul L. Nguyen, Felix Y. Feng	34
8	<p>Large-scale assessment of needs in low vision individuals using the Aira assistive technology</p> 2019 ·Clinical ophthalmology ·(unknown), William S. Chen, Allison J. Chen, (unknown), Emily B. Hill, (unknown), Daniel L. Chao	12
9	Germline polymorphisms associated with impaired survival outcomes and somatic tumor alterations in advanced prostate cancer 2019 ·Prostate Cancer and Prostatic Diseases ·William S. Chen, (unknown), Rahul Aggarwal, Adam Foye, Tomasz M. Beer, Joshi J. Alumkal, Martin Gleave, Kim N., Robert E. Reiter, Matthew B. Rettig, Christopher P. Evans, Eric J. Small, Nima Sharifi, Shuang G. Zhao	9
10	Transcriptomic and Clinical Characterization of Neuropeptide Y Expression in Localized and Metastatic Prostate Cancer: Identification of Novel Prostate Cancer Subtype with Clinical Implications 2019 ·European Urology Oncology ·Mohammed Alshalalfa, Paul L. Nguyen, Himisha Beltran, William S. Chen, Elai Davicioni, Shuang G. Zhao, Timothy R. Rebbeck, Edward M. Schaeffer, Tamara L. Lotan, Felix Y. Feng, Brandon A. Mahal	16
11	Abstract 977: Phenotypic analysis of single-cell breast cancer inhibition data reveals insights into EMT 2017 ·Cancer Research ·William S. Chen, Nevena Zivanovic, Dana Pe’er, Bernd Bodenmiller, Smita Krishnaswamy	1
12	Automated Detection of Off-Label Drug Use 2014 ·PLoS ONE ·Kenneth Jung, Paea LePendu, William S. Chen, Srinivasan Iyer, Ben Readhead, Joel T. Dudley, Nigam H. Shah	48
13	Akt1 in Osteoblasts and Osteoclasts Controls Bone Remodeling 2007 ·PLoS ONE ·Naohiro Kawamura, Fumitaka Kugimiya, Yasushi Oshima, Shinsuke Ohba, Toshiyuki Ikeda, Taku Saito, Yusuke Shinoda, Yosuke Kawasaki, Naoshi Ogata, Kazuto Hoshi, T. Akiyama, William S. Chen, Nissim Hay, Kazuyuki Tobe, Takashi Kadowaki, Yoshiaki Azuma, Sakae Tanaka, Kozo Nakamura, Ung Il Chung, Hiroshi Kawaguchi	225
14	The deficiency of Akt1 is sufficient to suppress tumor development in Pten ^+/− mice 2006 ·Genes & Development ·Mei-Ling Chen, (unknown), Xiao-ding Peng, William S. Chen, Grace Guzman, Xi‐Ming Yang, Antonio Di Cristofano, Pier Paolo Pandolfi, Nissim Hay	210
15	Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo 2005 ·Nature Medicine ·Juhua Chen, Payaningal R. Somanath, Olga V. Razorenova, William S. Chen, Nissim Hay, Paul Börnstein, Tatiana V. Byzova	369
16	Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2 breakdown → 2003 ·Genes & Development ·Xiao-ding Peng, (unknown), Mei-Ling Chen, Annett Hahn-Windgassen, (unknown), Joel Jacobs, (unknown), William S. Chen, Susan E. Crawford, Kevin Coleman, Nissim Hay	693
17	Growth retardation and increased apoptosis in mice with homozygous disruption of the akt1 gene breakdown → 2001 ·Genes & Development ·William S. Chen, (unknown), Kathrin Gottlob, Mei-Ling Chen, Karen Sokol, (unknown), Igor B. Roninson, Wei Weng, Ryo Suzuki, Kazuyuki Tobe, Takashi Kadowaki, Nissim Hay	777
18	Transcriptional regulation of the human cholesterol 7.alpha.-hydroxylase gene 1992 ·Biochemistry ·David T. Molowa, William S. Chen, George Cimis, Carina P. Tan	63
19	Murine chromosomal location of four hepatocyte-enriched transcription factors: HNf-3α, HNF-3β, HNF-3γ, and HNF-4 1992 ·Genomics ·Karen B. Avraham, Vincent R. Prezioso, William S. Chen, Eseng Lai, Frances M. Sladek, Weimin Zhong, James Darnell, Nancy A. Jenkins, Neal G. Copeland	22
20	Ligand-induced endocytosis of the EGF receptor is blocked by mutational inactivation and by microinjection of anti-phosphotyrosine antibodies 1988 ·Cell ·John R. Glenney, William S. Chen, Cheri S. Lazar, Gordon M. Walton, Liza Zokas, Michael G. Rosenfeld, Gordon N. Gill	221

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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