William C. Skarnes

8.1k total citations · 3 hit papers
29 papers, 4.9k citations indexed

About

William C. Skarnes is a scholar working on Molecular Biology, Genetics and Cell Biology. According to data from OpenAlex, William C. Skarnes has authored 29 papers receiving a total of 4.9k indexed citations (citations by other indexed papers that have themselves been cited), including 27 papers in Molecular Biology, 8 papers in Genetics and 4 papers in Cell Biology. Recurrent topics in William C. Skarnes's work include CRISPR and Genetic Engineering (17 papers), Pluripotent Stem Cells Research (13 papers) and Animal Genetics and Reproduction (5 papers). William C. Skarnes is often cited by papers focused on CRISPR and Genetic Engineering (17 papers), Pluripotent Stem Cells Research (13 papers) and Animal Genetics and Reproduction (5 papers). William C. Skarnes collaborates with scholars based in United States, United Kingdom and Germany. William C. Skarnes's co-authors include E. David Leonardo, Rosa Beddington, Marc Tessier‐Lavigne, Sophia A. Colamarino, Hao Wang, Tito Serafini, Vivek Iyer, Allan Bradley, Jun Fu and Manousos Koutsourakis and has published in prestigious journals such as Nature, Cell and Proceedings of the National Academy of Sciences.

In The Last Decade

William C. Skarnes

27 papers receiving 4.9k citations

Hit Papers

align trajectories sort by overperformance

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

A conditional knockout resource for the genome-wide study of mouse gene function

2011 1.2k citations William C. Skarnes, Barry P. Rosen et al. Nature profile →
Netrin-1 Is Required for Commissural Axon Guidance in the Developing Vertebrate Nervous System

1996 1.0k citations Tito Serafini, Sophia A. Colamarino et al. Cell profile →
Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects

2014 641 citations Bin Shen, Jun Zhang et al. Nature Methods profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
William C. Skarnes United States	20	3.4k	1.4k	919	825	694	29	4.9k
Seong‐Seng Tan Australia	38	3.3k 1.0×	1.1k 0.8×	1.0k 1.1×	492 0.6×	812 1.2×	96	5.0k
Andrew S. Peterson United States	39	4.0k 1.2×	1.3k 1.0×	1.4k 1.6×	733 0.9×	545 0.8×	65	6.1k
Xiaowei Lu United States	33	3.3k 1.0×	831 0.6×	532 0.6×	881 1.1×	243 0.4×	76	4.9k
Valeria Cavalli United States	33	2.4k 0.7×	2.0k 1.5×	480 0.5×	1.1k 1.3×	828 1.2×	66	4.5k
Rashmi Kothary Canada	50	5.1k 1.5×	1.1k 0.8×	1.1k 1.2×	1.2k 1.4×	354 0.5×	195	7.3k
Shanthini Sockanathan United States	29	2.9k 0.9×	634 0.5×	1.1k 1.2×	557 0.7×	709 1.0×	45	3.9k
Christopher P. Austin United States	36	3.8k 1.1×	1.4k 1.0×	395 0.4×	529 0.6×	508 0.7×	62	5.2k
Amir Rattner United States	33	4.1k 1.2×	951 0.7×	645 0.7×	607 0.7×	199 0.3×	62	5.3k
Weilan Ye United States	27	3.2k 0.9×	638 0.5×	436 0.5×	701 0.8×	304 0.4×	43	4.3k
Shinji Hirotsune Japan	34	3.9k 1.1×	924 0.7×	1.1k 1.2×	1.6k 2.0×	815 1.2×	60	5.3k

Countries citing papers authored by William C. Skarnes

Since Specialization

Citations

This map shows the geographic impact of William C. Skarnes's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by William C. Skarnes with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites William C. Skarnes more than expected).

Fields of papers citing papers by William C. Skarnes

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by William C. Skarnes. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by William C. Skarnes. The network helps show where William C. Skarnes may publish in the future.

Co-authorship network of co-authors of William C. Skarnes

This figure shows the co-authorship network connecting the top 25 collaborators of William C. Skarnes. A scholar is included among the top collaborators of William C. Skarnes based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with William C. Skarnes. William C. Skarnes is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Tan, Yuliana, William F. Flynn, Lili Sun, et al.. (2025). HAND1, partially mediated through ape-specific LTR binding, is essential for human extra-embryonic mesenchyme derivation from iPSCs. Cell Reports. 44(4). 115568–115568.

