Miranda E. Orr

3.4k citations

54 papers · 2.2k indexed · 3 hit papers · h-index 22

Impact in

Aging top 1%
- Genetics, Aging, and Longevity in Model Organisms
Neurology top 2%
- Neuroinflammation and Neurodegeneration Mechanisms

Papers in ⓘ

Aging 9
- Genetics, Aging, and Longevity in Model Organisms 9
Neurology 15
- Neuroinflammation and Neurodegeneration Mechanisms 12

Co-authors: Salvatore Oddo (4 shared papers)Valentina R. Garbarino (9 shared papers)Nicolas Musi (7 shared papers)Joseph M. Valentine (2 shared papers)Bess Frost (3 shared papers)Eric Baeuerle (1 shared paper)Qiang Shen (1 shared paper)Rochelle Buffenstein (7 shared papers)
Journals: Alzheimer s & Dementia (11 papers)Neurobiology of Aging (3 papers)Life (2 papers)The Journal of Prevention of Alzheimer s Disease (2 papers)Aging Cell (2 papers)
Partner nations: United States Italy Australia

In The Last Decade

Miranda E. Orr

51 papers receiving 2.2k citations

Hit Papers

align trajectories log scale

Senolytic therapy in mild Alzheimer’s disease: a phase 1 feasibility trial 2023 · 149 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2023 Nature Medicine
2022 Journal of Clinical Investigation
2018 Aging Cell

Peers

Countries citing papers authored by Miranda E. Orr

Since Specialization

Citations

This map shows the geographic impact of Miranda E. Orr's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Miranda E. Orr with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Miranda E. Orr more than expected).

Fields of papers citing papers by Miranda E. Orr

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Miranda E. Orr. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Miranda E. Orr. The network helps show where Miranda E. Orr may publish in the future.

