Xue‐hai Liang

7.5k total citations · 4 hit papers
93 papers, 5.8k citations indexed

About

Xue‐hai Liang is a scholar working on Molecular Biology, Epidemiology and Electrical and Electronic Engineering. According to data from OpenAlex, Xue‐hai Liang has authored 93 papers receiving a total of 5.8k indexed citations (citations by other indexed papers that have themselves been cited), including 73 papers in Molecular Biology, 12 papers in Epidemiology and 11 papers in Electrical and Electronic Engineering. Recurrent topics in Xue‐hai Liang's work include RNA Research and Splicing (31 papers), RNA modifications and cancer (30 papers) and RNA Interference and Gene Delivery (22 papers). Xue‐hai Liang is often cited by papers focused on RNA Research and Splicing (31 papers), RNA modifications and cancer (30 papers) and RNA Interference and Gene Delivery (22 papers). Xue‐hai Liang collaborates with scholars based in United States, Israel and China. Xue‐hai Liang's co-authors include Stanley T. Crooke, Timothy A. Vickers, Wen Shen, Hong Sun, Rosanne M. Crooke, Maurille J. Fournier, Brenda F. Baker, Shulamit Michaeli, Shiyu Wang and Shai Uliel and has published in prestigious journals such as Proceedings of the National Academy of Sciences, Journal of the American Chemical Society and Nucleic Acids Research.

In The Last Decade

Xue‐hai Liang

92 papers receiving 5.7k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Antisense technology: an overview and prospectus

2021 469 citations Stanley T. Crooke, Brenda F. Baker et al. Nature Reviews Drug Discovery profile →
Cellular uptake and trafficking of antisense oligonucleotides

2017 446 citations Stanley T. Crooke, Timothy A. Vickers et al. Nature Biotechnology profile →
Phosphorothioate modified oligonucleotide–protein interactions

2020 232 citations Stanley T. Crooke, Timothy A. Vickers et al. Nucleic Acids Research profile →
Antisense technology: A review

2021 217 citations Stanley T. Crooke, Xue‐hai Liang et al. Journal of Biological Chemistry profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Xue‐hai Liang United States	44	5.0k	719	568	355	283	93	5.8k
Hiroaki Honda Japan	37	2.1k 0.4×	468 0.7×	245 0.4×	108 0.3×	388 1.4×	125	4.4k
Pavel Hozák Czechia	37	4.0k 0.8×	230 0.3×	160 0.3×	225 0.6×	60 0.2×	147	5.1k
Pirjo Laakkonen Finland	37	3.2k 0.6×	419 0.6×	215 0.4×	73 0.2×	197 0.7×	86	5.8k
Youli Zu United States	37	3.1k 0.6×	387 0.5×	148 0.3×	81 0.2×	203 0.7×	141	5.2k
Zicai Liang China	45	3.8k 0.8×	1.2k 1.6×	289 0.5×	161 0.5×	40 0.1×	125	5.7k
Martina Anton Germany	33	2.5k 0.5×	351 0.5×	152 0.3×	137 0.4×	212 0.7×	88	4.3k
James E. Dahlman United States	40	5.0k 1.0×	694 1.0×	169 0.3×	415 1.2×	46 0.2×	76	7.3k
Gregg Fields United States	30	3.7k 0.7×	983 1.4×	147 0.3×	58 0.2×	84 0.3×	92	6.9k
William Querbes United States	25	3.8k 0.8×	585 0.8×	168 0.3×	130 0.4×	47 0.2×	37	5.1k
Sisareuth Tan France	25	2.6k 0.5×	930 1.3×	158 0.3×	177 0.5×	67 0.2×	37	3.7k

Countries citing papers authored by Xue‐hai Liang

Since Specialization

Citations

This map shows the geographic impact of Xue‐hai Liang's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Xue‐hai Liang with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Xue‐hai Liang more than expected).

Fields of papers citing papers by Xue‐hai Liang

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Xue‐hai Liang. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Xue‐hai Liang. The network helps show where Xue‐hai Liang may publish in the future.

Co-authorship network of co-authors of Xue‐hai Liang

This figure shows the co-authorship network connecting the top 25 collaborators of Xue‐hai Liang. A scholar is included among the top collaborators of Xue‐hai Liang based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Xue‐hai Liang. Xue‐hai Liang is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Zhang, Lingdi, Nima Niknejad, Jian Jian Li, et al.. (2025). Antisense oligonucleotide-mediated upregulation of Jag1 ameliorates liver disease phenotypes in a mouse model of Alagille syndrome. Molecular Therapy — Nucleic Acids. 36(4). 102694–102694.

