Matthew E. Gegg

9.3k citations

44 papers · 4.0k indexed · 2 hit papers · h-index 29

Impact in

Neurology top 0.5%
- Parkinson's Disease Mechanisms and Treatments
Physiology top 1%
- Lysosomal Storage Disorders Research
- Alzheimer's disease research and treatments
- Calcium signaling and nucleotide metabolism

Papers in

Neurology 23
- Parkinson's Disease Mechanisms and Treatments 21
Physiology 27
- Lysosomal Storage Disorders Research 22
- Nitric Oxide and Endothelin Effects 4

Co-authors: Anthony H.V. Schapira Jonathan M. Cooper Kai‐Yin Chau Jan‐Willem Taanman Manuel Rojo Simon Heales Joana Magalhães Nicholas Wood
Journals: Human Molecular Genetics (6 papers)Neurobiology of Disease (5 papers)Journal of Neurochemistry (3 papers)Scientific Reports (2 papers)Brain (2 papers)
Partner nations: United Kingdom United States Germany

In The Last Decade

Matthew E. Gegg

43 papers receiving 3.9k citations

Hit Papers

align trajectories log scale

Glucocerebrosidase deficiency in substantia nigra of parkinson disease brains 2012 · 440 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2012 Annals of Neurology
2010 Human Molecular Genetics

Peers

Countries citing papers authored by Matthew E. Gegg

Since Specialization

Citations

This map shows the geographic impact of Matthew E. Gegg's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Matthew E. Gegg with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Matthew E. Gegg more than expected).

