Valentina M. Factor

11.1k total citations · 4 hit papers
109 papers, 8.7k citations indexed

About

Valentina M. Factor is a scholar working on Molecular Biology, Oncology and Hepatology. According to data from OpenAlex, Valentina M. Factor has authored 109 papers receiving a total of 8.7k indexed citations (citations by other indexed papers that have themselves been cited), including 72 papers in Molecular Biology, 42 papers in Oncology and 33 papers in Hepatology. Recurrent topics in Valentina M. Factor's work include Liver physiology and pathology (33 papers), Cancer-related Molecular Pathways (23 papers) and Epigenetics and DNA Methylation (11 papers). Valentina M. Factor is often cited by papers focused on Liver physiology and pathology (33 papers), Cancer-related Molecular Pathways (23 papers) and Epigenetics and DNA Methylation (11 papers). Valentina M. Factor collaborates with scholars based in United States, South Korea and Russia. Valentina M. Factor's co-authors include Snorri S. Thorgeirsson, Elizabeth A. Conner, Jesper B. Andersen, Diego F. Calvisi, Cédric Coulouarn, Sara Ladu, Jens U. Marquardt, S S Thorgeirsson, Marian E. Durkin and Aranzazu Sánchez and has published in prestigious journals such as Nature, Proceedings of the National Academy of Sciences and Journal of Biological Chemistry.

In The Last Decade

Valentina M. Factor

108 papers receiving 8.6k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Hepatocyte growth factor/c-metsignaling pathway is required for efficient liver regeneration and repair

2004 611 citations Valentina M. Factor, Koichi Uchida et al. profile →
Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties

2009 601 citations Cédric Coulouarn, Valentina M. Factor et al. Oncogene profile →
Ubiquitous Activation of Ras and Jak/Stat Pathways in Human HCC

2006 558 citations Diego F. Calvisi, Sara Ladu et al. profile →
Genomic and Genetic Characterization of Cholangiocarcinoma Identifies Therapeutic Targets for Tyrosine Kinase Inhibitors

2011 384 citations Jesper B. Andersen, Itzhak Avital et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Valentina M. Factor United States	55	5.1k	2.7k	2.2k	2.1k	1.8k	109	8.7k
Isabel Fabregat Spain	53	4.8k 0.9×	2.3k 0.8×	1.4k 0.6×	2.4k 1.2×	1.1k 0.6×	168	8.8k
Diego F. Calvisi Germany	55	7.0k 1.4×	2.2k 0.8×	3.4k 1.5×	2.4k 1.2×	1.5k 0.9×	215	11.5k
Terence K. Lee Hong Kong	59	6.3k 1.2×	1.9k 0.7×	3.5k 1.6×	4.3k 2.1×	1.1k 0.6×	170	10.8k
Stephanie Ma Hong Kong	47	5.0k 1.0×	1.4k 0.5×	3.0k 1.3×	3.9k 1.9×	795 0.4×	125	8.8k
Jesús M. Bañales Spain	41	2.4k 0.5×	1.5k 0.6×	1.3k 0.6×	1.3k 0.6×	2.4k 1.3×	169	6.0k
Joe W. Grisham United States	38	3.0k 0.6×	2.4k 0.9×	1.2k 0.5×	1.4k 0.7×	1.8k 1.0×	121	6.3k
Nathan W. Werneburg United States	42	2.9k 0.6×	930 0.3×	1.2k 0.5×	1.2k 0.6×	1.5k 0.8×	56	6.3k
Wolfgang Mikulits Austria	44	4.1k 0.8×	955 0.4×	1.6k 0.7×	2.4k 1.2×	535 0.3×	116	6.9k
Elizabeth A. Conner United States	34	2.5k 0.5×	1.5k 0.5×	927 0.4×	1.0k 0.5×	1.0k 0.6×	46	4.4k
Goshi Shiota Japan	41	2.2k 0.4×	2.0k 0.7×	843 0.4×	788 0.4×	1.2k 0.7×	165	5.4k

Countries citing papers authored by Valentina M. Factor

Since Specialization

Citations

This map shows the geographic impact of Valentina M. Factor's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Valentina M. Factor with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Valentina M. Factor more than expected).

Fields of papers citing papers by Valentina M. Factor

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Valentina M. Factor. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Valentina M. Factor. The network helps show where Valentina M. Factor may publish in the future.

Co-authorship network of co-authors of Valentina M. Factor

This figure shows the co-authorship network connecting the top 25 collaborators of Valentina M. Factor. A scholar is included among the top collaborators of Valentina M. Factor based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Valentina M. Factor. Valentina M. Factor is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Baechler, Simone A., Anjali Dhall, Hongliang Zhang, et al.. (2025). Topoisomerase III-beta protects from immune dysregulation and tumorigenesis. Science Advances. 11(51). eady7028–eady7028.

