Jan de Wit

8.2k citations

54 papers · 6.7k indexed · 2 hit papers · h-index 32

Impact in

Aging top 0.5%
- Genetics, Aging, and Longevity in Model Organisms
Endocrine and Autonomic Systems top 0.5%
- Circadian rhythm and melatonin

Papers in

Cancer Research 12
- Carcinogens and Genotoxicity Assessment 12
Molecular Biology 47
- DNA Repair Mechanisms 37
- CRISPR and Genetic Engineering 16
- Genomics and Chromatin Dynamics 5
- DNA and Nucleic Acid Chemistry 4
- Glycosylation and Glycoproteins Research 3
- Cancer therapeutics and mechanisms 3

Co-authors: Jan H.J. Hoeijmakers D. Bootsma Gijsbertus T. J. van der Horst Geert Weeda Christine Troelstra Harry van Steeg Roland Kanaar Alain J. van Gool
Journals: Molecular and Cellular Biology (9 papers)DNA repair (4 papers)Cell (4 papers)Human Genetics (4 papers)PLoS Biology (4 papers)
Partner nations: Netherlands United States France

In The Last Decade

Jan de Wit

54 papers receiving 6.5k citations

Hit Papers

align trajectories log scale

Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms 1999 · 1.1k citations

Peers

Countries citing papers authored by Jan de Wit

Since Specialization

Citations

This map shows the geographic impact of Jan de Wit's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Jan de Wit with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Jan de Wit more than expected).

