Hiroshi Kawaguchi

34.7k total citations · 7 hit papers
333 papers, 27.0k citations indexed

About

Hiroshi Kawaguchi is a scholar working on Molecular Biology, Surgery and Rheumatology. According to data from OpenAlex, Hiroshi Kawaguchi has authored 333 papers receiving a total of 27.0k indexed citations (citations by other indexed papers that have themselves been cited), including 119 papers in Molecular Biology, 100 papers in Surgery and 99 papers in Rheumatology. Recurrent topics in Hiroshi Kawaguchi's work include Osteoarthritis Treatment and Mechanisms (85 papers), Bone Metabolism and Diseases (60 papers) and Bone health and treatments (47 papers). Hiroshi Kawaguchi is often cited by papers focused on Osteoarthritis Treatment and Mechanisms (85 papers), Bone Metabolism and Diseases (60 papers) and Bone health and treatments (47 papers). Hiroshi Kawaguchi collaborates with scholars based in Japan, United States and Germany. Hiroshi Kawaguchi's co-authors include Kozo Nakamura, Toru Akune, Ung‐il Chung, Hiroyuki Oka, Shigeyuki Muraki, Noriko Yoshimura, Makoto Kuro‐o, Kentaro Nakamura, Hirotaka Chikuda and Sakae Tanaka and has published in prestigious journals such as Nature, Science and Proceedings of the National Academy of Sciences.

In The Last Decade

Hiroshi Kawaguchi

323 papers receiving 26.4k citations

Hit Papers

Mutation of the mouse klotho gene leads to a syndrome res... 1997 2026 2006 2016 1997 2014 2005 2004 2004 500 1000 1.5k 2.0k 2.5k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Mutation of the mouse klotho gene leads to a syndrome resembling ageing
    1997 3.0k citations Makoto Kuro‐o, Yutaka Matsumura et al. profile →
  2. OARSI guidelines for the non-surgical management of knee osteoarthritis
    2014 2.2k citations T.E. McAlindon, Raveendhara R. Bannuru et al. Osteoarthritis and Cartilage profile →
  3. Suppression of Aging in Mice by the Hormone Klotho
    2005 1.5k citations Hirotaka Chikuda, Hiroshi Kawaguchi et al. profile →
  4. PPAR γ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors
    2004 677 citations Toru Akune, Shinsuke Ohba et al. Journal of Clinical Investigation profile →
  5. PPAR γ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors
    2004 631 citations Toru Akune, Shinsuke Ohba et al. Journal of Clinical Investigation profile →
  6. Prevalence of knee osteoarthritis, lumbar spondylosis, and osteoporosis in Japanese men and women: the research on osteoarthritis/osteoporosis against disability study
    2009 606 citations Noriko Yoshimura, Shigeyuki Muraki et al. profile →
  7. Prevalence and distribution of intervertebral disc degeneration over the entire spine in a population-based cohort: the Wakayama Spine Study
    2013 347 citations Shigeyuki Muraki, Hiroyuki Oka et al. Osteoarthritis and Cartilage profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Hiroshi Kawaguchi Japan 82 8.9k 7.3k 6.4k 4.2k 4.1k 333 27.0k
Claes Ohlsson Sweden 86 10.8k 1.2× 5.8k 0.8× 5.1k 0.8× 7.6k 1.8× 1.3k 0.3× 667 34.6k
Kozo Nakamura Japan 86 10.8k 1.2× 4.9k 0.7× 6.6k 1.0× 2.2k 0.5× 2.5k 0.6× 587 28.3k
M.A. Karsdal Denmark 78 7.8k 0.9× 7.3k 1.0× 3.8k 0.6× 1.8k 0.4× 2.8k 0.7× 860 25.4k
Nancy E. Lane United States 87 6.0k 0.7× 8.4k 1.1× 6.6k 1.0× 1.1k 0.3× 2.8k 0.7× 488 24.0k
Maria Luisa Brandi Italy 83 7.9k 0.9× 2.5k 0.3× 6.4k 1.0× 4.0k 0.9× 947 0.2× 770 29.6k
Patrick Garnero France 83 6.2k 0.7× 5.7k 0.8× 4.4k 0.7× 1.7k 0.4× 1.7k 0.4× 207 22.4k
Martin Lotz United States 97 9.5k 1.1× 12.3k 1.7× 4.2k 0.7× 1.3k 0.3× 3.4k 0.8× 363 29.4k
Lawrence G. Raisz United States 85 10.1k 1.1× 2.2k 0.3× 2.0k 0.3× 3.8k 0.9× 3.9k 1.0× 363 23.5k
Steven L. Teitelbaum United States 92 19.7k 2.2× 5.1k 0.7× 2.9k 0.5× 2.7k 0.6× 1.2k 0.3× 398 33.0k
Steffen Gay Switzerland 103 13.8k 1.6× 11.6k 1.6× 3.6k 0.6× 2.6k 0.6× 1.8k 0.4× 523 36.4k

Countries citing papers authored by Hiroshi Kawaguchi

Since Specialization
Citations

This map shows the geographic impact of Hiroshi Kawaguchi's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Hiroshi Kawaguchi with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Hiroshi Kawaguchi more than expected).

Fields of papers citing papers by Hiroshi Kawaguchi

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Hiroshi Kawaguchi. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Hiroshi Kawaguchi. The network helps show where Hiroshi Kawaguchi may publish in the future.

