Wouter de Laat

25.0k total citations · 8 hit papers
105 papers, 16.6k citations indexed

About

Wouter de Laat is a scholar working on Molecular Biology, Plant Science and Genetics. According to data from OpenAlex, Wouter de Laat has authored 105 papers receiving a total of 16.6k indexed citations (citations by other indexed papers that have themselves been cited), including 102 papers in Molecular Biology, 33 papers in Plant Science and 16 papers in Genetics. Recurrent topics in Wouter de Laat's work include Genomics and Chromatin Dynamics (81 papers), RNA Research and Splicing (39 papers) and Chromosomal and Genetic Variations (29 papers). Wouter de Laat is often cited by papers focused on Genomics and Chromatin Dynamics (81 papers), RNA Research and Splicing (39 papers) and Chromosomal and Genetic Variations (29 papers). Wouter de Laat collaborates with scholars based in Netherlands, United States and United Kingdom. Wouter de Laat's co-authors include Erik Splinter, Frank Grosveld, Elzo de Wit, Robert‐Jan Palstra, Petra Klous, Jan H.J. Hoeijmakers, N.G.J. Jaspers, Bas Tolhuis, Marieke Simonis and Denis Duboule and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Wouter de Laat

103 papers receiving 16.4k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions

2008 1.4k citations Wouter de Laat, Bas van Steensel et al. profile →
Looping and Interaction between Hypersensitive Sites in the Active β-globin Locus

2002 1.0k citations Robert‐Jan Palstra, Erik Splinter et al. profile →
Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture–on-chip (4C)

2006 1.0k citations Marieke Simonis, Petra Klous et al. Nature Genetics profile →
Molecular mechanism of nucleotide excision repair

1999 900 citations Wouter de Laat et al. Genes & Development profile →
Quantitative analysis of chromosome conformation capture assays (3C-qPCR)

2007 553 citations Petra Klous, Erik Splinter et al. Nature Protocols profile →
CTCF mediates long-range chromatin looping and local histone modification in the β-globin locus

2006 546 citations Erik Splinter, Jurgen Kooren et al. Genes & Development profile →
A decade of 3C technologies: insights into nuclear organization

2012 520 citations Elzo de Wit, Wouter de Laat Genes & Development profile →
CTCF Binding Polarity Determines Chromatin Looping

2015 448 citations Elzo de Wit, Sjoerd J.B. Holwerda et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Wouter de Laat Netherlands	62	15.1k	3.4k	2.7k	1.6k	931	105	16.6k
Wendy A. Bickmore United Kingdom	71	16.0k 1.1×	3.2k 0.9×	3.8k 1.4×	860 0.5×	597 0.6×	185	17.9k
Boris Lenhard United Kingdom	52	10.4k 0.7×	1.6k 0.5×	2.2k 0.8×	1.7k 1.1×	969 1.0×	132	12.7k
Geneviève Almouzni France	76	17.1k 1.1×	3.1k 0.9×	1.7k 0.7×	927 0.6×	656 0.7×	198	18.4k
Joanna Wysocka United States	51	16.6k 1.1×	2.0k 0.6×	2.4k 0.9×	2.7k 1.7×	1.4k 1.5×	112	19.5k
Bradley R. Cairns United States	73	16.1k 1.1×	2.1k 0.6×	2.4k 0.9×	1.2k 0.8×	829 0.9×	141	18.4k
Mariano Rocchi Italy	55	7.4k 0.5×	3.7k 1.1×	4.3k 1.6×	783 0.5×	1.4k 1.5×	321	11.6k
Craig L. Peterson United States	68	17.0k 1.1×	2.2k 0.6×	1.7k 0.6×	1.0k 0.6×	1.2k 1.3×	180	18.4k
Victor G. Corces United States	72	16.4k 1.1×	6.1k 1.8×	2.9k 1.1×	854 0.5×	942 1.0×	194	18.4k
Kenneth S. Zaret United States	56	11.5k 0.8×	1000 0.3×	2.2k 0.8×	1.4k 0.9×	810 0.9×	121	14.1k
Peter J. Sabo United States	21	8.5k 0.6×	2.0k 0.6×	2.1k 0.8×	702 0.4×	882 0.9×	41	10.2k

Countries citing papers authored by Wouter de Laat

Since Specialization

Citations

This map shows the geographic impact of Wouter de Laat's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Wouter de Laat with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Wouter de Laat more than expected).

Fields of papers citing papers by Wouter de Laat

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Wouter de Laat. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Wouter de Laat. The network helps show where Wouter de Laat may publish in the future.

Co-authorship network of co-authors of Wouter de Laat

This figure shows the co-authorship network connecting the top 25 collaborators of Wouter de Laat. A scholar is included among the top collaborators of Wouter de Laat based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Wouter de Laat. Wouter de Laat is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Verstegen, Marjon J.A.M., et al.. (2025). Long-range enhancer-controlled genes are hypersensitive to regulatory factor perturbations. Cell Genomics. 5(3). 100778–100778. 7 indexed citations

Verstegen, Marjon J.A.M., Jeffrey van Haren, Peter H.L. Krijger, et al.. (2025). Reactivation of developmentally silenced globin genes through forced linear recruitment of remote enhancers. Blood. 146(6). 732–744.

