Xue‐hai Liang

7.5k citations

93 papers · 5.8k indexed · 4 hit papers · h-index 44

Molecular Biology top 1%
Cancer Research top 2%
Epidemiology top 5%
Cardiology and Cardiovascular Medicine top 5%
Genetics top 5%

Co-authors: Stanley T. Crooke Timothy A. Vickers Wen Shen Hong Sun Rosanne M. Crooke Maurille J. Fournier Brenda F. Baker Shulamit Michaeli
Topics: RNA Research and Splicing (31 papers)RNA modifications and cancer (30 papers)RNA Interference and Gene Delivery (22 papers)
Cited by: Molecular Biology Cancer Research Genetics
Journals: Proceedings of the National Academy of Sciences Journal of the American Chemical Society Nucleic Acids Research
Partner nations: United States Israel China

In The Last Decade

Xue‐hai Liang

92 papers receiving 5.7k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Antisense technology: an overview and prospectus

2021 469 citations Stanley T. Crooke, Brenda F. Baker et al. Nature Reviews Drug Discovery profile →
Cellular uptake and trafficking of antisense oligonucleotides

2017 446 citations Stanley T. Crooke, Timothy A. Vickers et al. profile →
Phosphorothioate modified oligonucleotide–protein interactions

2020 232 citations Stanley T. Crooke, Timothy A. Vickers et al. Nucleic Acids Research profile →
Antisense technology: A review

2021 217 citations Stanley T. Crooke, Xue‐hai Liang et al. Journal of Biological Chemistry profile →

Peers

Countries citing papers authored by Xue‐hai Liang

Since Specialization

Citations

This map shows the geographic impact of Xue‐hai Liang's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Xue‐hai Liang with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Xue‐hai Liang more than expected).

Fields of papers citing papers by Xue‐hai Liang

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Xue‐hai Liang. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Xue‐hai Liang. The network helps show where Xue‐hai Liang may publish in the future.

