Hirdesh Uppal

2.8k total citations · 1 hit paper
33 papers, 2.0k citations indexed

About

Hirdesh Uppal is a scholar working on Oncology, Molecular Biology and Pharmacology. According to data from OpenAlex, Hirdesh Uppal has authored 33 papers receiving a total of 2.0k indexed citations (citations by other indexed papers that have themselves been cited), including 22 papers in Oncology, 8 papers in Molecular Biology and 7 papers in Pharmacology. Recurrent topics in Hirdesh Uppal's work include Drug Transport and Resistance Mechanisms (9 papers), Pharmacogenetics and Drug Metabolism (6 papers) and Cholesterol and Lipid Metabolism (6 papers). Hirdesh Uppal is often cited by papers focused on Drug Transport and Resistance Mechanisms (9 papers), Pharmacogenetics and Drug Metabolism (6 papers) and Cholesterol and Lipid Metabolism (6 papers). Hirdesh Uppal collaborates with scholars based in United States, China and Spain. Hirdesh Uppal's co-authors include Wen Xie, Songrong Ren, Ying Mu, David Toma, S. P. S. Saini, Haibiao Gong, Jie Zhou, Yonggong Zhai, Ronald M. Evans and Kamen P. Simeonov and has published in prestigious journals such as Science, Journal of Biological Chemistry and Journal of Clinical Oncology.

In The Last Decade

Hirdesh Uppal

33 papers receiving 2.0k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Enzalutamide for the Treatment of Androgen Receptor–Expressing Triple-Negative Breast Cancer

2018 348 citations Hirdesh Uppal et al. profile →

Peers

Hirdesh Uppal

ONCOL

PHARM

SURGE

Aliana Guerrieri‐Gonzaga Italy

Harriet Johansson Italy

Mitsunori Sasa Japan

Sung‐Jig Lim South Korea

Graham P. Pidgeon Ireland

Carsten Rose Sweden

Ina Koch Germany

Daniel R. Schmidt United States

R J Coffey United States

Kouichi Kurose Japan

Aliana Guerrieri‐Gonzaga Italy

Hirdesh Uppal

1.2k ×1.1

ONCOL

970 ×1.7

147 ×0.3

PHARM

181 ×0.4

SURGE

858 ×2.3

Citations per year, relative to Hirdesh Uppal Hirdesh Uppal (= 1×) peers Aliana Guerrieri‐Gonzaga

Countries citing papers authored by Hirdesh Uppal

Since Specialization

Citations

This map shows the geographic impact of Hirdesh Uppal's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Hirdesh Uppal with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Hirdesh Uppal more than expected).

Fields of papers citing papers by Hirdesh Uppal

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Hirdesh Uppal. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Hirdesh Uppal. The network helps show where Hirdesh Uppal may publish in the future.

Co-authorship network of co-authors of Hirdesh Uppal

This figure shows the co-authorship network connecting the top 25 collaborators of Hirdesh Uppal. A scholar is included among the top collaborators of Hirdesh Uppal based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Hirdesh Uppal. Hirdesh Uppal is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Lindquist, Jeffrey N., et al.. (2024). Abstract 4073: Decoy-resistant IL-18 enhances checkpoint inhibitor combinations beyond anti-PD-1 in vitro and in vivo. Cancer Research. 84(6_Supplement). 4073–4073. 3 indexed citations

Moser, Justin C., Ryan J. Sullivan, Matthew H. Taylor, et al.. (2023). 736 A phase 1/2 open-label, dose-escalation study of ST-067, a decoy-resistant IL-18 cytokine, given as a monotherapy and with pembrolizumab in advanced solid tumor malignancies. SHILAP Revista de lepidopterología. A829–A829. 2 indexed citations

Misner, Dinah, M. Ariel Kauss, Jatinder Singh, et al.. (2016). Cardiotoxicity Associated with Nicotinamide Phosphoribosyltransferase Inhibitors in Rodents and in Rat and Human-Derived Cells Lines. Cardiovascular Toxicology. 17(3). 307–318. 18 indexed citations

Tarrant, Jacqueline M., Preeti Dhawan, Jatinder Singh, et al.. (2015). Preclinical models of nicotinamide phosphoribosyltransferase inhibitor-mediated hematotoxicity and mitigation by co-treatment with nicotinic acid. Toxicology Mechanisms and Methods. 25(3). 201–211. 23 indexed citations

