Ernest Hamel

29.2k total citations · 1 hit paper
475 papers, 24.7k citations indexed

About

Ernest Hamel is a scholar working on Organic Chemistry, Molecular Biology and Oncology. According to data from OpenAlex, Ernest Hamel has authored 475 papers receiving a total of 24.7k indexed citations (citations by other indexed papers that have themselves been cited), including 356 papers in Organic Chemistry, 195 papers in Molecular Biology and 105 papers in Oncology. Recurrent topics in Ernest Hamel's work include Synthesis and biological activity (233 papers), Synthesis and Biological Evaluation (75 papers) and Click Chemistry and Applications (74 papers). Ernest Hamel is often cited by papers focused on Synthesis and biological activity (233 papers), Synthesis and Biological Evaluation (75 papers) and Click Chemistry and Applications (74 papers). Ernest Hamel collaborates with scholars based in United States, Italy and United Kingdom. Ernest Hamel's co-authors include George R. Pettit, Chii M. Lin, Ruoli Bai, C. Michael Lin, Sheo B. Singh, Pascal Verdier‐Pinard, Kuo‐Hsiung Lee, Paraskevi Giannakakou, Bernard L. Flynn and Richard Kowalski and has published in prestigious journals such as Nature, Proceedings of the National Academy of Sciences and Journal of the American Chemical Society.

In The Last Decade

Ernest Hamel

468 papers receiving 23.9k citations

Hit Papers

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What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4

1989 701 citations Ernest Hamel et al. profile →

Author Peers

Peers are selected by citation overlap in the author's most active subfields. citations · hero ref

Author						Papers	Cites
Ernest Hamel	15.5k	10.4k	5.2k	3.7k	3.1k	475	24.7k
George R. Pettit	10.3k 0.7×	11.7k 1.1×	3.6k 0.7×	4.9k 1.3×	1.3k 0.4×	680	24.4k
Samuel J. Danishefsky	33.4k 2.2×	19.9k 1.9×	4.7k 0.9×	5.0k 1.4×	1.3k 0.4×	850	41.6k
William A. Denny	8.4k 0.5×	12.4k 1.2×	4.3k 0.8×	827 0.2×	533 0.2×	600	21.1k
David T. Vistica	4.7k 0.3×	7.1k 0.7×	2.9k 0.6×	1.7k 0.5×	423 0.1×	56	14.2k
Philip Skehan	4.7k 0.3×	6.7k 0.6×	2.5k 0.5×	1.8k 0.5×	455 0.1×	40	13.6k
Sidney M. Hecht	5.2k 0.3×	14.6k 1.4×	4.0k 0.8×	1.4k 0.4×	362 0.1×	457	19.2k
Susan Band Horwitz	3.0k 0.2×	10.9k 1.0×	12.1k 2.3×	1.6k 0.4×	5.8k 1.8×	235	20.4k
Bruce C. Baguley	3.8k 0.2×	9.1k 0.9×	4.3k 0.8×	803 0.2×	1.1k 0.3×	384	15.0k
K. C. Nicolaou	7.7k 0.5×	4.4k 0.4×	1.7k 0.3×	1.9k 0.5×	517 0.2×	156	11.7k
Q. Ping Dou	2.9k 0.2×	9.3k 0.9×	6.2k 1.2×	718 0.2×	1.2k 0.4×	280	17.8k

Countries citing papers authored by Ernest Hamel

Since Specialization

Citations

This map shows the geographic impact of Ernest Hamel's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Ernest Hamel with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Ernest Hamel more than expected).

Fields of papers citing papers by Ernest Hamel

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Ernest Hamel. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Ernest Hamel. The network helps show where Ernest Hamel may publish in the future.

Co-authorship network of co-authors of Ernest Hamel

This figure shows the co-authorship network connecting the top 25 collaborators of Ernest Hamel. A scholar is included among the top collaborators of Ernest Hamel based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Ernest Hamel. Ernest Hamel is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Shi, Zhe, Yifan Wang, Mariusz Zimmer, et al.. (2025). Targeting tumor-associated hypoxia with bioreductively activatable prodrug conjugates derived from dihydronaphthalene, benzosuberene, and indole-based inhibitors of tubulin polymerization. RSC Medicinal Chemistry. 16(11). 5472–5487.

Mariotto, Elena, Andrea Brancale, Ernest Hamel, et al.. (2024). Synthesis and Biological Evaluation of Novel 2-Aroyl Benzofuran-Based Hydroxamic Acids as Antimicrotubule Agents. International Journal of Molecular Sciences. 25(14). 7519–7519. 3 indexed citations

Barreca, Marilia, Virginia Spanò, Roberta Rocca, et al.. (2023). Identification of pyrrolo[3′,4’:3,4]cyclohepta[1,2-d][1,2]oxazoles as promising new candidates for the treatment of lymphomas. European Journal of Medicinal Chemistry. 254. 115372–115372. 26 indexed citations

Ren, Wen, et al.. (2023). Structure Guided Design, Synthesis, and Biological Evaluation of Oxetane-Containing Indole Analogues. Bioorganic & Medicinal Chemistry. 92. 117400–117400. 2 indexed citations