Kim, Yohan, Daekwan Seo, Jeonghoon Choi, et al.. (2023). Human chemically-derived hepatic progenitors (hCdHs) as a source of liver organoid generation: Application in regenerative medicine, disease modeling, and toxicology testing. Biomaterials. 303. 122360–122360. 16 indexed citations

Kang, Kyojin, Ji Eun Lee, Young Won Kim, et al.. (2021). Transplantation of patient‐specific bile duct bioengineered with chemically reprogrammed and microtopographically differentiated cells. Bioengineering & Translational Medicine. 7(1). e10252–e10252. 10 indexed citations

O’Rourke, Colm J., Christian Dehlendorff, Ole Larsen, et al.. (2020). Serum IL6 as a Prognostic Biomarker and IL6R as a Therapeutic Target in Biliary Tract Cancers. Clinical Cancer Research. 26(21). 5655–5667. 21 indexed citations

Yim, Sun Young, Jae‐Jun Shim, Ji-Hyun Shin, et al.. (2018). Integrated Genomic Comparison of Mouse Models Reveals Their Clinical Resemblance to Human Liver Cancer. Molecular Cancer Research. 16(11). 1713–1723. 16 indexed citations

Lee, Yun-Han, Daekwan Seo, Kyung‐Ju Choi, et al.. (2014). Antitumor Effects in Hepatocarcinoma of Isoform-Selective Inhibition of HDAC2. Cancer Research. 74(17). 4752–4761. 77 indexed citations

Postnikov, Yuri V., Takashi Furusawa, Diana C. Haines, Valentina M. Factor, & Michael Bustin. (2013). Loss of the Nucleosome-Binding Protein HMGN1 Affects the Rate of N-Nitrosodiethylamine-Induced Hepatocarcinogenesis in Mice. Molecular Cancer Research. 12(1). 82–90. 10 indexed citations

Kitade, Mitsuteru, Valentina M. Factor, Jesper B. Andersen, et al.. (2013). Specific fate decisions in adult hepatic progenitor cells driven by MET and EGFR signaling. Genes & Development. 27(15). 1706–1717. 80 indexed citations

Marquardt, Jens U., Daekwan Seo, Luis E. Gómez-Quiroz, et al.. (2012). Loss of c-Met accelerates development of liver fibrosis in response to CCl4 exposure through deregulation of multiple molecular pathways. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1822(6). 942–951. 67 indexed citations

10.

Marquardt, Jens U., Chiara Raggi, Jesper B. Andersen, et al.. (2011). Human hepatic cancer stem cells are characterized by common stemness traits and diverse oncogenic pathways. Hepatology. 54(3). 1031–1042. 63 indexed citations

11.

Lee, Yun-Han, Jesper B. Andersen, Ho‐Taek Song, et al.. (2010). Definition of Ubiquitination Modulator COP1 as a Novel Therapeutic Target in Human Hepatocellular Carcinoma. Cancer Research. 70(21). 8264–8269. 60 indexed citations

12.

Factor, Valentina M., Daekwan Seo, Tsuyoshi Ishikawa, et al.. (2010). Loss of c-Met Disrupts Gene Expression Program Required for G2/M Progression during Liver Regeneration in Mice. PLoS ONE. 5(9). e12739–e12739. 59 indexed citations

13.

Kaposi-Novák, Pál, Louis Libbrecht, Hyun Goo Woo, et al.. (2009). Central Role of c-Myc during Malignant Conversion in Human Hepatocarcinogenesis. Cancer Research. 69(7). 2775–2782. 149 indexed citations

14.

Takami, Taro, Pál Kaposi-Novák, Koichi Uchida, et al.. (2007). Loss of Hepatocyte Growth Factor/c-Met Signaling Pathway Accelerates Early Stages of N -nitrosodiethylamine–Induced Hepatocarcinogenesis. Cancer Research. 67(20). 9844–9851. 80 indexed citations

15.

Calvisi, Diego F., Sara Ladu, Alexis Gorden, et al.. (2006). Molecular pathogenesis of human hepatocellular carcinoma: Mechanistic and prognostic significance of aberrant methylation. Cancer Research. 66. 763–763. 2 indexed citations

16.

Kaposi-Novák, Pál, Ju‐Seog Lee, Luis E. Gómez-Quiroz, et al.. (2006). HGF/c-met expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and an aggressive phenotype. Cancer Research. 66. 795–795. 1 indexed citations

17.

Takami, Taro, et al.. (2006). Loss of HGF/c-met signaling pathway accelerates early stages of DEN-induced hepatocarcinogenesis. Cancer Research. 66. 84–84. 1 indexed citations

18.

Ladu, Sara, Diego F. Calvisi, Elizabeth A. Conner, Valentina M. Factor, & Snorri S. Thorgeirsson. (2005). Co-expression of c-Myc and E2F1 in a mouse model of liver cancer suppresses apoptosis through activation of Akt/mTOR/p70S6K and COX-2 pathways: relevance for human hepatocellular carcinoma. Cancer Research. 65. 258–258. 1 indexed citations

19.

Novoselov, Sergey V., Diego F. Calvisi, Vyacheslav M. Labunskyy, et al.. (2005). Selenoprotein deficiency and high levels of selenium compounds can effectively inhibit hepatocarcinogenesis in transgenic mice. Oncogene. 24(54). 8003–8011. 98 indexed citations

20.

Cavin, Lakita G., Venkatraman Manickam, Valentina M. Factor, et al.. (2004). Regulation of α-Fetoprotein by Nuclear Factor-κB Protects Hepatocytes from Tumor Necrosis Factor-α Cytotoxicity during Fetal Liver Development and Hepatic Oncogenesis. Cancer Research. 64(19). 7030–7038. 32 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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