George L. Scheffer

18.5k citations

141 papers · 14.9k indexed · 6 hit papers · h-index 62

Impact in

Oncology top 0.05%
- Drug Transport and Resistance Mechanisms
Pediatrics, Perinatology and Child Health top 0.05%
- Pharmacological Effects and Toxicity Studies

Papers in

Oncology 119
- Drug Transport and Resistance Mechanisms 110
Pediatrics, Perinatology and Child Health 43
- Pharmacological Effects and Toxicity Studies 41

Co-authors: Rik J. Scheper Piet Borst Miguel Izquierdo Marcel de Haas Ronald P.J. Oude Elferink Frank Baas Marcel Kool Alfred H. Schinkel
Journals: International Journal of Cancer (7 papers)Epilepsia (5 papers)Biochemical Pharmacology (5 papers)British Journal of Cancer (4 papers)Molecular Pharmacology (3 papers)
Partner nations: Netherlands United States Israel

In The Last Decade

George L. Scheffer

141 papers receiving 14.6k citations

Hit Papers

6 papers align trajectories log scale

The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria 2002 · 672 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2002 Proceedings of the National Academy of Sciences
2001 PubMed
1999 Proceedings of the National Academy of Sciences
1997 PubMed
1996 Science
1995 Nature Medicine

Peers

Countries citing papers authored by George L. Scheffer

Since Specialization

Citations

This map shows the geographic impact of George L. Scheffer's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by George L. Scheffer with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites George L. Scheffer more than expected).

Fields of papers citing papers by George L. Scheffer

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by George L. Scheffer. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by George L. Scheffer. The network helps show where George L. Scheffer may publish in the future.

