Frank Mercurio

15.2k citations

53 papers · 12.6k indexed · 7 hit papers · h-index 36

Molecular Biology top 0.5%
Cancer Research top 0.1%
Immunology top 0.2%
Oncology top 0.5%
Epidemiology top 5%

Co-authors: Michael Karin Joseph A. DiDonato Anthony M. Manning Kathleen M. Sakamoto Raymond J. Deshaies Craig M. Crews Akiko Kumagai Matthias Mann
Topics: NF-κB Signaling Pathways (30 papers)Immune Response and Inflammation (14 papers)Ubiquitin and proteasome pathways (14 papers)
Cited by: Cancer Research Immunology Oncology
Journals: Nature Science Cell
Partner nations: United States Israel Switzerland

In The Last Decade

Frank Mercurio

53 papers receiving 12.4k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

1997 1.8k citations Frank Mercurio, Brydon L. Bennett et al. profile →
Protacs: Chimeric molecules that target proteins to the Skp1–Cullin–F box complex for ubiquitination and degradation

2001 1.8k citations Frank Mercurio et al. profile →
NF‐κB and the link between inflammation and cancer

2012 1.3k citations Joseph A. DiDonato, Frank Mercurio et al. profile →
Severe Liver Degeneration in Mice Lacking the IκB Kinase 2 Gene

1999 835 citations Frank Mercurio et al. profile →
Identification of a Dual Specificity Kinase That Activates the Jun Kinases and p38-Mpk2

1995 706 citations Frank Mercurio, Michael Karin et al. profile →
Mapping of the Inducible IκB Phosphorylation Sites That Signal Its Ubiquitination and Degradation†

1996 651 citations Joseph A. DiDonato, Frank Mercurio et al. Molecular and Cellular Biology profile →
Identification of the receptor component of the IκBα–ubiquitin ligase

1998 557 citations Avraham Yaron, Ada Hatzubai et al. Nature profile →

Peers

Countries citing papers authored by Frank Mercurio

Since Specialization

Citations

This map shows the geographic impact of Frank Mercurio's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Frank Mercurio with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Frank Mercurio more than expected).

Fields of papers citing papers by Frank Mercurio

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Frank Mercurio. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Frank Mercurio. The network helps show where Frank Mercurio may publish in the future.

