I Pastan

12.7k citations

48 papers · 10.8k indexed · 5 hit papers · h-index 29

Impact in

Oncology top 0.1%
- Drug Transport and Resistance Mechanisms
Pediatrics, Perinatology and Child Health top 0.2%
- Pharmacological Effects and Toxicity Studies

Papers in

Physiology 4
- Adenosine and Purinergic Signaling 4
Oncology 24
- Drug Transport and Resistance Mechanisms 20

Co-authors: Michael M. Gottesman Mark C. Willingham Hironobu Hamada T Tsuruo F Thiébaut M M Gottesman Suresh V. Ambudkar Antonio Tito Fojo
Journals: Proceedings of the National Academy of Sciences (7 papers)JNCI Journal of the National Cancer Institute (3 papers)Molecular Pharmacology (2 papers)Journal of Histochemistry & Cytochemistry (2 papers)Journal of Biological Chemistry (2 papers)
Partner nations: United States Japan India

In The Last Decade

I Pastan

48 papers receiving 10.5k citations

Hit Papers

5 papers align trajectories log scale

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER 1993 · 3.1k citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

1993 Annual Review of Biochemistry
1989 JNCI Journal of the National Cancer Institute
1988 Journal of Biological Chemistry
1987 Proceedings of the National Academy of Sciences
1986 Proceedings of the National Academy of Sciences

Peers

Countries citing papers authored by I Pastan

Since Specialization

Citations

This map shows the geographic impact of I Pastan's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by I Pastan with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites I Pastan more than expected).

Fields of papers citing papers by I Pastan

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by I Pastan. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by I Pastan. The network helps show where I Pastan may publish in the future.

