Walt F. Lima

4.4k citations

42 papers · 3.4k indexed · 1 hit paper · h-index 30

Molecular Biology top 2%
Cancer Research top 5%
Genetics top 10%
Cellular and Molecular Neuroscience top 10%
Cardiology and Cardiovascular Medicine top 10%

Co-authors: Stanley T. Crooke Hongjiang Wu Thazha P. Prakash George W. Rogers William C. Merrick Eric E. Swayze Josh G. Nichols Brett P. Monia
Topics: DNA and Nucleic Acid Chemistry (24 papers)RNA and protein synthesis mechanisms (23 papers)RNA Interference and Gene Delivery (17 papers)
Cited by: Molecular Biology Cancer Research Cellular and Molecular Neuroscience
Journals: Cell Proceedings of the National Academy of Sciences Journal of the American Chemical Society
Partner nations: United States United Kingdom Poland

In The Last Decade

Walt F. Lima

42 papers receiving 3.3k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Targeted delivery of antisense oligonucleotides to hepatocytes using triantennaryN-acetyl galactosamine improves potency 10-fold in mice

2014 468 citations Thazha P. Prakash, Alfred E. Chappell et al. Nucleic Acids Research profile →

Peers

Countries citing papers authored by Walt F. Lima

Since Specialization

Citations

This map shows the geographic impact of Walt F. Lima's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Walt F. Lima with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Walt F. Lima more than expected).

Fields of papers citing papers by Walt F. Lima

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Walt F. Lima. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Walt F. Lima. The network helps show where Walt F. Lima may publish in the future.

