Alexander Hoischen

25.3k citations

142 papers · 8.2k indexed · 3 hit papers · h-index 46

Impact in

Genetics top 0.2%
- Genomics and Rare Diseases
- Genomic variations and chromosomal abnormalities
- Genetics and Neurodevelopmental Disorders
Cancer Research top 2%
- Cancer Genomics and Diagnostics

Papers in

Genetics 72
- Genomics and Rare Diseases 34
- Genomic variations and chromosomal abnormalities 34
- Genetics and Neurodevelopmental Disorders 16
Cancer Research 21
- Cancer Genomics and Diagnostics 17

Co-authors: Joris A. Veltman Christian Gilissen Han G. Brunner Lisenka E.L.M. Vissers Rocío Acuña‐Hidalgo Bregje W.M. van Bon Petra de Vries Bert B.A. de Vries
Journals: European Journal of Human Genetics (11 papers)The American Journal of Human Genetics (11 papers)Human Molecular Genetics (5 papers)Human Mutation (5 papers)Scientific Reports (3 papers)
Partner nations: Netherlands United States Germany

In The Last Decade

Alexander Hoischen

136 papers receiving 8.1k citations

Hit Papers

align trajectories log scale

Diagnostic Exome Sequencing in Persons with Severe Intellectual Disability 2012 · 987 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2012 New England Journal of Medicine
2011 New England Journal of Medicine
2010 Nature Genetics

Peers

Countries citing papers authored by Alexander Hoischen

Since Specialization

Citations

This map shows the geographic impact of Alexander Hoischen's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Alexander Hoischen with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Alexander Hoischen more than expected).

Fields of papers citing papers by Alexander Hoischen

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Alexander Hoischen. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Alexander Hoischen. The network helps show where Alexander Hoischen may publish in the future.