Smits, Willem K., Carlo Vermeulen, Shunsuke Kimura, et al.. (2023). Elevated enhancer-oncogene contacts and higher oncogene expression levels by recurrent CTCF inactivating mutations in acute T cell leukemia. Cell Reports. 42(4). 112373–112373. 5 indexed citations

Krijger, Peter H.L., Alva Biran, Theo van Laar, et al.. (2023). CAF-1 deposits newly synthesized histones during DNA replication using distinct mechanisms on the leading and lagging strands. Nucleic Acids Research. 51(8). 3770–3792. 21 indexed citations

Stelloo, Ellen, Ruud W. J. Meijers, Joost F. Swennenhuis, et al.. (2023). Formalin-Fixed, Paraffin-Embedded–Targeted Locus Capture. Journal of Molecular Diagnostics. 25(10). 758–770. 3 indexed citations

Krijger, Peter H.L., Benoît Van Driessche, Caroline Vanhulle, et al.. (2022). Role of the cellular factor CTCF in the regulation of bovine leukemia virus latency and three-dimensional chromatin organization. Nucleic Acids Research. 50(6). 3190–3202. 8 indexed citations

Laat, Wouter de, et al.. (2020). Novel orthogonal methods to uncover the complexity and diversity of nuclear architecture. Current Opinion in Genetics & Development. 67. 10–17. 7 indexed citations

Huang, Yike, Roel Neijts, & Wouter de Laat. (2020). How chromosome topologies get their shape: views from proximity ligation and microscopy methods. FEBS Letters. 594(21). 3439–3449. 3 indexed citations

Vermeulen, Carlo, Amin Allahyar, Britta A. M. Bouwman, et al.. (2020). Multi-contact 4C: long-molecule sequencing of complex proximity ligation products to uncover local cooperative and competitive chromatin topologies. Nature Protocols. 15(2). 364–397. 30 indexed citations

10.

Duijvenboden, Karel van, Peter H.L. Krijger, Ingeborg B. Hooijkaas, et al.. (2020). Genetic Dissection of a Super Enhancer Controlling the Nppa-Nppb Cluster in the Heart. Circulation Research. 128(1). 115–129. 33 indexed citations

11.

Boogaard, Malou van den, Jan Hendrik van Weerd, Ingeborg B. Hooijkaas, et al.. (2019). Identification and Characterization of a Transcribed Distal Enhancer Involved in Cardiac Kcnh2 Regulation. Cell Reports. 28(10). 2704–2714.e5. 14 indexed citations

12.

Marks, Harold G., Hindrik H. D. Kerstens, Erik Splinter, et al.. (2016). Dynamics of gene silencing during X inactivation using allele-specific RNA-seq (vol 16, 149, 2015). Genome biology. 17. 2–3. 11 indexed citations

13.

Wit, Elzo de & Wouter de Laat. (2012). A decade of 3C technologies: insights into nuclear organization. Genes & Development. 26(1). 11–24. 520 indexed citations breakdown →

14.

Werken, Harmen J.G. van de, Erik Splinter, Sjoerd J.B. Holwerda, et al.. (2012). 4C Technology: Protocols and Data Analysis. Methods in enzymology on CD-ROM/Methods in enzymology. 513. 89–112. 162 indexed citations

15.

Noordermeer, Daan, Marion Leleu, Erik Splinter, et al.. (2011). The Dynamic Architecture of Hox Gene Clusters. Science. 334(6053). 222–225. 291 indexed citations

16.

Hakim, Ofir, Myong‐Hee Sung, Ty C. Voss, et al.. (2011). Diverse gene reprogramming events occur in the same spatial clusters of distal regulatory elements. Genome Research. 21(5). 697–706. 111 indexed citations

17.

Laat, Wouter de, Petra Klous, Jurgen Kooren, et al.. (2008). Chapter 5 Three‐Dimensional Organization of Gene Expression in Erythroid Cells. Current topics in developmental biology. 82. 117–139. 60 indexed citations

18.

Simonis, Marieke & Wouter de Laat. (2008). FISH-eyed and genome-wide views on the spatial organisation of gene expression. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1783(11). 2052–2060. 24 indexed citations

19.

Simonis, Marieke, Petra Klous, Erik Splinter, et al.. (2006). Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture–on-chip (4C). Nature Genetics. 38(11). 1348–1354. 1020 indexed citations breakdown →

20.

Splinter, Erik, Frank Grosveld, & Wouter de Laat. (2003). 3C Technology: Analyzing the Spatial Organization of Genomic Loci In Vivo. Methods in enzymology on CD-ROM/Methods in enzymology. 375. 493–507. 102 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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