Alfred E. Chappell

2.7k citations

24 papers · 1.9k indexed · 1 hit paper · h-index 19

Co-authors: Punit P. Seth Eric E. Swayze Hans Gaus Thazha P. Prakash Walt F. Lima Susan Murray Erich Koller Soma De
Topics: RNA Interference and Gene Delivery (10 papers)Advanced biosensing and bioanalysis techniques (9 papers)DNA and Nucleic Acid Chemistry (6 papers)
Cited by: Molecular Biology Cancer Research Genetics
Journals: Cell Nucleic Acids Research Analytical Biochemistry
Partner nations: United States Germany Switzerland

In The Last Decade

Alfred E. Chappell

24 papers receiving 1.8k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Targeted delivery of antisense oligonucleotides to hepatocytes using triantennaryN-acetyl galactosamine improves potency 10-fold in mice

2014 468 citations Thazha P. Prakash, Mark J. Graham et al. Nucleic Acids Research profile →

Peers

Countries citing papers authored by Alfred E. Chappell

Since Specialization

Citations

This map shows the geographic impact of Alfred E. Chappell's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Alfred E. Chappell with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Alfred E. Chappell more than expected).

Fields of papers citing papers by Alfred E. Chappell

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Alfred E. Chappell. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Alfred E. Chappell. The network helps show where Alfred E. Chappell may publish in the future.