Co-authors

The 25 scholars most cited alongside Alexander Hoischen, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Alexander Hoischen Line = papers co-authored together Alexander Hoischen links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Mitochondrial DNA disease discovery through evaluation of genotype and phenotype data: The Solve-RD experience The American Journal of Human Genetics ·Thiloka Ratnaike, Ida Paramonov, Catarina Olimpio, Alexander Hoischen, Sergi Beltrán, Leslie Matalonga, Rita Horváth	2025	2
2	Long-read technologies identify a hidden LINE-1/ERV1 insertion in IQCB1 as causative variant for Senior-Løken syndrome npj Genomic Medicine ·Suzanne E. de Bruijn, L. Ingeborgh van den Born, Ronny Derks, Lonneke Haer‐Wigman, Luke O’Gorman, Frans P.M. Cremers, Ronald van Beek, Alexander Hoischen, Susanne Roosing, Kornelia Neveling	2025	0
3	IMPRESS: Improved methylation profiling using restriction enzymes and smMIP sequencing, combined with a new biomarker panel, creating a multi-cancer detection assay British Journal of Cancer ·Janah Vandenhoeck, Isabelle Neefs, Thomas Vanpoucke, Joe Ibrahim, Arvid Suls, Dieter Peeters, Anne Schepers, Alexander Hoischen, Erik Fransén, Marc Peeters, Guy Van Camp, Ken Op de Beeck	2024	6
4	Association Between Clonal Hematopoiesis Driver Mutations, Immune Cell Function, and the Vasculometabolic Complications of Obesity Journal of the American Heart Association ·Helin Tercan, Benjamin C. Cossins, Rosanne C. van Deuren, Joost H.W. Rutten, Leo A. B. Joosten, Mihai G. Netea, Alexander Hoischen, Siroon Bekkering, Niels P. Riksen	2024	2
5	Multi-omic profiling of pathogen-stimulated primary immune cells iScience ·Renee Salz, Emil E. Vorsteveld, Caspar I. van der Made, Simone Kersten, Merel Stemerdink, Tabea Riepe, Tsung-han Hsieh, Musa M. Mhlanga, Mihai G. Netea, Pieter‐Jan Volders, Alexander Hoischen, Peter A.C. ’t Hoen	2024	0
6	Clonal Hematopoiesis of Indeterminate Potential From a Heart Failure Specialist's Point of View Journal of the American Heart Association ·Maurits A. Sikking, Sophie L.V.M. Stroeks, Olivia J. Waring, Michiel T.H.M. Henkens, Niels P. Riksen, Alexander Hoischen, Stéphane Heymans, Job A.J. Verdonschot	2023	22
7	Comprehensive SMN1 and SMN2 profiling for spinal muscular atrophy analysis using long-read PacBio HiFi sequencing The American Journal of Human Genetics ·Xiao Chen, John Harting, Emily Farrow, Isabelle Thiffault, Dalia Kasperavičiūtė, Alexander Hoischen, Christian Gilissen, Tomi Pastinen, Michael A. Eberle	2023	36
8	A complex structural variant near SOX3 causes X-linked split-hand/foot malformation Human Genetics and Genomics Advances ·Elke de Boer, Carlo Marcelis, Kornelia Neveling, Ellen van Beusekom, Alexander Hoischen, Willemijn M. Klein, Nicole de Leeuw, Tuomo Mantere, Uirá Souto Melo, Jeroen van Reeuwijk, Dominique Smeets, Malte Spielmann, Tjitske Kleefstra, Hans van Bokhoven, Lisenka E.L.M. Vissers	2023	1
9	Systematic analysis of paralogous regions in 41,755 exomes uncovers clinically relevant variation Nature Communications ·Wouter Steyaert, Lonneke Haer‐Wigman, Rolph Pfundt, Debby M.E.I. Hellebrekers, Marloes Steehouwer, Juliet E. Hampstead, Elke de Boer, Alexander P.A. Stegmann, Helger G. Yntema, Erik‐Jan Kamsteeg, Han G. Brunner, Alexander Hoischen, Christian Gilissen	2023	5
10	Precision oncology using organoids of a secretory carcinoma of the salivary gland treated with TRK-inhibitors Oral Oncology ·Gerben Lassche, Adriana C.H. van Engen - van Grunsven, Onno van Hooij, Tilly Aalders, Jetty A.M. Weijers, Emiliano Cocco, Alexander Drilon, Alexander Hoischen, Kornelia Neveling, Jack A. Schalken, Gerald W. Verhaegh, Carla M.L. van Herpen	2023	3
11	Trio-based whole exome sequencing in patients with suspected sporadic inborn errors of immunity: A retrospective cohort study eLife ·Anne Hebert, Annet Simons, Janneke Schuurs-Hoeijmakers, Hans JPM Koenen, Evelien Zonneveld‐Huijssoon, Stefanie Henriet, Ellen Schatorjé, Esther Hoppenreijs, Erika Leenders, E. Janssen, Gijs W.E. Santen, Sonja A. de Munnik, Simon V. van Reijmersdal, Esther van Rijssen, Simone Kersten, Mihai G. Netea, Ruben L. Smeets, Frank L. van de Veerdonk, Alexander Hoischen, Caspar I. van der Made	2022	4
12	The broader phenotypic spectrum of congenital caudal abnormalities associated with mutations in the caudal type homeobox 2 gene Clinical Genetics ·Servi J.C. Stevens, Constance T. R. M. Stumpel, Karin E. M. Diderich, Marjon A. van Slegtenhorst, Mary‐Alice Abbott, Courtney Manning, Jorune Balciuniene, Louise C. Pyle, Jacqueline Leonard, Jill R. Murrell, Romy van de Putte, Iris A.L.M. van Rooij, Alexander Hoischen, Paul Lasko, Han G. Brunner	2021	6
13	Clinical Validation of Whole Genome Sequencing for Cancer Diagnostics Journal of Molecular Diagnostics ·Paul Roepman, Ewart de Bruijn, Stef van Lieshout, Lieke Schoenmaker, Mirjam C. Boelens, Hendrikus J. Dubbink, Willemina R.R. Geurts-Giele, Floris H. Groenendijk, Manon M. H. Huibers, Mariëtte E.G. Kranendonk, Margaretha G.M. Roemer, Kris G. Samsom, Marloes Steehouwer, Wendy W.J. de Leng, Alexander Hoischen, Bauke Ylstra, Kim Monkhorst, Jacobus J. M. van der Hoeven, Edwin Cuppen	2021	39
14	Resequencing of candidate genes for Keratoconus reveals a role for Ehlers–Danlos Syndrome genes European Journal of Human Genetics ·Erik Fransén, Hanne Valgaeren, Katleen Janssens, Manou Sommen, R. de Ridder, Geert Vandeweyer, Luigi Bisceglia, Vincent Soler, Alexander Hoischen, Geert Mortier, François Malecaze, Carina Koppen, Guy Van Camp	2021	12
15	Optical genome mapping identifies a germline retrotransposon insertion in SMARCB1 in two siblings with atypical teratoid rhabdoid tumors The Journal of Pathology ·Mariangela Sabatella, Tuomo Mantere, Esmé Waanders, Kornelia Neveling, Arjen R. Mensenkamp, Freerk van Dijk, Jayne Y. Hehir‐Kwa, Ronnie Derks, Michael Kwint, Luke O’Gorman, Madalena Tropa Martins, Corrie Gidding, Maarten H. Lequin, Benno Küsters, Pieter Wesseling, Marcel Nelen, Jacklyn Biegel, Alexander Hoischen, Marjolijn C.J. Jongmans, Roland P. Kuiper	2021	28
16	Next-generation phenotyping using computer vision algorithms in rare genomic neurodevelopmental disorders Genetics in Medicine ·Roos van der Donk, Sandra Jansen, Janneke Schuurs-Hoeijmakers, David A. Koolen, Lia Goltstein, Alexander Hoischen, Han G. Brunner, Patrick Kemmeren, Christoffer Nellåker, Lisenka E.L.M. Vissers, Bert B.A. de Vries, Jayne Y. Hehir‐Kwa	2018	13
17	Next-generation DNA sequencing identifies novel gene variants and pathways involved in specific language impairment Scientific Reports ·Xiaowei Sylvia Chen, Rose H. Reader, Alexander Hoischen, Joris A. Veltman, Nuala H. Simpson, Clyde Francks, Dianne F. Newbury, Simon E. Fisher	2017	62
18	Validation and application of a novel integrated genetic screening method to a cohort of 1,112 men with idiopathic azoospermia or severe oligozoospermia Human Mutation ·Manon S. Oud, Liliana Ramos, Moira K. O’Bryan, Robert I. McLachlan, Özlem Okutman, Stéphane Viville, Petra F. de Vries, Dominique Smeets, Dorien Lugtenberg, Jayne Y. Hehir‐Kwa, Christian Gilissen, Maartje de Vorst, Lisenka E.L.M. Vissers, Alexander Hoischen, Aukje M. Meijerink, Kathrin Fleischer, Joris A. Veltman, Michiel J. Noordam	2017	44
19	Accurate detection of low-level mosaic mutations in pediatric acute lymphoblastic leukemia using single molecule tagging and deep-sequencing Leukemia & lymphoma ·Jiangyan Yu, Željko Antić, Simon V. van Reijmersdal, Alexander Hoischen, Edwin Sonneveld, Esmé Waanders, Roland P. Kuiper	2017	5
20	Parent-of-origin-specific signatures of de novo mutations Nature Genetics ·Jakob M. Goldmann, Wendy S.W. Wong, Michele Pinelli, Terry Farrah, Dale L. Bodian, Anna Stittrich, Gustavo Glusman, Lisenka E.L.M. Vissers, Alexander Hoischen, Jared C. Roach, Joseph G. Vockley, Joris A. Veltman, Benjamin D. Solomon, Christian Gilissen, John E. Niederhuber	2016	196