Co-authorship network

The 25 scholars most cited alongside George L. Scheffer, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with George L. Scheffer Line = papers co-authored together George L. Scheffer links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work
1	PD-L1 directed bispecific Vδ2-T cell engager combines lysis of PD-L1 expressing tumor cells with PD-1 immune checkpoint inhibition and modulation of the tumor immune microenvironment Journal for ImmunoTherapy of Cancer ·Lisa A. King, 徐建国, Małgorzata Roos, George L. Scheffer, Marko Popović, Tanja D. de Gruijl, Hans van Vliet	2025	1
2	A Bispecific Antibody Antagonizes Prosurvival CD40 Signaling and Promotes Vγ9Vδ2 T cell–Mediated Antitumor Responses in Human B-cell Malignancies Cancer Immunology Research ·Iris de Weerdt, Roeland Lameris, George L. Scheffer, Hough Douglas, Renate de Boer, Anita G.M. Stam, Rieneke van de Ven, Mark‐David Levin, Steven T. Pals, Rob C. Roovers, Paul W.H.I. Parren, Tanja D. de Gruijl, Arnon P. Kater, Hans van Vliet	2020	32
3	Substrate Overlap between Mrp4 and Abcg2/Bcrp Affects Purine Analogue Drug Cytotoxicity and Tissue Distribution Cancer Research ·Kazumasa Takenaka, James P. Morgan, George L. Scheffer, Masashi Adachi, Clinton F. Stewart, Daxi Sun, Markos Leggas, Karin F.K. Ejendal, Christine A. Hrycyna, John D. Schuetz	2007	73
4	Oxidative and electrophilic stress induces multidrug resistance–associated protein transporters via the nuclear factor-E2–related factor-2 transcriptional pathway Hepatology ·Jonathan Maher, Matthew Z. Dieter, Lauren M. Aleksunes, Angela L. Slitt, Grace L. Guo, Yuji Tanaka, George L. Scheffer, Jefferson Y. Chan, José E. Manautou, Ying Chen, Timothy P. Dalton, Masayuki Yamamoto, Curtis D. Klaassen	2007	263
5	Diminished expression of multidrug resistance-associated protein 1 (MRP1) in bronchial epithelium of COPD patients Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin ·Margaretha van der Deen, Hendrik Marks, Brigitte W.M. Willemse, Dirkje S. Postma, Michael Müller, Egbert F. Smit, George L. Scheffer, Rik J. Scheper, Elisabeth G.E. de Vries, Wim Timens	2006	55
6	Coordinated Expression of Multidrug Resistance-Associated Proteins (Mrps) in Mouse Liver during Toxicant-Induced Injury Toxicological Sciences ·Lauren M. Aleksunes, George L. Scheffer, Amy Jakowski, Ingrid Pruimboom‐Brees, José E. Manautou	2005	66
7	Mice lacking Mrp3 (Abcc3) have normal bile salt transport, but altered hepatic transport of endogenous glucuronides Journal of Hepatology ·Noam Zelcer, Koen van de Wetering, Rudi de Waart, George L. Scheffer, Hanns–Ulrich Marschall, Peter R. Wielinga, Annemieke Kuil, Cindy Kunne, Alexander J. Smith, Martin van der Valk, Jan Wijnholds, Ronald Oude Elferink, Piet Borst	2005	138
8	Disruption of Abcc6 in the mouse: novel insight in the pathogenesis of pseudoxanthoma elasticum Human Molecular Genetics ·Theo G. M. F. Gorgels, Xiao Hu, George L. Scheffer, Allard C. van der Wal, Johan Toonstra, Paulus T.V.M. de Jong, Toin H. Van Kuppevelt, Christiaan N. Levelt, Anneke de Wolf, Willem J.P Loves, Rik J. Scheper, Ron Peek, Arthur A. Bergen	2005	157
9	Disruption of the murine major vault protein (MVP/LRP) gene does not induce hypersensitivity to cytostatics. PubMed ·Marieke H. Mossink, Arend van Zon, Gary D. Thurber, Martijn Schoester, Valerie A. Kickhoefer, George L. Scheffer, Rik J. Scheper, Pieter Sonneveld, Erik A.C. Wiemer	2002	75
10	Up-Regulation of Drug Resistance-Related Vaults During Dendritic Cell Development The Journal of Immunology ·Anouk B. Schroeijers, Anneke W. Reurs, George L. Scheffer, Anita G.M. Stam, Mariska C. de Jong, Thomas Rustemeyer, Erik A.C. Wiemer, Tanja D. de Gruijl, Rik J. Scheper	2002	49
11	Peptide transport by the multidrug resistance protein MRP1. PubMed ·Mariska C. de Jong, Jerry W. Slootstra, George L. Scheffer, Anouk B. Schroeijers, Wouter C. Puijk, Armelle Dalomis, Marcel Kool, HJ Broxterman, Rob H. Meloen, Rik J. Scheper	2001	49
12	The Granzyme B Inhibitor, Protease Inhibitor 9, Is Mainly Expressed by Dendritic Cells and at Immune-Privileged Sites The Journal of Immunology ·Bellinda A. Bladergroen, Merel C. M. Strik, Niels Bovenschen, Y. Bar Khayim, George L. Scheffer, Chris J.L.M. Meijer, C. Erik Hack, J. Alain Kummer	2001	133
13	3-hydroxy-3-methylglutaryl–coenzyme a reductase inhibitors (statins) induce hepatic expression of the phospholipid translocase mdr2 in rats Gastroenterology ·Guido Hooiveld, 沈德新, George L. Scheffer, Harry van Goor, Hans Koning, Vincent W. Bloks, Annemarieke E. Loot, Dirk Meijer, Peter L. M. Jansen, Folkert Kuipers, Michael Müller	1999	50
14	Vaults Are Up-regulated in Multidrug-resistant Cancer Cell Lines Journal of Biological Chemistry ·Valerie A. Kickhoefer, 一法富永, George L. Scheffer, William S. Dalton, Rik J. Scheper, Leonard H. Rome	1998	207
15	Increased LRP mRNA expression is associated with the MDR phenotype in intrinsically resistant human cancer cell lines International Journal of Cancer ·Carolyn M. Laurençot, George L. Scheffer, Rik J. Scheper, Robert H. Shoemaker	1997	61
16	Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. PubMed ·Marcel Kool, Marcel de Haas, George L. Scheffer, Rik J. Scheper, Ema S. Dreseris, Jenneke A. Juijn, Frank Baas, Byung-Jin CH이 Hit paper breakdown →	1997	746
17	Broad distribution of the multidrug resistance-related vault lung resistance protein in normal human tissues and tumors. PubMed ·Miguel Izquierdo, George L. Scheffer, Miranda Sinnott-Armstrong, Giuseppe Giaccone, João Marcus Perelli dos Santos, Coby Meijer, Paul van der Valk, R.J. Scheper	1996	151
18	Tissue distribution of the multidrug resistance protein. PubMed ·M J Flens, G J Zaman, Paul van der Valk, Miguel Izquierdo, Anouk B. Schroeijers, George L. Scheffer, Mayly Pastora, Marcel de Haas, Coby Meijer, Rik J. Scheper	1996	406
19	Congenital Jaundice in Rats with a Mutation in a Multidrug Resistance-Associated Protein Gene Science ·Coen C. Paulusma, Piter J. Bosma, Guido J.R. Zaman, Conny Bakker, M. Ya. Otter, George L. Scheffer, Rik J. Scheper, Piet Borst, Ronald P.J. Oude Elferink Hit paper breakdown →	1996	699
20	A Monoclonal Antibody against Human β-Glucuronidase for Application in Antibody-Directed Enzyme Prodrug Therapy PubMed ·Hidde J. Haisma, Simone Wills, George L. Scheffer, Rik J. Scheper, Herbert M. Pinedo, Epie Boven	1995	10

About George L. Scheffer

George L. Scheffer is a scholar working on Oncology, Pediatrics, Perinatology and Child Health, Nutrition and Dietetics, Genetics and Pharmacology, having authored 141 papers that have together received 14.9k indexed citations. Recurring topics across this work include Drug Transport and Resistance Mechanisms (110 papers), Pharmacological Effects and Toxicity Studies (41 papers), Trace Elements in Health (19 papers), Cholangiocarcinoma and Gallbladder Cancer Studies (13 papers), Cancer therapeutics and mechanisms (12 papers), Pediatric Hepatobiliary Diseases and Treatments (11 papers), DNA Repair Mechanisms (10 papers) and Immunotherapy and Immune Responses (10 papers). The work is most often cited by research in Oncology (10.5k citations), Pediatrics, Perinatology and Child Health (4.1k citations), Pharmacology (1.1k citations), Nutrition and Dietetics (1.5k citations) and Molecular Biology (5.3k citations). George L. Scheffer has collaborated with scholars based in Netherlands, United States and Israel. Frequent co-authors include Rik J. Scheper, Piet Borst, Miguel Izquierdo, Marcel de Haas, Ronald P.J. Oude Elferink, Frank Baas, Marcel Kool, Alfred H. Schinkel, Paul van der Valk and Gerrit Jansen. Their work appears in journals such as International Journal of Cancer, Epilepsia, Biochemical Pharmacology, British Journal of Cancer and Molecular Pharmacology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact