Wouter de Laat

25.0k citations

105 papers · 16.6k indexed · 8 hit papers · h-index 62

Impact in

Molecular Biology top 0.1%
- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- DNA Repair Mechanisms
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- CRISPR and Genetic Engineering
Cancer Research top 1%

Papers in

Molecular Biology 102
- Genomics and Chromatin Dynamics 81
- RNA Research and Splicing 39
- Epigenetics and DNA Methylation 17
- RNA and protein synthesis mechanisms 15
- RNA modifications and cancer 11
- DNA Repair Mechanisms 9
Plant Science 33
- Chromosomal and Genetic Variations 29

Co-authors: Erik Splinter Frank Grosveld Elzo de Wit Robert‐Jan Palstra Petra Klous Jan H.J. Hoeijmakers N.G.J. Jaspers Bas Tolhuis
Journals: Genes & Development (10 papers)Molecular Cell (8 papers)Genome biology (6 papers)Nucleic Acids Research (6 papers)Cell Reports (4 papers)
Partner nations: Netherlands United States United Kingdom

In The Last Decade

Wouter de Laat

103 papers receiving 16.4k citations

Hit Papers

8 papers align trajectories log scale

CTCF Binding Polarity Determines Chromatin Looping 2015 · 448 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2015 Molecular Cell
2012 Genes & Development
2008 Nature
2007 Nature Protocols
2006 Genes & Development
2006 Nature Genetics
2002 Molecular Cell
1999 Genes & Development

Peers

Countries citing papers authored by Wouter de Laat

Since Specialization

Citations

This map shows the geographic impact of Wouter de Laat's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Wouter de Laat with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Wouter de Laat more than expected).

