José E. Manautou

6.3k citations

112 papers · 4.9k indexed · 2 hit papers · h-index 39

Impact in

Pharmacology top 0.1%
- Drug-Induced Hepatotoxicity and Protection
- Pharmacogenetics and Drug Metabolism
Hepatology top 2%

Papers in

Pharmacology 55
- Drug-Induced Hepatotoxicity and Protection 49
- Pharmacogenetics and Drug Metabolism 21
Hepatology 16
- Liver Disease and Transplantation 12

Co-authors: Lauren M. Aleksunes Xinsheng Gu Xiao‐bo Zhong Curtis D. Klaassen Theodore P. Rasmussen Michael Goedken Amy M. Bataille Nathan J. Cherrington
Journals: Drug Metabolism and Disposition (14 papers)Toxicology and Applied Pharmacology (10 papers)Toxicological Sciences (9 papers)Toxicology (7 papers)The FASEB Journal (6 papers)
Partner nations: United States Netherlands Argentina

In The Last Decade

José E. Manautou

109 papers receiving 4.9k citations

Hit Papers

align trajectories log scale

The growth of siRNA-based therapeutics: Updated clinical studies 2021 · 360 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2021 Biochemical Pharmacology
2016 Pharmacological Research

Peers

Countries citing papers authored by José E. Manautou

Since Specialization

Citations

This map shows the geographic impact of José E. Manautou's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by José E. Manautou with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites José E. Manautou more than expected).

Fields of papers citing papers by José E. Manautou

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by José E. Manautou. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by José E. Manautou. The network helps show where José E. Manautou may publish in the future.

