A. E. M. Holthuysen

2.2k citations

26 papers · 1.8k indexed · h-index 23

Rheumatology top 0.5%
Immunology top 5%
Molecular Biology
Radiology, Nuclear Medicine and Imaging top 5%
Immunology and Allergy top 2%

Co-authors: Wim B. van den Berg Peter L. E. M. van Lent Arjen B. Blom Nico van Rooijen P.M. van der Kraan Johannes Roth Karin C. Nabbe P.L. van Lent
Topics: Cell Adhesion Molecules Research (13 papers)Monoclonal and Polyclonal Antibodies Research (10 papers)Osteoarthritis Treatment and Mechanisms (10 papers)
Cited by: Rheumatology Immunology and Allergy Immunology
Journals: The Journal of Immunology American Journal Of Pathology Annals of the Rheumatic Diseases
Partner nations: Netherlands United States Germany

In The Last Decade

A. E. M. Holthuysen

26 papers receiving 1.8k citations

Peers

Countries citing papers authored by A. E. M. Holthuysen

Since Specialization

Citations

This map shows the geographic impact of A. E. M. Holthuysen's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by A. E. M. Holthuysen with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites A. E. M. Holthuysen more than expected).

Fields of papers citing papers by A. E. M. Holthuysen

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by A. E. M. Holthuysen. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by A. E. M. Holthuysen. The network helps show where A. E. M. Holthuysen may publish in the future.

