Walt F. Lima

4.4k total citations · 1 hit paper
42 papers, 3.4k citations indexed

About

Walt F. Lima is a scholar working on Molecular Biology, Genetics and Cellular and Molecular Neuroscience. According to data from OpenAlex, Walt F. Lima has authored 42 papers receiving a total of 3.4k indexed citations (citations by other indexed papers that have themselves been cited), including 42 papers in Molecular Biology, 5 papers in Genetics and 4 papers in Cellular and Molecular Neuroscience. Recurrent topics in Walt F. Lima's work include DNA and Nucleic Acid Chemistry (24 papers), RNA and protein synthesis mechanisms (23 papers) and RNA Interference and Gene Delivery (17 papers). Walt F. Lima is often cited by papers focused on DNA and Nucleic Acid Chemistry (24 papers), RNA and protein synthesis mechanisms (23 papers) and RNA Interference and Gene Delivery (17 papers). Walt F. Lima collaborates with scholars based in United States, United Kingdom and Poland. Walt F. Lima's co-authors include Stanley T. Crooke, Hongjiang Wu, Thazha P. Prakash, George W. Rogers, William C. Merrick, Eric E. Swayze, Josh G. Nichols, Brett P. Monia, Heather Murray and Punit P. Seth and has published in prestigious journals such as Cell, Proceedings of the National Academy of Sciences and Journal of the American Chemical Society.

In The Last Decade

Walt F. Lima

42 papers receiving 3.3k citations

Hit Papers

align trajectories sort by overperformance

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Targeted delivery of antisense oligonucleotides to hepatocytes using triantennaryN-acetyl galactosamine improves potency 10-fold in mice

2014 468 citations Thazha P. Prakash, Mark J. Graham et al. Nucleic Acids Research profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Walt F. Lima United States	30	3.1k	431	236	230	172	42	3.4k
Timothy A. Vickers United States	36	4.3k 1.4×	536 1.2×	315 1.3×	101 0.4×	219 1.3×	57	5.0k
David R. Corey United States	23	1.5k 0.5×	442 1.0×	194 0.8×	200 0.9×	41 0.2×	34	2.1k
Audrey Low United States	19	1.4k 0.4×	161 0.4×	113 0.5×	134 0.6×	113 0.7×	29	1.8k
Stefania Millevoi France	25	2.1k 0.7×	368 0.9×	123 0.5×	51 0.2×	255 1.5×	42	2.4k
Roscoe Klinck Canada	23	2.0k 0.6×	389 0.9×	87 0.4×	69 0.3×	173 1.0×	37	2.2k
James Stévenin France	34	3.0k 0.9×	183 0.4×	281 1.2×	54 0.2×	229 1.3×	71	3.2k
Florence Poy United States	20	1.9k 0.6×	322 0.7×	224 0.9×	167 0.7×	181 1.1×	28	2.8k
Evgeny M. Makarov United Kingdom	20	2.0k 0.6×	365 0.8×	121 0.5×	29 0.1×	62 0.4×	39	2.1k
Philippe Jeanteur France	25	2.3k 0.7×	163 0.4×	297 1.3×	40 0.2×	202 1.2×	70	2.8k
Marti F.A. Bierhuizen Netherlands	23	1.4k 0.4×	208 0.5×	274 1.2×	62 0.3×	360 2.1×	39	1.7k

Countries citing papers authored by Walt F. Lima

Since Specialization

Citations

This map shows the geographic impact of Walt F. Lima's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Walt F. Lima with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Walt F. Lima more than expected).

Fields of papers citing papers by Walt F. Lima

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Walt F. Lima. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Walt F. Lima. The network helps show where Walt F. Lima may publish in the future.

Co-authorship network of co-authors of Walt F. Lima

This figure shows the co-authorship network connecting the top 25 collaborators of Walt F. Lima. A scholar is included among the top collaborators of Walt F. Lima based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Walt F. Lima. Walt F. Lima is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Lima, Walt F., Heather Murray, Sagar Damle, et al.. (2016). ViableRNaseH1knockout mice show RNaseH1 is essential for R loop processing, mitochondrial and liver function. Nucleic Acids Research. 44(11). 5299–5312. 84 indexed citations

Lima, Walt F., Cheryl Li De Hoyos, Xue‐hai Liang, & Stanley T. Crooke. (2016). RNA cleavage products generated by antisense oligonucleotides and siRNAs are processed by the RNA surveillance machinery. Nucleic Acids Research. 44(7). 3351–3363. 54 indexed citations

Prakash, Thazha P., Garth A. Kinberger, Heather Murray, et al.. (2016). Synergistic effect of phosphorothioate, 5′-vinylphosphonate and GalNAc modifications for enhancing activity of synthetic siRNA. Bioorganic & Medicinal Chemistry Letters. 26(12). 2817–2820. 43 indexed citations