Co-authorship network of co-authors of Hiroshi Kawaguchi

This figure shows the co-authorship network connecting the top 25 collaborators of Hiroshi Kawaguchi. A scholar is included among the top collaborators of Hiroshi Kawaguchi based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Hiroshi Kawaguchi. Hiroshi Kawaguchi is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Kawaguchi, Hiroshi. (2025). Dark Clouds Looming Over Regenerative Medicine in Japan. Stem Cells and Development. 34(7-8). 149–151.
2.
Kawaguchi, Hiroshi. (2016). International and National Guidelines of Osteoarthritis Treatment. 35(1). 1–9. 2 indexed citations
3.
McAlindon, T.E., Raveendhara R. Bannuru, Matthew C. Sullivan, et al.. (2014). OARSI guidelines for the non-surgical management of knee osteoarthritis. Osteoarthritis and Cartilage. 22(3). 363–388. 2192 indexed citations breakdown →
4.
Muraki, Shigeyuki, Toru Akune, Keiji Nagata, et al.. (2014). Association of knee osteoarthritis with onset and resolution of pain and physical functional disability: The ROAD study. Modern Rheumatology. 24(6). 966–973. 8 indexed citations
5.
Saito, Taku, Makoto Hirata, Toshiyuki Ikeda, et al.. (2012). GSK-3α and GSK-3β Proteins Are Involved in Early Stages of Chondrocyte Differentiation with Functional Redundancy through RelA Protein Phosphorylation. Journal of Biological Chemistry. 287(35). 29227–29236. 44 indexed citations
6.
Hirata, Makoto, Fumitaka Kugimiya, Atsushi Fukai, et al.. (2011). C/EBPβ and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as the inducer in chondrocytes. Human Molecular Genetics. 21(5). 1111–1123. 129 indexed citations
7.
Muraki, Shigeyuki, Hiroyuki Oka, Toru Akune, et al.. (2011). Independent association of joint space narrowing and osteophyte formation at the knee with health-related quality of life in Japan: A cross-sectional study. Arthritis & Rheumatism. 63(12). 3859–3864. 23 indexed citations
8.
Takaishi, Hironari, Masaki Yoda, Takahide Tohmonda, et al.. (2010). GRIP1 enhances estrogen receptor α-dependent extracellular matrix gene expression in chondrogenic cells. Osteoarthritis and Cartilage. 18(7). 934–941. 21 indexed citations
9.
Kawaguchi, Hiroshi. (2009). [Hormones and osteoporosis update. Insulin/IGF-I and bone].. PubMed. 19(7). 1015–25. 2 indexed citations
10.
Kawaguchi, Hiroshi. (2009). [Progress of research in osteoarthritis. Molecular targeting for osteoarthritis treatment].. PubMed. 19(11). 1608–14. 4 indexed citations
11.
Kugimiya, Fumitaka, Hiroshi Kawaguchi, Shinsuke Ohba, et al.. (2007). GSK-3β Controls Osteogenesis through Regulating Runx2 Activity. PLoS ONE. 2(9). e837–e837. 130 indexed citations
12.
Yoshimura, Noriko, Hirofumi Kinoshita, Tatsuya Takeshita, et al.. (2006). Risk factors for knee osteoarthritis in Japanese men: a case-control study. Modern Rheumatology. 16(1). 24–29. 22 indexed citations
13.
Masuda, Hiroaki, Hirotaka Chikuda, Tatsuo Suga, Hiroshi Kawaguchi, & Makoto Kuro‐o. (2005). Regulation of multiple ageing-like phenotypes by inducible klotho gene expression in klotho mutant mice. Mechanisms of Ageing and Development. 126(12). 1274–1283. 97 indexed citations
14.
Matsudaira, Ko & Hiroshi Kawaguchi. (2005). [Drug management of low back pain].. PubMed. 15(3). 109–16. 1 indexed citations
15.
Kamekura, Satoru, Kazuto Hoshi, Takashi Shimoaka, et al.. (2005). Osteoarthritis development in novel experimental mouse models induced by knee joint instability. Osteoarthritis and Cartilage. 13(7). 632–641. 450 indexed citations
16.
Shimada, Junichi, et al.. (2004). [Reversible posterior leukoencephalopathy syndrome: experience in 3 cases].. PubMed. 56(12). 1036–41. 5 indexed citations
17.
Akune, Toru, Shinsuke Ohba, Satoru Kamekura, et al.. (2004). PPAR γ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. Journal of Clinical Investigation. 113(6). 846–855. 631 indexed citations breakdown →
18.
Ogata, N., Yutaka Matsumura, Masataka Shiraki, et al.. (2002). Association of klotho gene polymorphism with bone density and spondylosis of the lumbar spine in postmenopausal women. Bone. 31(1). 37–42. 89 indexed citations
19.
Akune, Toru, Naoshi Ogata, Atsushi Seichi, et al.. (2001). Insulin Secretory Response Is Positively Associated With the Extent of Ossification of the Posterior Longitudinal Ligament of the Spine. Journal of Bone and Joint Surgery. 83(10). 1537–1544. 86 indexed citations
20.
Ogata, Naoshi, Daichi Chikazu, Naoto Kubota, et al.. (2000). Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnover. Journal of Clinical Investigation. 105(7). 935–943. 218 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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