William Roush

25.3k total citations · 3 hit papers
406 papers, 18.9k citations indexed

About

William Roush is a scholar working on Organic Chemistry, Molecular Biology and Pharmacology. According to data from OpenAlex, William Roush has authored 406 papers receiving a total of 18.9k indexed citations (citations by other indexed papers that have themselves been cited), including 281 papers in Organic Chemistry, 127 papers in Molecular Biology and 51 papers in Pharmacology. Recurrent topics in William Roush's work include Synthetic Organic Chemistry Methods (130 papers), Asymmetric Synthesis and Catalysis (126 papers) and Carbohydrate Chemistry and Synthesis (61 papers). William Roush is often cited by papers focused on Synthetic Organic Chemistry Methods (130 papers), Asymmetric Synthesis and Catalysis (126 papers) and Carbohydrate Chemistry and Synthesis (61 papers). William Roush collaborates with scholars based in United States, Germany and Brazil. William Roush's co-authors include Joey L. Methot, Ming Chen, Eicke Latz, Gary D. Glick, Edward J. Olhava, Matthew Mangan, H. Martin Seidel, Alan D. Palkowitz, Bradley Brown and Scott A. Frank and has published in prestigious journals such as Nature, Chemical Reviews and Proceedings of the National Academy of Sciences.

In The Last Decade

William Roush

399 papers receiving 18.3k citations

Hit Papers

align trajectories sort by overperformance

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Targeting the NLRP3 inflammasome in inflammatory diseases

2018 1.5k citations William Roush, Gary D. Glick et al. profile →
Nucleophilic Phosphine Organocatalysis

2004 899 citations William Roush et al. profile →
Horner-wadsworth-emmons reaction: Use of lithium chloride and an amine for base-sensitive compounds

1984 815 citations William Roush et al. profile →

Author Peers

Peers are selected by citation overlap in the author's most active subfields. citations · hero ref

Author						Papers	Cites
William Roush	12.7k	6.6k	1.9k	1.6k	1.4k	406	18.9k
Dawei Ma	17.1k 1.3×	5.8k 0.9×	1.2k 0.7×	715 0.5×	2.1k 1.6×	416	22.9k
Michael E. Jung	7.6k 0.6×	4.7k 0.7×	988 0.5×	682 0.4×	878 0.7×	377	13.6k
John A. Porco	8.4k 0.7×	4.9k 0.7×	1.6k 0.9×	937 0.6×	820 0.6×	248	13.3k
Stephen Hanessian	14.5k 1.1×	9.2k 1.4×	1.9k 1.0×	1.3k 0.9×	1.5k 1.1×	571	19.1k
Dale L. Boger	20.4k 1.6×	14.6k 2.2×	8.1k 4.4×	1.1k 0.7×	1.2k 0.9×	639	34.2k
William A. Denny	8.4k 0.7×	12.4k 1.9×	827 0.4×	824 0.5×	625 0.5×	600	21.1k
Christian Bailly	5.6k 0.4×	10.6k 1.6×	1.5k 0.8×	607 0.4×	347 0.3×	520	17.4k
Gary H. Posner	8.5k 0.7×	5.0k 0.8×	624 0.3×	445 0.3×	842 0.6×	363	15.4k
David W. Christianson	3.4k 0.3×	13.6k 2.1×	4.4k 2.4×	870 0.6×	699 0.5×	292	18.7k
HAMAO UMEZAWA	6.6k 0.5×	13.1k 2.0×	5.3k 2.8×	2.0k 1.3×	483 0.4×	825	22.2k

Countries citing papers authored by William Roush

Since Specialization

Citations

This map shows the geographic impact of William Roush's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by William Roush with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites William Roush more than expected).

Fields of papers citing papers by William Roush

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by William Roush. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by William Roush. The network helps show where William Roush may publish in the future.

Co-authorship network of co-authors of William Roush

This figure shows the co-authorship network connecting the top 25 collaborators of William Roush. A scholar is included among the top collaborators of William Roush based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with William Roush. William Roush is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Schmitz, Maximilian, Solomon Tadesse, Vinayak Palve, et al.. (2024). Discovery and design of molecular glue enhancers of CDK12–DDB1 interactions for targeted degradation of cyclin K. RSC Chemical Biology. 6(1). 36–55. 3 indexed citations

Fuerst, Rita, Anna M. Knapinska, Michael D. Cameron, et al.. (2022). Development of a putative Zn2+-chelating but highly selective MMP-13 inhibitor. Bioorganic & Medicinal Chemistry Letters. 76. 129014–129014. 8 indexed citations

Sanders, Matthew A., Huamei Zhang, William Roush, et al.. (2022). Molecular Modeling of ABHD5 Structure and Ligand Recognition. Frontiers in Molecular Biosciences. 9. 935375–935375. 8 indexed citations

