Pamela J. McLean

24.5k total citations · 4 hit papers
112 papers, 12.0k citations indexed

About

Pamela J. McLean is a scholar working on Neurology, Cellular and Molecular Neuroscience and Physiology. According to data from OpenAlex, Pamela J. McLean has authored 112 papers receiving a total of 12.0k indexed citations (citations by other indexed papers that have themselves been cited), including 81 papers in Neurology, 41 papers in Cellular and Molecular Neuroscience and 38 papers in Physiology. Recurrent topics in Pamela J. McLean's work include Parkinson's Disease Mechanisms and Treatments (79 papers), Alzheimer's disease research and treatments (30 papers) and Nerve injury and regeneration (13 papers). Pamela J. McLean is often cited by papers focused on Parkinson's Disease Mechanisms and Treatments (79 papers), Alzheimer's disease research and treatments (30 papers) and Nerve injury and regeneration (13 papers). Pamela J. McLean collaborates with scholars based in United States, Germany and Canada. Pamela J. McLean's co-authors include Bradley T. Hyman, Jochen Klucken, Tiago F. Outeiro, Youngah Shin, Hibiki Kawamata, Darius Ebrahimi‐Fakhari, Karin M. Danzer, Eliezer Masliah, Preeti Putcha and Marion Delenclos and has published in prestigious journals such as Science, Cell and Proceedings of the National Academy of Sciences.

In The Last Decade

Pamela J. McLean

109 papers receiving 11.9k citations

Hit Papers

align trajectories sort by overperformance

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies

2011 1.0k citations Pamela J. McLean et al. profile →
Sirtuin 2 Inhibitors Rescue α-Synuclein-Mediated Toxicity in Models of Parkinson's Disease

2007 853 citations Tiago F. Outeiro, Stephen M. Altmann et al. Science profile →
Exosomal cell-to-cell transmission of alpha synuclein oligomers

2012 690 citations Charles Vanderburg, Pamela J. McLean et al. profile →
Widespread distribution of α-synuclein oligomers in LRRK2-related Parkinson’s disease

2025 14 citations Owen A. Ross, Pamela J. McLean et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Pamela J. McLean United States	55	6.4k	4.3k	4.3k	3.7k	2.2k	112	12.0k
Mel Β. Feany United States	54	5.2k 0.8×	5.4k 1.3×	4.8k 1.1×	4.8k 1.3×	2.0k 0.9×	106	13.4k
Tiago F. Outeiro Germany	71	8.3k 1.3×	6.4k 1.5×	5.3k 1.2×	4.6k 1.2×	2.0k 0.9×	341	16.9k
Leonidas Stefanis Greece	55	7.4k 1.2×	4.8k 1.1×	3.6k 0.8×	3.6k 1.0×	2.1k 0.9×	277	13.4k
Dimitri Krainc United States	57	5.0k 0.8×	8.3k 1.9×	4.5k 1.0×	4.8k 1.3×	2.4k 1.1×	135	15.5k
Philipp J. Kahle Germany	56	6.9k 1.1×	5.0k 1.1×	3.0k 0.7×	3.7k 1.0×	1.2k 0.6×	124	11.9k
Miquel Vila Spain	64	8.9k 1.4×	6.0k 1.4×	4.1k 0.9×	6.8k 1.9×	1.3k 0.6×	125	17.5k
William T. Dauer United States	39	6.2k 1.0×	3.5k 0.8×	1.6k 0.4×	4.5k 1.2×	1.3k 0.6×	91	10.6k
Vernice Jackson‐Lewis United States	58	8.7k 1.4×	5.9k 1.4×	3.5k 0.8×	7.6k 2.1×	1.1k 0.5×	92	17.9k
Darren J. Moore United States	49	6.8k 1.1×	4.5k 1.0×	2.6k 0.6×	2.8k 0.8×	1.7k 0.8×	86	10.2k
Robert L. Nussbaum United States	39	9.6k 1.5×	4.4k 1.0×	4.2k 1.0×	5.2k 1.4×	1.5k 0.7×	54	14.1k

Countries citing papers authored by Pamela J. McLean

Since Specialization

Citations

This map shows the geographic impact of Pamela J. McLean's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Pamela J. McLean with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Pamela J. McLean more than expected).

Fields of papers citing papers by Pamela J. McLean

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Pamela J. McLean. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Pamela J. McLean. The network helps show where Pamela J. McLean may publish in the future.

Co-authorship network of co-authors of Pamela J. McLean

This figure shows the co-authorship network connecting the top 25 collaborators of Pamela J. McLean. A scholar is included among the top collaborators of Pamela J. McLean based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Pamela J. McLean. Pamela J. McLean is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Neves, Sofia Pereira das, Yingxue Ren, Chiara Starvaggi Cucuzza, et al.. (2024). Meningeal lymphatic function promotes oligodendrocyte survival and brain myelination. Immunity. 57(10). 2328–2343.e8. 12 indexed citations

Olney, Kimberly C., Aleksandra Wojtas, Michael DeTure, et al.. (2024). Distinct transcriptional alterations distinguish Lewy body disease from Alzheimer’s disease. Brain. 148(1). 69–88. 3 indexed citations

McLean, Pamela J., et al.. (2023). Post‐inflammatory administration of N‐acetylcysteine reduces inflammation and alters receptor levels in a cellular model of Parkinson's disease. FASEB BioAdvances. 5(7). 263–276. 4 indexed citations

Boschen, Suelen L., Aishe Kurti, Virginia Phillips, et al.. (2023). Investigating the Pathogenic Interplay of Alpha-Synuclein, Tau, and Amyloid Beta in Lewy Body Dementia: Insights from Viral-Mediated Overexpression in Transgenic Mouse Models. Biomedicines. 11(10). 2863–2863. 3 indexed citations

Burgess, Jeremy D., et al.. (2020). In Vivo Detection of Extracellular Adenosine Triphosphate in a Mouse Model of Traumatic Brain Injury. Journal of Neurotrauma. 38(5). 655–664. 23 indexed citations

Delenclos, Marion, Jeremy D. Burgess, Agaristi Lamprokostopoulou, et al.. (2019). Cellular models of alpha‐synuclein toxicity and aggregation. Journal of Neurochemistry. 150(5). 566–576. 85 indexed citations

Delenclos, Marion, Teodora Trendafilova, Simon Moussaud, et al.. (2017). Investigation of Endocytic Pathways for the Internalization of Exosome-Associated Oligomeric Alpha-Synuclein. Frontiers in Neuroscience. 11. 172–172. 92 indexed citations

Lam, Hoa A., Michael Helwig, Nikolai Lorenzen, et al.. (2016). The neural chaperone proSAAS blocks α-synuclein fibrillation and neurotoxicity. Proceedings of the National Academy of Sciences. 113(32). E4708–15. 35 indexed citations

Hou, Steven S., William E. Klunk, Chester A. Mathis, et al.. (2013). Development and Screening of Contrast Agents for In Vivo Imaging of Parkinson’s Disease. Molecular Imaging and Biology. 15(5). 585–595. 20 indexed citations

10.

Unni, Vivek K., Tamily A. Weissman, Edward Rockenstein, et al.. (2010). In Vivo Imaging of α-Synuclein in Mouse Cortex Demonstrates Stable Expression and Differential Subcellular Compartment Mobility. PLoS ONE. 5(5). e10589–e10589. 46 indexed citations

11.

Unni, Vivek K., Darius Ebrahimi‐Fakhari, Charles Vanderburg, Pamela J. McLean, & Bradley T. Hyman. (2010). Studying protein degradation pathways in vivo using a cranial window-based approach. Methods. 53(3). 194–200. 3 indexed citations

12.

Chen, Li, Xu Wang, Alessandro Negro, et al.. (2009). Tyrosine and serine phosphorylation of α-synuclein have opposing effects on neurotoxicity and soluble oligomer formation. Journal of Clinical Investigation. 119(11). 3257–65. 171 indexed citations

13.

Outeiro, Tiago F., Stephen M. Altmann, Irina Kufareva, et al.. (2007). Sirtuin 2 Inhibitors Rescue α-Synuclein-Mediated Toxicity in Models of Parkinson's Disease. Science. 317(5837). 516–519. 853 indexed citations breakdown →

14.

Yacoubian, Talene A., et al.. (2007). Transcriptional dysregulation in a transgenic model of Parkinson disease. Neurobiology of Disease. 29(3). 515–528. 53 indexed citations

15.

Outeiro, Tiago F., Stephen M. Altmann, Michele M. Maxwell, et al.. (2006). Pharmacological promotion of inclusion formation: A therapeutic approach for Huntington’s and Parkinson’s diseases. Proceedings of the National Academy of Sciences. 103(11). 4246–4251. 203 indexed citations

16.

Klucken, Jochen, Tiago F. Outeiro, Paul Nguyen, Pamela J. McLean, & Bradley T. Hyman. (2006). Detection of novel intracellular O‐synuclein oligomeric species by fluorescence lifetime imaging. The FASEB Journal. 20(12). 2050–2057. 69 indexed citations

17.

Klucken, Jochen, Youngah Shin, Bradley T. Hyman, & Pamela J. McLean. (2004). A single amino acid substitution differentiates Hsp70-dependent effects on α-synuclein degradation and toxicity. Biochemical and Biophysical Research Communications. 325(1). 367–373. 32 indexed citations

18.

Klucken, Jochen, Youngah Shin, Eliezer Masliah, Bradley T. Hyman, & Pamela J. McLean. (2004). Hsp70 Reduces α-Synuclein Aggregation and Toxicity. Journal of Biological Chemistry. 279(24). 25497–25502. 419 indexed citations

19.

McLean, Pamela J., Hibiki Kawamata, Scott Ribich, & Bradley T. Hyman. (2000). Membrane Association and Protein Conformation of α-Synuclein in Intact Neurons. Journal of Biological Chemistry. 275(12). 8812–8816. 211 indexed citations

20.

McLean, Pamela J., et al.. (2000). A Minimal Promoter for the GABA_A Receptor α6‐Subunit Gene Controls Tissue Specificity. Journal of Neurochemistry. 74(5). 1858–1869. 20 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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