Huaxi Xu

29.6k citations

195 papers · 21.4k indexed · 8 hit papers · h-index 75

Physiology top 0.05%
Molecular Biology top 0.5%
Neurology top 0.05%
Cellular and Molecular Neuroscience top 0.2%
Pharmacology top 0.1%

Co-authors: Guojun Bu Takahisa Kanekiyo Yun‐wu Zhang Chia‐Chen Liu Paul Greengard Gunnar K. Gouras Han Zhang Yingjun Zhao
Topics: Alzheimer's disease research and treatments (113 papers)Neuroinflammation and Neurodegeneration Mechanisms (35 papers)Cellular transport and secretion (31 papers)
Cited by: Neurology Biological Psychiatry Physiology
Journals: Proceedings of the National Academy of Sciences Journal of Biological Chemistry Journal of Clinical Investigation
Partner nations: United States China Japan

In The Last Decade

Huaxi Xu

194 papers receiving 21.0k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

2013 2.4k citations Chia‐Chen Liu, Takahisa Kanekiyo et al. Nature Reviews Neurology profile →
Intraneuronal Aβ42 Accumulation in Human Brain

2000 833 citations Gunnar K. Gouras, Mark Edgar et al. American Journal Of Pathology profile →
APP processing in Alzheimer's disease

2011 715 citations Yun‐wu Zhang, Han Zhang et al. profile →
Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease

2020 636 citations Timothy Y. Huang, Huaxi Xu et al. Molecular Neurodegeneration profile →
Intraneuronal Alzheimer Aβ42 Accumulates in Multivesicular Bodies and Is Associated with Synaptic Pathology

2002 583 citations Reisuke H. Takahashi, Teresa A. Milner et al. American Journal Of Pathology profile →
TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function

2018 519 citations Yingjun Zhao, Xilin Wu et al. Neuron profile →
ApoE and Aβ in Alzheimer’s Disease: Accidental Encounters or Partners?

2014 458 citations Takahisa Kanekiyo, Huaxi Xu et al. Neuron profile →
Oligomeric Aβ-induced synaptic dysfunction in Alzheimer’s disease

2014 448 citations Huaxi Xu et al. Molecular Neurodegeneration profile →

Peers

Countries citing papers authored by Huaxi Xu

Since Specialization

Citations

This map shows the geographic impact of Huaxi Xu's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Huaxi Xu with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Huaxi Xu more than expected).

Fields of papers citing papers by Huaxi Xu

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Huaxi Xu. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Huaxi Xu. The network helps show where Huaxi Xu may publish in the future.

