Huaxi Xu

29.6k total citations · 8 hit papers
195 papers, 21.4k citations indexed

About

Huaxi Xu is a scholar working on Physiology, Molecular Biology and Cell Biology. According to data from OpenAlex, Huaxi Xu has authored 195 papers receiving a total of 21.4k indexed citations (citations by other indexed papers that have themselves been cited), including 118 papers in Physiology, 76 papers in Molecular Biology and 45 papers in Cell Biology. Recurrent topics in Huaxi Xu's work include Alzheimer's disease research and treatments (113 papers), Neuroinflammation and Neurodegeneration Mechanisms (35 papers) and Cellular transport and secretion (31 papers). Huaxi Xu is often cited by papers focused on Alzheimer's disease research and treatments (113 papers), Neuroinflammation and Neurodegeneration Mechanisms (35 papers) and Cellular transport and secretion (31 papers). Huaxi Xu collaborates with scholars based in United States, China and Japan. Huaxi Xu's co-authors include Guojun Bu, Takahisa Kanekiyo, Yun‐wu Zhang, Chia‐Chen Liu, Paul Greengard, Gunnar K. Gouras, Han Zhang, Yingjun Zhao, Timothy Y. Huang and Laura Gasparini and has published in prestigious journals such as Proceedings of the National Academy of Sciences, Journal of Biological Chemistry and Journal of Clinical Investigation.

In The Last Decade

Huaxi Xu

194 papers receiving 21.0k citations

Hit Papers

align trajectories sort by overperformance

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

2013 2.4k citations Chia‐Chen Liu, Takahisa Kanekiyo et al. Nature Reviews Neurology profile →
Intraneuronal Aβ42 Accumulation in Human Brain

2000 833 citations Gunnar K. Gouras, Mark Edgar et al. American Journal Of Pathology profile →
APP processing in Alzheimer's disease

2011 715 citations Yun‐wu Zhang, Han Zhang et al. profile →
Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease

2020 636 citations Denghong Zhang, Timothy Y. Huang et al. Molecular Neurodegeneration profile →
Intraneuronal Alzheimer Aβ42 Accumulates in Multivesicular Bodies and Is Associated with Synaptic Pathology

2002 583 citations Reisuke H. Takahashi, Teresa A. Milner et al. American Journal Of Pathology profile →
TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function

2018 519 citations Yingjun Zhao, Xilin Wu et al. Neuron profile →
ApoE and Aβ in Alzheimer’s Disease: Accidental Encounters or Partners?

2014 458 citations Takahisa Kanekiyo, Huaxi Xu et al. Neuron profile →
Oligomeric Aβ-induced synaptic dysfunction in Alzheimer’s disease

2014 448 citations Huaxi Xu et al. Molecular Neurodegeneration profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Huaxi Xu United States	75	11.9k	8.3k	4.7k	3.5k	2.9k	195	21.4k
Chad A. Dickey United States	54	10.1k 0.8×	8.2k 1.0×	3.7k 0.8×	3.5k 1.0×	2.2k 0.8×	119	17.9k
Guojun Bu United States	101	14.8k 1.2×	12.1k 1.5×	6.8k 1.5×	4.6k 1.3×	2.4k 0.8×	336	30.8k
Marcia N. Gordon United States	54	14.5k 1.2×	6.9k 0.8×	6.2k 1.3×	4.8k 1.4×	3.2k 1.1×	135	20.7k
Sam Gandy United States	74	13.2k 1.1×	8.1k 1.0×	2.8k 0.6×	3.7k 1.1×	3.3k 1.2×	292	21.5k
Thomas Wısnıewskı United States	76	11.7k 1.0×	8.8k 1.1×	4.0k 0.9×	3.4k 1.0×	2.3k 0.8×	389	20.5k
Cynthia A. Lemere United States	59	11.6k 1.0×	6.1k 0.7×	5.9k 1.3×	3.1k 0.9×	2.5k 0.9×	130	17.4k
Dave Morgan United States	47	12.0k 1.0×	5.8k 0.7×	5.5k 1.2×	4.0k 1.2×	2.6k 0.9×	106	17.8k
Todd E. Golde United States	94	18.8k 1.6×	14.2k 1.7×	5.4k 1.2×	5.7k 1.6×	5.3k 1.8×	314	32.1k
Hui Zheng United States	73	8.4k 0.7×	7.2k 0.9×	3.0k 0.6×	3.3k 1.0×	2.1k 0.7×	165	17.1k
Cheng‐Xin Gong United States	70	9.5k 0.8×	7.5k 0.9×	2.5k 0.5×	3.3k 1.0×	2.4k 0.8×	170	16.0k

Countries citing papers authored by Huaxi Xu

Since Specialization

Citations

This map shows the geographic impact of Huaxi Xu's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Huaxi Xu with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Huaxi Xu more than expected).

Fields of papers citing papers by Huaxi Xu

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Huaxi Xu. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Huaxi Xu. The network helps show where Huaxi Xu may publish in the future.

