C. Dirk Keene

40.4k total citations · 5 hit papers
234 papers, 8.5k citations indexed

About

C. Dirk Keene is a scholar working on Physiology, Molecular Biology and Neurology. According to data from OpenAlex, C. Dirk Keene has authored 234 papers receiving a total of 8.5k indexed citations (citations by other indexed papers that have themselves been cited), including 95 papers in Physiology, 77 papers in Molecular Biology and 52 papers in Neurology. Recurrent topics in C. Dirk Keene's work include Alzheimer's disease research and treatments (91 papers), Neuroinflammation and Neurodegeneration Mechanisms (39 papers) and Dementia and Cognitive Impairment Research (38 papers). C. Dirk Keene is often cited by papers focused on Alzheimer's disease research and treatments (91 papers), Neuroinflammation and Neurodegeneration Mechanisms (39 papers) and Dementia and Cognitive Impairment Research (38 papers). C. Dirk Keene collaborates with scholars based in United States, Canada and United Kingdom. C. Dirk Keene's co-authors include Walter C. Low, Thomas J. Montine, Catherine M. Verfaillie, Thomas D. Bird, Kathleen S. Montine, Li-Ru Zhao, Wei-Ming Duan, Kristen Dams-O’Connor, Morayma Reyes and Carlo Condello and has published in prestigious journals such as Proceedings of the National Academy of Sciences, Journal of Clinical Investigation and Nature Communications.

In The Last Decade

C. Dirk Keene

225 papers receiving 8.3k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Human Bone Marrow Stem Cells Exhibit Neural Phenotypes and Ameliorate Neurological Deficits after Grafting into the Ischemic Brain of Rats

2002 652 citations C. Dirk Keene et al. profile →
TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

2016 563 citations Carlo Condello, C. Dirk Keene et al. profile →
The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy

2015 559 citations C. Dirk Keene, Daniel P. Perl et al. Acta Neuropathologica profile →
Association of Traumatic Brain Injury With Late-Life Neurodegenerative Conditions and Neuropathologic Findings

2016 318 citations Paul K. Crane, Laura E. Gibbons et al. profile →
Traumatic Brain Injury and Risk of Neurodegenerative Disorder

2021 238 citations C. Dirk Keene et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
C. Dirk Keene United States	46	3.0k	2.5k	2.0k	1.8k	1.6k	234	8.5k
Kōji Abe Japan	46	3.3k 1.1×	1.8k 0.7×	2.1k 1.1×	1.4k 0.8×	2.5k 1.6×	390	9.1k
Stephen B. Wharton United Kingdom	51	2.8k 0.9×	2.7k 1.1×	2.3k 1.1×	2.6k 1.4×	1.3k 0.9×	170	8.9k
Elisabet Englund Sweden	51	2.2k 0.7×	3.1k 1.2×	2.4k 1.2×	3.3k 1.8×	1.6k 1.0×	208	10.5k
Hideki Mochizuki Japan	57	3.8k 1.3×	1.8k 0.7×	1.9k 1.0×	3.8k 2.1×	2.9k 1.8×	436	11.4k
Axel Petzold United Kingdom	58	3.1k 1.1×	1.5k 0.6×	1.4k 0.7×	5.7k 3.1×	1.6k 1.0×	287	13.4k
Jonathan D. Glass United States	48	2.7k 0.9×	1.7k 0.7×	2.1k 1.1×	2.9k 1.6×	1.7k 1.1×	131	8.6k
Turgay Dalkara Türkiye	47	3.3k 1.1×	2.6k 1.0×	3.6k 1.8×	1.8k 1.0×	2.0k 1.3×	158	11.5k
Axel Montagne United States	35	2.2k 0.7×	2.5k 1.0×	4.1k 2.1×	1.7k 0.9×	1.4k 0.9×	66	9.4k
Melanie D. Sweeney United States	20	2.5k 0.8×	2.7k 1.1×	4.4k 2.2×	1.8k 1.0×	1.5k 1.0×	23	9.7k
Masafumi Ihara Japan	57	2.1k 0.7×	2.4k 0.9×	4.7k 2.4×	2.3k 1.3×	1.1k 0.7×	357	11.2k

Countries citing papers authored by C. Dirk Keene

Since Specialization

Citations

This map shows the geographic impact of C. Dirk Keene's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by C. Dirk Keene with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites C. Dirk Keene more than expected).

Fields of papers citing papers by C. Dirk Keene

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by C. Dirk Keene. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by C. Dirk Keene. The network helps show where C. Dirk Keene may publish in the future.

Co-authorship network of co-authors of C. Dirk Keene

This figure shows the co-authorship network connecting the top 25 collaborators of C. Dirk Keene. A scholar is included among the top collaborators of C. Dirk Keene based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with C. Dirk Keene. C. Dirk Keene is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

McGrath, Stephanie, Matthew D. Dunbar, Evan L. MacLean, et al.. (2025). The companion dog as a translational model for Alzheimer's disease: Development of a longitudinal research platform and post mortem protocols. Alzheimer s & Dementia. 21(9). e70630–e70630.