Co-authorship network of co-authors of Xue‐hai Liang

This figure shows the co-authorship network connecting the top 25 collaborators of Xue‐hai Liang. A scholar is included among the top collaborators of Xue‐hai Liang based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Xue‐hai Liang. Xue‐hai Liang is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	The Combination of Mesyl-Phosphoramidate Inter-Nucleotide Linkages and 2′- O -Methyl in Selected Positions in the Antisense Oligonucleotide Enhances the Performance of RNaseH1 Active PS-ASOs 2022 ·Nucleic Acid Therapeutics ·Lingdi Zhang,Xue‐hai Liang,Cheryl Li De Hoyos,Michael T. Migawa,Joshua G Nichols,Graeme C. Freestone,(unknown),Punit P. Seth,Stanley T. Crooke	11
2	NAT10 and DDX21 Proteins Interact with RNase H1 and Affect the Performance of Phosphorothioate Oligonucleotides 2022 ·Nucleic Acid Therapeutics ·Lingdi Zhang,(unknown),Timothy A. Vickers,(unknown),Xue‐hai Liang,Stanley T. Crooke	6
3	Structural basis of dimerization and nucleic acid binding of human DBHS proteins NONO and PSPC1 2021 ·Nucleic Acids Research ·Gavin J. Knott,(unknown),Daniel M. Passon,Xue‐hai Liang,Evelyne Deplazes,Maria R. Conte,A.C. Marshall,Mihwa Lee,Archa H. Fox,Charles S. Bond	23
4	Antisense technology: A reviewbreakdown → 2021 ·Journal of Biological Chemistry ·Stanley T. Crooke,Xue‐hai Liang,Brenda F. Baker,Rosanne M. Crooke	217
5	Antisense technology: an overview and prospectusbreakdown → 2021 ·Nature Reviews Drug Discovery ·Stanley T. Crooke,Brenda F. Baker,Rosanne M. Crooke,Xue‐hai Liang	469
6	Hsc70 Facilitates Mannose-6-Phosphate Receptor-Mediated Intracellular Trafficking and Enhances Endosomal Release of Phosphorothioate-Modified Antisense Oligonucleotides 2021 ·Nucleic Acid Therapeutics ·Xue‐hai Liang,Joshua G Nichols,Chih‐Wei Hsu,Stanley T. Crooke	6
7	Solid-Phase Separation of Toxic Phosphorothioate Antisense Oligonucleotide-Protein Nucleolar Aggregates Is Cytoprotective 2021 ·Nucleic Acid Therapeutics ·Xue‐hai Liang,Cheryl Li De Hoyos,Wen Shen,Lingdi Zhang,Michael Fazio,Stanley T. Crooke	13
8	Phosphorothioate Antisense Oligonucleotides Bind P-Body Proteins and Mediate P-Body Assembly 2019 ·Nucleic Acid Therapeutics ·Ying Wang,Wen Shen,Xue‐hai Liang,Stanley T. Crooke	10
9	Lipid Conjugates Enhance Endosomal Release of Antisense Oligonucleotides Into Cells 2019 ·Nucleic Acid Therapeutics ·Shiyu Wang,Nickolas Allen,Thazha P. Prakash,Xue‐hai Liang,Stanley T. Crooke	51
10	Membrane Destabilization Induced by Lipid Species Increases Activity of Phosphorothioate-Antisense Oligonucleotides 2018 ·Molecular Therapy — Nucleic Acids ·Shiyu Wang,Nickolas Allen,Xue‐hai Liang,Stanley T. Crooke	17
11	RNA cleavage products generated by antisense oligonucleotides and siRNAs are processed by the RNA surveillance machinery 2016 ·Nucleic Acids Research ·Walt F. Lima,Cheryl Li De Hoyos,Xue‐hai Liang,Stanley T. Crooke	54
12	RNA helicase A is not required for RISC activity 2013 ·Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms ·Xue‐hai Liang,Stanley T. Crooke	11
13	Depletion of key protein components of the RISC pathway impairs pre-ribosomal RNA processing 2011 ·Nucleic Acids Research ·Xue‐hai Liang,Stanley T. Crooke	46
14	Loss of rRNA modifications in the decoding center of the ribosome impairs translation and strongly delays pre-rRNA processing 2009 ·RNA ·Xue‐hai Liang,Qing Liu,Maurille J. Fournier	171
15	The Helicase Has1p Is Required for snoRNA Release from Pre-rRNA 2006 ·Molecular and Cellular Biology ·Xue‐hai Liang,Maurille J. Fournier	66
16	Elucidating the Role of H/ACA-like RNAs in trans-Splicing and rRNA Processing via RNA Interference Silencing of the Trypanosoma brucei CBF5 Pseudouridine Synthase 2005 ·Journal of Biological Chemistry ·(unknown),(unknown),Xue‐hai Liang,Shulamit Michaeli	46
17	Analysis of spliceosomal complexes in Trypanosoma brucei and silencing of two splicing factors Prp31 and Prp43 2005 ·Molecular and Biochemical Parasitology ·Xue‐hai Liang,Qing Liu,Li Liu,Christian Tschudi,Shulamit Michaeli	24
18	Identification and Functional Characterization of Lsm Proteins in Trypanosoma brucei 2004 ·Journal of Biological Chemistry ·Qing Liu,Xue‐hai Liang,Shai Uliel,(unknown),Ron Unger,Shulamit Michaeli	33
19	Small nucleolar RNA interference induced by antisense or double-stranded RNA in trypanosomatids 2003 ·Proceedings of the National Academy of Sciences ·Xue‐hai Liang,Qing Liu,Shulamit Michaeli	33
20	Identification of the First Trypanosome H/ACA RNA That Guides Pseudouridine Formation on rRNA 2001 ·Journal of Biological Chemistry ·Xue‐hai Liang,Li Liu,Shulamit Michaeli	43

About Xue‐hai Liang

Xue‐hai Liang is a scholar working on Molecular Biology, Cancer Research and Cardiology and Cardiovascular Medicine, having authored 93 papers that have together received 5.8k indexed citations. Recurring topics across this work include RNA Research and Splicing (31 papers), RNA modifications and cancer (30 papers) and RNA Interference and Gene Delivery (22 papers). The work is most often cited by research in Molecular Biology (5.0k citations), Cancer Research (719 citations) and Genetics (283 citations). Xue‐hai Liang has collaborated with scholars based in United States, Israel and China. Frequent co-authors include Stanley T. Crooke, Timothy A. Vickers, Wen Shen, Hong Sun, Rosanne M. Crooke, Maurille J. Fournier, Brenda F. Baker, Shulamit Michaeli, Shiyu Wang and Shai Uliel. Their work appears in journals such as Proceedings of the National Academy of Sciences, Journal of the American Chemical Society and Nucleic Acids Research.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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