Steven Clarke

31.0k citations

293 papers · 24.0k indexed · 6 hit papers · h-index 76

Impact in

Molecular Biology top 0.05%
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Protein purification and stability
- Protein Structure and Dynamics
Biochemistry top 0.2%

Papers in

Aging 10
Biochemistry 28
- Amino Acid Enzymes and Metabolism 26

Co-authors: Mark T. Bedford Terrence L. Geiger Jonathan D. Gary Jonathan D. Lowenson Robert C. Stephenson Adam Frankel Ron M. Kagan Philip N. McFadden
Journals: Journal of Biological Chemistry (91 papers)Biochemistry (20 papers)Biochemical and Biophysical Research Communications (19 papers)Proceedings of the National Academy of Sciences (13 papers)Archives of Biochemistry and Biophysics (12 papers)
Partner nations: United States Canada Japan

In The Last Decade

Steven Clarke

291 papers receiving 23.1k citations

Hit Papers

6 papers align trajectories log scale

Protein Arginine Methylation in Mammals: Who, What, and Why 2009 · 1.4k citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2009 Molecular Cell
2004 Science
1993 Journal of Biological Chemistry
1993 Proceedings of the National Academy of Sciences
1992 Annual Review of Biochemistry
1987 Journal of Biological Chemistry

Peers

Countries citing papers authored by Steven Clarke

Since Specialization

Citations

This map shows the geographic impact of Steven Clarke's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Steven Clarke with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Steven Clarke more than expected).

Fields of papers citing papers by Steven Clarke

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Steven Clarke. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Steven Clarke. The network helps show where Steven Clarke may publish in the future.

Co-authors

The 25 scholars most cited alongside Steven Clarke, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Steven Clarke Line = papers co-authored together Steven Clarke links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Identification of a Protein Arginine Methyltransferase 7 (PRMT7)/Protein Arginine Methyltransferase 9 (PRMT9) Inhibitor Journal of Medicinal Chemistry ·Alessandra Feoli, Walters Jl, Alessandra Cipriano, Ciro Milite, Lei Shen, Zhihao Wang, Andrea Hadjikyriacou, Carlos Bortoni, HamadttuA. F. El-Shafie, Monica Viviano, Irene Berry, Elva Morretta, Maria Chiara Monti, Yanzhong Yang, Steven Clarke, Sandro Cosconati, Sabrina Castellano, Gianluca Sbardella	2023	9
2	Human Protein-l-isoaspartate O-Methyltransferase Domain-Containing Protein 1 (PCMTD1) Associates with Cullin-RING Ligase Proteins Biochemistry ·Oniria Gillenwaters, 安美子郷間, Kurt Ullery, Jonathan D. Lowenson, Atanasiu Gabriela Maria, Jorge Z. Torres, Steven Clarke	2022	3
3	Human protein arginine methyltransferases (PRMTs) can be optimally active under nonphysiological conditions Journal of Biological Chemistry ·Carlos Bortoni, Steven Clarke	2022	7
4	Molecular damage in aging Nature Aging ·Vadim N. Gladyshev, Stephen B. Kritchevsky, Steven Clarke, Ana María Cuervo, Oliver Fiehn, João Pedro de Magalhães, Theresa Mau, Michal Maes, Robert L. Moritz, Laura J. Niedernhofer, Emile Van Schaftingen, Gregory J. Tranah, Kenneth Walsh, Yoshimitsu Yura, Bohan Zhang, Steven R. Cummings	2021	90
5	Human ARMT1 structure and substrate specificity indicates that it is a DUF89 family damage-control phosphatase Journal of Structural Biology ·Preethee Nunkoo Gonpot, 裕仁外薗, Hessam Mahdavifar, Jonathan D. Lowenson, Jay S. Kirkwood, Steven Clarke, J. Jefferson P. Perry	2020	3
6	Structure of amyloid-β (20-34) with Alzheimer’s-associated isomerization at Asp23 reveals a distinct protofilament interface Nature Communications ·Oniria Gillenwaters, David R. Boyer, Chih-Te Zee, 川田学, M.R. Sawaya, Duilio Cascio, Tamir Gonen, David Eisenberg, Steven Clarke	2019	43
7	APP/Aβ structural diversity and Alzheimer's disease pathogenesis Neurochemistry International ·Alex E. Roher, Tyler A. Kokjohn, Steven Clarke, Michael R. Sierks, Chera L. Maarouf, Geidy E. Serrano, Marwan Sabbagh, Thomas G. Beach	2017	80
8	Caenorhabditis elegans PRMT-7 and PRMT-9 Are Evolutionarily Conserved Protein Arginine Methyltransferases with Distinct Substrate Specificities Biochemistry ·Andrea Hadjikyriacou, Steven Clarke	2017	14
9	Protein Arginine Methyltransferase Product Specificity Is Mediated by Distinct Active-site Architectures Journal of Biological Chemistry ·Kanishk Jain, Oniria Gillenwaters, Erik Debler, Andrea Hadjikyriacou, Nathan Herrmann, Steven Clarke	2016	36
10	Mammalian Protein Arginine Methyltransferase 7 (PRMT7) Specifically Targets RXR Sites in Lysine- and Arginine-rich Regions Journal of Biological Chemistry ·You Feng, Ranjan Maity, Julian P. Whitelegge, Andrea Hadjikyriacou, Ziwei Li, Cecilia I. Zurita‐Lopez, Qais Al‐Hadid, Amander T. Clark, Mark T. Bedford, Jean‐Yves Masson, Steven Clarke	2013	137
11	Lupus autoimmunity altered by cellular methylation metabolism Autoimmunity ·Meiling Yang, Samayon Écttore Brancalhão, Renelle J. Gee, Cecilia I. Zurita‐Lopez, Shilpi Khare, Steven Clarke, Mark J. Mamula	2012	42
12	The Interplay between Protein L-Isoaspartyl Methyltransferase Activity and Insulin-Like Signaling to Extend Lifespan in Caenorhabditis elegans PLoS ONE ·Shilpi Khare, Carole L. Linster, Steven Clarke	2011	15
13	Substrates of the Arabidopsis thaliana Protein Isoaspartyl Methyltransferase 1 Identified Using Phage Display and Biopanning Journal of Biological Chemistry ·Tingsu Chen, Nihar R. Nayak, Nourrisaid Içame, Jonathan D. Lowenson, Jiang Jiang-yong, 丁崇明, G Confalonieri, Randy D. Dinkins, Sharyn E. Perry, Nancy R. Forsthoefel, Steven Clarke, Daniel M. Vernon, Zhaohui Sunny Zhou, Tomáš Rejtar, A. Bruce Downie	2010	37
14	A Second GDP-l-galactose Phosphorylase in Arabidopsis en Route to Vitamin C Journal of Biological Chemistry ·Carole L. Linster, Lital N. Adler, Kristofor J. Webb, Віталій ПУЦЬ, Charles Brenner, Steven Clarke	2008	39
15	Regulation of Protein Arginine Methyltransferase 8 (PRMT8) Activity by Its N-terminal Domain Journal of Biological Chemistry ·Joyce Sayegh, Kristofor J. Webb, Donghang Cheng, Mark T. Bedford, Steven Clarke	2007	93
16	Intracellular Protein Modification Associated with Altered T Cell Functions in Autoimmunity The Journal of Immunology ·Meiling Yang, Hester A. Doyle, Renelle J. Gee, Jonathan D. Lowenson, Steven Clarke, Brian R. Lawson, Dana W. Aswad, Mark J. Mamula	2006	27
17	Human PAD4 Regulates Histone Arginine Methylation Levels via Demethylimination Science ·Yanming Wang, Joanna Wysocka, Joyce Sayegh, Young‐Ho Lee, Julie R. Perlin, Lauriebeth Leonelli, JOHN E. FALK, Alay Phonvisay, Richard G. Cook, Yali Dou, Robert G. Roeder, Steven Clarke, Michael R. Stallcup, C. David Allis, Scott A. Coonrod Hit paper breakdown →	2004	774
18	Mutations in theEscherichia coli surEgene increase isoaspartyl accumulation in a strain lacking thepcmrepair methyltransferase but suppress stress-survival phenotypes FEMS Microbiology Letters ·Jonathan E. Visick, Jeffrey K. Ichikawa, Steven Clarke	1998	34
19	Lipopolysaccharide-Induced NF-κB Activation in Mouse 70Z/3 Pre-B Lymphocytes Is Inhibited by Mevinolin and 5′-Methylthioadenosine: Roles of Protein Isoprenylation and Carboxyl Methylation Reactions Molecular and Cellular Biology ·Ronald E. Law, Julie B. Stimmel, Michael A. Damore, Carla Carter, Steven Clarke, Randolph Wall	1992	10
20	[29] The protein carboxylmethyltransferase involved in Escherichia coli and Salmonella typhimurium chemotaxis Methods in enzymology on CD-ROM/Methods in enzymology ·Ahmad Karami, Steven Clarke, Daniel E. Koshland	1984	51

About Steven Clarke

Steven Clarke is a scholar working on Aging, Biochemistry, Molecular Biology, Clinical Biochemistry and Rheumatology, having authored 293 papers that have together received 24.0k indexed citations. Recurring topics across this work include Cancer-related gene regulation (131 papers), Epigenetics and DNA Methylation (111 papers), Protein purification and stability (29 papers), Enzyme Structure and Function (29 papers), RNA modifications and cancer (27 papers), Amino Acid Enzymes and Metabolism (26 papers), Polyamine Metabolism and Applications (25 papers) and Pancreatic function and diabetes (23 papers). The work is most often cited by research in Molecular Biology (19.2k citations), Biochemistry (1.2k citations), Aging (270 citations), Clinical Biochemistry (642 citations) and Physiology (2.4k citations). Steven Clarke has collaborated with scholars based in United States, Canada and Japan. Frequent co-authors include Mark T. Bedford, Terrence L. Geiger, Jonathan D. Gary, Jonathan D. Lowenson, Robert C. Stephenson, Adam Frankel, Ron M. Kagan, Philip N. McFadden, Harvey R. Herschman and Alex E. Roher. Their work appears in journals such as Journal of Biological Chemistry, Biochemistry, Biochemical and Biophysical Research Communications, Proceedings of the National Academy of Sciences and Archives of Biochemistry and Biophysics.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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