Bukhari, Syed, Lei Xue, David Seong, et al.. (2025). Deep learning-based cell type profiles reveal signatures of Alzheimer’s disease resilience and resistance. Brain. 148(10). 3665–3678.

Chapman, Nicola H., Laura E. Gibbons, Mayumi Yagi, et al.. (2024). Neuropathological correlates of vulnerability and resilience in the cerebellum in Alzheimer's disease. Alzheimer s & Dementia. 21(2). e14428–e14428. 3 indexed citations

Cholerton, Brenna, Caitlin S. Latimer, Paul K. Crane, et al.. (2024). Neuropathologic Burden and Dementia in Nonagenarians and Centenarians. Neurology. 102(3). e208060–e208060. 4 indexed citations

Smukowski, Samuel N., Cassidy Danyko, Nadia Postupna, et al.. (2024). mRNA and circRNA mislocalization to synapses are key features of Alzheimer’s disease. PLoS Genetics. 20(7). e1011359–e1011359. 4 indexed citations

Tritt, Andrew, John K. Yue, Adam R. Ferguson, et al.. (2023). Data-driven distillation and precision prognosis in traumatic brain injury with interpretable machine learning. Scientific Reports. 13(1). 21200–21200. 3 indexed citations

Chan, Kwun Chuen Gary, et al.. (2023). Simultaneous mediation effect estimation of APOE through multiple neuropathological pathways on cognitive outcomes. Alzheimer s & Dementia. 19(S8).

Niere, Farr, Zhiyong Deng, Luisa P. Cacheaux, et al.. (2023). Aberrant DJ-1 expression underlies L-type calcium channel hypoactivity in dendrites in tuberous sclerosis complex and Alzheimer’s disease. Proceedings of the National Academy of Sciences. 120(45). e2301534120–e2301534120. 8 indexed citations

Adeniyi, Philip A., Xi Gong, Evelyn McClendon, et al.. (2023). Ferroptosis of Microglia in Aging Human White Matter Injury. Annals of Neurology. 94(6). 1048–1066. 33 indexed citations

10.

Prater, Katherine E., Wei Sun, C. Smith, et al.. (2023). Human microglia show unique transcriptional changes in Alzheimer’s disease. Nature Aging. 3(7). 894–907. 69 indexed citations

11.

Latimer, Caitlin S., et al.. (2022). TDP-43 promotes tau accumulation and selective neurotoxicity in bigenic Caenorhabditis elegans. Disease Models & Mechanisms. 15(4). 29 indexed citations

12.

Condello, Carlo, Alison M. Maxwell, Erika Castillo, et al.. (2022). Aβ and tau prions feature in the neuropathogenesis of Down syndrome. Proceedings of the National Academy of Sciences. 119(46). e2212954119–e2212954119. 17 indexed citations

13.

Scaduto, Pietro, Julie C. Lauterborn, Conor D. Cox, et al.. (2022). Functional excitatory to inhibitory synaptic imbalance and loss of cognitive performance in people with Alzheimer’s disease neuropathologic change. Acta Neuropathologica. 145(3). 303–324. 34 indexed citations

14.

Kiianitsa, Kostantin, Tuhin Virmani, Refugio A. Martinez, et al.. (2022). Reduced gene dosage is a common mechanism of neuropathologies caused by ATP6AP2 splicing mutations. Parkinsonism & Related Disorders. 101. 31–38. 3 indexed citations

15.

Lauterborn, Julie C., Pietro Scaduto, Conor D. Cox, et al.. (2021). Increased excitatory to inhibitory synaptic ratio in parietal cortex samples from individuals with Alzheimer’s disease. Nature Communications. 12(1). 2603–2603. 96 indexed citations

16.

Craft, Suzanne, Caitlin S. Latimer, C. Dirk Keene, et al.. (2021). Aging‐related Alzheimer's disease‐like neuropathology and functional decline in captive vervet monkeys (Chlorocebus aethiops sabaeus). American Journal of Primatology. 83(11). e23260–e23260. 20 indexed citations

17.

Zhang, Fang, Mary Gannon, Yunjia Chen, et al.. (2020). β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade. Science Translational Medicine. 12(526). 99 indexed citations

18.

Gauthreaux, Kathryn, Tyler Bonnett, Lilah M. Besser, et al.. (2020). Concordance of Clinical Alzheimer Diagnosis and Neuropathological Features at Autopsy. Journal of Neuropathology & Experimental Neurology. 79(5). 465–473. 30 indexed citations

19.

Huang, Ming, Martin Darvas, C. Dirk Keene, & Yinsheng Wang. (2019). Targeted Quantitative Proteomic Approach for High-Throughput Quantitative Profiling of Small GTPases in Brain Tissues of Alzheimer’s Disease Patients. Analytical Chemistry. 91(19). 12307–12314. 8 indexed citations

20.

Aoyagi, Atsushi, Carlo Condello, Jan Stöhr, et al.. (2019). Aβ and tau prion-like activities decline with longevity in the Alzheimer’s disease human brain. Science Translational Medicine. 11(490). 95 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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