Prakash, Thazha P., Walt F. Lima, Heather Murray, et al.. (2015). Identification of metabolically stable 5′-phosphate analogs that support single-stranded siRNA activity. Nucleic Acids Research. 43(6). 2993–3011. 78 indexed citations

Wan, Wei, Michael T. Migawa, Guillermo Vasquez, et al.. (2014). Synthesis, biophysical properties and biological activity of second generation antisense oligonucleotides containing chiral phosphorothioate linkages. Nucleic Acids Research. 42(22). 13456–13468. 93 indexed citations

Lima, Walt F., Thazha P. Prakash, Heather Murray, et al.. (2012). Single-Stranded siRNAs Activate RNAi in Animals. Cell. 150(5). 883–894. 205 indexed citations

Vickers, Timothy A., Walt F. Lima, Hongjiang Wu, et al.. (2009). Off-target and a portion of target-specific siRNA mediated mRNA degradation is Ago2 ‘Slicer’ independent and can be mediated by Ago1. Nucleic Acids Research. 37(20). 6927–6941. 29 indexed citations

Lima, Walt F., Heather Murray, Josh G. Nichols, et al.. (2008). Human Dicer Binds Short Single-strand and Double-strand RNA with High Affinity and Interacts with Different Regions of the Nucleic Acids. Journal of Biological Chemistry. 284(4). 2535–2548. 35 indexed citations

Vickers, Timothy A., Walt F. Lima, Josh G. Nichols, & Stanley T. Crooke. (2007). Reduced levels of Ago2 expression result in increased siRNA competition in mammalian cells. Nucleic Acids Research. 35(19). 6598–6610. 78 indexed citations

10.

Lima, Walt F., J. Bart Rose, Josh G. Nichols, et al.. (2006). Human RNase H1 Discriminates between Subtle Variations in the Structure of the Heteroduplex Substrate. Molecular Pharmacology. 71(1). 83–91. 62 indexed citations

11.

Wang, Zhiwei, et al.. (2006). Antisense oligonucleotides: Efficient synthesis of 2′-O-methoxyethyl phosphorothioate oligonucleotides using 4,5-dicyanoimidazole. Are these oligonucleotides comparable to those synthesized using 1H-tetrazole as coupling activator?. Bioorganic & Medicinal Chemistry. 14(14). 5049–5060. 10 indexed citations

12.

Lima, Walt F., J. Bart Rose, Josh G. Nichols, et al.. (2006). The Positional Influence of the Helical Geometry of the Heteroduplex Substrate on Human RNase H1 Catalysis. Molecular Pharmacology. 71(1). 73–82. 24 indexed citations

13.

Wu, Hongjiang, Walt F. Lima, Hong Zhang, et al.. (2004). Determination of the Role of the Human RNase H1 in the Pharmacology of DNA-like Antisense Drugs. Journal of Biological Chemistry. 279(17). 17181–17189. 267 indexed citations

14.

Lima, Walt F., Hongjiang Wu, Josh G. Nichols, et al.. (2003). Human RNase H1 Activity Is Regulated by a Unique Redox Switch Formed between Adjacent Cysteines. Journal of Biological Chemistry. 278(17). 14906–14912. 20 indexed citations

15.

Wu, Hongjiang, Walt F. Lima, & Stanley T. Crooke. (2001). Investigating the Structure of Human RNase H1 by Site-directed Mutagenesis. Journal of Biological Chemistry. 276(26). 23547–23553. 69 indexed citations

16.

Wu, Hongjiang, A. Robert MacLeod, Walt F. Lima, & Stanley T. Crooke. (1998). Identification and Partial Purification of Human Double Strand RNase Activity. Journal of Biological Chemistry. 273(5). 2532–2542. 44 indexed citations

17.

Lima, Walt F., V. Mohan, & Stanley T. Crooke. (1997). The Influence of Antisense Oligonucleotide-induced RNA Structure on Escherichia coli RNase H1 Activity. Journal of Biological Chemistry. 272(29). 18191–18199. 46 indexed citations

18.

Lima, Walt F. & Stanley T. Crooke. (1997). Cleavage of Single Strand RNA Adjacent to RNA-DNA Duplex Regions by Escherichia coli RNase H1. Journal of Biological Chemistry. 272(44). 27513–27516. 57 indexed citations

19.

Lima, Walt F. & Stanley T. Crooke. (1997). Binding Affinity and Specificity of Escherichia coli RNase H1: Impact on the Kinetics of Catalysis of Antisense Oligonucleotide−RNA Hybrids. Biochemistry. 36(2). 390–398. 103 indexed citations

20.

Lima, Walt F., Brett P. Monia, David J. Ecker, & Susan M. Freier. (1992). Implication of RNA structure on antisense oligonucleotide hybridization kinetics. Biochemistry. 31(48). 12055–12061. 186 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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