Simeonov, Kamen P. & Hirdesh Uppal. (2014). Direct Reprogramming of Human Fibroblasts to Hepatocyte-Like Cells by Synthetic Modified mRNAs. PLoS ONE. 9(6). e100134–e100134. 72 indexed citations

Zabka, Tanja S., Jatinder Singh, Preeti Dhawan, et al.. (2014). Retinal Toxicity, in vivo and in vitro, Associated with Inhibition of Nicotinamide Phosphoribosyltransferase. Toxicological Sciences. 144(1). 163–172. 58 indexed citations

Uppal, Hirdesh, Walter C. Darbonne, Daniela Bumbaca, et al.. (2014). Potential Mechanisms for Thrombocytopenia Development with Trastuzumab Emtansine (T-DM1). Clinical Cancer Research. 21(1). 123–133. 150 indexed citations

Dambach, Donna M. & Hirdesh Uppal. (2012). Improving Risk Assessment. Science Translational Medicine. 4(159). 159ps22–159ps22. 13 indexed citations

Saini, S. P. S., Bin Zhang, Yongdong Niu, et al.. (2010). Activation of liver X receptor increases acetaminophen clearance and prevents its toxicity in mice. Hepatology. 54(6). 2208–2217. 42 indexed citations

10.

Olaharski, Andrew, Hirdesh Uppal, Matthew N. Cooper, et al.. (2009). In vitro to in vivo concordance of a high throughput assay of bone marrow toxicity across a diverse set of drug candidates. Toxicology Letters. 188(2). 98–103. 21 indexed citations

11.

Fielden, Mark R., Hirdesh Uppal, Donald Button, et al.. (2009). Mechanism of subendocardial cell proliferation in the rat and relevance for understanding drug-induced valvular heart disease in humans. Experimental and Toxicologic Pathology. 62(6). 607–613. 7 indexed citations

12.

Olaharski, Andrew, Nina Gonzaludo, David Goldstein, et al.. (2009). Identification of a Kinase Profile that Predicts Chromosome Damage Induced by Small Molecule Kinase Inhibitors. PLoS Computational Biology. 5(7). e1000446–e1000446. 41 indexed citations

13.

Uppal, Hirdesh, et al.. (2008). Activation of liver X receptor sensitizes mice to gallbladder cholesterol crystallization†. Hepatology. 47(4). 1331–1342. 59 indexed citations

14.

Olaharski, Andrew, Silvio Albertini, Stephan Kirchner, et al.. (2008). Evaluation of the GreenScreen GADD45α-GFP indicator assay with non-proprietary and proprietary compounds. Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 672(1). 10–16. 14 indexed citations

15.

Uppal, Hirdesh, S. P. S. Saini, Antonio Moschetta, et al.. (2007). Activation of LXRs prevents bile acid toxicity and cholestasis in female mice. Hepatology. 45(2). 422–432. 108 indexed citations

16.

Zhou, Jie, Yonggong Zhai, Ying Mu, et al.. (2006). A Novel Pregnane X Receptor-mediated and Sterol Regulatory Element-binding Protein-independent Lipogenic Pathway. Journal of Biological Chemistry. 281(21). 15013–15020. 301 indexed citations

17.

Saini, S. P. S., Ying Mu, Haibiao Gong, et al.. (2005). Dual role of orphan nuclear receptor pregnane X receptor in bilirubin detoxification in mice†. Hepatology. 41(3). 497–505. 70 indexed citations

18.

Uppal, Hirdesh, David Toma, S. P. S. Saini, et al.. (2005). Combined loss of orphan receptors PXR and CAR heightens sensitivity to toxic bile acids in mice. Hepatology. 41(1). 168–176. 87 indexed citations

19.

Saini, S. P. S., Junichiro Sonoda, Li Xu, et al.. (2004). A Novel Constitutive Androstane Receptor-Mediated and CYP3A-Independent Pathway of Bile Acid Detoxification. Molecular Pharmacology. 65(2). 292–300. 200 indexed citations

20.

Xie, Wen, Hirdesh Uppal, S. P. S. Saini, et al.. (2004). Orphan nuclear receptor-mediated xenobiotic regulation in drug metabolism. Drug Discovery Today. 9(10). 442–449. 87 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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