Fields of papers citing papers by Matthew E. Gegg

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Matthew E. Gegg. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Matthew E. Gegg. The network helps show where Matthew E. Gegg may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Matthew E. Gegg, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Matthew E. Gegg Line = papers co-authored together Matthew E. Gegg links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Lysosomal TPC2 channels disrupt Ca2+ entry and dopaminergic function in models of LRRK2-Parkinson’s disease The Journal of Cell Biology ·Irené Dahl, Gustavo J.S. Pereira, J. V. STEWART, T. Imai, Kai‐Yin Chau, Xinjiang Cai, Ana Cely Rafael-Rubio, Stephen R. Bolsover, Marco Keller, Kathryn M. Grady, W. T. Lynn, Kirsten Harvey, Franz Bracher, Christian Grimm, Gaiti Hasan, Matthew E. Gegg, Anthony H.V. Schapira, Sean T. Sweeney, Sandip Patel	2025	3
2	The influence of the glymphatic system on α-synuclein propagation: the role of aquaporin-4 Brain ·Douglas M. Lopes, Jaime L. Kennedy, George Yohannes, 飯室芳男, Jack A. Wells, Matthew E. Gegg, Guglielmo Verona, Mark F. Lythgoe, Ian F. Harrison	2025	1
3	Combined assessment of blood glucocerebrosidase activity and α-synuclein levels in GBA1 mutation carriers: A novel potential biomarker Parkinsonism & Related Disorders ·Micol Avenali, Silvia Paola Caminiti, Matthew E. Gegg, Silvia Cerri, J. Owusu-Banahene, Rodionov Vg, Marco Toffoli, Derralynn Hughes, Chiara Cerami, Cristina Tassorelli, Enza Maria Valente, Anthony H.V. Schapira, Fabio Blandini	2025	1
4	α-Synuclein expression in response to bacterial ligands and metabolites in gut enteroendocrine cells: an in vitro proof of concept study Brain Communications ·Michael J. Hurley, Elisa Menozzi, Douglas St. Angelo, 武桜田, Matthew E. Gegg, Kai‐Yin Chau, Hervé M. Blottière, Jane Macnaughtan, Anthony H.V. Schapira	2023	6
5	The GBA variant E326K is associated with alpha-synuclein aggregation and lipid droplet accumulation in human cell lines Human Molecular Genetics ·Laura Smith, Wang I-Hsuan, Kai‐Yin Chau, Matthew E. Gegg, Anthony H.V. Schapira	2022	12
6	Glucocerebrosidase activity, cathepsin D and monomeric α-synuclein interactions in a stem cell derived neuronal model of a PD associated GBA1 mutation Neurobiology of Disease ·E. Shuvalova, Matthew E. Gegg, David Chau, Anthony H.V. Schapira	2019	37
7	Ablation of the pro-inflammatory master regulator miR-155 does not mitigate neuroinflammation or neurodegeneration in a vertebrate model of Gaucher's disease Neurobiology of Disease ·Lisa Watson, Marcus Keatinge, Matthew E. Gegg, Qing Bai, Surajit Sinha, Ayelet Vardi, Anthony H. Futerman, Anthony H.V. Schapira, Edward A. Burton, Oliver Bandmann	2019	18
8	The role of DJ-1 complexes and catecholamine metabolism: relevance for familial and idiopathic Parkinson’s disease Neural Regeneration Research ·Matthew E. Gegg, Bliss Adrian Richards	2018	7
9	Parkinson disease-linked GBA mutation effects reversed by molecular chaperones in human cell and fly models Scientific Reports ·Álvaro Sánchez-Martínez, Michelle Beavan, Matthew E. Gegg, Kai‐Yin Chau, Alexander J. Whitworth, Anthony H.V. Schapira	2016	120
10	Mitochondrial and lysosomal biogenesis are activated following PINK1/parkin‐mediated mitophagy Journal of Neurochemistry ·Davor Ivankovic, Kai‐Yin Chau, Anthony H.V. Schapira, Matthew E. Gegg	2015	209
11	Endoplasmic reticulum and lysosomal Ca2+ stores are remodelled in GBA1-linked Parkinson disease patient fibroblasts Cell Calcium ·Bethan S. Kilpatrick, Joana Magalhães, Michelle Beavan, Alisdair McNeill, Matthew E. Gegg, Michael W. J. Cleeter, Duncan Bloor-Young, Grant C. Churchill, Michael R. Duchen, Anthony H.V. Schapira, Sandip Patel	2015	64
12	Mitochondrial impairment increases FL-PINK1 levels by calcium-dependent gene expression Neurobiology of Disease ·Rubén Gómez‐Sánchez, Matthew E. Gegg, José Manuel Bravo‐San Pedro, Mireia Niso‐Santano, Lydia Alvarez‐Erviti, Elisa Pizarro‐Estrella, Yolanda Gutiérrez‐Martín, Alberto Álvarez, José M. Fuentes, Rosa A. González‐Polo, Anthony H.V. Schapira	2013	44
13	Glucocerebrosidase deficiency in substantia nigra of parkinson disease brains Annals of Neurology ·Matthew E. Gegg, Derek Burke, Simon Heales, Jonathan M. Cooper, John Hardy, Nicholas Wood, Anthony H.V. Schapira Hit paper breakdown →	2012	440
14	PINK1-parkin-dependent mitophagy involves ubiquitination of mitofusins 1 and 2: Implications for Parkinson disease pathogenesis Autophagy ·Matthew E. Gegg, Anthony H.V. Schapira	2011	79
15	Bioenergetic Consequences of PINK1 Mutations in Parkinson Disease PLoS ONE ·Andrey Y. Abramov, Matthew E. Gegg, Anne Grünewald, Nicholas Wood, Christine Klein, Anthony H.V. Schapira	2011	84
16	Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy Human Molecular Genetics ·Matthew E. Gegg, Jonathan M. Cooper, Kai‐Yin Chau, Manuel Rojo, Anthony H.V. Schapira, Jan‐Willem Taanman Hit paper breakdown →	2010	732
17	Differential effects of PINK1 nonsense and missense mutations on mitochondrial function and morphology Experimental Neurology ·Anne Grünewald, Matthew E. Gegg, Jan‐Willem Taanman, R. H. M. King, Norman Kock, Christine Klein, Anthony H.V. Schapira	2009	86
18	Suppression of Autoimmune Retinal Disease by Lovastatin Does Not Require Th2 Cytokine Induction The Journal of Immunology ·Matthew E. Gegg, Rachel A. Harry, Deborah J.R. Hankey, Hadi Zambarakji, Gareth Pryce, David Baker, Peter Adamson, Virginia L. Calder, John Greenwood	2005	59
19	Co-culture of neurones with glutathione deficient astrocytes leads to increased neuronal susceptibility to nitric oxide and increased glutamate-cysteine ligase activity Brain Research ·Matthew E. Gegg, J. B. Clark, Simon Heales	2005	57
20	Preservation of extracellular glutathione by an astrocyte derived factor with properties comparable to extracellular superoxide dismutase Journal of Neurochemistry ·Victoria C. Stewart, F. Rashidi, Matthew E. Gegg, Martyn A. Sharpe, Roger D. Hurst, John B. Clark, Simon Heales	2002	47

About Matthew E. Gegg

Matthew E. Gegg is a scholar working on Neurology, Physiology, Cell Biology, Biochemistry and Physiology, having authored 44 papers that have together received 4.0k indexed citations. Recurring topics across this work include Lysosomal Storage Disorders Research (22 papers), Parkinson's Disease Mechanisms and Treatments (21 papers), Cellular transport and secretion (15 papers), Autophagy in Disease and Therapy (9 papers), Nitric Oxide and Endothelin Effects (4 papers), Mitochondrial Function and Pathology (4 papers), Sulfur Compounds in Biology (4 papers) and Retinal Development and Disorders (3 papers). The work is most often cited by research in Neurology (1.8k citations), Physiology (1.8k citations), Physiology (300 citations), Cell Biology (1.0k citations) and Neurology (393 citations). Matthew E. Gegg has collaborated with scholars based in United Kingdom, United States and Germany. Frequent co-authors include Anthony H.V. Schapira, Jonathan M. Cooper, Kai‐Yin Chau, Jan‐Willem Taanman, Manuel Rojo, Simon Heales, Joana Magalhães, Nicholas Wood, John Hardy and Derek Burke. Their work appears in journals such as Human Molecular Genetics, Neurobiology of Disease, Journal of Neurochemistry, Scientific Reports and Brain.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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