Cassandra Koole

2.2k citations

23 papers · 1.6k indexed · h-index 19

Impact in

Cellular and Molecular Neuroscience top 2%
- Neuropeptides and Animal Physiology
Endocrinology, Diabetes and Metabolism top 2%
- Diabetes Treatment and Management

Papers in

Cellular and Molecular Neuroscience 17
- Neuropeptides and Animal Physiology 17
Endocrinology, Diabetes and Metabolism 14
- Diabetes Treatment and Management 14

Co-authors: Denise Wootten Patrick M. Sexton Arthur Christopoulos Laurence J. Miller John Simms Sebastian G. B. Furness Maryam Khoshouei Yi-Lynn Liang
Journals: Journal of Biological Chemistry (4 papers)Molecular Pharmacology (3 papers)Journal of Pharmacology and Experimental Therapeutics (2 papers)Nature (2 papers)British Journal of Pharmacology (2 papers)
Partner nations: Australia United States United Kingdom

In The Last Decade

Cassandra Koole

23 papers receiving 1.6k citations

Peers

Countries citing papers authored by Cassandra Koole

Since Specialization

Citations

This map shows the geographic impact of Cassandra Koole's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Cassandra Koole with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Cassandra Koole more than expected).

Fields of papers citing papers by Cassandra Koole

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Cassandra Koole. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Cassandra Koole. The network helps show where Cassandra Koole may publish in the future.

Co-authors

The 25 scholars most cited alongside Cassandra Koole, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Cassandra Koole Line = papers co-authored together Cassandra Koole links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Socs3b regulates the development and function of innate immune cells in zebrafish Frontiers in Immunology ·Jorge Forero-Muñoz, Irl H. Dulcbohn, Mauricio Durán-Martínez, Cassandra Koole, Clifford Liongue, Alister C. Ward	2023	6
2	Toward a Structural Understanding of Class B GPCR Peptide Binding and Activation Molecular Cell ·Yi-Lynn Liang, Matthew J. Belousoff, Peishen Zhao, Cassandra Koole, Madeleine M. Fletcher, Tin T. Truong, Doryun Chong, George Christopoulos, H. Eric Xu, Yan Zhang, Maryam Khoshouei, Arthur Christopoulos, Radostin Danev, Patrick M. Sexton, Denise Wootten	2020	79
3	Two distinct domains of the glucagon-like peptide-1 receptor control peptide-mediated biased agonism Journal of Biological Chemistry ·Saifei Lei, Lachlan Clydesdale, Antao Dai, Xiaoqing Cai, Yang Feng, Dehua Yang, Yi-Lynn Liang, Cassandra Koole, Peishen Zhao, Thomas Coudrat, Arthur Christopoulos, Ming‐Wei Wang, Denise Wootten, Patrick M. Sexton	2018	42
4	Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor Nature ·Yi-Lynn Liang, Maryam Khoshouei, Giuseppe Deganutti, Alisa Glukhova, Cassandra Koole, Thomas S. Peat, Mazdak Radjainia, Jürgen M. Plitzko, Wolfgang Baumeister, Laurence J. Miller, Debbie L. Hay, Arthur Christopoulos, Christopher A. Reynolds, Denise Wootten, Patrick M. Sexton	2018	178
5	Vascular and molecular pharmacology of the metabolically stable CGRP analogue, SAX European Journal of Pharmacology ·Majid Sheykhzade, Christine Ullmann, Cassandra Koole, Darryl S. Pickering, Karin Dreisig, Sara Ellinor Johansson, Chimuanya Christiana Agokei, Rasmus Dreier, 李孟军, Jørgen Jeppesen, Patrick M. Sexton, Lars Edvinsson, Denise Wootten, Anette Sams	2018	14
6	Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex Nature ·Yi-Lynn Liang, Maryam Khoshouei, Alisa Glukhova, Sebastian G. B. Furness, Peishen Zhao, Lachlan Clydesdale, Cassandra Koole, Tin T. Truong, David M. Thal, Saifei Lei, Mazdak Radjainia, Radostin Danev, Wolfgang Baumeister, Ming-Wei Wang, Laurence J. Miller, Arthur Christopoulos, Patrick M. Sexton, Denise Wootten	2018	234
7	Genetically encoded photocross-linkers determine the biological binding site of exendin-4 peptide in the N-terminal domain of the intact human glucagon-like peptide-1 receptor (GLP-1R) Journal of Biological Chemistry ·Cassandra Koole, Christopher A. Reynolds, Juan Carlos Mobarec, Caroline A. Hick, Patrick M. Sexton, Thomas P. Sakmar	2017	38
8	The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism Cell ·Denise Wootten, Christopher A. Reynolds, Kevin J. Smith, Juan Carlos Mobarec, Cassandra Koole, Emilia E. Savage, Kavita Pabreja, John Simms, Hartmut Henneken, Sebastian G. B. Furness, Mengjie Liu, Philip E. Thompson, Laurence J. Miller, Arthur Christopoulos, Patrick M. Sexton	2016	119
9	A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures Molecular Pharmacology ·Denise Wootten, Christopher A. Reynolds, Cassandra Koole, Kevin J. Smith, Juan Carlos Mobarec, John Simms, Tezz Quon, Thomas Coudrat, Sebastian G. B. Furness, Laurence J. Miller, Arthur Christopoulos, Patrick M. Sexton	2015	52
10	Differential Impact of Amino Acid Substitutions on Critical Residues of the Human Glucagon-Like Peptide-1 Receptor Involved in Peptide Activity and Small-Molecule Allostery Journal of Pharmacology and Experimental Therapeutics ·Cassandra Koole, Denise Wootten, John Simms, Laurence J. Miller, Arthur Christopoulos, Patrick M. Sexton	2015	16
11	Structural and functional insights into the juxtamembranous amino‐terminal tail and extracellular loop regions of class B GPCRs British Journal of Pharmacology ·Maoqing Dong, Cassandra Koole, Denise Wootten, Patrick M. Sexton, L J Miller	2013	18
12	Recent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) function Biochemical Society Transactions ·Cassandra Koole, Kavita Pabreja, Emilia E. Savage, Denise Wootten, Sebastian G. B. Furness, Laurence J. Miller, Arthur Christopoulos, Patrick M. Sexton	2013	66
13	Molecular mechanisms underlying physiological and receptor pleiotropic effects mediated by GLP‐1R activation British Journal of Pharmacology ·Kavita Pabreja, Mohd Effendy Abd Wahid, Cassandra Koole, Denise Wootten, Sebastian G. B. Furness	2013	65
14	Minireview: Signal Bias, Allosterism, and Polymorphic Variation at the GLP-1R: Implications for Drug Discovery Molecular Endocrinology ·Cassandra Koole, Emilia E. Savage, Arthur Christopoulos, Laurence J. Miller, Patrick M. Sexton, Denise Wootten	2013	34
15	Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery Proceedings of the National Academy of Sciences ·Kaleeckal G. Harikumar, Denise Wootten, Delia I. Pinon, Cassandra Koole, Damian Kała, Sebastian G. B. Furness, Bim Graham, Maoqing Dong, Arthur Christopoulos, Laurence J. Miller, Patrick M. Sexton	2012	61
16	Second Extracellular Loop of Human Glucagon-like Peptide-1 Receptor (GLP-1R) Has a Critical Role in GLP-1 Peptide Binding and Receptor Activation Journal of Biological Chemistry ·Cassandra Koole, Denise Wootten, John Simms, Laurence J. Miller, Arthur Christopoulos, Patrick M. Sexton	2011	77
17	Polymorphism and Ligand Dependent Changes in Human Glucagon-Like Peptide-1 Receptor (GLP-1R) Function: Allosteric Rescue of Loss of Function Mutation Molecular Pharmacology ·Cassandra Koole, Denise Wootten, John Simms, Céline Valant, Laurence J. Miller, Arthur Christopoulos, Patrick M. Sexton	2011	76
18	Second Extracellular Loop of Human Glucagon-like Peptide-1 Receptor (GLP-1R) Differentially Regulates Orthosteric but Not Allosteric Agonist Binding and Function Journal of Biological Chemistry ·Cassandra Koole, Denise Wootten, John Simms, Emilia E. Savage, Laurence J. Miller, Arthur Christopoulos, Patrick M. Sexton	2011	28
19	Modulation of the Glucagon-Like Peptide-1 Receptor Signaling by Naturally Occurring and Synthetic Flavonoids Journal of Pharmacology and Experimental Therapeutics ·Denise Wootten, John Simms, Cassandra Koole, Owen L. Woodman, Roger J. Summers, Arthur Christopoulos, Patrick M. Sexton	2010	70
20	Allosteric Ligands of the Glucagon-Like Peptide 1 Receptor (GLP-1R) Differentially Modulate Endogenous and Exogenous Peptide Responses in a Pathway-Selective Manner: Implications for Drug Screening Molecular Pharmacology ·Cassandra Koole, Denise Wootten, John Simms, Céline Valant, Hartmut Henneken, Owen L. Woodman, Laurence J. Miller, Roger J. Summers, Arthur Christopoulos, Patrick M. Sexton	2010	174

