Miranda E. Orr

3.4k total citations · 3 hit papers
54 papers, 2.2k citations indexed

About

Miranda E. Orr is a scholar working on Physiology, Molecular Biology and Neurology. According to data from OpenAlex, Miranda E. Orr has authored 54 papers receiving a total of 2.2k indexed citations (citations by other indexed papers that have themselves been cited), including 37 papers in Physiology, 19 papers in Molecular Biology and 15 papers in Neurology. Recurrent topics in Miranda E. Orr's work include Alzheimer's disease research and treatments (22 papers), Telomeres, Telomerase, and Senescence (14 papers) and Neuroinflammation and Neurodegeneration Mechanisms (12 papers). Miranda E. Orr is often cited by papers focused on Alzheimer's disease research and treatments (22 papers), Telomeres, Telomerase, and Senescence (14 papers) and Neuroinflammation and Neurodegeneration Mechanisms (12 papers). Miranda E. Orr collaborates with scholars based in United States, Italy and Australia. Miranda E. Orr's co-authors include Salvatore Oddo, Valentina R. Garbarino, Nicolas Musi, Joseph M. Valentine, Bess Frost, Qiang Shen, Eric Baeuerle, Rochelle Buffenstein, Mitzi M. Gonzales and Juan Pablo Palavicini and has published in prestigious journals such as Proceedings of the National Academy of Sciences, Journal of Clinical Investigation and Nature Medicine.

In The Last Decade

Miranda E. Orr

51 papers receiving 2.2k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Tau protein aggregation is associated with cellular senescence in the brain

2018 415 citations Nicolas Musi, Joseph M. Valentine et al. Aging Cell profile →
Biological aging processes underlying cognitive decline and neurodegenerative disease

2022 190 citations Mitzi M. Gonzales, Valentina R. Garbarino et al. profile →
Senolytic therapy in mild Alzheimer’s disease: a phase 1 feasibility trial

2023 149 citations Mitzi M. Gonzales, Valentina R. Garbarino et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Miranda E. Orr United States	22	1.1k	797	484	252	236	54	2.2k
Carmen Venegas Spain	21	1.1k 1.0×	1.2k 1.5×	582 1.2×	157 0.6×	286 1.2×	29	3.7k
Mina Königsberg Mexico	27	624 0.6×	945 1.2×	236 0.5×	148 0.6×	204 0.9×	96	2.1k
Atsuyoshi Shimada Japan	29	511 0.5×	637 0.8×	579 1.2×	139 0.6×	428 1.8×	85	2.1k
Evelyn Perez United States	27	575 0.5×	943 1.2×	219 0.5×	124 0.5×	306 1.3×	32	2.6k
Weikang Cai United States	26	1.1k 1.0×	1.2k 1.5×	279 0.6×	56 0.2×	322 1.4×	54	2.8k
Nicole M. Ashpole United States	27	533 0.5×	828 1.0×	430 0.9×	75 0.3×	413 1.8×	53	2.4k
Zheng Chen United States	33	887 0.8×	856 1.1×	108 0.2×	372 1.5×	386 1.6×	72	3.2k
Sudarshana Purkayastha United States	15	512 0.5×	560 0.7×	263 0.5×	123 0.5×	190 0.8×	20	1.7k
Daniele Bano Germany	28	469 0.4×	1.8k 2.2×	366 0.8×	147 0.6×	879 3.7×	64	2.9k

Countries citing papers authored by Miranda E. Orr

Since Specialization

Citations

This map shows the geographic impact of Miranda E. Orr's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Miranda E. Orr with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Miranda E. Orr more than expected).

Fields of papers citing papers by Miranda E. Orr

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Miranda E. Orr. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Miranda E. Orr. The network helps show where Miranda E. Orr may publish in the future.

Co-authorship network of co-authors of Miranda E. Orr

This figure shows the co-authorship network connecting the top 25 collaborators of Miranda E. Orr. A scholar is included among the top collaborators of Miranda E. Orr based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Miranda E. Orr. Miranda E. Orr is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Orr, Miranda E., et al.. (2025). Senescent brain cell types in Alzheimer's disease: Pathological mechanisms and therapeutic opportunities. Neurotherapeutics. 22(3). e00519–e00519. 2 indexed citations

Orr, Miranda E., et al.. (2024). PET Imaging of Microtubules in Cognitively Impaired and Normal Older Adults. Alzheimer s & Dementia. 20(S8). 1 indexed citations

Boccardi, Virginia, Miranda E. Orr, Maria Cristina Polidori, Carmelinda Ruggiero, & Patrizia Mecocci. (2024). Focus on senescence: Clinical significance and practical applications. Journal of Internal Medicine. 295(5). 599–619. 22 indexed citations

