Christoph Sachse

4.4k citations

32 papers · 3.3k indexed · 2 hit papers · h-index 22

Co-authors: Ivar Roots Jürgen Brockmöller Steffen Bauer Neelanjan Mukherjee Uwe Ohler Ravi Braich Bryan R. Cullen Muthiah Manoharan
Topics: Pharmacogenetics and Drug Metabolism (12 papers)Glutathione Transferases and Polymorphisms (6 papers)Schizophrenia research and treatment (4 papers)
Cited by: Pharmacology Cancer Research Oncology
Journals: NatureSHILAP Revista de lepidopterologíaOncogene
Partner nations: Germany United States United Kingdom

In The Last Decade

Christoph Sachse

30 papers receiving 3.2k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences.

1997 803 citations Christoph Sachse, Jürgen Brockmöller et al. PubMed profile →
Functional significance of a C→A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine

1999 579 citations Christoph Sachse, Jürgen Brockmöller et al. British Journal of Clinical Pharmacology profile →

Peers

Countries citing papers authored by Christoph Sachse

Since Specialization

Citations

This map shows the geographic impact of Christoph Sachse's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Christoph Sachse with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Christoph Sachse more than expected).

Fields of papers citing papers by Christoph Sachse

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Christoph Sachse. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Christoph Sachse. The network helps show where Christoph Sachse may publish in the future.