Co-authorship network of co-authors of Alfred E. Chappell

This figure shows the co-authorship network connecting the top 25 collaborators of Alfred E. Chappell. A scholar is included among the top collaborators of Alfred E. Chappell based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Alfred E. Chappell. Alfred E. Chappell is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Targeted Delivery of Antisense Oligonucleotides Through Angiotensin Type 1 Receptor 2022 ·Nucleic Acid Therapeutics ·(unknown),Mehran Nikan,Steve T. Yeh,Alfred E. Chappell,Michael Tanowitz,Punit P. Seth,(unknown),Adam E. Mullick	5
2	AMPK mediates inhibition of electrolyte transport and NKCC1 activity by reactive oxygen species 2019 ·American Journal of Physiology-Gastrointestinal and Liver Physiology ·(unknown),(unknown),Alfred E. Chappell,Michael Scharl,Michael J. Docherty,(unknown),Christian Lytle,Declan F. McCole	9
3	Fatty acid conjugation enhances potency of antisense oligonucleotides in muscle 2019 ·Nucleic Acids Research ·Thazha P. Prakash,Adam E. Mullick,Richard Lee,Jinghua Yu,Steve T. Yeh,Audrey Low,Alfred E. Chappell,Michael E. Østergaard,Sue Murray,Hans Gaus,Eric E. Swayze,Punit P. Seth	104
4	Conjugation of mono and di-GalNAc sugars enhances the potency of antisense oligonucleotides via ASGR mediated delivery to hepatocytes 2016 ·Bioorganic & Medicinal Chemistry Letters ·Garth A. Kinberger,Thazha P. Prakash,Jinghua Yu,Guillermo Vasquez,Audrey Low,Alfred E. Chappell,Karsten Schmidt,Heather Murray,Hans Gaus,Eric E. Swayze,Punit P. Seth	33
5	Down-regulation of the liver-derived plasma protein fetuin-B mediates reversible female infertility 2016 ·Molecular Human Reproduction ·Julia Floehr,(unknown),C. Schmitz,Alfred E. Chappell,Willi Jahnen‐Dechent	26
6	Synergistic effect of phosphorothioate, 5′-vinylphosphonate and GalNAc modifications for enhancing activity of synthetic siRNA 2016 ·Bioorganic & Medicinal Chemistry Letters ·Thazha P. Prakash,Garth A. Kinberger,Heather Murray,Alfred E. Chappell,(unknown),Mark J. Graham,Walt F. Lima,Eric E. Swayze,Punit P. Seth	43
7	Solid-phase synthesis of 5′-triantennary N-acetylgalactosamine conjugated antisense oligonucleotides using phosphoramidite chemistry 2015 ·Bioorganic & Medicinal Chemistry Letters ·Thazha P. Prakash,Wei Wan,Audrey Low,Jinghua Yu,Alfred E. Chappell,Hans Gaus,Garth A. Kinberger,Michael E. Østergaard,Michael T. Migawa,Eric E. Swayze,Punit P. Seth	17
8	Identification of metabolically stable 5′-phosphate analogs that support single-stranded siRNA activity 2015 ·Nucleic Acids Research ·Thazha P. Prakash,Walt F. Lima,Heather Murray,Wenyu Li,Garth A. Kinberger,Alfred E. Chappell,Hans Gaus,Punit P. Seth,Balkrishen Bhat,Stanley T. Crooke,Eric E. Swayze	78
9	Mechanistic Understanding for the Greater Sensitivity of Monkeys to Antisense Oligonucleotide–Mediated Complement Activation Compared with Humans 2014 ·Journal of Pharmacology and Experimental Therapeutics ·Lijiang Shen,Ashley Frazer‐Abel,Paul R. Reynolds,Patricia C. Giclas,Alfred E. Chappell,Michael K. Pangburn,Husam S. Younis,Scott P. Henry	34
10	Targeted delivery of antisense oligonucleotides to hepatocytes using triantennaryN-acetyl galactosamine improves potency 10-fold in micebreakdown → 2014 ·Nucleic Acids Research ·Thazha P. Prakash,Mark J. Graham,Jinghua Yu,(unknown),Audrey Low,Alfred E. Chappell,Karsten Schmidt,Chenguang Zhao,Mariam Aghajan,(unknown),(unknown),Sheri Booten,Susan Murray,Hans Gaus,Jeff Crosby,Walt F. Lima,Shuling Guo,Brett P. Monia,Eric E. Swayze,Punit P. Seth	468
11	Single-Stranded siRNAs Activate RNAi in Animals 2012 ·Cell ·Walt F. Lima,Thazha P. Prakash,Heather Murray,Garth A. Kinberger,Wenyu Li,Alfred E. Chappell,Cheryl Li,Susan Murray,Hans Gaus,Punit P. Seth,Eric E. Swayze,Stanley T. Crooke	205
12	TricycloDNA-modified oligo-2′-deoxyribonucleotides reduce scavenger receptor B1 mRNA in hepatic and extra-hepatic tissues—a comparative study of oligonucleotide length, design and chemistry 2012 ·Nucleic Acids Research ·Sue Murray,(unknown),Erich Koller,Andrés Berdeja,Alfred E. Chappell,Thazha P. Prakash,(unknown),Eric E. Swayze,Christian J. Leumann,Punit P. Seth	70
13	Mechanisms of single-stranded phosphorothioate modified antisense oligonucleotide accumulation in hepatocytes 2011 ·Nucleic Acids Research ·Erich Koller,Thomas M. Vincent,Alfred E. Chappell,Soma De,Muthiah Manoharan,C. Frank Bennett	227
14	Hydrogen peroxide inhibits Ca ²⁺ ‐dependent chloride secretion across colonic epithelial cells via distinct kinase signaling pathways and ion transport proteins 2008 ·The FASEB Journal ·Alfred E. Chappell,(unknown),Eric J. Smoll,Hui Dong,Christian Lytle,Kim E. Barrett,Declan F. McCole	15
15	5‐Hydroxytryptamine contributes significantly to a reflex pathway by which the duodenal mucosa protects itself from gastric acid injury 2006 ·The FASEB Journal ·(unknown),Alfred E. Chappell,André G. Buret,Kim E. Barrett,Hui Dong	23
16	Spinal distribution and metabolism of 2′-O-(2-methoxyethyl)-modified oligonucleotides after intrathecal administration in rats 2005 ·Neuroscience ·Madeline Butler,(unknown),Alfred E. Chappell,Susan Murray,Tony L. Yaksh,Xiaoyang Hua	36
17	PHARMACOKINETICS OF A TUMOR NECROSIS FACTOR-α PHOSPHOROTHIOATE 2′-O-(2-METHOXYETHYL) MODIFIED ANTISENSE OLIGONUCLEOTIDE: COMPARISON ACROSS SPECIES 2003 ·Drug Metabolism and Disposition ·Richard S. Geary,Rosie Z. Yu,Tanya Watanabe,Scott P. Henry,G. E. Hardee,Alfred E. Chappell,John Matson,Henri Sasmor,(unknown),Arthur A. Levin	141
18	Development of an Ultrasensitive Noncompetitive Hybridization–Ligation Enzyme-Linked Immunosorbent Assay for the Determination of Phosphorothioate Oligodeoxynucleotide in Plasma 2002 ·Analytical Biochemistry ·Rosie Z. Yu,Brenda F. Baker,Alfred E. Chappell,Richard S. Geary,Ellen Cheung,Arthur A. Levin	120
19	Development of a Disposable Amperometric NH Biosensor Based on a Chemically Modified Screen-Printed Carbon Electrode Coated with Glutamate Dehydrogenase, 2-Oxoglutarate, and NADH 1999 ·Electroanalysis ·John P. Hart,(unknown),David C. Cowell,Alfred E. Chappell	18
20	Development of an amperometric assay for NH+4 based on a chemically modified screen-printed NADH sensor 1998 ·Analytica Chimica Acta ·(unknown),John P. Hart,David C. Cowell,Alfred E. Chappell	30

About Alfred E. Chappell

Alfred E. Chappell is a scholar working on Bioengineering, Electrochemistry and Nephrology, having authored 24 papers that have together received 1.9k indexed citations. Recurring topics across this work include RNA Interference and Gene Delivery (10 papers), Advanced biosensing and bioanalysis techniques (9 papers) and DNA and Nucleic Acid Chemistry (6 papers). The work is most often cited by research in Molecular Biology (1.5k citations), Cancer Research (236 citations) and Genetics (125 citations). Alfred E. Chappell has collaborated with scholars based in United States, Germany and Switzerland. Frequent co-authors include Punit P. Seth, Eric E. Swayze, Hans Gaus, Thazha P. Prakash, Walt F. Lima, Susan Murray, Erich Koller, Soma De, Thomas M. Vincent and C. Frank Bennett. Their work appears in journals such as Cell, Nucleic Acids Research and Analytical Biochemistry.

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