William Roush

25.3k total citations · 3 hit papers
406 papers, 18.9k citations indexed

About

William Roush is a scholar working on Organic Chemistry, Molecular Biology and Pharmacology. According to data from OpenAlex, William Roush has authored 406 papers receiving a total of 18.9k indexed citations (citations by other indexed papers that have themselves been cited), including 281 papers in Organic Chemistry, 127 papers in Molecular Biology and 51 papers in Pharmacology. Recurrent topics in William Roush's work include Synthetic Organic Chemistry Methods (130 papers), Asymmetric Synthesis and Catalysis (126 papers) and Carbohydrate Chemistry and Synthesis (61 papers). William Roush is often cited by papers focused on Synthetic Organic Chemistry Methods (130 papers), Asymmetric Synthesis and Catalysis (126 papers) and Carbohydrate Chemistry and Synthesis (61 papers). William Roush collaborates with scholars based in United States, Germany and Brazil. William Roush's co-authors include Joey L. Methot, Ming Chen, Eicke Latz, Gary D. Glick, Matthew Mangan, Edward J. Olhava, H. Martin Seidel, Alan D. Palkowitz, Bradley Brown and Scott A. Frank and has published in prestigious journals such as Nature, Chemical Reviews and Proceedings of the National Academy of Sciences.

In The Last Decade

William Roush

399 papers receiving 18.3k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Targeting the NLRP3 inflammasome in inflammatory diseases

2018 1.5k citations William Roush, Eicke Latz et al. profile →
Nucleophilic Phosphine Organocatalysis

2004 899 citations William Roush et al. profile →
Horner-wadsworth-emmons reaction: Use of lithium chloride and an amine for base-sensitive compounds

1984 815 citations William Roush et al. profile →

Peers

Countries citing papers authored by William Roush

Since Specialization

Citations

This map shows the geographic impact of William Roush's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by William Roush with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites William Roush more than expected).

Fields of papers citing papers by William Roush

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by William Roush. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by William Roush. The network helps show where William Roush may publish in the future.