About Alexander Hoischen

Alexander Hoischen is a scholar working on Genetics, Cancer Research, Immunology, Hematology and Molecular Biology, having authored 142 papers that have together received 8.2k indexed citations. Recurring topics across this work include Genomics and Rare Diseases (34 papers), Genomic variations and chromosomal abnormalities (34 papers), Cancer Genomics and Diagnostics (17 papers), Genetics and Neurodevelopmental Disorders (16 papers), Acute Myeloid Leukemia Research (11 papers), Immunodeficiency and Autoimmune Disorders (9 papers), Genomics and Phylogenetic Studies (8 papers) and RNA modifications and cancer (8 papers). The work is most often cited by research in Genetics (4.0k citations), Cancer Research (940 citations), Genetics (659 citations), Molecular Biology (3.9k citations) and Immunology (1.0k citations). Alexander Hoischen has collaborated with scholars based in Netherlands, United States and Germany. Frequent co-authors include Joris A. Veltman, Christian Gilissen, Han G. Brunner, Lisenka E.L.M. Vissers, Rocío Acuña‐Hidalgo, Bregje W.M. van Bon, Petra de Vries, Bert B.A. de Vries, Peer Arts and Joep de Ligt. Their work appears in journals such as European Journal of Human Genetics, The American Journal of Human Genetics, Human Molecular Genetics, Human Mutation and Scientific Reports.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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