Co-authorship network of co-authors of Walt F. Lima

This figure shows the co-authorship network connecting the top 25 collaborators of Walt F. Lima. A scholar is included among the top collaborators of Walt F. Lima based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Walt F. Lima. Walt F. Lima is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Fluorinated Nucleotide Modifications Modulate Allele Selectivity of SNP-Targeting Antisense Oligonucleotides 2017 ·Molecular Therapy — Nucleic Acids ·Michael E. Østergaard,Josh G. Nichols,Timothy A. Dwight,Walt F. Lima,Michael E. Jung,Eric E. Swayze,Punit P. Seth	27
2	RNA cleavage products generated by antisense oligonucleotides and siRNAs are processed by the RNA surveillance machinery 2016 ·Nucleic Acids Research ·Walt F. Lima,Cheryl Li De Hoyos,Xue‐hai Liang,Stanley T. Crooke	54
3	ViableRNaseH1knockout mice show RNaseH1 is essential for R loop processing, mitochondrial and liver function 2016 ·Nucleic Acids Research ·Walt F. Lima,Heather Murray,Sagar Damle,Christopher E. Hart,Gene Hung,Cheryl Li De Hoyos,Xue‐hai Liang,Stanley T. Crooke	84
4	Synthesis, biophysical properties and biological activity of second generation antisense oligonucleotides containing chiral phosphorothioate linkages 2014 ·Nucleic Acids Research ·Wei Wan,Michael T. Migawa,Guillermo Vasquez,Heather Murray,Josh G. Nichols,Hans Gaus,Andrés Berdeja,Sam Lee,Christopher E. Hart,Walt F. Lima,Eric E. Swayze,Punit P. Seth	93
5	Human RNase H1 Is Associated with Protein P32 and Is Involved in Mitochondrial Pre-rRNA Processing 2013 ·PLoS ONE ·Hongjiang Wu,Hong Sun,Xue‐hai Liang,Walt F. Lima,Stanley T. Crooke	44
6	ss-siRNAs allele selectively inhibit ataxin-3 expression: multiple mechanisms for an alternative gene silencing strategy 2013 ·Nucleic Acids Research ·Jing Liu,Dongbo Yu,Yuichiro Aiba,Hannah M. Pendergraff,Eric E. Swayze,Walt F. Lima,Jiaxin Hu,Thazha P. Prakash,David R. Corey	32
7	Single-Stranded RNAs Use RNAi to Potently and Allele-Selectively Inhibit Mutant Huntingtin Expression 2012 ·Cell ·Dongbo Yu,Hannah M. Pendergraff,Jing Liu,Holly Kordasiewicz,Don W. Cleveland,Eric E. Swayze,Walt F. Lima,Stanley T. Crooke,Thazha P. Prakash,David R. Corey	218
8	Single-Stranded siRNAs Activate RNAi in Animals 2012 ·Cell ·Walt F. Lima,Thazha P. Prakash,Heather Murray,Garth A. Kinberger,Wenyu Li,Alfred E. Chappell,Cheryl Li,Susan Murray,Hans Gaus,Punit P. Seth,Eric E. Swayze,Stanley T. Crooke	205
9	Off-target and a portion of target-specific siRNA mediated mRNA degradation is Ago2 ‘Slicer’ independent and can be mediated by Ago1 2009 ·Nucleic Acids Research ·Timothy A. Vickers,Walt F. Lima,Hongjiang Wu,Josh G. Nichols,Peter S. Linsley,Stanley T. Crooke	29
10	Human Dicer Binds Short Single-strand and Double-strand RNA with High Affinity and Interacts with Different Regions of the Nucleic Acids 2008 ·Journal of Biological Chemistry ·Walt F. Lima,Heather Murray,Josh G. Nichols,Hongjiang Wu,Hong Sun,Thazha P. Prakash,Andrés Berdeja,Hans Gaus,Stanley T. Crooke	35
11	Human RNase H1 Discriminates between Subtle Variations in the Structure of the Heteroduplex Substrate 2006 ·Molecular Pharmacology ·Walt F. Lima,J. Bart Rose,Josh G. Nichols,Hongjiang Wu,Michael T. Migawa,Tadeusz K. Wyrzykiewicz,Andrew Siwkowski,Stanley T. Crooke	62
12	The Positional Influence of the Helical Geometry of the Heteroduplex Substrate on Human RNase H1 Catalysis 2006 ·Molecular Pharmacology ·Walt F. Lima,J. Bart Rose,Josh G. Nichols,Hongjiang Wu,Michael T. Migawa,Tadeusz K. Wyrzykiewicz,Guillermo Vasquez,Eric E. Swayze,Stanley T. Crooke	24
13	Antisense oligonucleotides: Efficient synthesis of 2′-O-methoxyethyl phosphorothioate oligonucleotides using 4,5-dicyanoimidazole. Are these oligonucleotides comparable to those synthesized using 1H-tetrazole as coupling activator? 2006 ·Bioorganic & Medicinal Chemistry ·Zhiwei Wang,(unknown),Walt F. Lima,(unknown),Vasulinga T. Ravikumar	10
14	Determination of the Role of the Human RNase H1 in the Pharmacology of DNA-like Antisense Drugs 2004 ·Journal of Biological Chemistry ·Hongjiang Wu,Walt F. Lima,Hong Zhang,Amy C. Fan,Hong Sun,Stanley T. Crooke	267
15	Structural Requirements at the Catalytic Site of the Heteroduplex Substrate for Human RNase H1 Catalysis 2004 ·Journal of Biological Chemistry ·Walt F. Lima,Josh G. Nichols,Hongjiang Wu,Thazha P. Prakash,(unknown),(unknown),Balkrishen Bhat,Stanley T. Crooke	65
16	Human RNase H1 Activity Is Regulated by a Unique Redox Switch Formed between Adjacent Cysteines 2003 ·Journal of Biological Chemistry ·Walt F. Lima,Hongjiang Wu,Josh G. Nichols,(unknown),Jared J. Drader,Steven A. Hofstadler,Stanley T. Crooke	20
17	Modulation of the Helicase Activity of eIF4A by eIF4B, eIF4H, and eIF4F 2001 ·Journal of Biological Chemistry ·George W. Rogers,(unknown),Walt F. Lima,William C. Merrick	263
18	Human RNases H 2001 ·Methods in enzymology on CD-ROM/Methods in enzymology ·Walt F. Lima,Hongjiang Wu,Stanley T. Crooke	30
19	Properties of Cloned and Expressed Human RNase H1 1999 ·Journal of Biological Chemistry ·Hongjiang Wu,Walt F. Lima,Stanley T. Crooke	138
20	Implication of RNA structure on antisense oligonucleotide hybridization kinetics 1992 ·Biochemistry ·Walt F. Lima,Brett P. Monia,David J. Ecker,Susan M. Freier	186

About Walt F. Lima

Walt F. Lima is a scholar working on Molecular Biology, Cellular and Molecular Neuroscience and Genetics, having authored 42 papers that have together received 3.4k indexed citations. Recurring topics across this work include DNA and Nucleic Acid Chemistry (24 papers), RNA and protein synthesis mechanisms (23 papers) and RNA Interference and Gene Delivery (17 papers). The work is most often cited by research in Molecular Biology (3.1k citations), Cancer Research (431 citations) and Cellular and Molecular Neuroscience (230 citations). Walt F. Lima has collaborated with scholars based in United States, United Kingdom and Poland. Frequent co-authors include Stanley T. Crooke, Hongjiang Wu, Thazha P. Prakash, George W. Rogers, William C. Merrick, Eric E. Swayze, Josh G. Nichols, Brett P. Monia, Heather Murray and Punit P. Seth. Their work appears in journals such as Cell, Proceedings of the National Academy of Sciences and Journal of the American Chemical Society.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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