Co-authorship network of co-authors of William Roush

This figure shows the co-authorship network connecting the top 25 collaborators of William Roush. A scholar is included among the top collaborators of William Roush based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with William Roush. William Roush is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Discovery and design of molecular glue enhancers of CDK12–DDB1 interactions for targeted degradation of cyclin K 2024 ·RSC Chemical Biology ·(unknown), Maximilian Schmitz, (unknown), Solomon Tadesse, (unknown), (unknown), (unknown), Vinayak Palve, (unknown), K. Anand, Sylvia M. Frydman, William Roush, E. Schönbrunn, Matthias Geyer, Derek R. Duckett, Andrii Monastyrskyi	3
2	Development of a putative Zn2+-chelating but highly selective MMP-13 inhibitor 2022 ·Bioorganic & Medicinal Chemistry Letters ·Rita Fuerst, (unknown), Anna M. Knapinska, Michael D. Cameron, Claudia Ruiz, Amber L. Delmas, Mark S. Sundrud, Gregg Fields, William Roush	8
3	Host-Derived Matrix Metalloproteinase-13 Activity Promotes Multiple Myeloma–Induced Osteolysis and Reduces Overall Survival 2021 ·Cancer Research ·Chen Hao Lo, Gemma Shay, Jeremy McGuire, Tao Li, Kenneth H. Shain, (unknown), Rita Fuerst, William Roush, Anna M. Knapinska, Gregg Fields, Conor C. Lynch	13
4	The Specific NLRP3 Antagonist IFM-514 Decreases Fibrosis and Inflammation in Experimental Murine Non-Alcoholic Steatohepatitis 2021 ·Frontiers in Molecular Biosciences ·Sandra Torres, Maximilian Joseph Brol, Fernando Magdaleno, Robert Schierwagen, Frank Erhard Uschner, Sabine Klein, Cristina Ortiz, Olaf Tyc, (unknown), (unknown), Damien Bertheloot, Ana Kitanovic, (unknown), Jacob Schrum, William Roush, Luigi Franchi, Kate F. Byth, Eicke Latz, Jonel Trebicka	22
5	Targeting Casein Kinase 1 Delta Sensitizes Pancreatic and Bladder Cancer Cells to Gemcitabine Treatment by Upregulating Deoxycytidine Kinase 2020 ·Molecular Cancer Therapeutics ·Francesca Vena, Simon Bayle, Ainhoa Nieto, Víctor Quereda, Massimiliano Aceti, Sylvia M. Frydman, (unknown), Wayne Grant, Andrii Monastyrskyi, Patricia McDonald, William Roush, Mingxiang Teng, Derek R. Duckett	8
6	Efficacy of novel selective NLRP3 inhibitors in human and murine retinal pigment epithelial cells 2019 ·Journal of Molecular Medicine ·Luping Wang, Sarah Schmidt, (unknown), (unknown), William Roush, Eicke Latz, Frank G. Holz, Tim U. Krohne	20
7	4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection 2017 ·PLoS neglected tropical diseases ·Cláudia M. Calvet, (unknown), Diane Thomas, Brian M. Suzuki, Ken Hirata, (unknown), (unknown), (unknown), Marcelo Meuser-Batista, (unknown), Jair L. Siqueira-Neto, William Roush, Mirian Cláudia de Souza Pereira, James H. McKerrow, Larissa M. Podust	25
8	Human Serum Albumin Domain I Fusion Protein for Antibody Conjugation 2016 ·Bioconjugate Chemistry ·James T Patterson, (unknown), Shigehiro Asano, (unknown), Roberta Fuller, William Roush, Christoph Rader, Carlos F. Barbas	18
9	Identification of Histone Deacetylase Inhibitors with Benzoylhydrazide Scaffold that Selectively Inhibit Class I Histone Deacetylases 2015 ·Chemistry & Biology ·Yunfei Wang, Ryan L. Stowe, (unknown), (unknown), Franck Madoux, Dawei Li, Lisa Zhao, Jian‐Liang Li, Yuren Wang, Yuan Wang, Haiching Ma, Peter Hodder, William Roush, Daiqing Liao	90
10	R-Configuration of 4-Aminopyridyl-Based Inhibitors of CYP51 Confers Superior Efficacy Against Trypanosoma cruzi 2014 ·ACS Medicinal Chemistry Letters ·Jun Yong Choi, Cláudia M. Calvet, Débora Vieira, Shamila S. Gunatilleke, Michael D. Cameron, James H. McKerrow, Larissa M. Podust, William Roush	15
11	Casein Kinase 1δ-dependent Wee1 Protein Degradation 2014 ·Journal of Biological Chemistry ·Clara Penas, Vimal Ramachandran, Scott Simanski, Choogon Lee, Franck Madoux, Ronald J. Rahaim, Ruchi Chauhan, Omar S. Barnaby, Stephan C. Schürer, Peter Hodder, Judith A. Steen, William Roush, Nagi G. Ayad	19
12	Small-Molecule Inhibitors of Acetyltransferase p300 Identified by High-Throughput Screening Are Potent Anticancer Agents 2013 ·Molecular Cancer Therapeutics ·Heng Yang, (unknown), Jian Luo, Dawei Li, Yunfei Wang, Lisa Zhao, Stephan C. Jahn, S. Adrian Saldanha, Jamie L. Planck, Kyla Geary, Haiching Ma, Brian K. Law, William Roush, Peter Hodder, Daiqing Liao	82
13	Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties 2013 ·Bioorganic & Medicinal Chemistry Letters ·Mathieu Bibian, Ronald J. Rahaim, Jun Yong Choi, Yoshihiko Noguchi, Stephan C. Schürer, Wei‐Min Chen, Shima Nakanishi, Konstantin Licht, Laura H. Rosenberg, Lin Li, Yangbo Feng, Michael D. Cameron, Derek R. Duckett, John L. Cleveland, William Roush	63
14	Diisopinocampheylborane‐Mediated Reductive Aldol Reactions: Highly Enantio‐ and Diastereoselective Synthesis of syn Aldols from N‐Acryloylmorpholine 2013 ·Angewandte Chemie International Edition ·Philippe Nuhant, Christophe Allais, William Roush	24
15	Studies on the synthesis of reidispongiolide A: stereoselective synthesis of the C(22)–C(36) fragment 2011 ·Tetrahedron ·(unknown), William Roush	14
16	Inhibitors of SARS-CoV entry – Identification using an internally-controlled dual envelope pseudovirion assay 2011 ·Antiviral Research ·Yanchen Zhou, Juliet Agudelo, Kai Lü, David H. Goetz, Elizabeth Hansell, Yen‐Ting Chen, William Roush, James H. McKerrow, Charles S. Craik, Sean M. Amberg, Graham Simmons	19
17	Development of a double allylboration reagent targeting 1,5-syn-(E)-diols: application to the synthesis of the C(23)–C(40) fragment of tetrafibricin 2011 ·Tetrahedron ·Philippe Nuhant, Jérémy Kister, Ricardo Lira, (unknown), William Roush	17
18	Total synthesis of amphidinolide E and amphidinolide E stereoisomers 2007 ·Tetrahedron ·Porino Va, William Roush	31
19	Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense 2001 ·Molecular and Biochemical Parasitology ·Conor R. Caffrey, Elizabeth Hansell, Kimberley D. Lucas, Linda S. Brinen, (unknown), (unknown), Stephen L. Gwaltney, William Roush, York‐Dieter Stierhof, Matthew Bogyo, Dietmar Steverding, James H. McKerrow	150
20	Activating agents and protecting groups 1999 ·John Wiley & Sons eBooks ·Anthony J. Pearson, William Roush	15

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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