Co-authorship network of co-authors of Christoph Sachse

This figure shows the co-authorship network connecting the top 25 collaborators of Christoph Sachse. A scholar is included among the top collaborators of Christoph Sachse based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Christoph Sachse. Christoph Sachse is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Combinatorial treatment with statins and niclosamide prevents CRC dissemination by unhinging the MACC1-β-catenin-S100A4 axis of metastasis 2022 ·Oncogene ·(unknown),(unknown),(unknown),Christoph Sachse,Susen Burock,Ulrich Keilholz,Mathias Dahlmann,Wolfgang Walther,Gunnar Dittmar,Dennis Kobelt,Ulrike Stein	18
2	Multiclass cancer classification in fresh frozen and formalin-fixed paraffin-embedded tissue by DigiWest multiplex protein analysis 2020 ·Laboratory Investigation ·(unknown),Gerrit Erdmann,Denise Treue,Philipp Jurmeister,Julia Schneider,(unknown),Daniel Heim,Michael Bockmayr,Christoph Sachse,Frederick Klauschen	3
3	Regenerative potential of adipocytes in hypertrophic scars is mediated by myofibroblast reprogramming 2019 ·Journal of Molecular Medicine ·(unknown),(unknown),Christoph Sachse,Oliver Klein,Uwe von Fritschen,Susan Gibbs,Sarah Hedtrich	31
4	Heterogeneous pathway activation and drug response modelled in colorectal-tumor-derived 3D cultures 2019 ·PLoS Genetics ·Dirk Schumacher,Geoffroy Andrieux,Karsten Boehnke,Marlen Keil,Alessandra Silvestri,(unknown),Ulrich Keilholz,Johannes Haybaeck,Gerrit Erdmann,Christoph Sachse,Markus F. Templin,Jens Hoffmann,Melanie Boerries,Reinhold Schäfer,Christian Regenbrecht	59
5	miR-196 is an essential early-stage regulator of tail regeneration, upstream of key spinal cord patterning events 2009 ·Developmental Biology ·Tina Sehm,Christoph Sachse,(unknown),Karen Echeverri	75
6	19-P002 miR-196 is an essential early-stage regulator of tail regeneration, upstream of key spinal cord patterning events 2009 ·Mechanisms of Development ·Tina Sehm,Christoph Sachse,(unknown),Karen Echeverri	1
7	LNA(R) incorporated siRNAs exhibit lower off-target effects compared to 2'-OMethoxy in Cell Phenotypic Assays and Microarray Analysis 2008 ·Nucleic Acids Symposium Series ·Nitin Puri,Xin Wang,(unknown),(unknown),Lilia M. Beauchamp,(unknown),Megan M. Young,(unknown),Keith E. Latham,Timothy J. Sendera,Christophe J. Echeverri,Christoph Sachse,Susan Magdaleno	21
8	A viral microRNA functions as an orthologue of cellular miR-155 2007 ·Nature ·Eva Gottwein,Neelanjan Mukherjee,Christoph Sachse,(unknown),William H. Majoros,Jen‐Tsan Chi,Ravi Braich,Muthiah Manoharan,Jürgen Soutschek,Uwe Ohler,Bryan R. Cullen	464
9	High-Throughput RNA Interference Strategies for Target Discovery and Validation by Using Synthetic Short Interfering RNAs: Functional Genomics Investigations of Biological Pathways 2005 ·Methods in enzymology on CD-ROM/Methods in enzymology ·Christoph Sachse,Eberhard Krausz,(unknown),Michael Hannus,Andrew Walsh,(unknown),Dmitriy Ovcharenko,David Dorris,Claude Trudel,Birte Sönnichsen,Christophe J. Echeverri	32
10	Oncology studies using siRNA libraries: the dawn of RNAi-based genomics 2004 ·Oncogene ·Christoph Sachse,Christophe J. Echeverri	42
11	Vegetable, fruit and meat consumption and potential risk modifying genes in relation to colorectal cancer 2004 ·International Journal of Cancer ·Faye Turner,Gillian Smith,Christoph Sachse,Tracy Lightfoot,R. Colin Garner,C. Roland Wolf,David Forman,D. Timothy Bishop,Jennifer H. Barrett,(unknown)	57
12	Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls: allele frequencies, linkage disequilibrium and influence on caffeine metabolism 2003 ·British Journal of Clinical Pharmacology ·Christoph Sachse,(unknown),Gillian Smith,Tracy Lightfoot,Jennifer H. Barrett,(unknown),R. Colin Garner,Alan R. Boobis,C. Roland Wolf,Nigel J. Gooderham,(unknown)	134
13	IgA and IgG autoantibodies against alpha-fodrin as markers for Sjögren's syndrome. Systemic lupus erythematosus. 2000 ·PubMed ·T Witte,Matthias Tenbusch,(unknown),H. H. Peter,K Hartung,Christoph Sachse,R. Wigand,(unknown),J. R. Kalden,(unknown),Reinhold E. Schmidt	44
14	CYP2D6 Genotyping as an alternative to phenotyping for determination of metabolic status in a clinical trial setting 2000 ·PubMed ·(unknown),(unknown),(unknown),David L. Friedman,B. Michael Silber,Patrice M. Milos,Christoph Sachse,Jürgen Brockmöller,Ivar Roots	67
15	Clozapine-induced Agranulocytosis and Hereditary Polymorphisms of Clozapine Metabolizing Enzymes: No Association with Myeloperoxidase and Cytochrome P4502D6 2000 ·Pharmacopsychiatry ·Michael Dettling,Christoph Sachse,B. Müller‐Oerlinghausen,I Roots,Jürgen Brockmöller,A. Rolfs,Ingolf Cascorbi	31
16	Long-term therapeutic drug monitoring of clozapine and metabolites in psychiatric in- and outpatients 2000 ·Psychopharmacology ·Michael Dettling,Christoph Sachse,Jürgen Brockmöller,(unknown),(unknown),(unknown),Arndt Rolfs,Rainer Schaub,Jürgen Schmider	38
17	Functional significance of a C→A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeinebreakdown → 1999 ·British Journal of Clinical Pharmacology ·Christoph Sachse,Jürgen Brockmöller,Steffen Bauer,Ivar Roots	579
18	Failure to respond to treatment with typical antipsychotics is not associated with CYP2D6 ultrarapid hydroxylation 1999 ·British Journal of Clinical Pharmacology ·Katherine J. Aitchison,Janet Munro,Pádraig Wright,(unknown),Andrew Makoff,Christoph Sachse,Pak C. Sham,Robin Murray,David Collier,Robert Kerwin	26
19	Polymorphisms in xenobiotic conjugation and disease predisposition 1998 ·Toxicology Letters ·(unknown),Ingolf Cascorbi,Reinhold Kerb,Christoph Sachse,I Roots	53
20	A rare insertion of T226 in exon 1 of CYP2D6 causes a frameshift and is associated with the poor metabolizer phenotype: CYP2D615 1996 ·Pharmacogenetics* ·Christoph Sachse,Jürgen Brockmöller,Steffen Bauer,Torsten Reum,Ivar Roots	16

About Christoph Sachse

Christoph Sachse is a scholar working on Pharmacology, Rehabilitation and Pharmaceutical Science, having authored 32 papers that have together received 3.3k indexed citations. Recurring topics across this work include Pharmacogenetics and Drug Metabolism (12 papers), Glutathione Transferases and Polymorphisms (6 papers) and Schizophrenia research and treatment (4 papers). The work is most often cited by research in Pharmacology (1.4k citations), Cancer Research (586 citations) and Oncology (861 citations). Christoph Sachse has collaborated with scholars based in Germany, United States and United Kingdom. Frequent co-authors include Ivar Roots, Jürgen Brockmöller, Steffen Bauer, Neelanjan Mukherjee, Uwe Ohler, Ravi Braich, Bryan R. Cullen, Muthiah Manoharan, William H. Majoros and Jen‐Tsan Chi. Their work appears in journals such as Nature, SHILAP Revista de lepidopterología and Oncogene.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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