Fields of papers citing papers by Jan de Wit

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Jan de Wit. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Jan de Wit. The network helps show where Jan de Wit may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Jan de Wit, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Jan de Wit Line = papers co-authored together Jan de Wit links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Disruption of TTDA Results in Complete Nucleotide Excision Repair Deficiency and Embryonic Lethality PLoS Genetics ·Arjan F. Theil, Julie Nonnekens, Barbara Steurer, Pierre‐Olivier Mari, Jan de Wit, Charlène Lemaître, Jurgen A. Marteijn, Anja Raams, Alex Maas, Marcel Vermeij, Jeroen Essers, Jan H.J. Hoeijmakers, Giuseppina Giglia‐Mari, Wim Vermeulen	2013	28
2	Differentiation Driven Changes in the Dynamic Organization of Basal Transcription Initiation PLoS Biology ·Giuseppina Giglia‐Mari, Arjan F. Theil, Pierre‐Olivier Mari, J. Sieler, Julie Nonnekens, Lise O. Andrieux, Jan de Wit, Catherine Miquel, Nils Wijgers, Alex Maas, Maria Fousteri, Jan H.J. Hoeijmakers, Wim Vermeulen	2009	42
3	A link between the accumulation of DNA damage and loss of multi‐potency of human mesenchymal stromal cells Journal of Cellular and Molecular Medicine ·Md Abu Zafor, Ursula Muñoz-Nájar, Jan de Wit, Justyna Wojtczak, Jan H.J. Hoeijmakers, John M. Sedivy, Clemens van Blitterswijk, Jan de Boer	2009	71
4	Impaired Genome Maintenance Suppresses the Growth Hormone–Insulin-Like Growth Factor 1 Axis in Mice with Cockayne Syndrome PLoS Biology ·Ingrid van der Pluijm, George A. Garinis, Renata M. C. Brandt, Theo G. M. F. Gorgels, S. Wijnhoven, Karin E. M. Diderich, Jan de Wit, James R. Mitchell, Conny van Oostrom, Rudolf B. Beems, Laura J. Niedernhofer, Susana Velasco, Errol C. Friedberg, Kiyoji Tanaka, Harry van Steeg, Jan H.J. Hoeijmakers, Gijsbertus T. J. van der Horst	2006	195
5	Repair characteristics and differentiation propensity of long-term cultures of epidermal keratinocytes derived from normal and NER-deficient mice DNA repair ·Claude Backendorf, Jan de Wit, Marijke van Oosten, Marta Casimiro Barbosa de Mora Moraes, James R. Mitchell, И.В. Буякова, Gijsbertus T. J. van der Horst, Frank R. de Gruijl, Jaap Brouwer, Leon H.F. Mullenders, Jan H.J. Hoeijmakers	2005	20
6	Selective DNA damage responses in murine Xpa−/−, Xpc−/− and Csb−/− keratinocyte cultures DNA repair ·Marta Casimiro Barbosa de Mora Moraes, Marijke van Oosten, Wulan Asriati, Jan de Wit, Wilbert P. Vermeij, Leon H.F. Mullenders, Frank R. de Gruijl, Claude Backendorf	2005	16
7	The Structure-Specific Endonuclease Ercc1-Xpf Is Required To Resolve DNA Interstrand Cross-Link-Induced Double-Strand Breaks Molecular and Cellular Biology ·Laura J. Niedernhofer, Hanny Odijk, Magda Budzowska, Ellen van Drunen, Alex Maas, Arjan F. Theil, Jan de Wit, N.G.J. Jaspers, H. Berna Beverloo, Jan H.J. Hoeijmakers, Roland Kanaar	2004	407
8	Premature Aging in Mice Deficient in DNA Repair and Transcription Science ·Jan de Boer, Jaan‐Olle Andressoo, Jan de Wit, J. G. M. Huijmans, Olabode O.S, Harry van Steeg, Geert Weeda, Gijsbertus T. J. van der Horst, G. Sanniti diBaja, Axel P. N. Themmen, M. Meradji, Jan H.J. Hoeijmakers	2002	426
9	Cell type-specific hypersensitivity to oxidative damage in CSB and XPA mice DNA repair ·Harm de Waard, Jan de Wit, Theo G. M. F. Gorgels, Siegfried Mattl, Jaan‐Olle Andressoo, Marcel Vermeij, Harry van Steeg, Jan H.J. Hoeijmakers, Gijsbertus T. J. van der Horst	2002	118
10	UVB radiation-induced cancer predisposition in Cockayne syndrome group A (Csa) mutant mice DNA repair ·Gijsbertus T. J. van der Horst, Lisiane B. Meira, Theo G. M. F. Gorgels, Jan de Wit, Susana Velasco-Miguel, James A. Richardson, T Parameshwaran, Maaike P.G. Vreeswijk, Bep Smit, D. Bootsma, Jan H.J. Hoeijmakers, Errol C. Friedberg	2002	81
11	Mouse Rad54 affects DNA conformation and DNA-damage-induced Rad51 foci formation Current Biology ·Thomas Tan, Jeroen Essers, Elisabetta Citterio, Sigrid Swagemakers, Jan de Wit, Fiona E. Benson, Jan H.J. Hoeijmakers, Roland Kanaar	1999	176
12	A Mouse Model for the Basal Transcription/DNA Repair Syndrome Trichothiodystrophy Molecular Cell ·Jan de Boer, Jan de Wit, Harry van Steeg, Rob J. W. Berg, Hans Morreau, Pim Visser, Alan R. Lehmann, Marinus Durán, A. Casanova, Geert Weeda	1998	161
13	Molecular Basis of DNA Repair Mechanisms and Syndromes Recent results in cancer research ·Geert Weeda, Jan de Boer, Ibn Khallikan, Jan de Wit, G. Sebastiaan Winkler, Gijsbertus T. J. van der Horst, Wim Vermeulen, D. Bootsma, Jan H.J. Hoeijmakers	1998	4
14	Defective Transcription-Coupled Repair in Cockayne Syndrome B Mice Is Associated with Skin Cancer Predisposition Cell ·Gijsbertus T. J. van der Horst, Harry van Steeg, Rob J. W. Berg, Alain J. van Gool, Jan de Wit, Geert Weeda, Hans Morreau, Rudolf B. Beems, Coen F. van Kreijl, Frank R. de Gruijl, D. Bootsma, Jan H.J. Hoeijmakers	1997	278
15	Inactivation of the HR6B Ubiquitin-Conjugating DNA Repair Enzyme in Mice Causes Male Sterility Associated with Chromatin Modification Cell ·Henk P. Roest, Justin Blair, Jan de Wit, Mehebubar Rahaman, Marcel Koken, Marcel Vermey, J. H. van Roijen, Jos W. Hoogerbrugge, J. T. M. Vreeburg, W. M. Baarends, D. Bootsma, J. Anton Grootegoed, Jan H.J. Hoeijmakers	1996	325
16	Expression of the Ubiquitin-Conjugating DNA Repair Enzymes HHR6A and B Suggests a Role in Spermatogenesis and Chromatin Modification Developmental Biology ·Marcel Koken, Jos W. Hoogerbrugge, Sui Moy, Jan de Wit, Rob Willemsen, Henk P. Roest, J. Anton Grootegoed, Jan H.J. Hoeijmakers	1996	77
17	DNA repair characteristics and mutability of the UV-sensitive V79 Chinese hamster cell mutant V-B11 (complementation group 7) Mutagenesis ·M.Z. Zdzienicka, David L. Mitchell, Jaap Venema, Anneke van Hoffen, A.A. van Zeeland, Leon H.F. Mullenders, Jan de Wit, J.W.I.M. Simons	1991	7
18	Molecular Cloning of the Human DNA Excision Repair Gene ERCC-6 Molecular and Cellular Biology ·Christine Troelstra, Hanny Odijk, Jan de Wit, A. Westerveld, L.H. Thompson, D. Bootsma, Jan H.J. Hoeijmakers	1990	27
19	Regional mapping of the human No. 1 and X chromosome in interspecific cell hybrids using an X/1 translocation Cytogenetic and Genome Research ·Jan de Wit, D. Bootsma, P. Pearson, A. Westerveld	1975	3
20	UV-induced DNA repair synthesis in cells of patients with different forms of xeroderma pigmentosum and of heterozygotes Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis ·Wim J. Kleijer, E.A. de Weerd-Kastelein, M. Luzzaa, W. Keijzer, Jan de Wit, D. Bootsma	1973	75

About Jan de Wit

Jan de Wit is a scholar working on Cancer Research, Molecular Biology, Aging, Genetics and Biotechnology, having authored 54 papers that have together received 6.7k indexed citations. Recurring topics across this work include DNA Repair Mechanisms (37 papers), CRISPR and Genetic Engineering (16 papers), Carcinogens and Genotoxicity Assessment (12 papers), Genomics and Chromatin Dynamics (5 papers), DNA and Nucleic Acid Chemistry (4 papers), Glycosylation and Glycoproteins Research (3 papers), Cancer therapeutics and mechanisms (3 papers) and Cancer-related Molecular Pathways (3 papers). The work is most often cited by research in Aging (452 citations), Endocrine and Autonomic Systems (990 citations), Cancer Research (1.3k citations), Molecular Biology (5.2k citations) and Oncology (939 citations). Jan de Wit has collaborated with scholars based in Netherlands, United States and France. Frequent co-authors include Jan H.J. Hoeijmakers, D. Bootsma, Gijsbertus T. J. van der Horst, Geert Weeda, Christine Troelstra, Harry van Steeg, Roland Kanaar, Alain J. van Gool, Wim Vermeulen and Hanny Odijk. Their work appears in journals such as Molecular and Cellular Biology, DNA repair, Cell, Human Genetics and PLoS Biology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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