John M. Pascal

8.7k total citations · 1 hit paper
90 papers, 6.1k citations indexed

About

John M. Pascal is a scholar working on Molecular Biology, Oncology and Electrical and Electronic Engineering. According to data from OpenAlex, John M. Pascal has authored 90 papers receiving a total of 6.1k indexed citations (citations by other indexed papers that have themselves been cited), including 72 papers in Molecular Biology, 59 papers in Oncology and 25 papers in Electrical and Electronic Engineering. Recurrent topics in John M. Pascal's work include PARP inhibition in cancer therapy (56 papers), DNA Repair Mechanisms (46 papers) and Integrated Circuits and Semiconductor Failure Analysis (23 papers). John M. Pascal is often cited by papers focused on PARP inhibition in cancer therapy (56 papers), DNA Repair Mechanisms (46 papers) and Integrated Circuits and Semiconductor Failure Analysis (23 papers). John M. Pascal collaborates with scholars based in United States, Canada and United Kingdom. John M. Pascal's co-authors include Marie-France Langelier, Jamie L. Planck, Amanda A. Riccio, Tom Ellenberger, Swati Roy, Alan E. Tomkinson, Jamin D. Steffen, Travis Eisemann, Ben E. Black and Michael McCauley and has published in prestigious journals such as Nature, Science and Chemical Reviews.

In The Last Decade

John M. Pascal

90 papers receiving 6.1k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Structural Basis for DNA Damage–Dependent Poly(ADP-ribosyl)ation by Human PARP-1

2012 530 citations Marie-France Langelier, Jamie L. Planck et al. Science profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
John M. Pascal United States	43	4.4k	3.8k	1.1k	1.0k	335	90	6.1k
Ivan Ahel United Kingdom	55	5.4k 1.2×	5.7k 1.5×	930 0.9×	2.4k 2.4×	303 0.9×	136	8.6k
Marie-France Langelier United States	30	2.7k 0.6×	2.9k 0.8×	884 0.8×	695 0.7×	215 0.6×	49	3.9k
Olga I. Lavrik Russia	41	6.4k 1.5×	2.5k 0.7×	401 0.4×	418 0.4×	264 0.8×	407	7.6k
T. Karlberg Sweden	31	2.0k 0.4×	1.4k 0.4×	397 0.4×	609 0.6×	113 0.3×	44	3.1k
Tsunehiro Mizushima Japan	29	4.2k 0.9×	539 0.1×	105 0.1×	502 0.5×	185 0.6×	60	5.5k
W. Tempel Canada	35	3.6k 0.8×	407 0.1×	152 0.1×	329 0.3×	242 0.7×	84	4.4k
Dmitry B. Veprintsev United Kingdom	52	6.1k 1.4×	2.4k 0.6×	57 0.1×	361 0.4×	169 0.5×	108	7.3k
Ben E. Black United States	52	7.0k 1.6×	929 0.2×	225 0.2×	379 0.4×	3.8k 11.4×	100	8.3k
Sirano Dhe‐Paganon United States	47	7.4k 1.7×	1.9k 0.5×	34 0.0×	1.1k 1.1×	164 0.5×	111	8.8k
A. Ruf Switzerland	26	2.2k 0.5×	597 0.2×	117 0.1×	532 0.5×	57 0.2×	36	3.1k

Countries citing papers authored by John M. Pascal

Since Specialization

Citations

This map shows the geographic impact of John M. Pascal's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John M. Pascal with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John M. Pascal more than expected).

Fields of papers citing papers by John M. Pascal

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John M. Pascal. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John M. Pascal. The network helps show where John M. Pascal may publish in the future.

Co-authorship network of co-authors of John M. Pascal

This figure shows the co-authorship network connecting the top 25 collaborators of John M. Pascal. A scholar is included among the top collaborators of John M. Pascal based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with John M. Pascal. John M. Pascal is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Billur, Ramya, et al.. (2025). A PARP2 active site helix melts to permit DNA damage-induced enzymatic activation. Molecular Cell. 85(5). 865–876.e4. 3 indexed citations

Sverzhinsky, Aleksandr, et al.. (2025). Regulation of stress granule maturation and dynamics by poly(ADP-ribose) interaction with PARP13. Nature Communications. 16(1). 621–621. 3 indexed citations