Co-authorship network of co-authors of Frank Mercurio

This figure shows the co-authorship network connecting the top 25 collaborators of Frank Mercurio. A scholar is included among the top collaborators of Frank Mercurio based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Frank Mercurio. Frank Mercurio is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	The novel protein homeostatic modulator BTX306 is active in myeloma and overcomes bortezomib and lenalidomide resistance 2020 ·Journal of Molecular Medicine ·(unknown),Richard J. Jones,Hua Wang,Isere Kuiatse,Fazal Shirazi,Elisabet E. Manasanch,Hans C. Lee,(unknown),(unknown),Normand Richard,Paul Erdman,(unknown),David Hecht,(unknown),(unknown),Aparajita H. Chourasia,Kyle Chan,Frank Mercurio,David Stirling,Robert Z. Orlowski	9
2	A Protective Role for the Human SMG-1 Kinase against Tumor Necrosis Factor-α-induced Apoptosis 2008 ·Journal of Biological Chemistry ·Vasco Oliveira,William J. Romanow,Christoph Geisen,Diane M. Otterness,Frank Mercurio,Hong‐Gang Wang,William S. Dalton,Robert T. Abraham	37
3	Genotoxic Stress Targets Human Chk1 for Degradation by the Ubiquitin-Proteasome Pathway 2005 ·Molecular Cell ·You-Wei Zhang,Diane M. Otterness,Gary G. Chiang,Weilin Xie,Yun‐Cai Liu,Frank Mercurio,Robert T. Abraham	235
4	In Vitro SCFβ‐Trcp1–Mediated IκBα Ubiquitination Assay for High‐Throughput Screen 2005 ·Methods in enzymology on CD-ROM/Methods in enzymology ·Shuichan Xu,(unknown),Mahan Abbasian,David A. Giegel,Weilin Xie,Frank Mercurio,Sarah Cox	11
5	Regulation of α-Fetoprotein by Nuclear Factor-κB Protects Hepatocytes from Tumor Necrosis Factor-α Cytotoxicity during Fetal Liver Development and Hepatic Oncogenesis 2004 ·Cancer Research ·Lakita G. Cavin,Venkatraman Manickam,Valentina M. Factor,Swayamjot Kaur,Insa S. Schroeder,Frank Mercurio,Amer A. Beg,Snorri S. Thorgeirsson,Marcello Arsura	32
6	Targeting of TAK1 by the NF-κB protein Relish regulates the JNK-mediated immune response in Drosophila 2004 ·Genes & Development ·Jin Mo Park,Helen Brady,Maria Grazia Ruocco,Huaiyu Sun,(unknown),Sang Hyuck Lee,Tomohisa Kato,(unknown),Kyle Chan,Frank Mercurio,Michael Karin,Steven A. Wasserman	149
7	IKKi/IKKϵ Plays a Key Role in Integrating Signals Induced by Pro-inflammatory Stimuli 2003 ·Journal of Biological Chemistry ·Vladimir V. Kravchenko,John C. Mathison,Klaus Schwamborn,Frank Mercurio,Richard J. Ulevitch	102
8	Detection and Purification of a Multiprotein Kinase Complex from Mammalian Cells: IKK Signalsome 2003 ·Humana Press eBooks ·Frank Mercurio,David B. Young,Anthony M. Manning	6
9	Potential new therapeutics for Waldenstrom's macroglobulinemia 2003 ·Seminars in Oncology ·Jerome B. Zeldis,Peter Schäfer,Brydon L. Bennett,Frank Mercurio,David Stirling	13
10	Interleukin-8 Gene Regulation in Intestinal Epithelial Cells Infected with Rotavirus: Role of Viral-Induced IκB Kinase Activation 2002 ·Virology ·Antonella Casola,Roberto P. Garofalo,Sue E. Crawford,Mary K. Estes,Frank Mercurio,Sheila E. Crowe,Allan R. Brasier	50
11	Fanconi anemia protein complex is a novel target of the IKK signalsome 2002 ·Journal of Cellular Biochemistry ·Tetsuya Otsuki,David B. Young,Dennis T. Sasaki,Matthew P. Pando,Jianwu Li,Anthony M. Manning,Merl F. Hoekstra,Maureen E. Hoatlin,Frank Mercurio,Johnson M. Liu	19
12	Expression and Regulation of Inducible IκB Kinase (IKK-i) in Human Fibroblast-like Synoviocytes 2001 ·Cellular Immunology ·Karlfried R. Aupperle,Yuji Yamanishi,Brydon L. Bennett,Frank Mercurio,David L. Boyle,Gary S. Firestein	33
13	Role of the IκB Kinase Complex in Oncogenic Ras- and Raf-Mediated Transformation of Rat Liver Epithelial Cells 2000 ·Molecular and Cellular Biology ·Marcello Arsura,Frank Mercurio,Aundrea L. Oliver,Snorri S. Thorgeirsson,Gail E. Sonenshein	111
14	HTLV-I Tax Protein Binds to MEKK1 to Stimulate IκB Kinase Activity and NF-κB Activation 1998 ·Cell ·(unknown),Lori B. Christerson,Yumi Yamamoto,Youn-Tae Kwak,Shuichan Xu,Frank Mercurio,Miguel Barbosa,Melanie H. Cobb,Richard B. Gaynor	235
15	Identification of the receptor component of the IκBα–ubiquitin ligasebreakdown → 1998 ·Nature ·Avraham Yaron,Ada Hatzubai,Matti Davis,Iris Lavon,Sharon Amit,Anthony M. Manning,Jens Andersen,Matthias Mann,Frank Mercurio,Yinon Ben‐Neriah	557
16	Role of IKK1 and IKK2 in Lipopolysaccharide Signaling in Human Monocytic Cells 1998 ·Journal of Biological Chemistry ·Maria A. O’Connell,Brydon L. Bennett,Frank Mercurio,Anthony M. Manning,Nigel Mackman	172
17	Transcription inhibitors in inflammation 1997 ·Expert Opinion on Investigational Drugs ·Anthony M. Manning,Frank Mercurio	12
18	Mapping of the Inducible IκB Phosphorylation Sites That Signal Its Ubiquitination and Degradation†breakdown → 1996 ·Molecular and Cellular Biology ·Joseph A. DiDonato,Frank Mercurio,Caridad Rosette,(unknown),(unknown),Sankar Ghosh,Michael Karin	651
19	Phosphorylation of IκBα Precedes but Is Not Sufficient for Its Dissociation from NF-κB 1995 ·Molecular and Cellular Biology ·Joseph A. DiDonato,Frank Mercurio,Michael Karin	310
20	Molecular Cloning and Characterization of a Novel Rel/NF-χB Family Member Displaying Structural and Functional Homology to NF-χB p50/p105 1992 ·DNA and Cell Biology ·Frank Mercurio,Joseph A. DiDonato,Caridad Rosette,Michael Karin	91

About Frank Mercurio

Frank Mercurio is a scholar working on Cancer Research, Immunology and Hematology, having authored 53 papers that have together received 12.6k indexed citations. Recurring topics across this work include NF-κB Signaling Pathways (30 papers), Immune Response and Inflammation (14 papers) and Ubiquitin and proteasome pathways (14 papers). The work is most often cited by research in Cancer Research (5.4k citations), Immunology (4.5k citations) and Oncology (3.3k citations). Frank Mercurio has collaborated with scholars based in United States, Israel and Switzerland. Frequent co-authors include Michael Karin, Joseph A. DiDonato, Anthony M. Manning, Kathleen M. Sakamoto, Raymond J. Deshaies, Craig M. Crews, Akiko Kumagai, Matthias Mann, Brydon L. Bennett and David B. Young. Their work appears in journals such as Nature, Science and Cell.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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