Pak C. Sham

129.2k total citations · 16 hit papers
695 papers, 62.0k citations indexed

About

Pak C. Sham is a scholar working on Genetics, Molecular Biology and Psychiatry and Mental health. According to data from OpenAlex, Pak C. Sham has authored 695 papers receiving a total of 62.0k indexed citations (citations by other indexed papers that have themselves been cited), including 282 papers in Genetics, 189 papers in Molecular Biology and 168 papers in Psychiatry and Mental health. Recurrent topics in Pak C. Sham's work include Genetic Associations and Epidemiology (214 papers), Schizophrenia research and treatment (118 papers) and Genetic Mapping and Diversity in Plants and Animals (75 papers). Pak C. Sham is often cited by papers focused on Genetic Associations and Epidemiology (214 papers), Schizophrenia research and treatment (118 papers) and Genetic Mapping and Diversity in Plants and Animals (75 papers). Pak C. Sham collaborates with scholars based in Hong Kong, United Kingdom and China. Pak C. Sham's co-authors include Shaun Purcell, Benjamin M. Neale, Mark J. Daly, Manuel A. R. Ferreira, Katherine EO Todd-Brown, Paul I. W. de Bakker, Julian Maller, D.B. Bender, Pamela Sklar and Robin Murray and has published in prestigious journals such as The Lancet, Nucleic Acids Research and Circulation.

In The Last Decade

Pak C. Sham

679 papers receiving 60.6k citations

Hit Papers

PLINK: A Tool Set for Whole-Genome Association and Po... 1995 2026 2005 2015 2007 2002 2015 2003 2007 5.0k 10.0k 15.0k 20.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses
    2007 21.9k citations Shaun Purcell, Pak C. Sham et al. The American Journal of Human Genetics profile →
  2. Genetic Power Calculator: design of linkage andassociation genetic mapping studies of complex traits
    2002 1.6k citations Stacey S. Cherny, Pak C. Sham et al. Bioinformatics profile →
  3. The support of human genetic evidence for approved drug indications
    2015 874 citations Pak C. Sham, Mulin Jun Li et al. profile →
  4. The Heritability of Bipolar Affective Disorder and the Genetic Relationship to Unipolar Depression
    2003 841 citations Pak C. Sham et al. profile →
  5. Stress and Psychological Distress among SARS Survivors 1 Year after the Outbreak
    2007 823 citations Pak C. Sham et al. profile →
  6. Monte Carlo tests for associations between disease and alleles at highly polymorphic loci
    1995 802 citations Pak C. Sham et al. profile →
  7. Prevalence and Pattern of Lumbar Magnetic Resonance Imaging Changes in a Population Study of One Thousand Forty-Three Individuals
    2009 674 citations Kmc Cheung, Danny Chan et al. profile →
  8. Evaluating the effective numbers of independent tests and significant p-value thresholds in commercial genotyping arrays and public imputation reference datasets
    2011 603 citations Miaoxin Li, Stacey S. Cherny et al. profile →
  9. Heritability estimates for psychotic disorders: the Maudsley twin psychosis series.
    1999 569 citations Shôn Lewis, Pak C. Sham et al. profile →
  10. A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders.
    1996 558 citations Tao Li, Robin Murray et al. profile →
  11. Statistical methods of estimation and inference for functional MR image analysis
    1996 556 citations Pak C. Sham et al. profile →
  12. Immediate and Sustained Psychological Impact of an Emerging Infectious Disease Outbreak on Health Care Workers
    2007 548 citations Pak C. Sham et al. profile →
  13. Gene–environment interaction analysis of serotonin system markers with adolescent depression
    2004 509 citations Pak C. Sham et al. profile →
  14. An extended transmission/disequilibrium test (TDT) for multi‐allele marker loci
    1995 501 citations Pak C. Sham et al. profile →
  15. Statistical power and significance testing in large-scale genetic studies
    2014 367 citations Pak C. Sham, Shaun Purcell profile →
  16. Single-cell RNA sequencing shows the immunosuppressive landscape and tumor heterogeneity of HBV-associated hepatocellular carcinoma
    2021 214 citations Pak C. Sham et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Pak C. Sham Hong Kong 97 24.3k 16.4k 11.0k 6.0k 6.0k 695 62.0k
Nicholas G. Martin Australia 115 15.7k 0.6× 10.6k 0.6× 5.0k 0.4× 6.3k 1.0× 11.7k 1.9× 1.4k 63.3k
Neil Risch United States 96 18.8k 0.8× 10.4k 0.6× 2.9k 0.3× 2.7k 0.4× 1.9k 0.3× 318 40.0k
Michael J. Owen United Kingdom 107 11.7k 0.5× 16.4k 1.0× 8.5k 0.8× 5.7k 0.9× 3.0k 0.5× 615 40.9k
Andrew C. Heath United States 99 8.2k 0.3× 11.2k 0.7× 4.6k 0.4× 3.2k 0.5× 12.5k 2.1× 614 47.0k
David Goldman United States 102 6.3k 0.3× 12.8k 0.8× 7.0k 0.6× 8.6k 1.4× 7.6k 1.3× 651 48.6k
George P. Chrousos Greece 147 6.6k 0.3× 11.4k 0.7× 6.2k 0.6× 5.3k 0.9× 7.6k 1.3× 1.4k 96.8k
Ian J. Deary United Kingdom 131 8.5k 0.3× 5.9k 0.4× 10.5k 1.0× 10.8k 1.8× 7.5k 1.2× 1.3k 72.0k
Dorret I. Boomsma Netherlands 105 10.0k 0.4× 5.8k 0.4× 6.1k 0.6× 9.9k 1.6× 10.8k 1.8× 1.0k 47.4k
Daniel H. Geschwind United States 122 14.7k 0.6× 24.9k 1.5× 3.0k 0.3× 13.7k 2.3× 1.6k 0.3× 428 50.5k
Jaakko Kaprio Finland 117 9.6k 0.4× 8.6k 0.5× 5.6k 0.5× 5.2k 0.9× 7.7k 1.3× 1.2k 61.3k

Countries citing papers authored by Pak C. Sham

Since Specialization
Citations

This map shows the geographic impact of Pak C. Sham's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Pak C. Sham with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Pak C. Sham more than expected).