Pascal, John M.. (2023). PARP–nucleic acid interactions: Allosteric signaling, PARP inhibitor types, DNA bridges, and viral RNA surveillance. Current Opinion in Structural Biology. 81. 102643–102643. 4 indexed citations

Kaur, Parminder, Sofiane Y. Mersaoui, Hai Dang Nguyen, et al.. (2023). PARP1 associates with R-loops to promote their resolution and genome stability. Nucleic Acids Research. 51(5). 2215–2237. 58 indexed citations

Pascal, John M., et al.. (2023). Structural and biochemical analysis of the PARP1-homology region of PARP4/vault PARP. Nucleic Acids Research. 51(22). 12492–12507. 9 indexed citations

Yin, Yandong, Carel Fijen, Lianglin Zhang, et al.. (2022). A two-step mechanism governing PARP1-DNA retention by PARP inhibitors. Science Advances. 8(36). eabq0414–eabq0414. 35 indexed citations

Langelier, Marie-France, Ilsa T. Kirby, Daniel S. Bejan, et al.. (2022). Allosteric regulation of DNA binding and target residence time drive the cytotoxicity of phthalazinone-based PARP-1 inhibitors. Cell chemical biology. 29(12). 1694–1708.e10. 7 indexed citations

Yang, Ji‐Chun, Marianne Schimpl, Laura E. Easton, et al.. (2021). Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition. Nucleic Acids Research. 49(4). 2266–2288. 46 indexed citations

Langelier, Marie-France, Ramya Billur, Aleksandr Sverzhinsky, Ben E. Black, & John M. Pascal. (2021). HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications. Nature Communications. 12(1). 6675–6675. 54 indexed citations

10.

Zandarashvili, Levani, Marie-France Langelier, Uday Kiran Velagapudi, et al.. (2020). Structural basis for allosteric PARP-1 retention on DNA breaks. Science. 368(6486). 233 indexed citations

11.

Shao, Zhengping, Brian J. Lee, Marie-France Langelier, et al.. (2020). Clinical PARP inhibitors do not abrogate PARP1 exchange at DNA damage sites in vivo. Nucleic Acids Research. 48(17). 9694–9709. 65 indexed citations

12.

Klein, Jonathon, Yumei Zheng, Travis Eisemann, et al.. (2020). Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase. Cell Reports. 32(3). 107922–107922. 10 indexed citations

13.

Caron, Marie‐Christine, Ajit Kumar Sharma, Julia O’Sullivan, et al.. (2019). Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks. Nature Communications. 10(1). 2954–2954. 141 indexed citations

14.

Chand, Saswati N., Mahsa Zarei, Matthew J. Schiewer, et al.. (2017). Posttranscriptional Regulation of PARG mRNA by HuR Facilitates DNA Repair and Resistance to PARP Inhibitors. Cancer Research. 77(18). 5011–5025. 64 indexed citations

15.

Pascal, John M., et al.. (2016). Evaluating Parp1 domains as gossypol targets. Moscow University Biological Sciences Bulletin. 71(4). 235–239. 2 indexed citations

16.

Riccio, Amanda A., Gino Cingolani, & John M. Pascal. (2015). PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damage. Nucleic Acids Research. 44(4). 1691–1702. 83 indexed citations

17.

Zhang, Miao, Xuan-Yu Meng, Meng Cui, et al.. (2014). Selective phosphorylation modulates the PIP2 sensitivity of the CaM–SK channel complex. Nature Chemical Biology. 10(9). 753–759. 63 indexed citations

18.

Steffen, Jamin D., Renee Tholey, Marie-France Langelier, et al.. (2013). Targeting PARP-1 Allosteric Regulation Offers Therapeutic Potential against Cancer. Cancer Research. 74(1). 31–37. 52 indexed citations

19.

Langelier, Marie-France, Jamie L. Planck, Swati Roy, & John M. Pascal. (2012). Structural Basis for DNA Damage–Dependent Poly(ADP-ribosyl)ation by Human PARP-1. Science. 336(6082). 728–732. 530 indexed citations breakdown →

20.

Langelier, Marie-France, et al.. (2007). A Third Zinc-binding Domain of Human Poly(ADP-ribose) Polymerase-1 Coordinates DNA-dependent Enzyme Activation. Journal of Biological Chemistry. 283(7). 4105–4114. 167 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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