Lawrence Lum

8.7k citations

64 papers · 6.5k indexed · 2 hit papers · h-index 37

Impact in

Molecular Biology top 1%
- Hedgehog Signaling Pathway Studies
- Wnt/β-catenin signaling in development and cancer
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Developmental Biology and Gene Regulation
- Renal and related cancers
- CRISPR and Genetic Engineering
Immunology and Allergy top 1%
- Cell Adhesion Molecules Research

Papers in

Molecular Biology 53
- Wnt/β-catenin signaling in development and cancer 18
- Cancer-related gene regulation 13
- Hedgehog Signaling Pathway Studies 13
- Epigenetics and DNA Methylation 12
- RNA Interference and Gene Delivery 5
- Genomics and Chromatin Dynamics 5
- Signaling Pathways in Disease 5
Immunology and Allergy 4

Co-authors: Philip A. Beachy Carl Blobel Chuo Chen Michael Dodge James F. Amatruda Shenqin Yao Noelle S. Williams Chih-Wei Fan
Journals: Journal of Biological Chemistry (9 papers)Science (5 papers)Proceedings of the National Academy of Sciences (5 papers)Molecular and Cellular Biology (3 papers)Bioorganic & Medicinal Chemistry Letters (2 papers)
Partner nations: United States Germany Italy

In The Last Decade

Lawrence Lum

63 papers receiving 6.4k citations

Hit Papers

align trajectories log scale

Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer 2009 · 1.1k citations

Peers

Countries citing papers authored by Lawrence Lum

Since Specialization

Citations

This map shows the geographic impact of Lawrence Lum's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Lawrence Lum with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Lawrence Lum more than expected).

Fields of papers citing papers by Lawrence Lum

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Lawrence Lum. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Lawrence Lum. The network helps show where Lawrence Lum may publish in the future.