Co-authors

The 25 scholars most cited alongside José E. Manautou, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with José E. Manautou Line = papers co-authored together José E. Manautou links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	A holistic analysis of the intrinsic and delivery-mediated toxicity of siRNA therapeutics Advanced Drug Delivery Reviews ·Nofar Adadi, Xiao‐bo Zhong, José E. Manautou, Xiuling Lü	2023	35
2	Multivalent Lactobionic Acid and N‐Acetylgalactosamine‐Conjugated Peptide Nucleic Acids for Efficient In Vivo Targeting of Hepatocytes Advanced Healthcare Materials ·Vikas Kumar, Aniket Wahane, Anisha Gupta, José E. Manautou, Raman Bahal	2023	12
3	Role and Regulation of Hepatobiliary ATP-Binding Cassette Transporters during Chemical-Induced Liver Injury Drug Metabolism and Disposition ·Carolina I. Ghanem, José E. Manautou	2022	6
4	Lack of Multidrug Resistance-associated Protein 4 Prolongs Partial Hepatectomy-induced Hepatic Steatosis Toxicological Sciences ·Ajay C. Donepudi, Gregory J. Smith, Enid Hughes, Yoojin Lee, Monosi, Marisa Pfohl, Angela L. Slitt, Li Wang, Ji‐Young Lee, John D. Schuetz, José E. Manautou	2020	3
5	Lack of multidrug resistance-associated protein 4 (Mrp4) alters the kinetics of acetaminophen toxicity Toxicology Reports ·Ajay C. Donepudi, Michael Goedken, John D. Schuetz, José E. Manautou	2019	6
6	Modulation of Hepatic MRP3/ABCC3 by Xenobiotics and Pathophysiological Conditions: Role in Drug Pharmacokinetics Current Medicinal Chemistry ·Carolina I. Ghanem, José E. Manautou	2018	14
7	Gender-specific expression of ATP-binding cassette (Abc) transporters and cytoprotective genes in mouse choroid plexus Toxicology ·Frank L Panuzio, José E. Manautou, J. Larry Renfro	2017	16
8	Histone deacetylase 9 plays a role in the antifibrogenic effect of astaxanthin in hepatic stellate cells The Journal of Nutritional Biochemistry ·Yue Yang, Minkyung Bae, Young‐Ki Park, Yoojin Lee, Tho X. Pham, Swetha Rudraiah, José E. Manautou, Sung I. Koo, Ji‐Young Lee	2016	40
9	Transgenic Expression of the Human MRP2 Transporter Reduces Cisplatin Accumulation and Nephrotoxicity in Mrp2-Null Mice American Journal Of Pathology ·Wen Xia, Brian Buckley, Elizabeth McCandlish, Michael Goedken, Samira Syed, Ryan M. Pelis, José E. Manautou, Lauren M. Aleksunes	2014	52
10	Cholesterol-Secreting and Statin-Responsive Hepatocytes from Human ES and iPS Cells to Model Hepatic Involvement in Cardiovascular Health PLoS ONE ·Winfried Krueger, Borko Tanasijevic, Roger Hall, Anthony Flamier, Xinsheng Gu, José E. Manautou, Theodore P. Rasmussen	2013	20
11	Constitutive activation of nuclear factor‐E2‐related factor 2 induces biotransformation enzyme and transporter expression in livers of mice with hepatocyte‐specific deletion ofKelch‐like ECH‐associated protein 1 Journal of Biochemical and Molecular Toxicology ·Qiuqiong Cheng, Keiko Taguchi, Lauren M. Aleksunes, José E. Manautou, Nathan J. Cherrington, Masayuki Yamamoto, Angela L. Slitt	2011	11
12	Nrf2- and PPARα-Mediated Regulation of Hepatic Mrp Transporters after Exposure to Perfluorooctanoic Acid and Perfluorodecanoic Acid Toxicological Sciences ·Jonathan Maher, Lauren M. Aleksunes, Matthew Z. Dieter, Yuji Tanaka, Jeffrey M. Peters, José E. Manautou, Curtis D. Klaassen	2008	93
13	Acquired Resistance to Acetaminophen Hepatotoxicity is Associated with Induction of Multidrug Resistance-Associated Protein 4 (Mrp4) in Proliferating Hepatocytes Toxicological Sciences ·Lauren M. Aleksunes, Sarah N. Campion, Michael Goedken, José E. Manautou	2008	60
14	Hepatic Mrp4 induction following acetaminophen exposure is dependent on Kupffer cell function American Journal of Physiology-Gastrointestinal and Liver Physiology ·Sarah N. Campion, Rachel M. Johnson, Lauren M. Aleksunes, Michael Goedken, Nico van Rooijen, George L. Scheffer, Nathan J. Cherrington, José E. Manautou	2008	50
15	Oxidative and electrophilic stress induces multidrug resistance–associated protein transporters via the nuclear factor-E2–related factor-2 transcriptional pathway Hepatology ·Jonathan Maher, Matthew Z. Dieter, Lauren M. Aleksunes, Angela L. Slitt, Grace L. Guo, Yuji Tanaka, George L. Scheffer, Jefferson Y. Chan, José E. Manautou, Ying Chen, Timothy P. Dalton, Masayuki Yamamoto, Curtis D. Klaassen	2007	263
16	Coordinated Expression of Multidrug Resistance-Associated Proteins (Mrps) in Mouse Liver during Toxicant-Induced Injury Toxicological Sciences ·Lauren M. Aleksunes, George L. Scheffer, Amy Jakowski, Ingrid Pruimboom‐Brees, José E. Manautou	2005	66
17	Altered Disposition of Acetaminophen in Mice With a Disruption of the Mrp3 Gene * # Hepatology ·José E. Manautou, Dirk R. de Waart, Cindy Kunne, Noam Zelcer, Michael Goedken, Piet Borst, Ronald Oude Elferink	2005	79
18	Transport deficient (TR−) hyperbilirubinemic rats are resistant to acetaminophen hepatotoxicity Biochemical Pharmacology ·Vanessa M. Silva, Michael S. Thibodeau, Chuan Chen, José E. Manautou	2005	14
19	HEPATOBILIARY EXCRETION OF ACETAMINOPHEN GLUTATHIONE CONJUGATE AND ITS DERIVATIVES IN TRANSPORT-DEFICIENT (TR-) HYPERBILIRUBINEMIC RATS Drug Metabolism and Disposition ·Chuan Chen, Maria Ángeles Magallón Botaya, José E. Manautou	2003	70
20	Clofibrate Pretreatment Diminishes Acetaminophen′s Selective Covalent Binding and Hepatotoxicity Toxicology and Applied Pharmacology ·José E. Manautou, Debie J. Hoivik, V V Mitrofovich, Susan Hart, Edward A. Khairallah, Steven D. Cohen	1994	55

About José E. Manautou

José E. Manautou is a scholar working on Pharmacology, Hepatology, Oncology, Biochemistry and Epidemiology, having authored 112 papers that have together received 4.9k indexed citations. Recurring topics across this work include Drug-Induced Hepatotoxicity and Protection (49 papers), Drug Transport and Resistance Mechanisms (48 papers), Liver Disease Diagnosis and Treatment (23 papers), Pharmacogenetics and Drug Metabolism (21 papers), Genomics, phytochemicals, and oxidative stress (20 papers), Liver Disease and Transplantation (12 papers), Pharmacological Effects and Toxicity Studies (12 papers) and Peroxisome Proliferator-Activated Receptors (9 papers). The work is most often cited by research in Pharmacology (1.4k citations), Hepatology (501 citations), Oncology (1.3k citations), Molecular Biology (2.1k citations) and Pathology and Forensic Medicine (548 citations). José E. Manautou has collaborated with scholars based in United States, Netherlands and Argentina. Frequent co-authors include Lauren M. Aleksunes, Xinsheng Gu, Xiao‐bo Zhong, Curtis D. Klaassen, Theodore P. Rasmussen, Michael Goedken, Amy M. Bataille, Nathan J. Cherrington, Raman Bahal and Angela L. Slitt. Their work appears in journals such as Drug Metabolism and Disposition, Toxicology and Applied Pharmacology, Toxicological Sciences, Toxicology and The FASEB Journal.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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