Ruben L. Smeets

3.7k citations

46 papers · 2.0k indexed · 1 hit paper · h-index 21

Co-authors: Hans J. P. M. Koenen Irma Joosten Annemieke M. H. Boots Paul Vink Esther van Rijssen Wim B. van den Berg Leo A. B. Joosten Fons A. J. van de Loo
Topics: T-cell and B-cell Immunology (7 papers)Immune Cell Function and Interaction (6 papers)Immune Response and Inflammation (6 papers)
Cited by: Immunology Rheumatology Oncology
Journals: New England Journal of Medicine Blood The Journal of Immunology
Partner nations: Netherlands Germany United States

In The Last Decade

Ruben L. Smeets

42 papers receiving 2.0k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Human CD25highFoxp3pos regulatory T cells differentiate into IL-17–producing cells

2008 604 citations Hans J. P. M. Koenen, Ruben L. Smeets et al. profile →

Peers

Countries citing papers authored by Ruben L. Smeets

Since Specialization

Citations

This map shows the geographic impact of Ruben L. Smeets's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Ruben L. Smeets with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Ruben L. Smeets more than expected).

Fields of papers citing papers by Ruben L. Smeets

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Ruben L. Smeets. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Ruben L. Smeets. The network helps show where Ruben L. Smeets may publish in the future.

Co-authorship network of co-authors of Ruben L. Smeets

This figure shows the co-authorship network connecting the top 25 collaborators of Ruben L. Smeets. A scholar is included among the top collaborators of Ruben L. Smeets based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Ruben L. Smeets. Ruben L. Smeets is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Ex vivo pembrolizumab pharmacology for personalized PD-1 inhibitor therapy reveals a critical gap between receptor occupancy and T cell functionality 2025 ·International Immunopharmacology ·(unknown),Berber Piet,Rob ter Heine,Michel M. van den Heuvel,Ruben L. Smeets,Hans J. P. M. Koenen	0
2	Systemic sclerosis-associated pulmonary arterial hypertension is characterized by a distinct peripheral T helper cell profile 2024 ·Lara D. Veeken ·(unknown),(unknown),A. van Caam,Jacqueline L Vos,E.L. Vitters,(unknown),Sander I. van Leuven,Marije I. Koenders,P.M. van der Kraan,Hans J. P. M. Koenen,Ruben L. Smeets,Robin Nijveldt,Madelon C Vonk,Rogier M. Thurlings	1
3	Development and validation of a bioanalytical assay for the measurement of total and unbound teicoplanin in human serum 2023 ·Journal of Antimicrobial Chemotherapy ·(unknown),J. A. M. Raaijmakers,(unknown),(unknown),Rob ter Heine,Ruben L. Smeets,Roger J. M. Brüggemann,Lindsey te Brake,Nynke G L Jager	5
4	Evidence‐based rationale for low dose nivolumab in critically ill patients with sepsis‐induced immunosuppression 2023 ·Clinical and Translational Science ·(unknown),(unknown),Hans J. P. M. Koenen,Ruben L. Smeets,Berber Piet,Peter Pickkers,Matthijs Kox,Rob ter Heine	10
5	Molecular mechanisms and treatment responses of pulmonary fibrosis in severe COVID-19 2023 ·Respiratory Research ·Emma J. Kooistra,K. Dahm,Antonius E. van Herwaarden,Jelle Gerretsen,(unknown),(unknown),Ruben L. Smeets,(unknown),(unknown),Johannes G. van der Hoeven,Anna C. Aschenbrenner,Joachim L. Schultze,Thomas Ulas,Matthijs Kox,Peter Pickkers	10
6	Severe Immune-Related Enteritis after In Utero Exposure to Pembrolizumab 2023 ·New England Journal of Medicine ·Manuel A. Baarslag,Joosje H. Heimovaara,Jessica S.W. Borgers,Koen van Aerde,Hans J. P. M. Koenen,Ruben L. Smeets,(unknown),Dick Pluim,Shoko Vos,Stefanie Henriet,Jan Willem B. de Groot,Martine van Grotel,Hilde Rosing,Jos H. Beijnen,Alwin D. R. Huitema,John B.A.G. Haanen,Frédéric Amant,(unknown)	14
7	Validation of non-invasive point of care blood content analysis using the TensorTip™ MTX device: a method comparison study 2023 ·Clinical Chemistry and Laboratory Medicine (CCLM) ·(unknown),(unknown),Ruben L. Smeets,An K. Stroobants,Lucas T. van Eijk,Ignacio Malagon,Cornelis Slagt	1
8	CD7 activation regulates cytotoxicity-driven pathology in systemic sclerosis, yielding a target for selective cell depletion 2023 ·Annals of the Rheumatic Diseases ·(unknown),Prashant Singh,A. van Caam,Birgitte Walgreen,Mark A.J. Gorris,E.L. Vitters,(unknown),Marije I. Koenders,Ruben L. Smeets,Madelon C Vonk,(unknown),P.M. van der Kraan,(unknown),Martijn A. Huynen,Hans J. P. M. Koenen,Rogier M. Thurlings	5
9	Trio-based whole exome sequencing in patients with suspected sporadic inborn errors of immunity: A retrospective cohort study 2022 ·eLife ·(unknown),Annet Simons,Janneke Schuurs-Hoeijmakers,(unknown),Evelien Zonneveld‐Huijssoon,Stefanie Henriet,Ellen Schatorjé,Esther Hoppenreijs,Erika Leenders,(unknown),Gijs W.E. Santen,Sonja A. de Munnik,Simon V. van Reijmersdal,Esther van Rijssen,Simone Kersten,Mihai G. Netea,Ruben L. Smeets,Frank L. van de Veerdonk,Alexander Hoischen,Caspar I. van der Made	4
10	Autoantibodies in the disease criteria for systemic sclerosis: The need for specification for optimal application 2022 ·Journal of Translational Autoimmunity ·Jan Damoiseaux,Judith Potjewijd,Ruben L. Smeets,Carolien Bonroy	8
11	Diagnostic profiles for precision medicine in systemic sclerosis; stepping forward from single biomarkers towards pathophysiological panels 2020 ·Autoimmunity Reviews ·Ruben L. Smeets,(unknown),Irma Joosten,(unknown),Wynand Alkema,Hans J. P. M. Koenen,Madelon C Vonk	19
12	Targeting PKC in Human T Cells Using Sotrastaurin (AEB071) Preserves Regulatory T Cells and Prevents IL-17 Production 2013 ·Journal of Investigative Dermatology ·Xuehui He,Hans J. P. M. Koenen,Ruben L. Smeets,R.R.M.C. Keijsers,Esther van Rijssen,(unknown),P C van de Kerkhof,Annemieke M. H. Boots,Irma Joosten	33
13	Molecular pathway profiling of T lymphocyte signal transduction pathways; Th1 and Th2 genomic fingerprints are defined by TCR and CD28-mediated signaling 2012 ·BMC Immunology ·Ruben L. Smeets,Wilco Fleuren,Xuehui He,Paul Vink,(unknown),Monika Górecka,(unknown),(unknown),Anja Garritsen,Hans J. P. M. Koenen,Irma Joosten,Annemieke M. H. Boots,Wynand Alkema	39
14	Structure-based lead identification of ATP-competitive MK2 inhibitors 2011 ·Bioorganic & Medicinal Chemistry Letters ·Tjeerd Barf,Allard Kaptein,(unknown),(unknown),(unknown),Dennis Demont,Carsten Schultz‐Fademrecht,(unknown),(unknown),(unknown),Bert Kazemier,Bas van de Kar,(unknown),(unknown),(unknown),Ruben L. Smeets,Claudia L. Hofstra,Jorrit J. Hornberg,Arthur Oubrie	19
15	A novel role for suppressor of cytokine signaling 3 in cartilage destruction via induction of chondrocyte desensitization toward insulin‐like growth factor 2006 ·Arthritis & Rheumatism ·Ruben L. Smeets,Sharon Veenbergen,Onno J. Arntz,M.B. Bennink,Leo A. B. Joosten,Wim B. van den Berg,Fons A. J. van de Loo	41
16	Inhibition of TNFα during maturation of dendritic cells results in the development of semi-mature cells: a potential mechanism for the beneficial effects of TNFα blockade in rheumatoid arthritis 2004 ·Annals of the Rheumatic Diseases ·Antoine W.T. van Lieshout,Pilar Barrera,Ruben L. Smeets,G. J. Pesman,Piet L. C. M. van Riel,Wim B. van den Berg,Timothy R. D. J. Radstake	45
17	Crucial role of synovial lining macrophages in the promotion of transforming growth factor β–mediated osteophyte formation 2004 ·Arthritis & Rheumatism ·Peter L. E. M. van Lent,Arjen B. Blom,P. van der Kraan,A. E. M. Holthuysen,E.L. Vitters,Nico van Rooijen,Ruben L. Smeets,Karin C. Nabbe,Wim B. van den Berg	153
18	Toll-Like Receptor 2 Pathway Drives Streptococcal Cell Wall-Induced Joint Inflammation: Critical Role of Myeloid Differentiation Factor 88 2003 ·The Journal of Immunology ·Leo A. B. Joosten,Marije I. Koenders,Ruben L. Smeets,(unknown),Monique M. Helsen,Kiyoshi Takeda,Shizuo Akira,Erik Lubberts,Fons A. J. van de Loo,Wim B. van den Berg	181
19	Adenoviral delivery of IL-18 binding protein C ameliorates Collagen-Induced Arthritis in mice 2003 ·Gene Therapy ·Ruben L. Smeets,Fons A. J. van de Loo,Onno J. Arntz,M.B. Bennink,Leo A. B. Joosten,Wim B. van den Berg	71
20	Effectiveness of the soluble form of the interleukin‐1 receptor accessory protein as an inhibitor of interleukin‐1 in collagen‐induced arthritis 2003 ·Arthritis & Rheumatism ·Ruben L. Smeets,Fons A. J. van de Loo,Leo A. B. Joosten,Onno J. Arntz,M.B. Bennink,(unknown),Igor P. Dmitriev,David T. Curiel,Myriam Martin,Wim B. van den Berg	39

About Ruben L. Smeets

Ruben L. Smeets is a scholar working on Immunology, Pathology and Forensic Medicine and Transplantation, having authored 46 papers that have together received 2.0k indexed citations. Recurring topics across this work include T-cell and B-cell Immunology (7 papers), Immune Cell Function and Interaction (6 papers) and Immune Response and Inflammation (6 papers). The work is most often cited by research in Immunology (1.1k citations), Rheumatology (434 citations) and Oncology (365 citations). Ruben L. Smeets has collaborated with scholars based in Netherlands, Germany and United States. Frequent co-authors include Hans J. P. M. Koenen, Irma Joosten, Annemieke M. H. Boots, Paul Vink, Esther van Rijssen, Wim B. van den Berg, Leo A. B. Joosten, Fons A. J. van de Loo, Onno J. Arntz and Marije I. Koenders. Their work appears in journals such as New England Journal of Medicine, Blood and The Journal of Immunology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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