Fields of papers citing papers by Pak C. Sham

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Pak C. Sham. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Pak C. Sham. The network helps show where Pak C. Sham may publish in the future.

Co-authorship network of co-authors of Pak C. Sham

This figure shows the co-authorship network connecting the top 25 collaborators of Pak C. Sham. A scholar is included among the top collaborators of Pak C. Sham based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Pak C. Sham. Pak C. Sham is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
2.
Ni, Tong, Zefeng Li, Tao Tan, et al.. (2024). Integrated Transcriptome Analysis Reveals Novel Molecular Signatures for Schizophrenia Characterization. Advanced Science. 12(2). e2407628–e2407628. 3 indexed citations
3.
Cai, Jia, Min Xie, Liansheng Zhao, et al.. (2023). White matter changes and its relationship with clinical symptom in medication-naive first-episode early onset schizophrenia. Asian Journal of Psychiatry. 82. 103482–103482. 3 indexed citations
4.
Jiang, Lin, Hui Jiang, Sheng Dai, et al.. (2021). Deviation from baseline mutation burden provides powerful and robust rare-variants association test for complex diseases. Nucleic Acids Research. 50(6). e34–e34. 5 indexed citations
5.
Sala, Luca, Manuela Mura, Marcella Rocchetti, et al.. (2020). MTMR4 SNVs modulate ion channel degradation and clinical severity in congenital long QT syndrome: insights in the mechanism of action of protective modifier genes. Cardiovascular Research. 117(3). 767–779. 32 indexed citations
6.
Dong, Xiaobao, Dandan Huang, Xianfu Yi, et al.. (2020). Diversity spectrum analysis identifies mutation-specific effects of cancer driver genes. Communications Biology. 3(1). 6–6. 9 indexed citations
7.
8.
Li, Gloria Hoi‐Yee, et al.. (2019). Positive effects of low LDL-C and statins on bone mineral density: an integrated epidemiological observation analysis and Mendelian randomization study. International Journal of Epidemiology. 49(4). 1221–1235. 47 indexed citations
9.
Zhang, Shijie, Yukun He, Huanhuan Liu, et al.. (2019). regBase: whole genome base-wise aggregation and functional prediction for human non-coding regulatory variants. Nucleic Acids Research. 47(21). e134–e134. 33 indexed citations
10.
Zhang, Yamin, Mingli Li, Qiang Wang, et al.. (2019). A joint study of whole exome sequencing and structural MRI analysis in major depressive disorder. Psychological Medicine. 50(3). 384–395. 20 indexed citations
11.
Campbell, Desmond, et al.. (2017). Multifactorial disease risk calculator: Risk prediction for multifactorial disease pedigrees. Genetic Epidemiology. 42(2). 130–133. 6 indexed citations
12.
So, Hon‐Cheong & Pak C. Sham. (2016). Exploring the predictive power of polygenic scores derived from genome-wide association studies: a study of 10 complex traits. Bioinformatics. 33(6). 886–892. 33 indexed citations
13.
Li, Mulin Jun, Jiaen Deng, Panwen Wang, et al.. (2015). wKGGSeq: A Comprehensive Strategy-Based and Disease-Targeted Online Framework to Facilitate Exome Sequencing Studies of Inherited Disorders. Human Mutation. 36(5). 496–503. 8 indexed citations
14.
Fu, Li, Alissa M. Wong, Yanhui Fan, et al.. (2013). Fine mapping candidate loci for nasopharyngeal carcinoma in southern Chinese specifically linked to Epstein- Barr virus aetiopathogenesis. Hong Kong Medical Journal. 19(5). 1 indexed citations
15.
So, Hon‐Cheong, Johnny S. H. Kwan, Stacey S. Cherny, & Pak C. Sham. (2011). Risk Prediction of Complex Diseases from Family History and Known Susceptibility Loci, with Applications for Cancer Screening. The American Journal of Human Genetics. 88(5). 548–565. 54 indexed citations
16.
Chua, Daniel, Mandy Ng, Li Fu, et al.. (2006). High-throughput Loss-of-Heterozygosity Study of Chromosome 3p in Lung Cancer Using Single-Nucleotide Polymorphism Markers. Cancer Research. 66(8). 4133–4138. 47 indexed citations
17.
Fearon, Paul, Pak C. Sham, Peter B. Jones, et al.. (2002). The relationship between predisposing factors, premorbid function and symptom dimensions in psychosis: an integrated approach. European Psychiatry. 17(6). 311–320. 20 indexed citations
18.
Purcell, Shaun & Pak C. Sham. (2001). Gene-by-environment Interaction in Twin and Sib-pair Analysis. Twin Research and Human Genetics. 4(3). 204. 1 indexed citations
19.
MacLean, Charles J., Pak C. Sham, Lynn Ploughman, Scott R. Diehl, & Kenneth S. Kendler. (1994). Reply to Faraway. The American Journal of Human Genetics. 54(3). 564–567. 1 indexed citations
20.
O’Callaghan, E., Pak C. Sham, N Takei, Robin Murray, & Gyles Glover. (1991). Schizophrenia after prenatal exposure to 1957 A2 influenza epidemic. The Lancet. 337(8752). 1248–1250. 308 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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