Tung O. Chan

7.6k citations

51 papers · 6.6k indexed · 2 hit papers · h-index 31

Co-authors: Philip N. Tsichlis Ketaki Datta S E Rittenhouse Thomas Franke Deborah K. Morrison Andrius Kazlauskas David R. Kaplan Sung‐Il Yang
Topics: PI3K/AKT/mTOR signaling in cancer (16 papers)Protein Kinase Regulation and GTPase Signaling (15 papers)Ion channel regulation and function (11 papers)
Cited by: Molecular Biology Immunology and Allergy Immunology
Journals: Cell Proceedings of the National Academy of Sciences Journal of Biological Chemistry
Partner nations: United States Canada Spain

In The Last Decade

Tung O. Chan

51 papers receiving 6.5k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 1.8k citations Thomas Franke, Sung‐Il Yang et al. Cell profile →
AKT/PKB and Other D3 Phosphoinositide-Regulated Kinases: Kinase Activation by Phosphoinositide-Dependent Phosphorylation

1999 835 citations Tung O. Chan, S E Rittenhouse et al. Annual Review of Biochemistry profile →

Peers

Countries citing papers authored by Tung O. Chan

Since Specialization

Citations

This map shows the geographic impact of Tung O. Chan's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Tung O. Chan with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Tung O. Chan more than expected).

Fields of papers citing papers by Tung O. Chan

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Tung O. Chan. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Tung O. Chan. The network helps show where Tung O. Chan may publish in the future.

