Alfred E. Chappell

2.7k total citations · 1 hit paper
24 papers, 1.9k citations indexed

About

Alfred E. Chappell is a scholar working on Molecular Biology, Surgery and Organic Chemistry. According to data from OpenAlex, Alfred E. Chappell has authored 24 papers receiving a total of 1.9k indexed citations (citations by other indexed papers that have themselves been cited), including 17 papers in Molecular Biology, 3 papers in Surgery and 2 papers in Organic Chemistry. Recurrent topics in Alfred E. Chappell's work include RNA Interference and Gene Delivery (10 papers), Advanced biosensing and bioanalysis techniques (9 papers) and DNA and Nucleic Acid Chemistry (6 papers). Alfred E. Chappell is often cited by papers focused on RNA Interference and Gene Delivery (10 papers), Advanced biosensing and bioanalysis techniques (9 papers) and DNA and Nucleic Acid Chemistry (6 papers). Alfred E. Chappell collaborates with scholars based in United States, Germany and Switzerland. Alfred E. Chappell's co-authors include Punit P. Seth, Eric E. Swayze, Hans Gaus, Thazha P. Prakash, Walt F. Lima, Susan Murray, Erich Koller, Soma De, Thomas M. Vincent and C. Frank Bennett and has published in prestigious journals such as Cell, Nucleic Acids Research and Analytical Biochemistry.

In The Last Decade

Alfred E. Chappell

24 papers receiving 1.8k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Targeted delivery of antisense oligonucleotides to hepatocytes using triantennaryN-acetyl galactosamine improves potency 10-fold in mice

2014 468 citations Thazha P. Prakash, Mark J. Graham et al. Nucleic Acids Research profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Alfred E. Chappell United States	19	1.5k	236	125	99	91	24	1.9k
Petra Hååg Sweden	19	804 0.5×	267 1.1×	95 0.8×	99 1.0×	56 0.6×	43	1.3k
Daniel J. D. Johnson United Kingdom	19	576 0.4×	425 1.8×	231 1.8×	127 1.3×	85 0.9×	29	1.6k
Siqing Shan United States	17	893 0.6×	469 2.0×	148 1.2×	80 0.8×	46 0.5×	25	1.7k
Debby M.E.I. Hellebrekers Netherlands	18	1.1k 0.7×	178 0.8×	39 0.3×	135 1.4×	41 0.5×	36	1.3k
Vrushank Davé United States	22	1.1k 0.7×	191 0.8×	57 0.5×	134 1.4×	57 0.6×	33	1.7k
John W. Marks United States	27	1.3k 0.9×	113 0.5×	81 0.6×	86 0.9×	69 0.8×	58	2.4k
Zee-Fen Chang Taiwan	23	1.0k 0.7×	170 0.7×	184 1.5×	136 1.4×	48 0.5×	59	1.7k
Tomohiro Kato Japan	18	826 0.5×	263 1.1×	44 0.4×	70 0.7×	21 0.2×	35	1.3k
Tao Fang China	25	1.0k 0.7×	446 1.9×	104 0.8×	113 1.1×	49 0.5×	53	1.8k
Stephen Wincovitch United States	20	909 0.6×	132 0.6×	41 0.3×	79 0.8×	22 0.2×	37	1.3k

Countries citing papers authored by Alfred E. Chappell

Since Specialization

Citations

This map shows the geographic impact of Alfred E. Chappell's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Alfred E. Chappell with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Alfred E. Chappell more than expected).

Fields of papers citing papers by Alfred E. Chappell

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Alfred E. Chappell. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Alfred E. Chappell. The network helps show where Alfred E. Chappell may publish in the future.

Co-authorship network of co-authors of Alfred E. Chappell

This figure shows the co-authorship network connecting the top 25 collaborators of Alfred E. Chappell. A scholar is included among the top collaborators of Alfred E. Chappell based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Alfred E. Chappell. Alfred E. Chappell is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Nikan, Mehran, Steve T. Yeh, Alfred E. Chappell, et al.. (2022). Targeted Delivery of Antisense Oligonucleotides Through Angiotensin Type 1 Receptor. Nucleic Acid Therapeutics. 32(4). 300–311. 5 indexed citations

Chappell, Alfred E., et al.. (2019). AMPK mediates inhibition of electrolyte transport and NKCC1 activity by reactive oxygen species. American Journal of Physiology-Gastrointestinal and Liver Physiology. 317(2). G171–G181. 9 indexed citations

Prakash, Thazha P., Adam E. Mullick, Richard Lee, et al.. (2019). Fatty acid conjugation enhances potency of antisense oligonucleotides in muscle. Nucleic Acids Research. 47(12). 6029–6044. 104 indexed citations

Kinberger, Garth A., Thazha P. Prakash, Jinghua Yu, et al.. (2016). Conjugation of mono and di-GalNAc sugars enhances the potency of antisense oligonucleotides via ASGR mediated delivery to hepatocytes. Bioorganic & Medicinal Chemistry Letters. 26(15). 3690–3693. 33 indexed citations