Co-authorship network of co-authors of Huaxi Xu

This figure shows the co-authorship network connecting the top 25 collaborators of Huaxi Xu. A scholar is included among the top collaborators of Huaxi Xu based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Huaxi Xu. Huaxi Xu is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Zhang, Denghong, Ming Chen, Xuheng Gao, et al.. (2024). P-tau217 correlates with neurodegeneration in Alzheimer’s disease, and targeting p-tau217 with immunotherapy ameliorates murine tauopathy. Neuron. 112(10). 1676–1693.e12. 29 indexed citations

Zhang, Wenlong, Liuyan Ding, Mengran Zhang, et al.. (2023). Dietary intake of α-ketoglutarate ameliorates α-synuclein pathology in mouse models of Parkinson’s disease. Cellular and Molecular Life Sciences. 80(6). 155–155. 16 indexed citations

Li, Xin, Yuhang Zhou, Hao Sun, et al.. (2023). Minocycline protects against microgliopathy in a Csf1r haplo-insufficient mouse model of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP). Journal of Neuroinflammation. 20(1). 134–134. 13 indexed citations

Zhang, Wenlong, Liuyan Ding, Huaqing Chen, et al.. (2023). Cntnap4 partial deficiency exacerbates α-synuclein pathology through astrocyte–microglia C3-C3aR pathway. Cell Death and Disease. 14(4). 285–285. 29 indexed citations

Zhang, Hongsheng, Zhihao Lin, Quanxin Long, et al.. (2022). APOE interacts with ACE2 inhibiting SARS-CoV-2 cellular entry and inflammation in COVID-19 patients. Signal Transduction and Targeted Therapy. 7(1). 261–261. 40 indexed citations

Zhao, Peng, Yuanzhong Xu, Lu-Lin Jiang, et al.. (2022). A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer’s disease. Science Translational Medicine. 14(661). eabq0095–eabq0095. 92 indexed citations

Xu, Peng, Jerry C. Chang, Xiaopu Zhou, et al.. (2021). GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer’s disease. The Journal of Experimental Medicine. 218(8). 23 indexed citations

Gong, Junwei, Wenlong Zhang, Liuyan Ding, et al.. (2021). 4,4′-Dimethoxychalcone regulates redox homeostasis by targeting riboflavin metabolism in Parkinson's disease therapy. Free Radical Biology and Medicine. 174. 40–56. 12 indexed citations

Zhang, Fang, Mary Gannon, Yunjia Chen, et al.. (2020). β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade. Science Translational Medicine. 12(526). 99 indexed citations

10.

Zhu, Qiang, Jie Jiang, Tania F. Gendron, et al.. (2020). Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72. Nature Neuroscience. 23(5). 615–624. 155 indexed citations

11.

Zhao, Yingjun, Xilin Wu, Xiaoguang Li, et al.. (2018). TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function. Neuron. 97(5). 1023–1031.e7. 519 indexed citations breakdown →

12.

Zhong, Li, Zongqi Wang, Daxin Wang, et al.. (2018). Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2). Molecular Neurodegeneration. 13(1). 15–15. 130 indexed citations

13.

Li, Yanfang, Zhicai Chen, Yue Gao, et al.. (2017). Synaptic Adhesion Molecule Pcdh-γC5 Mediates Synaptic Dysfunction in Alzheimer's Disease. Journal of Neuroscience. 37(38). 9259–9268. 25 indexed citations

14.

Liu, Chia‐Chen, Takahisa Kanekiyo, Huaxi Xu, & Guojun Bu. (2013). Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy. Nature Reviews Neurology. 9(2). 106–118. 2379 indexed citations breakdown →

15.

Zhang, Yun‐wu, Ruishan Wang, Qiang Liu, et al.. (2007). Presenilin/γ-secretase-dependent processing of β-amyloid precursor protein regulates EGF receptor expression. Proceedings of the National Academy of Sciences. 104(25). 10613–10618. 131 indexed citations

16.

Xu, Huaxi, Ruishan Wang, Yun‐wu Zhang, & Xue Zhang. (2006). Estrogen, β‐Amyloid Metabolism/Trafficking, and Alzheimer's Disease. Annals of the New York Academy of Sciences. 1089(1). 324–342. 60 indexed citations

17.

Greenfield, Jeffrey P., Lawrence W. Leung, Dongming Cai, et al.. (2002). Estrogen Lowers Alzheimer β-Amyloid Generation by Stimulating trans-Golgi Network Vesicle Biogenesis. Journal of Biological Chemistry. 277(14). 12128–12136. 113 indexed citations

18.

Takahashi, Reisuke H., Teresa A. Milner, Feng Li, et al.. (2002). Intraneuronal Alzheimer Aβ42 Accumulates in Multivesicular Bodies and Is Associated with Synaptic Pathology. American Journal Of Pathology. 161(5). 1869–1879. 583 indexed citations breakdown →

19.

Luo, Yuan, et al.. (2002). Inhibition of amyloid-beta aggregation and caspase-3 activation by the Ginkgo biloba extract EGb761.. Neurobiology of Aging. 99(19). 12197–202. 21 indexed citations

20.

Gasparini, Laura, Gunnar K. Gouras, Rong Wang, et al.. (2001). Stimulation of β-Amyloid Precursor Protein Trafficking by Insulin Reduces Intraneuronal β-Amyloid and Requires Mitogen-Activated Protein Kinase Signaling. Journal of Neuroscience. 21(8). 2561–2570. 417 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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