Rießland, Markus, Methodios Ximerakis, Andrew A. Jarjour, Bin Zhang, & Miranda E. Orr. (2024). Therapeutic targeting of senescent cells in the CNS. Nature Reviews Drug Discovery. 23(11). 817–837. 20 indexed citations

Register, Thomas C., Akiva Mintz, Miranda E. Orr, et al.. (2023). Preliminary PET Imaging of Microtubule-Based PET Radioligand [¹¹C]MPC-6827 in a Nonhuman Primate Model of Alzheimer’s Disease. ACS Chemical Neuroscience. 14(20). 3745–3751. 5 indexed citations

Walker, Jamie M., Miranda E. Orr, Emma L Thorn, et al.. (2023). Spatial proteomics of hippocampal subfield‐specific pathology in Alzheimer's disease and primary age‐related tauopathy. Alzheimer s & Dementia. 20(2). 783–797. 17 indexed citations

Orr, Miranda E., et al.. (2023). Investigating neuronal senescence marker, p19^INK4d, in mouse and human brains. Alzheimer s & Dementia. 19(S24). 1 indexed citations

Walker, Jamie M., Shiva Kazempour Dehkordi, Anna Fracassi, et al.. (2022). Differential protein expression in the hippocampi of resilient individuals identified by digital spatial profiling. Acta Neuropathologica Communications. 10(1). 23–23. 31 indexed citations

Xu, Peng, Minghui Wang, Won‐Min Song, et al.. (2022). The landscape of human tissue and cell type specific expression and co-regulation of senescence genes. Molecular Neurodegeneration. 17(1). 5–5. 72 indexed citations

10.

Orr, Miranda E., Shannon L. Macauley, Christopher T. Whitlow, et al.. (2022). Preliminary mechanistic insights of a brain-penetrant microtubule imaging PET ligand in a tau-knockout mouse model. EJNMMI Research. 12(1). 41–41. 9 indexed citations

11.

Krishnamurthy, Sudarshan, et al.. (2021). The Cellular Senescence Stress Response in Post-Mitotic Brain Cells: Cell Survival at the Expense of Tissue Degeneration. Life. 11(3). 229–229. 39 indexed citations

12.

Craft, Suzanne, Caitlin S. Latimer, C. Dirk Keene, et al.. (2021). Aging‐related Alzheimer's disease‐like neuropathology and functional decline in captive vervet monkeys (Chlorocebus aethiops sabaeus). American Journal of Primatology. 83(11). e23260–e23260. 20 indexed citations

13.

Gonzales, Mitzi M., Sudarshan Krishnamurthy, Valentina R. Garbarino, et al.. (2021). A geroscience motivated approach to treat Alzheimer’s disease: Senolytics move to clinical trials. Mechanisms of Ageing and Development. 200. 111589–111589. 19 indexed citations

14.

Gillispie, Gregory J., et al.. (2021). Evidence of the Cellular Senescence Stress Response in Mitotically Active Brain Cells—Implications for Cancer and Neurodegeneration. Life. 11(2). 153–153. 21 indexed citations

15.

Orr, Miranda E., Paul W. Czoty, Jeffrey L. Weiner, et al.. (2021). Effect of ethanol and cocaine on [11C]MPC-6827 uptake in SH-SY5Y cells. Molecular Biology Reports. 48(4). 3871–3876. 11 indexed citations

16.

Musi, Nicolas, et al.. (2018). Tau protein aggregation is associated with cellular senescence in the brain. Aging Cell. 17(6). e12840–e12840. 415 indexed citations breakdown →

17.

Triplett, Judy C., Antonella Tramutola, Aaron M. Swomley, et al.. (2015). Age-related changes in the proteostasis network in the brain of the naked mole-rat: Implications promoting healthy longevity. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1852(10). 2213–2224. 54 indexed citations

18.

Orr, Miranda E., et al.. (2014). Sustained high levels of neuroprotective, high molecular weight, phosphorylated tau in the longest-lived rodent. Neurobiology of Aging. 36(3). 1496–1504. 28 indexed citations

19.

George, Lynn, et al.. (2013). Familial dysautonomia model reveals Ikbkap deletion causes apoptosis of Pax3 ⁺ progenitors and peripheral neurons. Proceedings of the National Academy of Sciences. 110(46). 18698–18703. 60 indexed citations

20.

Orr, Miranda E., Rose Pitstick, Brenda Canine, Karen H. Ashe, & George A. Carlson. (2012). Genotype-Specific Differences between Mouse CNS Stem Cell Lines Expressing Frontotemporal Dementia Mutant or Wild Type Human Tau. PLoS ONE. 7(6). e39328–e39328. 7 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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