Lo, Chen Hao, Gemma Shay, Jeremy McGuire, et al.. (2021). Host-Derived Matrix Metalloproteinase-13 Activity Promotes Multiple Myeloma–Induced Osteolysis and Reduces Overall Survival. Cancer Research. 81(9). 2415–2428. 13 indexed citations

Roush, William, et al.. (2021). An Engineered Arginine Residue of Unusual pH-Sensitive Reactivity Facilitates Site-Selective Antibody Conjugation. Biochemistry. 60(14). 1080–1087. 5 indexed citations

Vena, Francesca, Simon Bayle, Ainhoa Nieto, et al.. (2020). Targeting Casein Kinase 1 Delta Sensitizes Pancreatic and Bladder Cancer Cells to Gemcitabine Treatment by Upregulating Deoxycytidine Kinase. Molecular Cancer Therapeutics. 19(8). 1623–1635. 8 indexed citations

Wang, Luping, Sarah Schmidt, William Roush, et al.. (2019). Efficacy of novel selective NLRP3 inhibitors in human and murine retinal pigment epithelial cells. Journal of Molecular Medicine. 97(4). 523–532. 20 indexed citations

Patterson, James T, Shigehiro Asano, Roberta Fuller, et al.. (2016). Human Serum Albumin Domain I Fusion Protein for Antibody Conjugation. Bioconjugate Chemistry. 27(10). 2271–2275. 18 indexed citations

Wang, Yunfei, Ryan L. Stowe, Franck Madoux, et al.. (2015). Identification of Histone Deacetylase Inhibitors with Benzoylhydrazide Scaffold that Selectively Inhibit Class I Histone Deacetylases. Chemistry & Biology. 22(2). 273–284. 90 indexed citations

10.

Yang, Heng, Jian Luo, Dawei Li, et al.. (2013). Small-Molecule Inhibitors of Acetyltransferase p300 Identified by High-Throughput Screening Are Potent Anticancer Agents. Molecular Cancer Therapeutics. 12(5). 610–620. 82 indexed citations

11.

Nuhant, Philippe, Christophe Allais, & William Roush. (2013). Diisopinocampheylborane‐Mediated Reductive Aldol Reactions: Highly Enantio‐ and Diastereoselective Synthesis of syn Aldols from N‐Acryloylmorpholine. Angewandte Chemie International Edition. 52(33). 8703–8707. 24 indexed citations

12.

Bibian, Mathieu, Ronald J. Rahaim, Jun Yong Choi, et al.. (2013). Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties. Bioorganic & Medicinal Chemistry Letters. 23(15). 4374–4380. 63 indexed citations

13.

Chen, Ming & William Roush. (2013). Reprint of: Enantiodivergent hydroboration reactions of a racemic allenylsilane with diisopinocampheylborane and Curtin–Hammett controlled double asymmetric crotylboration reactions of (S)-E-α-phenyldimethylsilyl(ddiisopinocampheyl)-crotylborane. Tetrahedron. 69(36). 7551–7558. 1 indexed citations

14.

Roush, William, et al.. (2011). Studies on the synthesis of reidispongiolide A: stereoselective synthesis of the C(22)–C(36) fragment. Tetrahedron. 67(52). 10274–10280. 14 indexed citations

15.

Lee, Younjoo, Jun Yong Choi, Hong Fu, et al.. (2011). Chemistry and Biology of Macrolide Antiparasitic Agents. Journal of Medicinal Chemistry. 54(8). 2792–2804. 26 indexed citations

16.

Boitano, Anthony E., Cory D. Emal, Francesco Leonetti, et al.. (2003). Structure activity studies of a novel cytotoxic benzodiazepine. Bioorganic & Medicinal Chemistry Letters. 13(19). 3327–3330. 11 indexed citations

17.

Roush, William, et al.. (2002). Recent advances in the synthesis, design and selection of cysteine protease inhibitors. Current Opinion in Chemical Biology. 6(4). 459–465. 61 indexed citations

18.

Caffrey, Conor R., Elizabeth Hansell, Kimberley D. Lucas, et al.. (2001). Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense. Molecular and Biochemical Parasitology. 118(1). 61–73. 150 indexed citations

19.

Pearson, Anthony J. & William Roush. (1999). Activating agents and protecting groups. John Wiley & Sons eBooks. 15 indexed citations

20.

Scheidt, Karl A., Akihiro Tasaka, Thomas D. Bannister, Michael Wendt, & William Roush. (1999). Total Synthesis of (−)-Bafilomycin A1: Application of Diastereoselective Crotylboration and Methyl Ketone Aldol Reactions. Angewandte Chemie International Edition. 38(11). 1652–1655. 42 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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