Johnson, Kory R., Adrian Lita, Alexandra Beilina, et al.. (2025). Triglyceride metabolism controls inflammation and microglial phenotypes associated with APOE4. Cell Reports. 44(7). 115961–115961. 3 indexed citations

Skarnes, William C., et al.. (2025). Chromosome 4 Duplication Associated with Strabismus Leads to Gene Expression Changes in iPSC-Derived Cortical Neurons. Genes. 16(1). 80–80.

Ruiz‐Babot, Gerard, Fernando Abollo‐Jiménez, Diana L. Carlone, et al.. (2023). Generation of glucocorticoid-producing cells derived from human pluripotent stem cells. Cell Reports Methods. 3(11). 100627–100627. 8 indexed citations

Ivanova, Elena V., et al.. (2023). Generation of four gene-edited human induced pluripotent stem cell lines with mutations in the ATM gene to model Ataxia-Telangiectasia. Stem Cell Research. 73. 103247–103247. 2 indexed citations

Lin, Yen‐Chen, Nandini Ramesh, Eric N. Anderson, et al.. (2021). Interactions between ALS-linked FUS and nucleoporins are associated with defects in the nucleocytoplasmic transport pathway. Nature Neuroscience. 24(8). 1077–1088. 63 indexed citations

Ramos, Daniel M., William C. Skarnes, Andrew Singleton, Mark Cookson, & Michael E. Ward. (2021). Tackling neurodegenerative diseases with genomic engineering: A new stem cell initiative from the NIH. Neuron. 109(7). 1080–1083. 42 indexed citations

Tripathi, Jaishree, Charis‐Patricia Segeritz, Gareth Griffiths, et al.. (2020). A Novel Chemically Differentiated Mouse Embryonic Stem Cell-Based Model to Study Liver Stages of Plasmodium berghei. Stem Cell Reports. 14(6). 1123–1134. 3 indexed citations

Skarnes, William C., Enrica Pellegrino, & Justin A. McDonough. (2019). Improving homology-directed repair efficiency in human stem cells. Methods. 164-165. 18–28. 57 indexed citations

10.

Bressan, Raul Bardini, Ester Gangoso, Carla Blin, et al.. (2017). Efficient CRISPR/Cas9-assisted gene targeting enables rapid and precise genetic manipulation of mammalian neural stem cells. Development. 144(4). 635–648. 72 indexed citations

11.

Shen, Bin, Jun Zhang, Jiankui Zhou, et al.. (2014). Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects. Nature Methods. 11(4). 399–402. 641 indexed citations breakdown →

12.

Skarnes, William C., Barry P. Rosen, Anthony P. West, et al.. (2011). A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 474(7351). 337–342. 1208 indexed citations breakdown →

13.

Fu, Jun, et al.. (2010). A Recombineering Pipeline to Make Conditional Targeting Constructs. Methods in enzymology on CD-ROM/Methods in enzymology. 477. 125–144. 70 indexed citations

14.

Pettitt, Stephen J., Qi Liang, Jennifer L. Moran, et al.. (2009). Agouti C57BL/6N embryonic stem cells for mouse genetic resources. Nature Methods. 6(7). 493–495. 266 indexed citations

15.

Nord, Alex S., Karen Vranizan, Whittemore G. Tingley, et al.. (2007). Modeling Insertional Mutagenesis Using Gene Length and Expression in Murine Embryonic Stem Cells. PLoS ONE. 2(7). e617–e617. 10 indexed citations

16.

Henion, Timothy R., et al.. (2005). β1,3-N-Acetylglucosaminyltransferase 1 Glycosylation Is Required for Axon Pathfinding by Olfactory Sensory Neurons. Journal of Neuroscience. 25(8). 1894–1903. 38 indexed citations

17.

Beigneux, Anne P., Cynthia Kosinski, Bryant J. Gavino, et al.. (2004). ATP-Citrate Lyase Deficiency in the Mouse. Journal of Biological Chemistry. 279(10). 9557–9564. 125 indexed citations

18.

Leighton, Philip A., Kevin J. Mitchell, Lisa V. Goodrich, et al.. (2001). Defining brain wiring patterns and mechanisms through gene trapping in mice. Nature. 410(6825). 174–179. 338 indexed citations

19.

Paine‐Saunders, Stephenie, Beth L. Viviano, Joel Zupicich, William C. Skarnes, & Scott Saunders. (2000). glypican-3 Controls Cellular Responses to Bmp4 in Limb Patterning and Skeletal Development. Developmental Biology. 225(1). 179–187. 157 indexed citations

20.

Serafini, Tito, Sophia A. Colamarino, E. David Leonardo, et al.. (1996). Netrin-1 Is Required for Commissural Axon Guidance in the Developing Vertebrate Nervous System. Cell. 87(6). 1001–1014. 1047 indexed citations breakdown →

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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