Co-authorship network of co-authors of Tung O. Chan

This figure shows the co-authorship network connecting the top 25 collaborators of Tung O. Chan. A scholar is included among the top collaborators of Tung O. Chan based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Tung O. Chan. Tung O. Chan is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	AKT inhibition in the central nervous system induces signaling defects resulting in psychiatric symptomatology 2022 ·Cell & Bioscience ·Apostolia M. Tsimberidou,(unknown),Alan Valentine,(unknown),Ursula Hering,Henry Hiep Vo,Tung O. Chan,Roger S. Armen,Jeffrey R. Cottrell,Jen Q. Pan,Philip N. Tsichlis	14
2	A tripartite cooperative mechanism confers resistance of the protein kinase A catalytic subunit to dephosphorylation 2020 ·Journal of Biological Chemistry ·Tung O. Chan,Roger S. Armen,(unknown),Sushrut D. Shah,Jin Zhang,(unknown),(unknown),(unknown),Deepak A. Deshpande,Ulrich Rodeck,Raymond B. Penn	2
3	Regulation of macrophage migration in ischemic mouse hearts via an AKT2/NBA1/SPK1 pathway 2017 ·Oncotarget ·Yanping Yang,Jieqiong Zhao,Juan Zhang,Yonghong Lei,Yuan Fang,Lu Liu,Haibo Gao,Hua Guo,Xiaolin Niu,Rui-Rui Chen,Xiaobing Fu,Yan Han,Hua Han,Tung O. Chan,Lianyou Zhao,Haichang Wang,Qiangsun Zheng,Xue Li	2
4	Autoregulation of kinase dephosphorylation by ATP binding in AGC protein kinases 2012 ·Cell Cycle ·Tung O. Chan,John M. Pascal,Roger S. Armen,Ulrich Rodeck	9
5	Induced Overexpression of Na+/Ca2+ Exchanger Does Not Aggravate Myocardial Dysfunction Induced by Transverse Aortic Constriction 2012 ·Journal of Cardiac Failure ·JuFang Wang,Erhe Gao,Tung O. Chan,Xue-Qian Zhang,Jianliang Song,Xiying Shang,Walter J. Koch,Arthur M. Feldman,Joseph Y. Cheung	17
6	The Interplay between NF-kappaB and E2F1 Coordinately Regulates Inflammation and Metabolism in Human Cardiac Cells 2011 ·PLoS ONE ·Xavier Palomer,David Álvarez-Guardia,Mercy M. Davidson,Tung O. Chan,Arthur M. Feldman,Manuel Vázquez‐Carrera	26
7	The p65 subunit of NF-κB binds to PGC-1α, linking inflammation and metabolic disturbances in cardiac cells 2010 ·Cardiovascular Research ·David Álvarez-Guardia,Xavier Palomer,Teresa Coll,Mercy M. Davidson,Tung O. Chan,Arthur M. Feldman,Juan C. Laguna,Manuel Vázquez‐Carrera	166
8	Review Article: Phospholemman: A Novel Cardiac Stress Protein 2010 ·Clinical and Translational Science ·Joseph Y. Cheung,(unknown),Jianliang Song,Erhe Gao,Joseph E. Rabinowitz,Tung O. Chan,JuFang Wang	23
9	Cardiac‐Restricted Overexpression of the A_2A‐Adenosine Receptor in FVB Mice Transiently Increases Contractile Performance and Rescues the Heart Failure Phenotype in Mice Overexpressing the A₁‐Adenosine Receptor 2008 ·Clinical and Translational Science ·Tung O. Chan,Hajime Funakoshi,Jianliang Song,(unknown),JuFang Wang,Paul H. Chung,Brent R. DeGeorge,Xue Li,Jin Zhang,(unknown),Maura Diamond,Abdullah Hamad,Steven R. Houser,Walter J. Koch,Joseph Y. Cheung,Arthur M. Feldman	19
10	TNF-α reduces PGC-1α expression through NF-κB and p38 MAPK leading to increased glucose oxidation in a human cardiac cell model 2008 ·Cardiovascular Research ·Xavier Palomer,David Álvarez-Guardia,Ricardo Rodríguez‐Calvo,Teresa Coll,Juan C. Laguna,Mercy M. Davidson,Tung O. Chan,Arthur M. Feldman,Manuel Vázquez‐Carrera	150
11	Regulation of cardiac myocyte contractility by phospholemman: Na⁺/Ca²⁺ exchange versus Na⁺-K⁺-ATPase 2008 ·American Journal of Physiology-Heart and Circulatory Physiology ·Jianliang Song,Xue-Qian Zhang,JuFang Wang,(unknown),Tung O. Chan,Arthur M. Feldman,Amy L. Tucker,Joseph Y. Cheung	41
12	AKT and CDK5/p35 Mediate Brain-derived Neurotrophic Factor Induction of DARPP-32 in Medium Size Spiny Neurons in Vitro 2007 ·Journal of Biological Chemistry ·Alexey Bogush,Steve Pedrini,(unknown),Tung O. Chan,Qian Yang,Zixu Mao,(unknown),(unknown),Michelle E. Ehrlich	50
13	Cardioprotection afforded by NF-κB ablation is associated with activation of Akt in mice overexpressing TNF-α 2005 ·American Journal of Physiology-Heart and Circulatory Physiology ·Yoshihiro Higuchi,Tung O. Chan,(unknown),Jin Zhang,Brent R. DeGeorge,Hajime Funakoshi,Gregory A. Gibson,Charles F. McTiernan,Toru Kubota,W. Keith Jones,Arthur M. Feldman	48
14	The Balance Between Pro-Apoptotic and Anti-Apoptotic Pathways in the Failing Myocardium 2003 ·Cardiovascular Toxicology ·Brian McGowan,Eugene Ciccimaro,Tung O. Chan,Arthur M. Feldman	22
15	Small GTPases and tyrosine kinases coregulate a molecular switch in the phosphoinositide 3-kinase regulatory subunit 2002 ·Cancer Cell ·Tung O. Chan,Ulrich Rodeck,Andrew M. Chan,Alec C. Kimmelman,S E Rittenhouse,George Panayotou,Philip N. Tsichlis	122
16	Rit, a non-lipid-modified Ras-related protein, transforms NIH3T3 cells without activating the ERK, JNK, p38 MAPK or PI3K/Akt pathways 2000 ·Oncogene ·Elena V. Rusyn,(unknown),Haipeng Shao,Theresa M. Grana,Tung O. Chan,Douglas Andres,Adrienne D. Cox	41
17	AKT/PKB and Other D3 Phosphoinositide-Regulated Kinases: Kinase Activation by Phosphoinositide-Dependent Phosphorylationbreakdown → 1999 ·Annual Review of Biochemistry ·Tung O. Chan,S E Rittenhouse,Philip N. Tsichlis	835
18	Phosphatidylinositol 3-Kinase Is Required for Integrin-Stimulated AKT and Raf-1/Mitogen-Activated Protein Kinase Pathway Activation 1997 ·Molecular and Cellular Biology ·W G King,(unknown),Tung O. Chan,Philip N. Tsichlis,Joan S. Brugge	390
19	Akt Is a Direct Target of the Phosphatidylinositol 3-Kinase 1996 ·Journal of Biological Chemistry ·Ketaki Datta,Alfonso Bellacosa,Tung O. Chan,Philip N. Tsichlis	243
20	The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinasebreakdown → 1995 ·Cell ·Thomas Franke,Sung‐Il Yang,Tung O. Chan,Ketaki Datta,Andrius Kazlauskas,Deborah K. Morrison,David R. Kaplan,Philip N. Tsichlis	1780

About Tung O. Chan

Tung O. Chan is a scholar working on Physiology, Cardiology and Cardiovascular Medicine and Molecular Biology, having authored 51 papers that have together received 6.6k indexed citations. Recurring topics across this work include PI3K/AKT/mTOR signaling in cancer (16 papers), Protein Kinase Regulation and GTPase Signaling (15 papers) and Ion channel regulation and function (11 papers). The work is most often cited by research in Molecular Biology (4.7k citations), Immunology and Allergy (320 citations) and Immunology (985 citations). Tung O. Chan has collaborated with scholars based in United States, Canada and Spain. Frequent co-authors include Philip N. Tsichlis, Ketaki Datta, S E Rittenhouse, Thomas Franke, Deborah K. Morrison, Andrius Kazlauskas, David R. Kaplan, Sung‐Il Yang, Alfonso Bellacosa and H. Leighton Grimes. Their work appears in journals such as Cell, Proceedings of the National Academy of Sciences and Journal of Biological Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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