Zhang, Lingdi, Xue‐hai Liang, Cheryl Li De Hoyos, et al.. (2022). The Combination of Mesyl-Phosphoramidate Inter-Nucleotide Linkages and 2′- O -Methyl in Selected Positions in the Antisense Oligonucleotide Enhances the Performance of RNaseH1 Active PS-ASOs. Nucleic Acid Therapeutics. 32(5). 401–411. 11 indexed citations

Zhang, Lingdi, et al.. (2022). NAT10 and DDX21 Proteins Interact with RNase H1 and Affect the Performance of Phosphorothioate Oligonucleotides. Nucleic Acid Therapeutics. 32(4). 280–299. 6 indexed citations

Knott, Gavin J., Daniel M. Passon, Xue‐hai Liang, et al.. (2021). Structural basis of dimerization and nucleic acid binding of human DBHS proteins NONO and PSPC1. Nucleic Acids Research. 50(1). 522–535. 23 indexed citations

Liang, Xue‐hai, Joshua G Nichols, Chih‐Wei Hsu, & Stanley T. Crooke. (2021). Hsc70 Facilitates Mannose-6-Phosphate Receptor-Mediated Intracellular Trafficking and Enhances Endosomal Release of Phosphorothioate-Modified Antisense Oligonucleotides. Nucleic Acid Therapeutics. 31(4). 284–297. 6 indexed citations

Crooke, Stanley T., Xue‐hai Liang, Brenda F. Baker, & Rosanne M. Crooke. (2021). Antisense technology: A review. Journal of Biological Chemistry. 296. 100416–100416. 217 indexed citations breakdown →

Crooke, Stanley T., Brenda F. Baker, Rosanne M. Crooke, & Xue‐hai Liang. (2021). Antisense technology: an overview and prospectus. Nature Reviews Drug Discovery. 20(6). 427–453. 469 indexed citations breakdown →

Wang, Shiyu, Nickolas Allen, Thazha P. Prakash, Xue‐hai Liang, & Stanley T. Crooke. (2019). Lipid Conjugates Enhance Endosomal Release of Antisense Oligonucleotides Into Cells. Nucleic Acid Therapeutics. 29(5). 245–255. 51 indexed citations

Wang, Ying, Wen Shen, Xue‐hai Liang, & Stanley T. Crooke. (2019). Phosphorothioate Antisense Oligonucleotides Bind P-Body Proteins and Mediate P-Body Assembly. Nucleic Acid Therapeutics. 29(6). 343–358. 10 indexed citations

10.

Liang, Xue‐hai, Joshua G Nichols, Chih‐Wei Hsu, Timothy A. Vickers, & Stanley T. Crooke. (2019). mRNA levels can be reduced by antisense oligonucleotides via no-go decay pathway. Nucleic Acids Research. 47(13). 6900–6916. 41 indexed citations

11.

Migawa, Michael T., Wen Shen, Wei Wan, et al.. (2019). Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins. Nucleic Acids Research. 47(11). 5465–5479. 92 indexed citations

12.

Shen, Wen, Xue‐hai Liang, Hong Sun, Cheryl Li De Hoyos, & Stanley T. Crooke. (2017). Depletion of NEAT1 lncRNA attenuates nucleolar stress by releasing sequestered P54nrb and PSF to facilitate c-Myc translation. PLoS ONE. 12(3). e0173494–e0173494. 27 indexed citations

13.

Lima, Walt F., Heather Murray, Sagar Damle, et al.. (2016). ViableRNaseH1knockout mice show RNaseH1 is essential for R loop processing, mitochondrial and liver function. Nucleic Acids Research. 44(11). 5299–5312. 84 indexed citations

14.

Liang, Xue‐hai, Wen‐Hui Shen, Hong Sun, et al.. (2016). Translation efficiency of mRNAs is increased by antisense oligonucleotides targeting upstream open reading frames. Nature Biotechnology. 34(8). 875–880. 152 indexed citations

15.

Liang, Xue‐hai, Wen Shen, Hong Sun, Thazha P. Prakash, & Stanley T. Crooke. (2014). TCP1 complex proteins interact with phosphorothioate oligonucleotides and can co-localize in oligonucleotide-induced nuclear bodies in mammalian cells. Nucleic Acids Research. 42(12). 7819–7832. 80 indexed citations

16.

Liang, Xue‐hai & Stanley T. Crooke. (2013). RNA helicase A is not required for RISC activity. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1829(10). 1092–1101. 11 indexed citations

17.

Liang, Xue‐hai & Maurille J. Fournier. (2006). The Helicase Has1p Is Required for snoRNA Release from Pre-rRNA. Molecular and Cellular Biology. 26(20). 7437–7450. 66 indexed citations

18.

Liang, Xue‐hai, et al.. (2005). Elucidating the Role of H/ACA-like RNAs in trans-Splicing and rRNA Processing via RNA Interference Silencing of the Trypanosoma brucei CBF5 Pseudouridine Synthase. Journal of Biological Chemistry. 280(41). 34558–34568. 46 indexed citations

19.

Liu, Qing, et al.. (2004). Identification and Functional Characterization of Lsm Proteins in Trypanosoma brucei. Journal of Biological Chemistry. 279(18). 18210–18219. 33 indexed citations

20.

Liang, Xue‐hai, Qing Liu, & Shulamit Michaeli. (2003). Small nucleolar RNA interference induced by antisense or double-stranded RNA in trypanosomatids. Proceedings of the National Academy of Sciences. 100(13). 7521–7526. 33 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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