Floehr, Julia, et al.. (2016). Down-regulation of the liver-derived plasma protein fetuin-B mediates reversible female infertility. Molecular Human Reproduction. 23(1). 34–44. 26 indexed citations

Prakash, Thazha P., Garth A. Kinberger, Heather Murray, et al.. (2016). Synergistic effect of phosphorothioate, 5′-vinylphosphonate and GalNAc modifications for enhancing activity of synthetic siRNA. Bioorganic & Medicinal Chemistry Letters. 26(12). 2817–2820. 43 indexed citations

Prakash, Thazha P., Wei Wan, Audrey Low, et al.. (2015). Solid-phase synthesis of 5′-triantennary N-acetylgalactosamine conjugated antisense oligonucleotides using phosphoramidite chemistry. Bioorganic & Medicinal Chemistry Letters. 25(19). 4127–4130. 17 indexed citations

Prakash, Thazha P., Walt F. Lima, Heather Murray, et al.. (2015). Identification of metabolically stable 5′-phosphate analogs that support single-stranded siRNA activity. Nucleic Acids Research. 43(6). 2993–3011. 78 indexed citations

Shen, Lijiang, Ashley Frazer‐Abel, Paul R. Reynolds, et al.. (2014). Mechanistic Understanding for the Greater Sensitivity of Monkeys to Antisense Oligonucleotide–Mediated Complement Activation Compared with Humans. Journal of Pharmacology and Experimental Therapeutics. 351(3). 709–717. 34 indexed citations

10.

Prakash, Thazha P., Mark J. Graham, Jinghua Yu, et al.. (2014). Targeted delivery of antisense oligonucleotides to hepatocytes using triantennaryN-acetyl galactosamine improves potency 10-fold in mice. Nucleic Acids Research. 42(13). 8796–8807. 468 indexed citations breakdown →

11.

Lima, Walt F., Thazha P. Prakash, Heather Murray, et al.. (2012). Single-Stranded siRNAs Activate RNAi in Animals. Cell. 150(5). 883–894. 205 indexed citations

12.

Murray, Sue, Erich Koller, Andrés Berdeja, et al.. (2012). TricycloDNA-modified oligo-2′-deoxyribonucleotides reduce scavenger receptor B1 mRNA in hepatic and extra-hepatic tissues—a comparative study of oligonucleotide length, design and chemistry. Nucleic Acids Research. 40(13). 6135–6143. 70 indexed citations

13.

Koller, Erich, Thomas M. Vincent, Alfred E. Chappell, et al.. (2011). Mechanisms of single-stranded phosphorothioate modified antisense oligonucleotide accumulation in hepatocytes. Nucleic Acids Research. 39(11). 4795–4807. 227 indexed citations

14.

Chappell, Alfred E., Eric J. Smoll, Hui Dong, et al.. (2008). Hydrogen peroxide inhibits Ca ²⁺ ‐dependent chloride secretion across colonic epithelial cells via distinct kinase signaling pathways and ion transport proteins. The FASEB Journal. 22(6). 2023–2036. 15 indexed citations

15.

Chappell, Alfred E., et al.. (2006). 5‐Hydroxytryptamine contributes significantly to a reflex pathway by which the duodenal mucosa protects itself from gastric acid injury. The FASEB Journal. 20(14). 2486–2495. 23 indexed citations

16.

Butler, Madeline, et al.. (2005). Spinal distribution and metabolism of 2′-O-(2-methoxyethyl)-modified oligonucleotides after intrathecal administration in rats. Neuroscience. 131(3). 705–715. 36 indexed citations

17.

Geary, Richard S., Rosie Z. Yu, Tanya Watanabe, et al.. (2003). PHARMACOKINETICS OF A TUMOR NECROSIS FACTOR-α PHOSPHOROTHIOATE 2′-O-(2-METHOXYETHYL) MODIFIED ANTISENSE OLIGONUCLEOTIDE: COMPARISON ACROSS SPECIES. Drug Metabolism and Disposition. 31(11). 1419–1428. 141 indexed citations

18.

Yu, Rosie Z., Brenda F. Baker, Alfred E. Chappell, et al.. (2002). Development of an Ultrasensitive Noncompetitive Hybridization–Ligation Enzyme-Linked Immunosorbent Assay for the Determination of Phosphorothioate Oligodeoxynucleotide in Plasma. Analytical Biochemistry. 304(1). 19–25. 120 indexed citations

19.

Hart, John P., et al.. (1999). Development of a Disposable Amperometric NH Biosensor Based on a Chemically Modified Screen-Printed Carbon Electrode Coated with Glutamate Dehydrogenase, 2-Oxoglutarate, and NADH. Electroanalysis. 11(6). 406–411. 18 indexed citations

20.

Hart, John P., et al.. (1998). Development of an amperometric assay for NH+4 based on a chemically modified screen-printed NADH sensor. Analytica Chimica Acta. 373(1). 1–8. 30 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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