A. E. M. Holthuysen
About
A. E. M. Holthuysen is a scholar working on Rheumatology, Immunology and Allergy and Radiology, Nuclear Medicine and Imaging.
According to data from OpenAlex, A. E. M. Holthuysen has authored 26 papers receiving a total of 1.8k indexed citations (citations by other indexed papers that have themselves been cited), including 13 papers in Rheumatology, 13 papers in Immunology and Allergy and 10 papers in Radiology, Nuclear Medicine and Imaging. Recurrent topics in A. E. M. Holthuysen's work include Cell Adhesion Molecules Research (13 papers), Monoclonal and Polyclonal Antibodies Research (10 papers) and Osteoarthritis Treatment and Mechanisms (10 papers). A. E. M. Holthuysen is often cited by papers focused on Cell Adhesion Molecules Research (13 papers), Monoclonal and Polyclonal Antibodies Research (10 papers) and Osteoarthritis Treatment and Mechanisms (10 papers). A. E. M. Holthuysen collaborates with scholars based in Netherlands, United States and Germany. A. E. M. Holthuysen's co-authors include Wim B. van den Berg, Peter L. E. M. van Lent, Arjen B. Blom, Nico van Rooijen, P.M. van der Kraan, Johannes Roth, Karin C. Nabbe, P.L. van Lent, Sten F.W.M. Libregts and Joyce B. J. van Meurs and has published in prestigious journals such as The Journal of Immunology, American Journal Of Pathology and Annals of the Rheumatic Diseases.
In The Last Decade
A. E. M. Holthuysen
26 papers receiving 1.8k citations
Peers
A. E. M. Holthuysen
Thomas Häupl Germany
Gernot Keyszer Germany
Klaus M. Hummel Switzerland
Tsaiwei Olee United States
G. Weseloh Germany
Robert Dinser Germany
Helen Weedon Australia
Ayako Suematsu Japan
Tamás Bárdos United States
Yefu Li United States
Citations per year, relative to A. E. M. Holthuysen A. E. M. Holthuysen (= 1×)
peers
Thomas Häupl
Countries citing papers authored by A. E. M. Holthuysen
Since
Specialization
Citations
This map shows the geographic impact of A. E. M. Holthuysen's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by A. E. M. Holthuysen with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites A. E. M. Holthuysen more than expected).
Fields of papers citing papers by A. E. M. Holthuysen
Since
Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences
This network shows the impact of papers produced by A. E. M. Holthuysen. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by A. E. M. Holthuysen. The network helps show where A. E. M. Holthuysen may publish in the future.
Co-authorship network of co-authors of A. E. M. Holthuysen
This figure shows the co-authorship network connecting the top 25 collaborators of A. E. M. Holthuysen. A scholar is included among the top collaborators of A. E. M. Holthuysen based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with A. E. M. Holthuysen. A. E. M. Holthuysen is excluded from the visualization to improve readability, since they are connected to all nodes in the network.
All Works
1.
Blom, Arjen B., P.L. van Lent, Sten F.W.M. Libregts, et al.. (2006). Crucial role of macrophages in matrix metalloproteinase–mediated cartilage destruction during experimental osteoarthritis : Involvement of matrix metalloproteinase 3. Arthritis & Rheumatism. 56(1). 147–157.
2.
Lent, Peter LEM van, Karin C. Nabbe, Arjen B. Blom, et al.. (2005). NADPH-oxidase-driven oxygen radical production determines chondrocyte death and partly regulates metalloproteinase-mediated cartilage matrix degradation during interferon-γ-stimulated immune complex arthritis. Arthritis Research & Therapy. 7(4). R885–95.
3.
Nabbe, Karin C., Péter Boross, A. E. M. Holthuysen, et al.. (2005). Joint inflammation and chondrocyte death become independent of Fcγ receptor type III by local overexpression of interferon‐γ during immune complex–mediated arthritis. Arthritis & Rheumatism. 52(3). 967–974.
4.
Nabbe, Karin C., Peter LEM van Lent, A. E. M. Holthuysen, et al.. (2005). Local IL-13 gene transfer prior to immune-complex arthritis inhibits chondrocyte death and matrix-metalloproteinase-mediated cartilage matrix degradation despite enhanced joint inflammation. Arthritis Research & Therapy. 7(2). R392–401.
5.
Lent, Peter L. E. M. van, Arjen B. Blom, P. van der Kraan, et al.. (2004). Crucial role of synovial lining macrophages in the promotion of transforming growth factor β–mediated osteophyte formation. Arthritis & Rheumatism. 50(1). 103–111.
6.
Blom, Arjen B., Peter L. E. M. van Lent, A. E. M. Holthuysen, et al.. (2004). Synovial lining macrophages mediate osteophyte formation during experimental osteoarthritis. Osteoarthritis and Cartilage. 12(8). 627–635.
7.
Blom, Arjen B., Timothy R. D. J. Radstake, A. E. M. Holthuysen, et al.. (2003). Increased expression of Fcγ receptors II and III on macrophages of rheumatoid arthritis patients results in higher production of tumor necrosis factor α and matrix metalloproteinase. Arthritis & Rheumatism. 48(4). 1002–1014.
8.
Nabbe, Karin C., Arjen B. Blom, A. E. M. Holthuysen, et al.. (2003). Coordinate expression of activating Fcγ receptors I and III and inhibiting Fcγ receptor type II in the determination of joint inflammation and cartilage destruction during immune complex–mediated arthritis. Arthritis & Rheumatism. 48(1). 255–265.
9.
Nabbe, Karin C., P.L. van Lent, A. E. M. Holthuysen, et al.. (2003). FcγRI Up-Regulation Induced by Local Adenoviral-Mediated Interferon-γ Production Aggravates Chondrocyte Death during Immune Complex-Mediated Arthritis. American Journal Of Pathology. 163(2). 743–752.
10.
Lent, Peter van, Karin C. Nabbe, Péter Boross, et al.. (2003). The Inhibitory Receptor FcγRII Reduces Joint Inflammation and Destruction in Experimental Immune Complex-Mediated Arthritides Not Only by Inhibition of FcγRI/III but Also by Efficient Clearance and Endocytosis of Immune Complexes. American Journal Of Pathology. 163(5). 1839–1848.
11.
Lent, Peter L. E. M. van, A. E. M. Holthuysen, A. Sloëtjes, Erik Lubberts, & Wim B. van den Berg. (2002). Local overexpression of adeno-viral IL-4 protects cartilage from metallo proteinase-induced destruction during immune complex-mediated arthritis by preventing activation of pro-MMPs. Osteoarthritis and Cartilage. 10(3). 234–243.
12.
Lent, Peter L. E. M. van, Karin C. Nabbe, Arjen B. Blom, et al.. (2001). Role of Activatory FcγRI and FcγRIII and Inhibitory FcγRII in Inflammation and Cartilage Destruction during Experimental Antigen-Induced Arthritis. American Journal Of Pathology. 159(6). 2309–2320.
13.
Blom, Arjen B., P.L. van Lent, A. E. M. Holthuysen, et al.. (2000). FcγR expression on macrophages is related to severity and chronicity of synovial inflammation and cartilage destruction during experimental immune-complex-mediated arthritis (ICA). Arthritis Research & Therapy. 2(6). 489–503.
14.
Blom, Arjen B., Peter L. E. M. van Lent, A. E. M. Holthuysen, & Wim B. van den Berg. (1999). IMMUNE COMPLEXES, BUT NOT STREPTOCOCCAL CELL WALLS OR ZYMOSAN, CAUSE CHRONIC ARTHRITIS IN MOUSE STRAINS SUSCEPTIBLE FOR COLLAGEN TYPE II AUTO-IMMUNE ARTHRITIS. Cytokine. 11(12). 1046–1056.
15.
Meurs, Joyce B. J. van, Peter van Lent, A. E. M. Holthuysen, et al.. (1999). Active Matrix Metalloproteinases Are Present in Cartilage During Immune Complex-Mediated Arthritis: A Pivotal Role for Stromelysin-1 in Cartilage Destruction. The Journal of Immunology. 163(10). 5633–5639.
16.
Meurs, Joyce B. J. van, Peter LEM van Lent, A. E. M. Holthuysen, et al.. (1999). Increased vulnerability of postarthritic cartilage to a second arthritic insult: accelerated MMP activity in a flare up of arthritis. Annals of the Rheumatic Diseases. 58(6). 350–356.
17.
Lent, Peter L. E. M. van, A. E. M. Holthuysen, Nico van Rooijen, L.B.A. van de Putte, & Wim B. van den Berg. (1998). Local removal of phagocytic synovial lining cells by clodronate-liposomes decreases cartilage destruction during collagen type II arthritis. Annals of the Rheumatic Diseases. 57(7). 408–413.
18.
Lent, Peter L. E. M. van, A. E. M. Holthuysen, L. A. M. Van Den Bersselaar, et al.. (1996). Phagocytic lining cells determine local expression of inflammation in type II collagen–induced arthritis. Arthritis & Rheumatism. 39(9). 1545–1555.
19.
Lent, Peter LEM van, et al.. (1995). Major role for interleukin 1 but not for tumor necrosis factor in early cartilage damage in immune complex arthritis in mice.. PubMed. 22(12). 2250–8.
20.
Lent, Peter L. E. M. van, A. E. M. Holthuysen, Liduine van den Bersselaar, et al.. (1995). Role of Macrophage-Like Synovial Lining Cells in Localization and Expression of Experimental Arthritis. Scandinavian Journal of Rheumatology. 24(sup101). 83–89.
Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.
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