Co-authors

The 25 scholars most cited alongside Miranda E. Orr, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Miranda E. Orr Line = papers co-authored together Miranda E. Orr links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 54 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Tau protein aggregation is associated with cellular senescence in the brain Aging Cell ·Nicolas Musi, Joseph M. Valentine, Kathryn R. Sickora, Eric Baeuerle, Cody S. Thompson, Qiang Shen, Miranda E. Orr Hit paper breakdown →	2018	415
2	Biological aging processes underlying cognitive decline and neurodegenerative disease Journal of Clinical Investigation ·Mitzi M. Gonzales, Valentina R. Garbarino, Erin Pollet, Juan Pablo Palavicini, Dean L. Kellogg, Ellen Kraig, Miranda E. Orr Hit paper breakdown →	2022	190
3	A Brief Overview of Tauopathy: Causes, Consequences, and Therapeutic Strategies Trends in Pharmacological Sciences ·Miranda E. Orr, Anna Campbell Sullivan, Bess Frost	2017	166
4	Autophagic/lysosomal dysfunction in Alzheimer’s disease Alzheimer s Research & Therapy ·Miranda E. Orr, Salvatore Oddo	2013	156
5	Senolytic therapy in mild Alzheimer’s disease: a phase 1 feasibility trial Nature Medicine ·Mitzi M. Gonzales, Valentina R. Garbarino, Tiffany F. Kautz, Juan Pablo Palavicini, Marisa Lopez‐Cruzan, Shiva Kazempour Dehkordi, Julia Mathews, Habil Zare, Peng Xu, Bin Zhang, Crystal Franklin, Mohamad Habes, Suzanne Craft, Ronald C. Petersen, Tamar Tchkonia, James L. Kirkland, Arash Salardini, Sudha Seshadri, Nicolas Musi, Miranda E. Orr Hit paper breakdown →	2023	149
6	Senolytic Therapy to Modulate the Progression of Alzheimer's Disease (SToMP-AD): A Pilot Clinical Trial The Journal of Prevention of Alzheimer s Disease ·Mitzi M. Gonzales, Valentina R. Garbarino, Eduardo Zilli, Ronald C. Petersen, James L. Kirkland, Tamar Tchkonia, Nicolas Musi, Sudha Seshadri, Suzanne Craft, Miranda E. Orr	2021	137
7	Mechanisms of oxidative stress resistance in the brain: Lessons learned from hypoxia tolerant extremophilic vertebrates Archives of Biochemistry and Biophysics ·Valentina R. Garbarino, Miranda E. Orr, Karl A. Rodriguez, Rochelle Buffenstein	2015	76
8	The landscape of human tissue and cell type specific expression and co-regulation of senescence genes Molecular Neurodegeneration ·Peng Xu, Minghui Wang, Won‐Min Song, Qian Wang, Guo‐Cheng Yuan, Peter H. Sudmant, Habil Zare, Zhidong Tu, Miranda E. Orr, Bin Zhang	2022	72
9	Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology Neurobiology of Aging ·Miranda E. Orr, Angelica Salinas, Rochelle Buffenstein, Salvatore Oddo	2013	65
10	Familial dysautonomia model reveals Ikbkap deletion causes apoptosis of Pax3 ⁺ progenitors and peripheral neurons Proceedings of the National Academy of Sciences ·Lynn George, Martha Chaverra, Lindsey Wolfe, Julian Thorne, Mattheson Close-Davis, Amy Eibs, Vickie Riojas, Andrea Grindeland, Miranda E. Orr, George A. Carlson, Frances Lefcort	2013	60
11	Guidelines for bioinformatics of single-cell sequencing data analysis in Alzheimer’s disease: review, recommendation, implementation and application Molecular Neurodegeneration ·Minghui Wang, Won‐Min Song, Ming Chen, Qian Wang, Xianxiao Zhou, Peng Xu, Azra Krek, Yonejung Yoon, Lap Ho, Miranda E. Orr, Guo‐Cheng Yuan, Bin Zhang	2022	57
12	Age-related changes in the proteostasis network in the brain of the naked mole-rat: Implications promoting healthy longevity Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease ·Judy C. Triplett, Antonella Tramutola, Aaron M. Swomley, Jessime Kirk, Kelly M. Grimes, Kaitilyn N. Lewis, Miranda E. Orr, Karl A. Rodriguez, Jian Cai, Jon B. Klein, Marzia Perluigi, Rochelle Buffenstein, D. Allan Butterfield	2015	54
13	Pathogenic tau accelerates aging-associated activation of transposable elements in the mouse central nervous system Progress in Neurobiology ·Paulino Ramirez, Gabrielle Zuniga, Wenyan Sun, Adrian Beckmann, Elizabeth Ochoa, Sarah L. DeVos, Bradley T. Hyman, Gabriel S. Chiu, Ethan R. Roy, Wei Cao, Miranda E. Orr, Virginie Buggia-Prévot, William J. Ray, Bess Frost	2021	50
14	Accumulation of C-terminal fragments of transactive response DNA-binding protein 43 leads to synaptic loss and cognitive deficits in human TDP-43 transgenic mice Neurobiology of Aging ·David X. Medina, Miranda E. Orr, Salvatore Oddo	2013	43
15	The Cellular Senescence Stress Response in Post-Mitotic Brain Cells: Cell Survival at the Expense of Tissue Degeneration Life ·Eric Sah, Sudarshan Krishnamurthy, Mohamed Y. Ahmidouch, Gregory J. Gillispie, Carol Milligan, Miranda E. Orr	2021	39
16	The role ofFLO11inSaccharomyces cerevisiaebiofilm development in a laboratory based flow-cell system FEMS Yeast Research ·B. Purevdorj-Gage, Miranda E. Orr, Paul Stoodley, Kathy B. Sheehan, Linda E. Hyman	2007	37
17	Can oral health and oral‐derived biospecimens predict progression of dementia? Oral Diseases ·Miranda E. Orr, Kelly R. Reveles, Chih‐Ko Yeh, Eric H. Young, Xianlin Han	2019	35
18	Extended Postnatal Brain Development in the Longest-Lived Rodent: Prolonged Maintenance of Neotenous Traits in the Naked Mole-Rat Brain Frontiers in Neuroscience ·Miranda E. Orr, Valentina R. Garbarino, Angelica Salinas, Rochelle Buffenstein	2016	34
19	Differential protein expression in the hippocampi of resilient individuals identified by digital spatial profiling Acta Neuropathologica Communications ·Jamie M. Walker, Shiva Kazempour Dehkordi, Anna Fracassi, Alison VanSchoiack, Anna Pavenko, Giulio Taglialatela, Randall L. Woltjer, Timothy E. Richardson, Habil Zare, Miranda E. Orr	2022	31
20	Sustained high levels of neuroprotective, high molecular weight, phosphorylated tau in the longest-lived rodent Neurobiology of Aging ·Miranda E. Orr, Valentina R. Garbarino, Angelica Salinas, Rochelle Buffenstein	2014	28

About Miranda E. Orr

Miranda E. Orr is a scholar working on Aging, Neurology, Physiology, Biological Psychiatry and Endocrine and Autonomic Systems, having authored 54 papers that have together received 2.2k indexed citations. Recurring topics across this work include Alzheimer's disease research and treatments (22 papers), Telomeres, Telomerase, and Senescence (14 papers), Neuroinflammation and Neurodegeneration Mechanisms (12 papers), Genetics, Aging, and Longevity in Model Organisms (9 papers), Neuroscience and Neuropharmacology Research (5 papers), Mitochondrial Function and Pathology (5 papers), Microtubule and mitosis dynamics (4 papers) and Tryptophan and brain disorders (3 papers). The work is most often cited by research in Aging (252 citations), Neurology (484 citations), Biological Psychiatry (141 citations), Physiology (1.1k citations) and Endocrine and Autonomic Systems (117 citations). Miranda E. Orr has collaborated with scholars based in United States, Italy and Australia. Frequent co-authors include Salvatore Oddo, Valentina R. Garbarino, Nicolas Musi, Joseph M. Valentine, Bess Frost, Eric Baeuerle, Qiang Shen, Rochelle Buffenstein, Mitzi M. Gonzales and Juan Pablo Palavicini. Their work appears in journals such as Alzheimer s & Dementia, Neurobiology of Aging, Life, The Journal of Prevention of Alzheimer s Disease and Aging Cell.

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