Bai, Ruoli, et al.. (2021). Novel pyrazolo[4,3-d]pyrimidine microtubule targeting agents (MTAs): Synthesis, structure–activity relationship, in vitro and in vivo evaluation as antitumor agents. Bioorganic & Medicinal Chemistry Letters. 41. 127923–127923. 20 indexed citations

Romagnoli, Romeo, Paola Oliva, María Kimatrai Salvador, et al.. (2021). A facile synthesis of diaryl pyrroles led to the discovery of potent colchicine site antimitotic agents. European Journal of Medicinal Chemistry. 214. 113229–113229. 16 indexed citations

Spanò, Virginia, Marilia Barreca, Roberta Rocca, et al.. (2020). Insight on [1,3]thiazolo[4,5-e]isoindoles as tubulin polymerization inhibitors. European Journal of Medicinal Chemistry. 212. 113122–113122. 33 indexed citations

Oliva, Paola, Valentina Onnis, Ernest Hamel, et al.. (2020). Synthesis and Biological Evaluation of 2-Substituted Benzyl-/Phenylethylamino-4-amino-5-aroylthiazoles as Apoptosis-Inducing Anticancer Agents. Molecules. 25(9). 2177–2177. 7 indexed citations

Xiang, Weiguo, et al.. (2020). The 3-D conformational shape of N-naphthyl-cyclopenta[d]pyrimidines affects their potency as microtubule targeting agents and their antitumor activity. Bioorganic & Medicinal Chemistry. 29. 115887–115887. 6 indexed citations

10.

Spanò, Virginia, Roberta Rocca, Marilia Barreca, et al.. (2020). Pyrrolo[2′,3′:3,4]cyclohepta[1,2-d][1,2]oxazoles, a New Class of Antimitotic Agents Active against Multiple Malignant Cell Types. Journal of Medicinal Chemistry. 63(20). 12023–12042. 50 indexed citations

11.

Zhang, Yu, Masuo Goto, Akifumi Oda, et al.. (2019). Antiproliferative Aspidosperma-Type Monoterpenoid Indole Alkaloids from Bousigonia mekongensis Inhibit Tubulin Polymerization. Molecules. 24(7). 1256–1256. 18 indexed citations

12.

Morigi, Rita, Alessandra Locatelli, Alberto Leoni, et al.. (2019). Synthesis, in vitro and in vivo biological evaluation of substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones as new potent anticancer agents. European Journal of Medicinal Chemistry. 166. 514–530. 8 indexed citations

13.

Bortolozzi, Roberta, Davide Carta, Elena Mattiuzzo, et al.. (2019). Evaluating the effects of fluorine on biological properties and metabolic stability of some antitubulin 3-substituted 7-phenyl-pyrroloquinolinones. European Journal of Medicinal Chemistry. 178. 297–314. 15 indexed citations

14.

Bai, Ruoli, Ernest Hamel, James C. Burnett, et al.. (2019). S‐(4‐Methoxyphenyl)‐4‐methoxybenzenesulfonothioate as a Promising Lead Compound for the Development of a Renal Carcinoma Agent. ChemMedChem. 15(5). 449–458. 3 indexed citations

15.

Strecker, Tracy E., et al.. (2019). Synthesis and biological evaluation of structurally diverse α-conformationally restricted chalcones and related analogues. MedChemComm. 10(8). 1445–1456. 11 indexed citations

16.

Margarucci, Luigi, Maria Chiara Monti, Roberta Esposito, et al.. (2013). N -Formyl-7-amino-11-cycloamphilectene, a marine sponge metabolite, binds to tubulin and modulates microtubule depolymerization. Molecular BioSystems. 10(4). 862–867. 1 indexed citations

17.

Nguyen, Tam Luong, Maria Rosaria, Andrea Pinto, et al.. (2012). Evading Pgp Activity in Drug-Resistant Cancer Cells: A Structural and Functional Study of Antitubulin Furan Metotica Compounds. Molecular Cancer Therapeutics. 11(5). 1103–1111. 12 indexed citations

18.

Kanakkanthara, Arun, Anja Wilmes, Aurora O’Brate, et al.. (2011). Peloruside- and Laulimalide-Resistant Human Ovarian Carcinoma Cells Have βI-Tubulin Mutations and Altered Expression of βII- and βIII-Tubulin Isotypes. Molecular Cancer Therapeutics. 10(8). 1419–1429. 33 indexed citations

19.

Thomas, Shala L., Diansheng Zhong, Wei Zhou, et al.. (2008). EF24, a novel curcumin analog, disrupts the microtubule cytoskeleton and inhibits HIF-1. Cell Cycle. 7(15). 2409–2417. 96 indexed citations

20.

Marcus, Adam I., Jun Zhou, Aurora O’Brate, et al.. (2005). The Synergistic Combination of the Farnesyl Transferase Inhibitor Lonafarnib and Paclitaxel Enhances Tubulin Acetylation and Requires a Functional Tubulin Deacetylase. Cancer Research. 65(9). 3883–3893. 93 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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