Co-authorship network of co-authors of Huaxi Xu

This figure shows the co-authorship network connecting the top 25 collaborators of Huaxi Xu. A scholar is included among the top collaborators of Huaxi Xu based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Huaxi Xu. Huaxi Xu is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Loss of RAB39B does not alter MPTP-induced Parkinson’s disease-like phenotypes in mice 2023 ·Frontiers in Aging Neuroscience ·Zijie Wang,(unknown),Yiru Jiang,Yong Wang,(unknown),Chong Wang,Hong Luo,Huaxi Xu,Jingwen Li,Yun‐wu Zhang,Xian Zhang	2
2	Cntnap4 partial deficiency exacerbates α-synuclein pathology through astrocyte–microglia C3-C3aR pathway 2023 ·Cell Death and Disease ·Wenlong Zhang,Liuyan Ding,Huaqing Chen,Mengran Zhang,Runfang Ma,Shaohui Zheng,Junwei Gong,Zhiling Zhang,Huaxi Xu,Pingyi Xu,Yunlong Zhang	29
3	Minocycline protects against microgliopathy in a Csf1r haplo-insufficient mouse model of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) 2023 ·Journal of Neuroinflammation ·Xin Li,(unknown),(unknown),(unknown),Yuhang Zhou,Hao Sun,Xian Zhang,Yanfang Li,Xiaohua Huang,Yingjun Zhao,(unknown),Huaxi Xu,Yun‐wu Zhang,Zhanxiang Wang,Honghua Zheng	13
4	A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer’s disease 2022 ·Science Translational Medicine ·Peng Zhao,Yuanzhong Xu,Lu-Lin Jiang,Xuejun Fan,Leike Li,Xin Li,Hisashi Arase,Yingjun Zhao,Wei Cao,Hui Zheng,Huaxi Xu,Qingchun Tong,Ningyan Zhang,Zhiqiang An	92
5	GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer’s disease 2021 ·The Journal of Experimental Medicine ·Peng Xu,Jerry C. Chang,Xiaopu Zhou,Wei Wang,(unknown),Eitan Wong,Karima Bettayeb,Lu-Lin Jiang,Timothy Y. Huang,Wenjie Luo,Huaxi Xu,Angus C. Nairn,Marc Flajolet,Nancy Y. Ip,Yue‐Ming Li,Paul Greengard	23
6	4,4′-Dimethoxychalcone regulates redox homeostasis by targeting riboflavin metabolism in Parkinson's disease therapy 2021 ·Free Radical Biology and Medicine ·Junwei Gong,Wenlong Zhang,Liuyan Ding,Mengran Zhang,Shaohui Zheng,Runfang Ma,Junyuan Tang,Wei Yi,Huaxi Xu,Yunlong Zhang	12
7	β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade 2020 ·Science Translational Medicine ·Fang Zhang,Mary Gannon,Yunjia Chen,(unknown),Sixue Zhang,Wendy Feng,Jiahui Tao,Bingdong Sha,Zhenghui Liu,Takashi Saito,Takaomi C. Saido,C. Dirk Keene,Kai Jiao,Erik D. Roberson,Huaxi Xu,Qin Wang	99
8	Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72 2020 ·Nature Neuroscience ·Qiang Zhu,Jie Jiang,Tania F. Gendron,Melissa McAlonis‐Downes,Lu-Lin Jiang,Amy E. Taylor,(unknown),Somasish Ghosh Dastidar,María José Gómez-Rodríguez,Patrick King,Yong‐Jie Zhang,Albert R. La Spada,Huaxi Xu,Leonard Petrucelli,John Ravits,Sandrine Da Cruz,Clotilde Lagier‐Tourenne,Don W. Cleveland	155
9	Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2) 2018 ·Molecular Neurodegeneration ·Li Zhong,Zongqi Wang,Daxin Wang,Zhe Wang,Yuka A. Martens,(unknown),Ying Xu,Kai Wang,Jianguo Li,(unknown),Dan Can,Huaxi Xu,Guojun Bu,Xiao‐Fen Chen	130
10	TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Functionbreakdown → 2018 ·Neuron ·Yingjun Zhao,Xilin Wu,Xiaoguang Li,Lu-Lin Jiang,Xun Gui,Yan Liu,Yu Sun,Bing Zhu,Juan Piña-Crespo,Muxian Zhang,Ningyan Zhang,Xiaochun Chen,Guojun Bu,Zhiqiang An,Timothy Y. Huang,Huaxi Xu	519
11	Synaptic Adhesion Molecule Pcdh-γC5 Mediates Synaptic Dysfunction in Alzheimer's Disease 2017 ·Journal of Neuroscience ·Yanfang Li,Zhicai Chen,Yue Gao,(unknown),Honghua Zheng,Yun‐wu Zhang,Huaxi Xu,Guojun Bu,Hui Zheng	25
12	Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapybreakdown → 2013 ·Nature Reviews Neurology ·Chia‐Chen Liu,Takahisa Kanekiyo,Huaxi Xu,Guojun Bu	2379
13	Rac1 signalling mediates doxorubicin-induced cardiotoxicity through both reactive oxygen species-dependent and -independent pathways 2012 ·Cardiovascular Research ·Jian Ma,(unknown),Zheng Dong,Wei Meng,Huaxi Xu,Tianqing Peng	114
14	Presenilin/γ-secretase-dependent processing of β-amyloid precursor protein regulates EGF receptor expression 2007 ·Proceedings of the National Academy of Sciences ·Yun‐wu Zhang,Ruishan Wang,Qiang Liu,Han Zhang,Francesca‐Fang Liao,Huaxi Xu	131
15	Estrogen, β‐Amyloid Metabolism/Trafficking, and Alzheimer's Disease 2006 ·Annals of the New York Academy of Sciences ·Huaxi Xu,Ruishan Wang,Yun‐wu Zhang,Xue Zhang	60
16	Inhibition of amyloid-beta aggregation and caspase-3 activation by the Ginkgo biloba extract EGb761. 2002 ·Neurobiology of Aging ·Yuan Luo,Julie V Smith,(unknown),(unknown),Kenneth J. Curry,(unknown),(unknown),(unknown),Huaxi Xu,Peter Butko	21
17	Intraneuronal Alzheimer Aβ42 Accumulates in Multivesicular Bodies and Is Associated with Synaptic Pathologybreakdown → 2002 ·American Journal Of Pathology ·Reisuke H. Takahashi,Teresa A. Milner,Feng Li,(unknown),Mark Edgar,Haruyasu Yamaguchi,M. Flint Beal,Huaxi Xu,Paul Greengard,Gunnar K. Gouras	583
18	Estrogen Lowers Alzheimer β-Amyloid Generation by Stimulating trans-Golgi Network Vesicle Biogenesis 2002 ·Journal of Biological Chemistry ·Jeffrey P. Greenfield,Lawrence W. Leung,Dongming Cai,Krista Kaasik,Rachel S. Gross,Enrique Rodríguez-Boulan,Paul Greengard,Huaxi Xu	113
19	Transforming Growth Factor β Activates Smad2 in the Absence of Receptor Endocytosis 2002 ·Journal of Biological Chemistry ·Zhongxian Lu,James T. Murray,Wenjie Luo,Hongling Li,Xiaoping Wu,Huaxi Xu,Jonathan Backer,(unknown)	74
20	Stimulation of β-Amyloid Precursor Protein Trafficking by Insulin Reduces Intraneuronal β-Amyloid and Requires Mitogen-Activated Protein Kinase Signaling 2001 ·Journal of Neuroscience ·Laura Gasparini,Gunnar K. Gouras,Rong Wang,Rachel S. Gross,M. Flint Beal,Paul Greengard,Huaxi Xu	417

About Huaxi Xu

Huaxi Xu is a scholar working on Neurology, Physiology and Cell Biology, having authored 195 papers that have together received 21.4k indexed citations. Recurring topics across this work include Alzheimer's disease research and treatments (113 papers), Neuroinflammation and Neurodegeneration Mechanisms (35 papers) and Cellular transport and secretion (31 papers). The work is most often cited by research in Neurology (4.7k citations), Biological Psychiatry (1.2k citations) and Physiology (11.9k citations). Huaxi Xu has collaborated with scholars based in United States, China and Japan. Frequent co-authors include Guojun Bu, Takahisa Kanekiyo, Yun‐wu Zhang, Chia‐Chen Liu, Paul Greengard, Gunnar K. Gouras, Han Zhang, Yingjun Zhao, Timothy Y. Huang and Laura Gasparini. Their work appears in journals such as Proceedings of the National Academy of Sciences, Journal of Biological Chemistry and Journal of Clinical Investigation.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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