About Cassandra Koole

Cassandra Koole is a scholar working on Cellular and Molecular Neuroscience, Endocrinology, Diabetes and Metabolism, Molecular Biology, Neurology and Animal Science and Zoology, having authored 23 papers that have together received 1.6k indexed citations. Recurring topics across this work include Receptor Mechanisms and Signaling (21 papers), Neuropeptides and Animal Physiology (17 papers), Diabetes Treatment and Management (14 papers), Pancreatic function and diabetes (4 papers), Glycosylation and Glycoproteins Research (2 papers), Protein Kinase Regulation and GTPase Signaling (2 papers), Signaling Pathways in Disease (1 paper) and Nitric Oxide and Endothelin Effects (1 paper). The work is most often cited by research in Cellular and Molecular Neuroscience (855 citations), Endocrinology, Diabetes and Metabolism (692 citations), Structural Biology (28 citations), Molecular Biology (1.3k citations) and Endocrine and Autonomic Systems (57 citations). Cassandra Koole has collaborated with scholars based in Australia, United States and United Kingdom. Frequent co-authors include Denise Wootten, Patrick M. Sexton, Arthur Christopoulos, Laurence J. Miller, John Simms, Sebastian G. B. Furness, Maryam Khoshouei, Yi-Lynn Liang, Christopher A. Reynolds and Kavita Pabreja. Their work appears in journals such as Journal of Biological Chemistry, Molecular Pharmacology, Journal of Pharmacology and Experimental Therapeutics, Nature and British Journal of Pharmacology.

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