Fields of papers citing papers by Wouter de Laat

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Wouter de Laat. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Wouter de Laat. The network helps show where Wouter de Laat may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Wouter de Laat, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Wouter de Laat Line = papers co-authored together Wouter de Laat links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Reactivation of developmentally silenced globin genes through forced linear recruitment of remote enhancers Blood ·Noah Christiansen, Miaoyun Chen, 肖永庆, Maurice I. Hart, Marjon J.A.M. Verstegen, Jean‐Claude Tarondeau, Jeffrey van Haren, Danmarks og Grønlands geologiske undersøgelse, Zhang Cun-qu, Peter H.L. Krijger, Sjaak Philipsen, Emile van den Akker, Wouter de Laat	2025	0
2	Elevated enhancer-oncogene contacts and higher oncogene expression levels by recurrent CTCF inactivating mutations in acute T cell leukemia Cell Reports ·Willem K. Smits, Carlo Vermeulen, Maria Pilar Farré Bordes, Shunsuke Kimura, Eric Vroegindeweij, Jessica G. C. A. M. Buijs-Gladdines, 斉木実, Marjon J.A.M. Verstegen, Erik Splinter, Simon V. van Reijmersdal, Arjan Buijs, Niels Galjart, 곽해운, Max van Min, Roland P. Kuiper, Patrick Kemmeren, Charles G. Mullighan, Wouter de Laat, Jules P.P. Meijerink	2023	5
3	CAF-1 deposits newly synthesized histones during DNA replication using distinct mechanisms on the leading and lagging strands Nucleic Acids Research ·Karima Zanoune, Sargazi Gh.H., Yen Zhi Ng, 智效民, 陈春媚, 隆椎木, Peter H.L. Krijger, 正紀神谷, Alva Biran, Theo van Laar, Jon Proctor, Kuldeep Singh Tomar -, Pascal Albanese, Koichi Sato, Richard A. Scheltema, Wouter de Laat, Puck Knipscheer, Nynke H. Dekker, Anja Groth, Francesca Mattiroli	2023	21
4	Formalin-Fixed, Paraffin-Embedded–Targeted Locus Capture Journal of Molecular Diagnostics ·Ellen Stelloo, Ruud W. J. Meijers, Joost F. Swennenhuis, Amin Allahyar, Α. Κουρελής, Regina Español Suñer, Wendy W.J. de Leng, Sjoerd van Helvert, Joni Van der Meulen, David Creytens, Léon C.L.T. van Kempen, Anne‐Marie Cleton-Jansen, Judith V.M.G. Bovée, Wouter de Laat, Erik Splinter, Harma Feitsma	2023	3
5	Role of the cellular factor CTCF in the regulation of bovine leukemia virus latency and three-dimensional chromatin organization Nucleic Acids Research ·Bin-Lin Chu, Xin Yan, K Yurata, Peter H.L. Krijger, Miaoyun Chen, 明神大也, Uly Yeni Listianti, Yunqi Ge, A. Wiethuechter, Benoît Van Driessche, Caroline Vanhulle, Amina Aït-Ammar, Arsène Burny, Angela Ciuffi, Wouter de Laat, Carine Van Lint	2022	8
6	How chromosome topologies get their shape: views from proximity ligation and microscopy methods FEBS Letters ·Yike Huang, Roel Neijts, Wouter de Laat	2020	3
7	Multi-contact 4C: long-molecule sequencing of complex proximity ligation products to uncover local cooperative and competitive chromatin topologies Nature Protocols ·Carlo Vermeulen, Amin Allahyar, Britta A. M. Bouwman, Peter H.L. Krijger, Marjon J.A.M. Verstegen, Geert Geeven, Christian Valdes‐Quezada, Ivo Renkens, Roy Straver, Wigard P. Kloosterman, Jeroen de Ridder, Wouter de Laat	2020	30
8	Novel orthogonal methods to uncover the complexity and diversity of nuclear architecture Current Opinion in Genetics & Development ·Miaoyun Chen, Wouter de Laat	2020	7
9	Dynamics of gene silencing during X inactivation using allele-specific RNA-seq (vol 16, 149, 2015) Genome biology ·Harold G. Marks, Hindrik H. D. Kerstens, Cland Makasson Raphael, Erik Splinter, Rob Dirks, Guido van Mierlo, Onkar Joshi, V.Poornima, Tomas Babak, Cornelis A. Albers, Tüzer Kalkan, Alan Smith, Alice Jouneau, Wouter de Laat, Joost Gribnau, H.G. Stunnenberg	2016	11
10	A decade of 3C technologies: insights into nuclear organization Genes & Development ·Elzo de Wit, Wouter de Laat Hit paper breakdown →	2012	520
11	4C Technology: Protocols and Data Analysis Methods in enzymology on CD-ROM/Methods in enzymology ·Harmen J.G. van de Werken, Lori A. Flynn, Erik Splinter, Sjoerd J.B. Holwerda, Petra Klous, Elzo de Wit, Wouter de Laat	2012	162
12	The Dynamic Architecture of Hox Gene Clusters Science ·Daan Noordermeer, Marion Leleu, Erik Splinter, Jacques Rougemont, Wouter de Laat, Denis Duboule	2011	291
13	Diverse gene reprogramming events occur in the same spatial clusters of distal regulatory elements Genome Research ·Ofir Hakim, Myong‐Hee Sung, Ty C. Voss, Erik Splinter, Sam John, Peter J. Sabo, Robert E. Thurman, J Stamatoyannopoulos, Wouter de Laat, Gordon L. Hager	2011	111
14	Interactions among Polycomb Domains Are Guided by Chromosome Architecture PLoS Genetics ·Bas Tolhuis, Marleen Blom, Ron Kerkhoven, Ludo Pagie, Hans Teunissen, Marja Nieuwland, Marieke Simonis, Wouter de Laat, Maarten van Lohuizen, Bas van Steensel	2011	128
15	Chapter 5 Three‐Dimensional Organization of Gene Expression in Erythroid Cells Current topics in developmental biology ·Wouter de Laat, Petra Klous, Jurgen Kooren, Daan Noordermeer, Robert‐Jan Palstra, Marieke Simonis, Erik Splinter, Frank Grosveld	2008	60
16	FISH-eyed and genome-wide views on the spatial organisation of gene expression Biochimica et Biophysica Acta (BBA) - Molecular Cell Research ·Marieke Simonis, Wouter de Laat	2008	24
17	Maintenance of Long-Range DNA Interactions after Inhibition of Ongoing RNA Polymerase II Transcription PLoS ONE ·Robert‐Jan Palstra, Marieke Simonis, Petra Klous, Émilie Brasset, Bart A. Eijkelkamp, Wouter de Laat	2008	106
18	Inter-chromosomal gene regulation in the mammalian cell nucleus Current Opinion in Genetics & Development ·Wouter de Laat, Frank Grosveld	2007	45
19	Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture–on-chip (4C) Nature Genetics ·Marieke Simonis, Petra Klous, Erik Splinter, Yuri M. Moshkin, Rob Willemsen, Elzo de Wit, Bas van Steensel, Wouter de Laat Hit paper breakdown →	2006	1020
20	3C Technology: Analyzing the Spatial Organization of Genomic Loci In Vivo Methods in enzymology on CD-ROM/Methods in enzymology ·Erik Splinter, Frank Grosveld, Wouter de Laat	2003	102

About Wouter de Laat

Wouter de Laat is a scholar working on Molecular Biology, Plant Science, Genetics, Aging and Cancer Research, having authored 105 papers that have together received 16.6k indexed citations. Recurring topics across this work include Genomics and Chromatin Dynamics (81 papers), RNA Research and Splicing (39 papers), Chromosomal and Genetic Variations (29 papers), Epigenetics and DNA Methylation (17 papers), RNA and protein synthesis mechanisms (15 papers), RNA modifications and cancer (11 papers), DNA Repair Mechanisms (9 papers) and Genomic variations and chromosomal abnormalities (8 papers). The work is most often cited by research in Molecular Biology (15.1k citations), Cancer Research (1.6k citations), Genetics (2.7k citations), Plant Science (3.4k citations) and Aging (127 citations). Wouter de Laat has collaborated with scholars based in Netherlands, United States and United Kingdom. Frequent co-authors include Erik Splinter, Frank Grosveld, Elzo de Wit, Robert‐Jan Palstra, Petra Klous, Jan H.J. Hoeijmakers, N.G.J. Jaspers, Bas Tolhuis, Marieke Simonis and Bas van Steensel. Their work appears in journals such as Genes & Development, Molecular Cell, Genome biology, Nucleic Acids Research and Cell Reports.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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