Co-authors

The 25 scholars most cited alongside Lawrence Lum, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Lawrence Lum Line = papers co-authored together Lawrence Lum links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase Cell Reports ·Ying-Juan Luo, Jonathon Klein, Yumei Zheng, Christian Mai, Travis Eisemann, Klementina Fon Tacer, Darcie J. Miller, Sheila Flynn, Tatum Wilhelm, David Finkelstein, Geoffrey Neale, Heather Tillman, Peter Vogel, Douglas W. Strand, Lawrence Lum, Chad A. Brautigam, John M. Pascal, Wilson K. Clements, Patrick Ryan Potts	2020	10
2	Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1 Journal of Biological Chemistry ·Kevin Ryan, Ben Bolaños, Marissa L. Smith, Prakash B. Palde, И. С. Казловский, Todd VanArsdale, Sherry Niessen, Lianglin Zhang, Douglas C. Behenna, Martha A. Ornelas, Khanh Tran, Stephen E. Kaiser, Lawrence Lum, Al Stewart, K.S. Gajiwala	2020	54
3	CRISPR-Cas9-based mutagenesis frequently provokes on-target mRNA misregulation Nature Communications ·Rubina Tuladhar, Yunku Yeu, John T. Piazza, Zhen Tan, Jean R. Clemenceau, Xiaofeng Wu, Risca Octaviyani Hutapea, Techale Tilet, David H. Mathews, James Kim, Tae Hyun Hwang, Lawrence Lum	2019	147
4	Stereoselective fatty acylation is essential for the release of lipidated WNT proteins from the acyltransferase Porcupine (PORCN) Journal of Biological Chemistry ·Rubina Tuladhar, Y Strainers, Yuyong Ma, Chengwei Zhang, Techale Tilet, James Kim, Chuo Chen, Lawrence Lum	2019	15
5	EGF Receptor and mTORC1 Are Novel Therapeutic Targets in Nonseminomatous Germ Cell Tumors Molecular Cancer Therapeutics ·Kenneth Chen, Niang Coumba Diouf, Abhay A. Shukla, Emily K. Stroup, 明美庄司, Nadiya Destriantari, T Banta Gary, Kiyoshi Yamaguchi, Payal Kapur, A. Lindsay Frazier, Lawrence Lum, Leendert H. J. Looijenga, Theodore W. Laetsch, Dinesh Rakheja, James F. Amatruda	2018	11
6	Chemical Modulation of WNT Signaling in Cancer Progress in molecular biology and translational science ·姚圣, Lawrence Lum	2018	17
7	Development of a triazole class of highly potent Porcn inhibitors Bioorganic & Medicinal Chemistry Letters ·Lin You, Chengwei Zhang, Y Strainers, Lorraine Morlock, Xiaolei Wang, Li-Shu Zhang, Noelle S. Williams, Lawrence Lum, Chuo Chen	2016	22
8	Delivery of the Porcupine Inhibitor WNT974 in Mice Methods in molecular biology ·姚圣, Lawrence Lum	2016	14
9	Identification of Therapeutic Small-Molecule Leads in Cultured Cells Using Multiplexed Pathway Reporter Readouts Methods in molecular biology ·Sheila Flynn, Kiyoshi Yamaguchi, Lawrence Lum	2014	1
10	The Hedgehog Pathway Effector Smoothened Exhibits Signaling Competency in the Absence of Ciliary Accumulation Chemistry & Biology ·Chih-Wei Fan, Baozhi Chen, Irene Franco, Jianming Lü, Heping Shi, Shuguang Wei, Changguang Wang, Xiaofeng Wu, Wei Tang, Michael G. Roth, Noelle S. Williams, Emilio Hirsch, Chuo Chen, Lawrence Lum	2014	20
11	A Targeted RNAi Screen of the Breast Cancer Genome Identifies KIF14 and TLN1 as Genes That Modulate Docetaxel Chemosensitivity in Triple-Negative Breast Cancer Clinical Cancer Research ·Stina Mui Singel, Crystal Cornelius, Kimberly Batten, E. R. Cross, Woodring E. Wright, Lawrence Lum, Jerry W. Shay	2013	54
12	In vivo Wnt signaling tracing through a transgenic biosensor fish reveals novel activity domains Developmental Biology ·Enrico Moro, Günes Özhan, Alessandro Mongera, Dimitris Beis, Claudia Wierzbicki, Rodrigo Young, 真一伊野, Alice Domenichini, Leonardo E. Valdivia, Lawrence Lum, Chuo Chen, James F. Amatruda, Natascia Tiso, Gilbert Weidinger, Francesco Argenton	2012	188
13	Interaction between tumor and myeloid cells induce/expand Th17 cells in malignant gliomas (48.28) The Journal of Immunology ·Prahlad Parajuli, Sandeep Mittal, Sreenivasa R. Chinni, Lawrence Lum, Archana Thakur, Murali Guthikonda	2011	1
14	Tankyrase is necessary for canonical Wnt signaling during kidney development Developmental Dynamics ·Courtney M. Karner, Calli E. Merkel, Michael Dodge, Zhiqiang Ma, Jianming Lü, Chuo Chen, Lawrence Lum, Thomas J. Carroll	2010	36
15	The Ihog Cell-Surface Proteins Bind Hedgehog and Mediate Pathway Activation Cell ·Shenqin Yao, Lawrence Lum, Philip A. Beachy	2006	188
16	Hedgehog Signal Transduction via Smoothened Association with a Cytoplasmic Complex Scaffolded by the Atypical Kinesin, Costal-2 Molecular Cell ·Lawrence Lum, Chi Zhang, Sekyung Oh, Randall K. Mann, Doris P. von Kessler, Jussi Taipale, Frances Weis‐Garcia, Ruoyu Gong, Baolin Wang, Philip A. Beachy	2003	196
17	Biochemical and Pharmacological Criteria Define Two Shedding Activities for TRANCE/OPGL That Are Distinct from the Tumor Necrosis Factor α Convertase Journal of Biological Chemistry ·Johannes Schlöndorff, Lawrence Lum, Carl Blobel	2001	113
18	Cloning and Initial Characterization of Mouse Meltrin β and Analysis of the Expression of Four MetalloproteaseDisintegrins in Bone Cells Journal of Biological Chemistry ·Daisuke Inoue, Martha S. Reid, Lawrence Lum, Jörn Krätzschmar, Gisela Weskamp, Andreas Neuenschwander, Roland Baron, Carl Blobel	1998	83
19	Intracellular Maturation of the Mouse Metalloprotease Disintegrin MDC15 Journal of Biological Chemistry ·Lawrence Lum, Martha S. Reid, Carl Blobel	1998	141
20	Evidence for Distinct Serine Protease Activities with a Potential Role in Processing the Sperm Protein Fertilin Developmental Biology ·Lawrence Lum, Carl Blobel	1997	90

About Lawrence Lum

Lawrence Lum is a scholar working on Molecular Biology, Immunology and Allergy, Cancer Research, Oncology and Genetics, having authored 64 papers that have together received 6.5k indexed citations. Recurring topics across this work include Wnt/β-catenin signaling in development and cancer (18 papers), Cancer-related gene regulation (13 papers), Hedgehog Signaling Pathway Studies (13 papers), Epigenetics and DNA Methylation (12 papers), RNA Interference and Gene Delivery (5 papers), Peptidase Inhibition and Analysis (5 papers), Genomics and Chromatin Dynamics (5 papers) and Signaling Pathways in Disease (5 papers). The work is most often cited by research in Molecular Biology (5.3k citations), Immunology and Allergy (457 citations), Oncology (1.2k citations), Cancer Research (613 citations) and Cell Biology (652 citations). Lawrence Lum has collaborated with scholars based in United States, Germany and Italy. Frequent co-authors include Philip A. Beachy, Carl Blobel, Chuo Chen, Michael Dodge, James F. Amatruda, Shenqin Yao, Noelle S. Williams, Chih-Wei Fan, Michael G. Roth and Jianming Lü. Their work appears in journals such as Journal of Biological Chemistry, Science, Proceedings of the National Academy of Sciences, Molecular and Cellular Biology and Bioorganic & Medicinal Chemistry Letters.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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