Co-authors

The 25 scholars most cited alongside I Pastan, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with I Pastan Line = papers co-authored together I Pastan links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work
1	Effect of mAb B3 and paclitaxel doses on accumulation and penetration of B3 into tumor European Journal of Physical and Rehabilitation Medicine ·Jin Su Kim, Sung‐Jin Lee, In‐Sook Kim, Zhengsheng Yao, Jae‐Ho Lee, I Pastan, Chang H. Paik	2013	1
2	Modulation by the ATP/GTP ratio of the phosphorylation level of P-glycoprotein and of various plasma membrane proteins of KB-V1 multidrug resistant cells. PubMed ·Isabelle Lelong-Rebel, G. Rebel, Carol Cardarelli, I Pastan, Michael M. Gottesman	2003	8
3	The Extracellular Loop between TM5 and TM6 of P-Glycoprotein Is Required for Reactivity with Monoclonal Antibody UIC2 Archives of Biochemistry and Biophysics ·Yi Zhou, Michael M. Gottesman, I Pastan	1999	30
4	A bivalent disulfide-stabilized fv with improved antigen binding to erbb2 Journal of Molecular Biology ·Tapan K. Bera, Masanori Onda, Ulrich Brinkmann, I Pastan	1998	30
5	Co-Expression of Human Adenosine Deaminase and Multidrug Resistance Using a Bicistronic Retroviral Vector Human Gene Therapy ·Yi Zhou, Josep M. Aran, Michael M. Gottesman, I Pastan	1998	48
6	Efficient Long-Term Coexpression of a Hammerhead Ribozyme Targeted to the U5 Region of HIV-1 LTR by Linkage to the Multidrug-Resistance Gene Antisense and Nucleic Acid Drug Development ·Caroline Lee, Kuan-Teh Jeang, Malcolm A. Martin, I Pastan, Michael M. Gottesman	1997	13
7	A form of anti-Tac(Fv) which is both single-chain and disulfide stabilized: comparison with its single-chain and disulfide-stabilized homologs Protein Engineering Design and Selection ·Vivek Rajagopal, I Pastan, Robert J. Kreitman	1997	23
8	P-glycoprotein and multidrug resistance Current Opinion in Genetics & Development ·Michael M. Gottesman, I Pastan, Suresh V. Ambudkar	1996	467
9	Heterologous expression systems for P-glycoprotein:E. coli, yeast, and baculovirus Journal of Bioenergetics and Biomembranes ·Wendi Abraham, Baofu Ni, Christine A. Hrycyna, David D. Y. Chen, Suresh V. Ambudkar, I Pastan, Ursula A. Germann, Michael M. Gottesman	1995	41
10	Circularly permuted interleukin 4 retains proliferative and binding activity Cytokine ·Robert J. Kreitman, Raj K. Puri, P McPhie, I Pastan	1995	14
11	PR1--a Monoclonal Antibody That Reacts With an Antigen on the Surface of Normal and Malignant Prostate Cells JNCI Journal of the National Cancer Institute ·I Pastan, Elizabeth Lovelace, A V Rutherford, Sushma Kunwar, Mark C. Willingham, D M Peehl	1993	12
12	BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER Annual Review of Biochemistry ·Michael M. Gottesman, I Pastan Hit paper breakdown →	1993	3107
13	Redirecting Pseudomonas exotoxin. PubMed ·David FitzGerald, I Pastan	1991	13
14	Detection of Multidrug Resistance (MDR1) Gene RNA Expression in Human Tumors by a Sensitive Ribonuclease Protection Assay Japanese Journal of Cancer Research ·Kazumitsu Ueda, Yoshiaki Yamano, Noriyuki Kioka, Xin Tian, O Yoshida, Michael M. Gottesman, I Pastan, Tohru Komano	1989	22
15	P-Glycoprotein gene (MDR1) cDNA from human adrenal: Normal P-glycoprotein carries Gly185 with an altered pattern of multidrug resistance Biochemical and Biophysical Research Communications ·Noriyuki Kioka, F Islamgalieva, Yoshiyuki Kakehi, Tohru Komano, Michael M. Gottesman, I Pastan, Kazumitsu Ueda	1989	141
16	Expression of a Multidrug Resistance Gene in Blast Crisis of Chronic Myelogenous Leukemia PubMed ·Robert Pirker, Lori J. Goldstein, Y Kamin, 田荣娜, Christian Lechner, M M Gottesman, I Pastan	1989	37
17	Characterization of a monoclonal antibody, OVB1, which binds to a unique determinant in human ovarian carcinomas and myeloid cells. Journal of Histochemistry & Cytochemistry ·Regina Kurrasch, A V Rutherford, Margaret E. Rick, Ελισσάβετ Χαραλαμπίδη, Elizabeth Lovelace, I Pastan, Mark C. Willingham	1989	3
18	A monoclonal antibody-Pseudomonas toxin conjugate that specifically kills multidrug-resistant cells. Proceedings of the National Academy of Sciences ·D J FitzGerald, M C Willingham, Carol Cardarelli, Hiroyuki Hamada, T Tsuruo, M M Gottesman, I Pastan	1987	120
19	Ultrastructural immunocytochemical localization of the transferrin receptor using a monoclonal antibody in human KB cells. Journal of Histochemistry & Cytochemistry ·Mark C. Willingham, I Pastan	1985	42
20	Thyroglobulin: Evidence for Crystallization and Association Science ·William B. Jakoby, L. W. Labaw, Harold Edelhoch, I Pastan, J. E. RALL	1966	9

About I Pastan

I Pastan is a scholar working on Physiology, Oncology, Biotechnology, Radiology, Nuclear Medicine and Imaging and Infectious Diseases, having authored 48 papers that have together received 10.8k indexed citations. Recurring topics across this work include Drug Transport and Resistance Mechanisms (20 papers), HIV/AIDS drug development and treatment (8 papers), Monoclonal and Polyclonal Antibodies Research (8 papers), Toxin Mechanisms and Immunotoxins (8 papers), Glycosylation and Glycoproteins Research (5 papers), Cancer therapeutics and mechanisms (4 papers), Transgenic Plants and Applications (4 papers) and Adenosine and Purinergic Signaling (4 papers). The work is most often cited by research in Oncology (8.4k citations), Pediatrics, Perinatology and Child Health (2.6k citations), Pharmacology (974 citations), Infectious Diseases (1.5k citations) and Molecular Biology (4.7k citations). I Pastan has collaborated with scholars based in United States, Japan and India. Frequent co-authors include Michael M. Gottesman, Michael M. Gottesman, Mark C. Willingham, Hironobu Hamada, T Tsuruo, F Thiébaut, M M Gottesman, Suresh V. Ambudkar, Antonio Tito Fojo and Carol Cardarelli. Their work appears in journals such as Proceedings of the National Academy of Sciences, JNCI Journal of the National Cancer Institute, Molecular Pharmacology, Journal of Histochemistry & Cytochemistry and Journal of Biological Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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