Co-authorship network of co-authors of A. E. M. Holthuysen

This figure shows the co-authorship network connecting the top 25 collaborators of A. E. M. Holthuysen. A scholar is included among the top collaborators of A. E. M. Holthuysen based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with A. E. M. Holthuysen. A. E. M. Holthuysen is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Crucial role of macrophages in matrix metalloproteinase–mediated cartilage destruction during experimental osteoarthritis : Involvement of matrix metalloproteinase 3 2006 ·Arthritis & Rheumatism ·Arjen B. Blom,P.L. van Lent,Sten F.W.M. Libregts,A. E. M. Holthuysen,P.M. van der Kraan,Nico van Rooijen,Wim B. van den Berg	286
2	NADPH-oxidase-driven oxygen radical production determines chondrocyte death and partly regulates metalloproteinase-mediated cartilage matrix degradation during interferon-γ-stimulated immune complex arthritis 2005 ·Arthritis Research & Therapy ·Peter LEM van Lent,Karin C. Nabbe,Arjen B. Blom,A. Sloëtjes,A. E. M. Holthuysen,Jay K. Kolls,(unknown),Steven M. Holland,Wim B. van den Berg	34
3	Joint inflammation and chondrocyte death become independent of Fcγ receptor type III by local overexpression of interferon‐γ during immune complex–mediated arthritis 2005 ·Arthritis & Rheumatism ·Karin C. Nabbe,Péter Boross,A. E. M. Holthuysen,A. Sloëtjes,Jay K. Kolls,(unknown),Peter L. E. M. van Lent,Wim B. van den Berg	10
4	Local IL-13 gene transfer prior to immune-complex arthritis inhibits chondrocyte death and matrix-metalloproteinase-mediated cartilage matrix degradation despite enhanced joint inflammation 2005 ·Arthritis Research & Therapy ·Karin C. Nabbe,Peter LEM van Lent,A. E. M. Holthuysen,A. Sloëtjes,Alisa E. Koch,Timothy R. D. J. Radstake,Wim B. van den Berg	30
5	Crucial role of synovial lining macrophages in the promotion of transforming growth factor β–mediated osteophyte formation 2004 ·Arthritis & Rheumatism ·Peter L. E. M. van Lent,Arjen B. Blom,P. van der Kraan,A. E. M. Holthuysen,E.L. Vitters,Nico van Rooijen,Ruben L. Smeets,Karin C. Nabbe,Wim B. van den Berg	153
6	Synovial lining macrophages mediate osteophyte formation during experimental osteoarthritis 2004 ·Osteoarthritis and Cartilage ·Arjen B. Blom,Peter L. E. M. van Lent,A. E. M. Holthuysen,P.M. van der Kraan,Johannes Roth,Nico van Rooijen,Wim B. van den Berg	289
7	Increased expression of Fcγ receptors II and III on macrophages of rheumatoid arthritis patients results in higher production of tumor necrosis factor α and matrix metalloproteinase 2003 ·Arthritis & Rheumatism ·Arjen B. Blom,Timothy R. D. J. Radstake,A. E. M. Holthuysen,A. Sloëtjes,Gerard J. Pesman,Fred C.G.J. Sweep,Fons A. J. van de Loo,Leo A. B. Joosten,Pilar Barrera,Peter L. E. M. van Lent,Wim B. van den Berg	70
8	Coordinate expression of activating Fcγ receptors I and III and inhibiting Fcγ receptor type II in the determination of joint inflammation and cartilage destruction during immune complex–mediated arthritis 2003 ·Arthritis & Rheumatism ·Karin C. Nabbe,Arjen B. Blom,A. E. M. Holthuysen,Péter Boross,Johannes Roth,(unknown),Peter L. E. M. van Lent,Wim B. van den Berg	58
9	FcγRI Up-Regulation Induced by Local Adenoviral-Mediated Interferon-γ Production Aggravates Chondrocyte Death during Immune Complex-Mediated Arthritis 2003 ·American Journal Of Pathology ·Karin C. Nabbe,P.L. van Lent,A. E. M. Holthuysen,Jay K. Kolls,Sjef Verbeek,Wim B. van den Berg	25
10	The Inhibitory Receptor FcγRII Reduces Joint Inflammation and Destruction in Experimental Immune Complex-Mediated Arthritides Not Only by Inhibition of FcγRI/III but Also by Efficient Clearance and Endocytosis of Immune Complexes 2003 ·American Journal Of Pathology ·Peter van Lent,Karin C. Nabbe,Péter Boross,Arjen B. Blom,Johannes Roth,A. E. M. Holthuysen,A. Sloëtjes,Sjef Verbeek,W. van den Berg	50
11	Local overexpression of adeno-viral IL-4 protects cartilage from metallo proteinase-induced destruction during immune complex-mediated arthritis by preventing activation of pro-MMPs 2002 ·Osteoarthritis and Cartilage ·Peter L. E. M. van Lent,A. E. M. Holthuysen,A. Sloëtjes,Erik Lubberts,Wim B. van den Berg	36
12	Role of Activatory FcγRI and FcγRIII and Inhibitory FcγRII in Inflammation and Cartilage Destruction during Experimental Antigen-Induced Arthritis 2001 ·American Journal Of Pathology ·Peter L. E. M. van Lent,Karin C. Nabbe,Arjen B. Blom,A. E. M. Holthuysen,A. Sloëtjes,Leo B. A. Van De Putte,Sjef Verbeek,Wim B. van den Berg	73
13	FcγR expression on macrophages is related to severity and chronicity of synovial inflammation and cartilage destruction during experimental immune-complex-mediated arthritis (ICA) 2000 ·Arthritis Research & Therapy ·Arjen B. Blom,P.L. van Lent,(unknown),A. E. M. Holthuysen,Cor Jacobs,L B van de Putte,J G van de Winkel,Wim B. van den Berg	45
14	IMMUNE COMPLEXES, BUT NOT STREPTOCOCCAL CELL WALLS OR ZYMOSAN, CAUSE CHRONIC ARTHRITIS IN MOUSE STRAINS SUSCEPTIBLE FOR COLLAGEN TYPE II AUTO-IMMUNE ARTHRITIS 1999 ·Cytokine ·Arjen B. Blom,Peter L. E. M. van Lent,A. E. M. Holthuysen,Wim B. van den Berg	14
15	Active Matrix Metalloproteinases Are Present in Cartilage During Immune Complex-Mediated Arthritis: A Pivotal Role for Stromelysin-1 in Cartilage Destruction 1999 ·The Journal of Immunology ·Joyce B. J. van Meurs,Peter van Lent,A. E. M. Holthuysen,(unknown),E K Bayne,Irwin Singer,W. van den Berg	62
16	Increased vulnerability of postarthritic cartilage to a second arthritic insult: accelerated MMP activity in a flare up of arthritis 1999 ·Annals of the Rheumatic Diseases ·Joyce B. J. van Meurs,Peter LEM van Lent,(unknown),A. E. M. Holthuysen,E K Bayne,Irwin Singer,Wim B. van den Berg	30
17	Local removal of phagocytic synovial lining cells by clodronate-liposomes decreases cartilage destruction during collagen type II arthritis 1998 ·Annals of the Rheumatic Diseases ·Peter L. E. M. van Lent,A. E. M. Holthuysen,Nico van Rooijen,L.B.A. van de Putte,Wim B. van den Berg	73
18	Phagocytic lining cells determine local expression of inflammation in type II collagen–induced arthritis 1996 ·Arthritis & Rheumatism ·Peter L. E. M. van Lent,A. E. M. Holthuysen,L. A. M. Van Den Bersselaar,Nico van Rooijen,Leo A. B. Joosten,Fons A. J. van de Loo,L. B. A. van de Putte,Wim B. van den Berg	62
19	Major role for interleukin 1 but not for tumor necrosis factor in early cartilage damage in immune complex arthritis in mice. 1995 ·PubMed ·Peter LEM van Lent,F.A. van de Loo,A. E. M. Holthuysen,Liduine A. van den Bersselaar,(unknown),Wim B. van den Berg	71
20	Role of Macrophage-Like Synovial Lining Cells in Localization and Expression of Experimental Arthritis 1995 ·Scandinavian Journal of Rheumatology ·Peter L. E. M. van Lent,A. E. M. Holthuysen,Liduine van den Bersselaar,Nico van Rooijen,L.B.A. van de Putte,Wim B. van den Berg	24

About A. E. M. Holthuysen

A. E. M. Holthuysen is a scholar working on Immunology and Allergy, Rheumatology and Immunology, having authored 26 papers that have together received 1.8k indexed citations. Recurring topics across this work include Cell Adhesion Molecules Research (13 papers), Monoclonal and Polyclonal Antibodies Research (10 papers) and Osteoarthritis Treatment and Mechanisms (10 papers). The work is most often cited by research in Rheumatology (1.1k citations), Immunology and Allergy (307 citations) and Immunology (640 citations). A. E. M. Holthuysen has collaborated with scholars based in Netherlands, United States and Germany. Frequent co-authors include Wim B. van den Berg, Peter L. E. M. van Lent, Arjen B. Blom, Nico van Rooijen, P.M. van der Kraan, Johannes Roth, Karin C. Nabbe, P.L. van Lent, Sten F.W.M. Libregts and Joyce B. J. van Meurs. Their work appears in journals such as The Journal of Immunology, American Journal Of Pathology and Annals of the Rheumatic Diseases.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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